Elliot Stieglitz

Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome.

Nat Commun 2021 Feb 26;12(1):1334. Epub 2021 Feb 26.

Department of Medical Oncology, Division of Hematological Malignancies Dana-Farber Cancer Institute, Boston, MA, USA.

February 2021

Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-risk Leukemias: A Report from the LEAP Consortium.

Authors:

Yana Pikman Sarah K Tasian Maria Luisa Sulis Kristen Stevenson Traci M Blonquist Beth Apsel Winger Todd M Cooper Melinda Pauly Kelly W Maloney Michael J Burke Patrick A Brown Nathan Gossai Jennifer L McNeer Neerav N Shukla Peter D Cole Justine M Kahn Jing Chen Matthew J Barth Jeffrey A Magee Lisa Gennarini Asmani A Adhav Catherine M Clinton Nicole Ocasio-Martinez Giacomo Gotti Yuting Li Shan Lin Alma Imamovic Cristina E Tognon Tasleema Patel Haley L Faust Cristina F Contreras Anjali Cremer Wilian A Cortopassi Diego Garrido Ruiz Matthew P Jacobson Neekesh V Dharia Angela Su Amanda L Robichaud Amy Saur Conway Katherine Tarlock Elliot Stieglitz Andrew E Place Alexandre Puissant Stephen P Hunger Annette S Kim Neal I Lindeman Lia Gore Katherine A Janeway Lewis B Silverman Jeffrey W Tyner Marian H Harris Mignon L Loh Kimberly Stegmaier

Cancer Discov 2021 Feb 9. Epub 2021 Feb 9.

Department of Pediatric Oncology, Dana-Farber Cancer Institute

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February 2021

Targeting the Ras pathway in pediatric hematologic malignancies.

Authors:

Yana Pikman Elliot Stieglitz

Curr Opin Pediatr 2021 02 29;33(1):49-58. Epub 2020 Dec 29.

Department of Pediatrics, Benioff Children's Hospital, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.

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February 2021

Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia.

Haematologica 2020 12 30;Online ahead of print. Epub 2020 Dec 30.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco.

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December 2020

Complete Response to PD-1 Inhibition in an Adolescent With Relapsed Clear Cell Adenocarcinoma of the Cervix Predicted by Neoepitope Burden and APOBEC Signature.

Authors:

Anya Levinson Alex G Lee Henry J Martell Marcus R Breese Charles Zaloudek Jessica Van Ziffle Benjamin Laguna Stanley G Leung M Dwight Chen Lee-May Chen Jacob Pfeil Nicholas R Ladwig Avanthi Tayi Shah Inge Behroozfard Arjun Arkal Rao Sofie R Salama E Alejandro Sweet-Cordero Elliot Stieglitz

JCO Precis Oncol 2020 2;4. Epub 2020 Nov 2.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.

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November 2020

International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia.

Authors:

Maximilian Schönung Julia Meyer Peter Nöllke Adam B Olshen Mark Hartmann Norihiro Murakami Manabu Wakamatsu Yusuke Okuno Christoph Plass Mignon L Loh Charlotte M Niemeyer Hideki Muramatsu Christian Flotho Elliot Stieglitz Daniel B Lipka

Clin Cancer Res 2021 Jan 2;27(1):158-168. Epub 2020 Nov 2.

Section Translational Cancer Epigenomics, Division Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT), Heidelberg, Germany.

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January 2021

Clinical utilization of blinatumomab and inotuzumab immunotherapy in children with relapsed or refractory B-acute lymphoblastic leukemia.

Authors:

Cristina F Contreras Christine S Higham Astrid Behnert Kailyn Kim Elliot Stieglitz Sarah K Tasian

Pediatr Blood Cancer 2021 Jan 24;68(1):e28718. Epub 2020 Oct 24.

Children's Hospital of Philadelphia, Division of Oncology and Center for Childhood Cancer Research, Philadelphia, Pennsylvania.

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January 2021

NUP98-NSD1 Driven MDS/MPN in Childhood Masquerading as JMML.

Authors:

Astrid Behnert Alex G Lee Elizabeth P Young Marcus R Breese Stanley G Leung Inge Behroozfard Maria Maruffi E Alejandro Sweet-Cordero Christopher C Dvorak Julia Chu Elliot Stieglitz

J Pediatr Hematol Oncol 2020 Aug 18. Epub 2020 Aug 18.

Department of Pediatrics, Benioff Children's Hospital.

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August 2020

Low toxicity and favorable overall survival in relapsed/refractory B-ALL following CAR T cells and CD34-selected T-cell depleted allogeneic hematopoietic cell transplant.

Authors:

Vanessa A Fabrizio Nancy A Kernan Farid Boulad Maria Cancio Jennifer Allen Meghan Higman Steven P Margossian Audrey Mauguen Susan Prockop Andromachi Scaradavou Niketa Shah Barbara Spitzer Elliot Stieglitz Nicholas Yeager Richard J O'Reilly Renier J Brentjens Jaap Jan Boelens Kevin J Curran

Bone Marrow Transplant 2020 11 10;55(11):2160-2169. Epub 2020 May 10.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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November 2020

Precision cancer monitoring using a novel, fully integrated, microfluidic array partitioning digital PCR platform.

Authors:

Megan E Dueck Robert Lin Andrew Zayac Steve Gallagher Alexander K Chao Lingxia Jiang Sammy S Datwani Paul Hung Elliot Stieglitz

Sci Rep 2019 12 20;9(1):19606. Epub 2019 Dec 20.

Department of Pediatrics, UCSF Benioff Children's Hospital, San Francisco, CA, USA.

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December 2019

The impact of total body irradiation-based regimens on outcomes in children and young adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation.

Authors:

Brian D Friend Mara Bailey-Olson Alexis Melton Kristin A Shimano Sandhya Kharbanda Christine Higham Lena E Winestone James Huang Elliot Stieglitz Christopher C Dvorak

Pediatr Blood Cancer 2020 02 14;67(2):e28079. Epub 2019 Nov 14.

Division of Pediatric Allergy, Immunology, and Blood & Marrow Transplantation, UCSF Benioff Children's Hospital, San Francisco, California.

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February 2020

Fusion driven JMML: a novel CCDC88C-FLT3 fusion responsive to sorafenib identified by RNA sequencing.

Authors:

Alexander K Chao Julia A Meyer Alex G Lee Anna Hecht Theodore Tarver Jessica Van Ziffle Ashley K Koegel Carla Golden Benjamin S Braun E Alejandro Sweet-Cordero Catherine C Smith Christopher C Dvorak Mignon L Loh Elliot Stieglitz

Leukemia 2020 02 12;34(2):662-666. Epub 2019 Sep 12.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA, USA.

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February 2020

Molecular assessment of pretransplant chemotherapy in the treatment of juvenile myelomonocytic leukemia.

Authors:

Anna Hecht Julia Meyer Farid F Chehab Kristie L White Kevin Magruder Christopher C Dvorak Mignon L Loh Elliot Stieglitz

Pediatr Blood Cancer 2019 11 26;66(11):e27948. Epub 2019 Jul 26.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, California.

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November 2019

Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome.

Am J Hum Genet 2019 06 23;104(6):1223-1232. Epub 2019 May 23.

Institute of Human Genetics, University Hospital Magdeburg, 39120 Magdeburg, Germany. Electronic address:

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June 2019

Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children.

Authors:

Adam J de Smith Geneviève Lavoie Kyle M Walsh Sumeet Aujla Erica Evans Helen M Hansen Ivan Smirnov Alice Y Kang Martin Zenker John J Ceremsak Elliot Stieglitz Ivo S Muskens William Roberts Roberta McKean-Cowdin Catherine Metayer Philippe P Roux Joseph L Wiemels

Genes Chromosomes Cancer 2019 10 27;58(10):723-730. Epub 2019 May 27.

Center for Genetic Epidemiology, Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, California.

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October 2019

Genomic subtyping and therapeutic targeting of acute erythroleukemia.

Nat Genet 2019 04 29;51(4):694-704. Epub 2019 Mar 29.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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April 2019

Downregulating Notch counteracts Kras-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm.

Leukemia 2019 03 11;33(3):671-685. Epub 2018 Sep 11.

McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.

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March 2019

Disease burden and conditioning regimens in ASCT1221, a randomized phase II trial in children with juvenile myelomonocytic leukemia: A Children's Oncology Group study.

Pediatr Blood Cancer 2018 07 12;65(7):e27034. Epub 2018 Mar 12.

Division of Pediatric Hematology/Oncology, Benioff Children's Hospital, University of California San Francisco, San Francisco, California.

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July 2018

ABVD Without Radiation for Newly Diagnosed Pediatric and Young Adult Patients With Hodgkin Lymphoma: A Single Center Retrospective Analysis of 28 Consecutive Patients.

Authors:

Elliot Stieglitz Tu Dinh Andrew S Phelps Miguel H Pampaloni Adam B Olshen Elizabeth Robbins

J Pediatr Hematol Oncol 2018 05;40(4):290-294

Department of Pediatrics, Benioff Children's Hospital.

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May 2018

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia.

Authors:

Elliot Stieglitz Tali Mazor Adam B Olshen Huimin Geng Laura C Gelston Jon Akutagawa Daniel B Lipka Christoph Plass Christian Flotho Farid F Chehab Benjamin S Braun Joseph F Costello Mignon L Loh

Nat Commun 2017 12 19;8(1):2127. Epub 2017 Dec 19.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.

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December 2017

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML.

Blood 2017 07 2;130(4):397-407. Epub 2017 Jun 2.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY.

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July 2017

International Interlaboratory Digital PCR Study Demonstrating High Reproducibility for the Measurement of a Rare Sequence Variant.

Anal Chem 2017 02 18;89(3):1724-1733. Epub 2017 Jan 18.

Molecular and Cell Biology Team, LGC , Queens Road, Teddington, Middlesex TW11 0LY, United Kingdom.

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February 2017

Germline mutations are not associated with Noonan syndrome.

Authors:

John J Ceremsak Ariel Yu Emilio Esquivel Christina Lissewski Martin Zenker Mignon L Loh Elliot Stieglitz

J Med Genet 2016 Nov 7;53(11):728. Epub 2016 Apr 7.

Department of Pediatrics, University of California, San Francisco, Benioff Children's Hospital, San Francisco, California, USA.

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November 2016

Pediatric MDS: GATA screen the germline.

Authors:

Elliot Stieglitz Mignon L Loh

Blood 2016 Mar;127(11):1377-8

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO.

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March 2016

Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia.

Nat Genet 2016 Jan;48(1):101

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January 2016

The genomic landscape of juvenile myelomonocytic leukemia.

Nat Genet 2015 Nov 12;47(11):1326-1333. Epub 2015 Oct 12.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.

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November 2015

Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: a report from the Children's Oncology Group.

Authors:

Elliot Stieglitz Ashley F Ward Robert B Gerbing Todd A Alonzo Robert J Arceci Y Lucy Liu Peter D Emanuel Brigitte C Widemann Jennifer W Cheng Nalini Jayaprakash Frank M Balis Robert P Castleberry Nancy J Bunin Mignon L Loh Todd M Cooper

Pediatr Blood Cancer 2015 Apr 8;62(4):629-36. Epub 2014 Dec 8.

Department of Pediatrics, Helen Diller Comprehensive Cancer Center, University of California San Francisco School of Medicine and Benioff Children's Hospital, San Francisco, California.

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April 2015

Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia.

Authors:

Elliot Stieglitz Camille B Troup Laura C Gelston John Haliburton Eric D Chow Kristie B Yu Jon Akutagawa Amaro N Taylor-Weiner Y Lucy Liu Yong-Dong Wang Kyle Beckman Peter D Emanuel Benjamin S Braun Adam Abate Robert B Gerbing Todd A Alonzo Mignon L Loh

Blood 2015 Jan 13;125(3):516-24. Epub 2014 Nov 13.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.

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January 2015