Publications by authors named "Ellen Sapp"

52Publications

Protein changes in synaptosomes of Huntington's disease knock-in mice are dependent on age and brain region.

Neurobiol Dis 2020 07 19;141:104950. Epub 2020 May 19.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA.

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July 2020

Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.

Cells 2020 05 4;9(5). Epub 2020 May 4.

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

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May 2020

Assessing average somatic CAG repeat instability at the protein level.

Sci Rep 2019 12 16;9(1):19152. Epub 2019 Dec 16.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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December 2019

Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes.

PLoS One 2019 15;14(2):e0212337. Epub 2019 Feb 15.

Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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November 2019

Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity.

Mol Ther 2018 12 22;26(12):2838-2847. Epub 2018 Sep 22.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address:

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December 2018

Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.

Cell Rep 2018 09;24(10):2553-2560.e5

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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September 2018

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.

Mol Ther 2018 11 8;26(11):2580-2591. Epub 2018 Aug 8.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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November 2018

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.

Mol Ther 2018 08 21;26(8):1973-1982. Epub 2018 Jun 21.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address:

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August 2018

The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.

Sci Rep 2018 05 22;8(1):8000. Epub 2018 May 22.

Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.

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May 2018