Publications by authors named "Elmar Kirches"

44Publications

Loss of PTPRJ/DEP-1 enhances NF2/Merlin-dependent meningioma development.

J Neurol Sci 2020 Jan 9;408:116553. Epub 2019 Nov 9.

Department of Neuropathology, Otto-von-Guericke-University, D-39120 Magdeburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.116553DOI Listing
January 2020

Mitoferrin-1 is required for brain energy metabolism and hippocampus-dependent memory.

Neurosci Lett 2019 11 26;713:134521. Epub 2019 Sep 26.

Institute of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2019.134521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254743PMC
November 2019

The expression of the MSC-marker CD73 and of NF2/Merlin are correlated in meningiomas.

J Neurooncol 2018 Jun 21;138(2):251-259. Epub 2018 Feb 21.

Institute of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1007/s11060-018-2807-7DOI Listing
June 2018

ASA404, a vascular disrupting agent, as an experimental treatment approach for brain tumors.

Oncol Lett 2017 Nov 28;14(5):5443-5451. Epub 2017 Aug 28.

Institute of Neurology (Edinger-Institute), Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.3892/ol.2017.6832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652230PMC
November 2017

MtDNA As a Cancer Marker: A Finally Closed Chapter?

Authors:
Elmar Kirches

Curr Genomics 2017 Jun;18(3):255-267

Otto-von-Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.2174/1389202918666170105093635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476953PMC
June 2017

Frequent AKT1E17K mutations in skull base meningiomas are associated with mTOR and ERK1/2 activation and reduced time to tumor recurrence.

Neuro Oncol 2017 Aug;19(8):1088-1096

Departments of Neuropathology and Biometry and Medical Informatics, Otto-von-Guericke University, Magdeburg,Germany; Departments of Neuropathology and Neurosurgery, Hannover Medical School, Hannover, Germany; Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany; Department of Neurosurgery, Krankenhaus Köln MerheimKliniken der Stadt Köln gGmbH, University of Witten/Herdecke, Köln, Germany; Center for Behavioural Brain Sciences, Magdeburg,Germany.

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http://dx.doi.org/10.1093/neuonc/nox018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570238PMC
August 2017

Receptor tyrosine kinase inhibition by regorafenib/sorafenib inhibits growth and invasion of meningioma cells.

Eur J Cancer 2017 03 9;73:9-21. Epub 2017 Jan 9.

Department of Neuropathology & Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.12.004DOI Listing
March 2017

Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model.

Front Behav Neurosci 2015 20;9:58. Epub 2015 Mar 20.

Institute of Physiology, Medical Faculty, Otto-von-Guericke-University Magdeburg Magdeburg, Germany ; Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke University Magdeburg Magdeburg, Germany.

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http://dx.doi.org/10.3389/fnbeh.2015.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367180PMC
April 2015

Survival in granular cell astrocytomas.

J Neurol Surg A Cent Eur Neurosurg 2015 Jan 29;76(1):30-8. Epub 2014 Jul 29.

Department of Neurosurgery, Otto von Guericke-University, Magdeburg, Germany.

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http://dx.doi.org/10.1055/s-0034-1382781DOI Listing
January 2015

Re-evaluation of cytostatic therapies for meningiomas in vitro.

J Cancer Res Clin Oncol 2014 Aug 11;140(8):1343-52. Epub 2014 May 11.

Department of Neuropathology, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany.

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http://link.springer.com/10.1007/s00432-014-1683-6
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http://dx.doi.org/10.1007/s00432-014-1683-6DOI Listing
August 2014

The integrin inhibitor cilengitide affects meningioma cell motility and invasion.

Clin Cancer Res 2013 Oct 15;19(19):5402-12. Epub 2013 Aug 15.

Authors' Affiliations: Departments of Neuropathology, Neurosurgery and Radiotherapy, Otto vonGuericke University; Neurosurgery, City Hospital; Special Lab for Non-Invasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg; Neurosurgery, Paracelsus Hospital, Zwickau; and Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0299DOI Listing
October 2013

mTORC1 inhibitors suppress meningioma growth in mouse models.

Clin Cancer Res 2013 Mar 13;19(5):1180-9. Epub 2013 Feb 13.

Department of Neuropathology and Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1904DOI Listing
March 2013

Adhesion molecule expression precedes brain damages of lupus-prone mice and correlates with kidney pathology.

J Neuroimmunol 2012 Nov 20;252(1-2):24-32. Epub 2012 Aug 20.

Department of Neuropathology, Otto-von-Guericke-University, Magdeburg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01655728120022
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http://dx.doi.org/10.1016/j.jneuroim.2012.07.011DOI Listing
November 2012

Sunitinib targets PDGF-receptor and Flt3 and reduces survival and migration of human meningioma cells.

Eur J Cancer 2012 Aug 3;48(12):1831-41. Epub 2012 Mar 3.

Department of Neuropathology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049120009
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http://dx.doi.org/10.1016/j.ejca.2012.01.032DOI Listing
August 2012

Dual role of the mitochondrial protein frataxin in astrocytic tumors.

Lab Invest 2011 Dec 22;91(12):1766-76. Epub 2011 Aug 22.

Department of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1038/labinvest.2011.130DOI Listing
December 2011

Cytotoxic effect of different statins and thiazolidinediones on malignant glioma cells.

Cancer Chemother Pharmacol 2011 May 1;67(5):1193-201. Epub 2010 Dec 1.

Department of Neurosurgery, Otto von Guericke University Magdeburg, Magdeburg, Germany.

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http://link.springer.com/10.1007/s00280-010-1535-2
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http://dx.doi.org/10.1007/s00280-010-1535-2DOI Listing
May 2011

Cytotoxic effects of statins and thiazolidinediones on meningioma cells.

J Neurooncol 2011 May 30;102(3):383-93. Epub 2010 Aug 30.

Department of Neuropathology, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.

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http://link.springer.com/10.1007/s11060-010-0351-1
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http://dx.doi.org/10.1007/s11060-010-0351-1DOI Listing
May 2011

Unusual presentations of patients with the mitochondrial MERRF mutation A8344G.

Clin Neurol Neurosurg 2008 Sep 26;110(8):859-63. Epub 2008 Jul 26.

Klinik für Neurologie, Otto-von-Guericke Universität, D-39120 Magdeburg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S030384670800213
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http://dx.doi.org/10.1016/j.clineuro.2008.06.010DOI Listing
September 2008

Minocycline, a possible neuroprotective agent in Leber's hereditary optic neuropathy (LHON): studies of cybrid cells bearing 11,778 mutation.

Neurobiol Dis 2007 Dec 28;28(3):237-50. Epub 2007 Jul 28.

Institute of Medical Neurobiology, Otto-von-Guericke University of Magdeburg, Leipziger Strasse 44, D-39120 Magdeburg, Germany.

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http://dx.doi.org/10.1016/j.nbd.2007.07.021DOI Listing
December 2007

Intraventricular meningioma with fatal haemorrhage: clinical and autopsy findings.

Clin Neurol Neurosurg 2007 Dec 30;109(10):884-7. Epub 2007 Aug 30.

Abteilung für Neuropathologie, Friedrich-Schiller-Universität, D-07747 Jena, Germany.

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http://dx.doi.org/10.1016/j.clineuro.2007.07.016DOI Listing
December 2007

Novel chromosomal aberrations in a recurrent malignant meningioma.

Cancer Genet Cytogenet 2007 Apr;174(1):48-53

Department of Human Genetics, Otto-von-Guericke University, Leipziger Strasse 44, D-39120 Magdeburg, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2006.10.008DOI Listing
April 2007

Expression of transforming growth factor-beta receptor type 1 and type 2 in human sporadic vestibular Schwannoma.

Pathol Res Pract 2007 20;203(4):245-9. Epub 2007 Feb 20.

Department of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1016/j.prp.2006.12.007DOI Listing
July 2007

Evaluation of molecular genetic alterations associated with tumor progression in a case of gliomatosis cerebri.

J Neurooncol 2007 Mar 6;82(1):23-7. Epub 2006 Sep 6.

Department of Neuropathology, Otto-von-Guericke-University, Leipziger Str 44, D-39120, Magdeburg, Germany.

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http://link.springer.com/10.1007/s11060-006-9245-7
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http://dx.doi.org/10.1007/s11060-006-9245-7DOI Listing
March 2007

Analysis of a single nucleotide polymorphism in codon 388 of the FGFR4 gene in malignant gliomas.

Cancer Lett 2006 Aug 29;239(2):239-45. Epub 2005 Sep 29.

Department of Neuropathology, Otto-von-Guericke-University, Leipziger Strasse 44, D-39120 Magdeburg, Germany.

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http://dx.doi.org/10.1016/j.canlet.2005.08.013DOI Listing
August 2006

June 2004: a male in his late 60s with recurrent extracerebral tumor.

Brain Pathol 2004 Oct;14(4):457-9

Department of Neuropathology, University of Magdeburg Medical School, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2004.tb00092.xDOI Listing
October 2004

Single-cell analysis of mtDNA deletion levels in sporadic amyotrophic lateral sclerosis.

Neuroreport 2004 Apr;15(6):939-43

Department of Neuropathology, Otto-von-Guericke-University, Leipziger Strasse 44, D-39120 Magdeburg, Germany.

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http://dx.doi.org/10.1097/00001756-200404290-00002DOI Listing
April 2004

Region-specific analysis of mitochondrial DNA deletions in neurodegenerative disorders in humans.

Neurosci Lett 2004 Mar;357(2):111-4

Department of Neuropathology, Otto-von-Guericke-University, Leipziger Strasse 44, D-39120 Magdeburg, Germany.

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http://dx.doi.org/10.1016/j.neulet.2003.11.073DOI Listing
March 2004

Single-cell analysis of mtDNA in amyotrophic lateral sclerosis: towards the characterization of individual neurons in neurodegenerative disorders.

Pathol Res Pract 2003 ;199(6):415-8

Department of Neuropathology, Otto-von-Guericke-University, Magdeburg, Germany.

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http://dx.doi.org/10.1078/0344-0338-00439DOI Listing
September 2003

Prognostic relevance of MAPK expression in glioblastoma multiforme.

Int J Oncol 2003 Sep;23(3):641-8

Department of Neuropathology, Otto-von-Guericke-University, D-39120 Magdeburg, Germany.

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September 2003

Expression pattern of apoptotic markers in vestibular schwannomas.

Pathol Res Pract 2002 ;198(12):813-9

Department of Neuropathology, Otto-von-Guericke-University, Magdeburg, Germany.

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http://dx.doi.org/10.1078/0344-0338-00340DOI Listing
August 2003

Distribution of p53 alterations in a case of gliomatosis cerebri.

Hum Pathol 2003 Jan;34(1):102-6

Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1053/hupa.2003.1DOI Listing
January 2003

Post-traumatic atrophy of the olfactory tract: clinicopathological features.

Adv Clin Path 2002 Jul-Oct;6(3-4):113-8

Department of Neuropathology, Otto-von-Guericke-University, Leipziger Strasse 44, 39120 Magdeburg, Germany.

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September 2009

Immunohistochemical and molecular analysis of p53, RB, and PTEN in malignant peripheral nerve sheath tumors.

Virchows Arch 2002 Jun 16;440(6):610-5. Epub 2001 Nov 16.

Department of Neuropathology, Otto-von-Guericke-University, Magdeburg, Germany.

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http://link.springer.com/10.1007/s00428-001-0550-4
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http://dx.doi.org/10.1007/s00428-001-0550-4DOI Listing
June 2002

Primary primitive neuroectodermal tumor of the spinal cord: case report and review of the literature.

Clin Neurol Neurosurg 2002 Jan;104(1):36-40

Department of Neuropathology, Otto-von-Guericke-University, Leipziger Strasse 44, D-39120, Magdeburg, Germany.

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http://dx.doi.org/10.1016/s0303-8467(01)00171-8DOI Listing
January 2002