Publications by authors named "Ellen O"

2 Publications

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The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells.

Virulence 2021 12;12(1):2214-2227

Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

An oral antiviral against SARS-CoV-2 that also attenuates inflammatory instigators of severe COVID-19 is not available to date. Herein, we show that the apoA-I mimetic peptide 4 F inhibits Spike mediated viral entry and has antiviral activity against SARS-CoV-2 in human lung epithelial Calu3 and Vero-E6 cells. In SARS-CoV-2 infected Calu3 cells, 4 F upregulated inducers of the interferon pathway such as MX-1 and Heme oxygenase 1 (HO-1) and downregulated mitochondrial reactive oxygen species (mito-ROS) and CD147, a host protein that mediates viral entry. 4 F also reduced associated cellular apoptosis and secretion of IL-6 in both SARS-CoV-2 infected Vero-E6 and Calu3 cells. Thus, 4 F attenuates SARS-CoV-2 replication, associated apoptosis in epithelial cells and secretion of IL-6, a major cytokine related to COVID-19 morbidity. Given established safety of 4 F in humans, clinical studies are warranted to establish 4 F as therapy for COVID-19.
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http://dx.doi.org/10.1080/21505594.2021.1964329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437485PMC
December 2021

Active Surveillance Doing Well Under Surveillance.

Eur Urol Oncol 2020 02 13;3(1):92-93. Epub 2019 Dec 13.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2019.11.006DOI Listing
February 2020
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