Elli Papaemmanuil

Elli Papaemmanuil

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Elli Papaemmanuil

Elli Papaemmanuil

Publications by authors named "Elli Papaemmanuil"

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Multifaceted modes of action of azacytidine: a riddle wrapped up in an enigma.

Leuk Lymphoma 2019 Jun 12:1-5. Epub 2019 Jun 12.

a Department of Hematology , Democritus University of Thrace Medical School , Alexandroupolis , Greece.

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http://dx.doi.org/10.1080/10428194.2019.1627542DOI Listing
June 2019

Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

N Engl J Med 2018 10;379(15):1416-1430

From the Wellcome-MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research (J.G., C.E.M., F.L.N., A.R.G., P.J.C.), the Department of Haematology, University of Cambridge (J.G., E.J.B., C.M., J.C., C.E.M., F.L.N., A.R.G.), and the Department of Haematology, Cambridge University Hospitals NHS Foundation Trust (J.G., E.J.B., A.L.G., C.M., J.C., A.R.G.), Cambridge, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus (J.N., D.C.W., N.A., E.P., G.G., L.O., S.O., J.W.T., A.P.B., N.W., P.J.C.), and the European Molecular Biology Laboratory, European Bioinformatics Institute (R.C., M.G.), Hinxton, Big Data Institute, University of Oxford, Oxford (D.C.W.), the Department of Haematology, Queen's University Belfast, Belfast (M.F.M.), and the Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London (C.N.H.) - all in the United Kingdom; the Center for Molecular Oncology and the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York (E.P., G.G.); the Department of Hematology, Zealand University Hospital, Roskilde, and the University of Copenhagen, Copenhagen (C.L.A., H.C.H.); and the Department of Experimental and Clinical Medicine, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy (P.G., A.M.V.).

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http://www.nejm.org/doi/10.1056/NEJMoa1716614
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http://dx.doi.org/10.1056/NEJMoa1716614DOI Listing
October 2018

Prediction of acute myeloid leukaemia risk in healthy individuals.

Nature 2018 07 9;559(7714):400-404. Epub 2018 Jul 9.

Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-018-0317-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485381PMC
July 2018

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Cancer Cell 2018 02;33(2):274-291.e8

Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.006DOI Listing
February 2018

Classification and risk assessment in AML: integrating cytogenetics and molecular profiling.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):37-44

Department of Epidemiology-Biostatistics, Center for Heme Malignancies, Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1182/asheducation-2017.1.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142605PMC
December 2017

-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells.

Blood 2017 08 20;130(7):881-890. Epub 2017 Jun 20.

Center for Hematology and Regenerative Medicine, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1182/blood-2017-03-776070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572789PMC
August 2017

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.

Genes Chromosomes Cancer 2017 05 18;56(5):363-372. Epub 2017 Jan 18.

Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1002/gcc.22439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396319PMC
May 2017

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.

Cell Stem Cell 2017 03 16;20(3):315-328.e7. Epub 2017 Feb 16.

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337161PMC
March 2017

Clinical Effects of Driver Somatic Mutations on the Outcomes of Patients With Myelodysplastic Syndromes Treated With Allogeneic Hematopoietic Stem-Cell Transplantation.

J Clin Oncol 2016 Oct;34(30):3627-3637

Matteo G. Della Porta, Anna Gallì, Silvia Zibellini, Ettore Rizzo, Marianna Rossi, Marta Ubezio, Virginia V. Ferretti, Silvia Catricalà, Chiara Milanesi, Emilio P. Alessandrino, and Mario Cazzola, Fondazione IRCCS Policlinico, San Matteo; Matteo G. Della Porta, Alberto Malovini, Ivan Limongelli, Riccardo Bellazzi, and Mario Cazzola, University of Pavia, Pavia; Andrea Bacigalupo, Maria Teresa van Lint, Sarah Pozzi, and Silvia Luchetti, San Martino Hospital, Genova; Massimo Bernardi, Cristina Tresoldi, and Fabio Ciceri, San Raffaele Scientific Institute; Paola Marenco and Laura Pezzetti, Ospedale Niguarda Ca' Granda, Milan; Bernardino Allione and Benedetto Bruno, University of Torino, Torino; Pietro Pioltelli, Ospedale San Gerardo, Monza; Alberto Bosi, Azienda Ospedaliera Universitaria Careggi, Florence; Maria Teresa Voso and Simona Sica, Catholic University of the Sacred Heart, Rome; Mariella Cuzzola, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria; Emanuele Angelucci, Ospedale Oncologico di Riferimento Regionale A. Businco, Cagliari; Orietta Spinelli and Alessandro Rambaldi, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo; Francesca Bonifazi, University of Bologna, Bologna; Armando Santoro, Humanitas University, Rozzano, Italy; Alberto Riva, University of Florida, Gainesville, FL; and Elli Papaemmanuil, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.67.3616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366344PMC
October 2016

Genomic Classification in Acute Myeloid Leukemia.

N Engl J Med 2016 09;375(9):900-1

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http://dx.doi.org/10.1056/NEJMc1608739DOI Listing
September 2016

Impact of socioeconomic status on disease phenotype, genomic landscape and outcomes in myelodysplastic syndromes.

Br J Haematol 2016 07 20;174(2):227-34. Epub 2016 Apr 20.

Dundee Cancer Centre, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/bjh.14042DOI Listing
July 2016

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

N Engl J Med 2016 Jun;374(23):2209-2221

Cancer Genome Project, Wellcome Trust Sanger Institute (E.P., M.G., N.D.R., N.B., G.G., P.V.L., I.M., L.M., S.M., S.O., K.R., D.R.J., J.W.T., A.P.B., P.J.C.), and the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) (M.G.), Hinxton, the Centre for Evolution and Cancer, Institute of Cancer Research, London (N.E.P., M.F.G.), and the Department of Haematology, University of Cambridge, Cambridge (N.B.) - all in the United Kingdom; the Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York (E.P.); the Department of Internal Medicine III, Ulm University, Ulm (L.B., V.I.G., P.P., K.D., R.F.S., H.D.), and the Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover (M.H., F.T., A.G.) - both in Germany; the Division of Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, and Department of Oncology and Onco-Hematology, University of Milan, Milan (N.B.); the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.); and the Department of Pathology, University of Otago, Christchurch, New Zealand (P.G., P.J.C.).

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http://dx.doi.org/10.1056/NEJMoa1516192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979995PMC
June 2016

Effect of mutation order on myeloproliferative neoplasms.

N Engl J Med 2015 Feb;372(7):601-612

Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Stem Cell Institute (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., A.R.G.) and Department of Hematology (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., G.S.V., P.J.C., A.R.G.), University of Cambridge, Department of Haematology, Addenbrooke's Hospital (C.A.O., J.N., J.G., E.J.B., A.L.G., G.S.V., P.J.C., A.R.G.), Wellcome Trust Sanger Institute (D.C.W., E.P., G.S.V., P.J.C.), and Cancer Research U.K. Cambridge Institute, Li Ka Shing Centre (S.M.), Cambridge, and Guy's and St. Thomas' National Health Service Foundation Trust, Guy's Hospital, London (C.N.H.) - all in the United Kingdom; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy (P.G., A.V.); Departments of Pathology (B.B.) and Hematology (C.B.), Hospital del Mar, Barcelona; and the Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany (K.D.).

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http://dx.doi.org/10.1056/NEJMoa1412098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660033PMC
February 2015

Nongenetic stochastic expansion of JAK2V617F-homozygous subclones in polycythemia vera?

Blood 2014 Nov;124(22):3332-4

Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council, Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2014-09-603043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239339PMC
November 2014

Driver somatic mutations identify distinct disease entities within myeloid neoplasms with myelodysplasia.

Blood 2014 Aug 26;124(9):1513-21. Epub 2014 Jun 26.

Department of Molecular Medicine, University of Pavia, Pavia, Italy; Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy;

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http://dx.doi.org/10.1182/blood-2014-03-560227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148773PMC
August 2014

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Cancer Cell 2014 Jun 15;25(6):794-808. Epub 2014 May 15.

Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.036DOI Listing
June 2014

Subclonal variant calling with multiple samples and prior knowledge.

Bioinformatics 2014 May 16;30(9):1198-204. Epub 2014 Jan 16.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK, Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK and Department of Haematology, University of Cambridge, Cambridge CB22XY, UK.

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http://dx.doi.org/10.1093/bioinformatics/btt750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998123PMC
May 2014

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk.

Blood 2010 Jun 15;115(22):4472-7. Epub 2010 Mar 15.

Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1182/blood-2009-09-244483DOI Listing
June 2010