Publications by authors named "Elly M Hol"

100Publications

Viscoelastic mapping of mouse brain tissue: Relation to structure and age.

J Mech Behav Biomed Mater 2020 Oct 28;113:104159. Epub 2020 Oct 28.

Department of Physics and Astronomy and LaserLaB, VU Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jmbbm.2020.104159DOI Listing
October 2020

Denser brain capillary network with preserved pericytes in Alzheimer's disease.

Brain Pathol 2020 Sep 2. Epub 2020 Sep 2.

Laboratory of Molecular Psychiatry, Department of Neuropsychiatry, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1111/bpa.12897DOI Listing
September 2020

A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells.

Brain Behav Immun 2020 Nov 13;90:196-207. Epub 2020 Aug 13.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands; Mental Illness Research, Education and Clinical Center (MIRECC), James J Peters VA Medical Center, Bronx, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2020.08.012DOI Listing
November 2020

Cannabinoids and psychotic symptoms: A potential role for a genetic variant in the P2X purinoceptor 7 (P2RX7) gene.

Brain Behav Immun 2020 Aug 21;88:573-581. Epub 2020 Apr 21.

Department of Psychiatry, UMC Utrecht Brain Center, University Medical Centre Utrecht, Utrecht University, The Netherlands; Department of psychiatry, Icahn School of Medicine at Mount Sinai, New York City, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2020.04.051DOI Listing
August 2020

Complement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage.

Transl Stroke Res 2020 08 6;11(4):678-688. Epub 2019 Dec 6.

UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s12975-019-00757-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340633PMC
August 2020

From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation.

Transl Stroke Res 2020 08 28;11(4):601-614. Epub 2019 Nov 28.

Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s12975-019-00755-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340665PMC
August 2020

Microglial activation in schizophrenia: Is translocator 18 kDa protein (TSPO) the right marker?

Schizophr Res 2020 01 4;215:167-172. Epub 2019 Nov 4.

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584, CG, Utrecht, the Netherlands; Department of Psychiatry, Icahn School of Medicine, New York, USA; Mental Illness Research, Education and Clinical Center (MIRECC), James J Peters VA Medical Center, Bronx, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.10.045DOI Listing
January 2020

Increased number of T-lymphocytes in post-mortem brain tissue of patients with schizophrenia.

Schizophr Res 2020 02 29;216:526-528. Epub 2019 Oct 29.

Department of Psychiatry, Icahn School of Medicine, New York, USA; Mental Illness Research, Education and Clinical Center (MIRECC), James J Peters VA Medical Center, Bronx, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.10.032DOI Listing
February 2020

GFAP alternative splicing regulates glioma cell-ECM interaction in a DUSP4-dependent manner.

FASEB J 2019 11 31;33(11):12941-12959. Epub 2019 Aug 31.

Department of Translational Neurosciences, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1096/fj.201900916RDOI Listing
November 2019

Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease.

Acta Neuropathol Commun 2019 06 3;7(1):84. Epub 2019 Jun 3.

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s40478-019-0736-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545684PMC
June 2019

Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated.

Transl Psychiatry 2019 05 24;9(1):153. Epub 2019 May 24.

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584 CG, Utrecht, The Netherlands.

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http://www.nature.com/articles/s41398-019-0490-x
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http://dx.doi.org/10.1038/s41398-019-0490-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534632PMC
May 2019

DNA methylation changes related to nutritional deprivation: a genome-wide analysis of population and in vitro data.

Clin Epigenetics 2019 05 16;11(1):80. Epub 2019 May 16.

Brain Center University Medical Center Utrecht, Department of Psychiatry, Utrecht University, A01.468, PO Box 85500, 3508, GA, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s13148-019-0680-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524251PMC
May 2019

Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function.

Eur Neuropsychopharmacol 2019 05 15;29(5):643-652. Epub 2019 Mar 15.

Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2019.03.004DOI Listing
May 2019

Importance of GFAP isoform-specific analyses in astrocytoma.

Glia 2019 08 22;67(8):1417-1433. Epub 2019 Jan 22.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/glia.23594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617972PMC
August 2019

Microglia innately develop within cerebral organoids.

Nat Commun 2018 10 9;9(1):4167. Epub 2018 Oct 9.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University, P.O. Box 85500, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-018-06684-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177485PMC
October 2018

Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping.

Sci Rep 2018 08 21;8(1):12517. Epub 2018 Aug 21.

Department of Physics and Astronomy and LaserLab Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-31035-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104037PMC
August 2018

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo.

Cell Rep 2018 07;24(5):1203-1217.e6

Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Wytemaweg 80, 3015 CN Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.113DOI Listing
July 2018

Cell adhesion and matricellular support by astrocytes of the tripartite synapse.

Prog Neurobiol 2018 Jun - Aug;165-167:66-86. Epub 2018 Feb 11.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 XH Amsterdam, The Netherlands; Department of Neuroimmunology, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2018.02.002DOI Listing
February 2019

Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions.

Front Immunol 2017 21;8:1810. Epub 2017 Dec 21.

Neuroimmunology Research Group, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2017.01810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742619PMC
December 2017

Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin.

Cold Spring Harb Perspect Biol 2017 Dec 1;9(12). Epub 2017 Dec 1.

Center of Basic Research, Biomedical Research Foundation Academy of Athens, Athens 11527, Greece.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a021642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710105PMC
December 2017

GFAPδ/GFAPα ratio directs astrocytoma gene expression towards a more malignant profile.

Oncotarget 2017 Oct 4;8(50):88104-88121. Epub 2017 Oct 4.

Netherlands Institute for Neuroscience, an Institute of The Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.21540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675697PMC
October 2017

Characterization of macrophages from schizophrenia patients.

NPJ Schizophr 2017 Nov 14;3(1):41. Epub 2017 Nov 14.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), P.O. Box 85500, Heidelberglaan 100, 3508 GA, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41537-017-0042-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686077PMC
November 2017

Clinical and immunological characteristics of the spectrum of GFAP autoimmunity: a case series of 22 patients.

J Neurol Neurosurg Psychiatry 2018 02 26;89(2):138-146. Epub 2017 Sep 26.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2017-316583DOI Listing
February 2018

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease.

Neurobiol Aging 2017 07 27;55:115-122. Epub 2017 Mar 27.

Section Medical Physiology, Department of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.03.021DOI Listing
July 2017

The Indispensable Roles of Microglia and Astrocytes during Brain Development.

Front Hum Neurosci 2016 8;10:566. Epub 2016 Nov 8.

Swammerdam Institute for Life Sciences, University of AmsterdamAmsterdam, Netherlands; Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center UtrechtUtrecht, Netherlands; Netherlands Institute for NeuroscienceAmsterdam, Netherlands.

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http://dx.doi.org/10.3389/fnhum.2016.00566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099170PMC
November 2016

Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease.

Biochim Biophys Acta 2016 10 15;1862(10):1847-60. Epub 2016 Jul 15.

Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, The Netherlands; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.bbadis.2016.07.007DOI Listing
October 2016

GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions.

Cell Mol Life Sci 2016 11 3;73(21):4101-20. Epub 2016 May 3.

Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00018-016-2239-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043008PMC
November 2016

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease.

Prog Neurobiol 2016 09 12;144:121-41. Epub 2016 Jan 12.

Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 XH Amsterdam, The Netherlands; Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2016.01.001DOI Listing
September 2016

Astrocytes: a central element in neurological diseases.

Acta Neuropathol 2016 Mar 15;131(3):323-45. Epub 2015 Dec 15.

Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1007/s00401-015-1513-1DOI Listing
March 2016

Glial cell response after aneurysmal subarachnoid hemorrhage - Functional consequences and clinical implications.

Biochim Biophys Acta 2016 03 19;1862(3):492-505. Epub 2015 Oct 19.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands; Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 XH Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.10.013DOI Listing
March 2016

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis.

Acta Neuropathol Commun 2015 May 23;3:31. Epub 2015 May 23.

Department of Neuroscience, section Medical Physiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1186/s40478-015-0203-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489356PMC
May 2015

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells.

Int J Cancer 2015 Oct 7;137(7):1630-42. Epub 2015 Apr 7.

Department of Neurosurgery, Brain Center Rudolf Magnus Institute of Neurosciences, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/ijc.29521DOI Listing
October 2015

Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release.

J Immunol 2015 Apr 13;194(8):3623-33. Epub 2015 Mar 13.

Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, the Netherlands; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, the Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1401334DOI Listing
April 2015

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease.

Glia 2015 Jun 2;63(6):1036-56. Epub 2015 Mar 2.

Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience (NIN), An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands; Synaptic Plasticity & Behavior, Netherlands Institute for Neuroscience (NIN), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/glia.22800DOI Listing
June 2015

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system.

Curr Opin Cell Biol 2015 Feb 2;32:121-30. Epub 2015 Mar 2.

Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, SE-405 30 Gothenburg, Sweden; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09550674150001
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http://dx.doi.org/10.1016/j.ceb.2015.02.004DOI Listing
February 2015

Editorial overview: cell architecture: intermediate filaments - from molecules to patients.

Curr Opin Cell Biol 2015 Feb 6;32:v-vi. Epub 2015 Feb 6.

Institut Pasteur - CNRS UMR 3691, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux, 75724 Paris Cedex 15, France. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2015.01.007DOI Listing
February 2015

Activation of endogenous neural stem cells for multiple sclerosis therapy.

Front Neurosci 2014 20;8:454. Epub 2015 Jan 20.

Department of Astrocyte Biology and Neurodegeneration, The Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Sciences Amsterdam, Netherlands ; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht, Netherlands.

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http://dx.doi.org/10.3389/fnins.2014.00454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299409PMC
February 2015

The ubiquitin proteasome system in glia and its role in neurodegenerative diseases.

Front Mol Neurosci 2014 8;7:73. Epub 2014 Aug 8.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht, Netherlands ; Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences Amsterdam, Netherlands ; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam Netherlands.

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http://dx.doi.org/10.3389/fnmol.2014.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126450PMC
August 2014

Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network.

J Cell Sci 2014 Oct 15;127(Pt 20):4368-80. Epub 2014 Aug 15.

Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1090 GE Amsterdam, The Netherlands Department of Translational Neuroscience, Brain Center Rudolf Magus, University Medical Center Utrecht, Universiteitsweg 100, 3584 CX, Utrecht, The Netherlands

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http://dx.doi.org/10.1242/jcs.145912DOI Listing
October 2014

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction.

Neurobiol Aging 2014 Dec 14;35(12):2746-2760. Epub 2014 Jun 14.

Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands; Cellular and Systems Neurobiology, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, the Netherlands; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.06.004DOI Listing
December 2014

Aicardi-Goutières syndrome harbours abundant systemic and brain-reactive autoantibodies.

Ann Rheum Dis 2015 Oct 6;74(10):1931-9. Epub 2014 Jun 6.

Department of Experimental Immunology, Academic Medical Center, University of Amsterdam (UvA), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2014-205396DOI Listing
October 2015

Enteric GFAP expression and phosphorylation in Parkinson's disease.

J Neurochem 2014 Sep 6;130(6):805-15. Epub 2014 Jun 6.

Inserm U913, Nantes, France; University Nantes, Nantes, France; CHU Nantes, Institut des Maladies de l'Appareil Digestif, Nantes, France.

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http://dx.doi.org/10.1111/jnc.12742DOI Listing
September 2014

Silencing GFAP isoforms in astrocytoma cells disturbs laminin-dependent motility and cell adhesion.

FASEB J 2014 Jul 2;28(7):2942-54. Epub 2014 Apr 2.

Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands

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http://dx.doi.org/10.1096/fj.13-245837DOI Listing
July 2014

Isolation of neural progenitor cells from the human adult subventricular zone based on expression of the cell surface marker CD271.

Stem Cells Transl Med 2014 Apr 6;3(4):470-80. Epub 2014 Mar 6.

Department of Astrocyte Biology and Neurodegeneration, The Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Sciences, Amsterdam, The Netherlands; Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA; Department of Neuropathology, Academic Medical Center, Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.5966/sctm.2013-0038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973708PMC
April 2014

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease.

Neurobiol Aging 2014 Mar 23;35(3):492-510. Epub 2013 Oct 23.

Netherlands Institute for Neuroscience-an Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Department of Astrocyte Bology and Neurodegeneration, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.09.035DOI Listing
March 2014

Shades of gray: The delineation of marker expression within the adult rodent subventricular zone.

Prog Neurobiol 2013 Dec 28;111:1-16. Epub 2013 Aug 28.

Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience - An Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.pneurobio.2013.07.003DOI Listing
December 2013

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice.

Neurobiol Aging 2014 Jan 15;35(1):1-14. Epub 2013 Aug 15.

Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.07.008DOI Listing
January 2014

A star is born: new insights into the mechanism of astrogenesis.

Cell Mol Life Sci 2014 Feb 2;71(3):433-47. Epub 2013 Aug 2.

Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00018-013-1435-9DOI Listing
February 2014

Resident adult neural stem cells in Parkinson's disease--the brain's own repair system?

Eur J Pharmacol 2013 Nov 18;719(1-3):117-127. Epub 2013 Jul 18.

Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience (NIN), An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2013.04.058DOI Listing
November 2013

Reactive glia show increased immunoproteasome activity in Alzheimer's disease.

Brain 2013 May 19;136(Pt 5):1415-31. Epub 2013 Apr 19.

Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/brain/awt083DOI Listing
May 2013

Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models.

Aging Cell 2013 Jun 23;12(3):499-507. Epub 2013 Apr 23.

Department of Cell Biology and Histology, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/acel.12074DOI Listing
June 2013

Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutieres syndrome.

Brain 2013 Jan;136(Pt 1):245-58

Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience–an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/brain/aws321DOI Listing
January 2013

Expression of vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue.

J Neuropathol Exp Neurol 2013 Feb;72(2):91-105

Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/NEN.0b013e31827f4fccDOI Listing
February 2013

GFAPδ expression in glia of the developmental and adolescent mouse brain.

PLoS One 2012 21;7(12):e52659. Epub 2012 Dec 21.

Department of Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience-Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052659PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528700PMC
June 2013

Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model.

Neurobiol Aging 2013 May 12;34(5):1328-42. Epub 2012 Dec 12.

Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.11.008DOI Listing
May 2013

GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease.

PLoS One 2012 13;7(8):e42823. Epub 2012 Aug 13.

Netherlands Institute for Neuroscience - an Institute of the Royal Netherlands Academy of Arts and Sciences, Department of Astrocyte Biology & Neurodegeneration, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042823PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418292PMC
April 2013

Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis.

Parkinsons Dis 2012 22;2012:420957. Epub 2012 Apr 22.

Department of Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands.

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http://dx.doi.org/10.1155/2012/420957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347756PMC
August 2012

Differential cell proliferation in the cortex of the APPswePS1dE9 Alzheimer's disease mouse model.

Glia 2012 Apr 19;60(4):615-29. Epub 2012 Jan 19.

Netherlands Institute for Neuroscience-an Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Department of Astrocyte Biology and Neurodegeneration, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/glia.22295DOI Listing
April 2012

The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain.

Brain 2011 Nov;134(Pt 11):3249-63

Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/brain/awr256DOI Listing
November 2011

Migrating neuroblasts in the adult human brain: a stream reduced to a trickle.

Cell Res 2011 Nov 21;21(11):1523-5. Epub 2011 Jun 21.

Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/cr.2011.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364722PMC
November 2011

Presenilin mouse and zebrafish models for dementia: focus on neurogenesis.

Prog Neurobiol 2011 Feb 5;93(2):149-64. Epub 2010 Nov 5.

Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.pneurobio.2010.10.008DOI Listing
February 2011

In vivo targeting of subventricular zone astrocytes.

Prog Neurobiol 2010 Sep 2;92(1):19-32. Epub 2010 May 2.

Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.pneurobio.2010.04.007DOI Listing
September 2010

GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex.

Development 2010 Jan;137(2):313-21

Department of Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1242/dev.041632DOI Listing
January 2010

Specific human astrocyte subtype revealed by affinity purified GFAP antibody; unpurified serum cross-reacts with neurofilament-L in Alzheimer.

PLoS One 2009 Nov 4;4(11):e7663. Epub 2009 Nov 4.

Department of Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007663PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766629PMC
November 2009

Intermediate filament transcription in astrocytes is repressed by proteasome inhibition.

FASEB J 2009 Aug 30;23(8):2710-26. Epub 2009 Mar 30.

Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1096/fj.08-127696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221645PMC
August 2009

Observation of hand movements by older persons with dementia: effects on cognition: a pilot study.

Dement Geriatr Cogn Disord 2009 24;27(4):366-74. Epub 2009 Mar 24.

Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000209311DOI Listing
June 2009

Hand motor activity, cognition, mood, and the rest-activity rhythm in dementia: a clustered RCT.

Behav Brain Res 2009 Jan 24;196(2):271-8. Epub 2008 Sep 24.

VU University, Department of Clinical Neuropsychology, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbr.2008.09.012DOI Listing
January 2009

Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin.

Neurobiol Aging 2009 Jun 28;30(6):847-63. Epub 2008 Aug 28.

Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2008.06.009DOI Listing
June 2009

GFAPdelta immunostaining improves visualization of normal and pathologic astrocytic heterogeneity.

Neuropathology 2009 Feb 17;29(1):31-9. Epub 2008 Jun 17.

Department of Pathology, Centre Hospitalier Sainte-Anne, Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1111/j.1440-1789.2008.00936.xDOI Listing
February 2009

The neuronal ubiquitin-proteasome system: murine models and their neurological phenotype.

Prog Neurobiol 2008 Jun 18;85(2):176-93. Epub 2008 Mar 18.

Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.pneurobio.2008.03.001DOI Listing
June 2008

Proteasome subunit proteins and neuropathology in tauopathies and synucleinopathies: Consequences for proteomic analyses.

Proteomics 2008 Mar;8(6):1221-36

Faculté des Sciences Biologiques, Université des Sciences et des Technologies Houari Boumediène, Algiers, Algeria.

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http://dx.doi.org/10.1002/pmic.200700679DOI Listing
March 2008

Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation.

PLoS One 2008 Jan 30;3(1):e1503. Epub 2008 Jan 30.

Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001503PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200796PMC
January 2008

Developmental lineage of cell types in cortical dysplasia with balloon cells.

Brain 2007 Sep;130(Pt 9):2267-76

PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA.

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https://academic.oup.com/brain/article-lookup/doi/10.1093/br
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http://dx.doi.org/10.1093/brain/awm175DOI Listing
September 2007

Cell-replacement and gene-therapy strategies for Parkinson's and Alzheimer's disease.

Regen Med 2007 Jul;2(4):425-46

Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/17460751.2.4.425DOI Listing
July 2007

Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease.

J Cell Sci 2007 May 3;120(Pt 9):1615-23. Epub 2007 Apr 3.

Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.

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http://dx.doi.org/10.1242/jcs.03438DOI Listing
May 2007

Ubiquitin proteasome system as a pharmacological target in neurodegeneration.

Expert Rev Neurother 2006 Sep;6(9):1337-47

Netherlands Institute for Neuroscience, Research Group Cellular Quality Control, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.

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http://dx.doi.org/10.1586/14737175.6.9.1337DOI Listing
September 2006

hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay.

Mol Cell Biol 2006 Feb;26(4):1272-87

Division of Molecular Immunology, Department of Internal Medicine III, Nikolaus Fiebiger Center, University of Erlangen-Nürnberg, Glückstrasse 6, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1128/MCB.26.4.1272-1287.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367210PMC
February 2006

Alzheimer-associated APP+1 transgenic mice: frameshift beta-amyloid precursor protein is secreted in cerebrospinal fluid without inducing neuropathology.

Neurobiol Aging 2006 Oct 7;27(10):1445-50. Epub 2005 Oct 7.

Netherlands Institute for Brain Research, Graduate School for Neurosciences Amsterdam, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2005.09.010DOI Listing
October 2006

The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1.

Trends Mol Med 2005 Nov 6;11(11):488-95. Epub 2005 Oct 6.

Research group Cellular Quality Control, The Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.molmed.2005.09.001DOI Listing
November 2005

Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP.

FASEB J 2005 Sep;19(11):1451-8

Netherlands Institute for Brain Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1096/fj.04-3395.comDOI Listing
September 2005

Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton.

Glia 2005 Dec;52(4):289-300

Netherlands Institute for Brain Research, Graduate School Neurosciences, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/glia.20243DOI Listing
December 2005

Diminished aromatase immunoreactivity in the hypothalamus, but not in the basal forebrain nuclei in Alzheimer's disease.

Neurobiol Aging 2005 Feb;26(2):173-94

Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2004.03.010DOI Listing
February 2005

Molecular misreading: the frequency of dinucleotide deletions in neuronal mRNAs for beta-amyloid precursor protein and ubiquitin B.

Neurobiol Aging 2005 Feb;26(2):145-55

Department of Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam 1105 AZ, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S019745800400159
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http://dx.doi.org/10.1016/j.neurobiolaging.2004.03.011DOI Listing
February 2005