Ellen M Gravallese

Ellen M Gravallese

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Ellen M Gravallese

Ellen M Gravallese

Publications by authors named "Ellen M Gravallese"

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60Publications

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mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation and .

Front Immunol 2019 27;10:2344. Epub 2020 Feb 27.

Department of Experimental Immunology, Infection and Immunity Institute, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2019.02344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065603PMC
February 2020

An image-based method to measure joint deformity in inflammatory arthritis: development and pilot study.

Comput Methods Biomech Biomed Engin 2019 Aug 8;22(10):942-952. Epub 2019 May 8.

a Department of Biomedical Engineering , Worcester Polytechnic Institute , Worcester , Massachusetts , USA.

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http://dx.doi.org/10.1080/10255842.2019.1607315DOI Listing
August 2019

Breathing New Life into Interstitial Lung Disease in Rheumatoid Arthritis.

N Engl J Med 2018 12 20;379(23):2265-2266. Epub 2018 Oct 20.

From the Feinstein Institute for Medical Research, Robert S. Boas Center for Genomics and Human Genetics, Manhasset, NY (P.K.G.); and the Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester (E.M.G.).

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http://dx.doi.org/10.1056/NEJMe1811767DOI Listing
December 2018

Effects of the IL-23-IL-17 pathway on bone in spondyloarthritis.

Nat Rev Rheumatol 2018 11;14(11):631-640

Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1038/s41584-018-0091-8DOI Listing
November 2018

Bone Wasn't Built in a Day: Destruction and Formation of Bone in the Rheumatic Diseases.

Trans Am Clin Climatol Assoc 2017 ;128:24-43

WORCESTER, MASSACHUSETTS.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525397PMC
May 2018

Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications.

Calcif Tissue Int 2018 05 4;102(5):533-546. Epub 2017 Dec 4.

Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA, 01605, USA.

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http://dx.doi.org/10.1007/s00223-017-0373-1DOI Listing
May 2018

Reply.

Arthritis Rheumatol 2018 03 6;70(3):476. Epub 2018 Feb 6.

Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1002/art.40387DOI Listing
March 2018

The Science Behind Biosimilars: Entering a New Era of Biologic Therapy.

Arthritis Rheumatol 2018 03 7;70(3):334-344. Epub 2018 Feb 7.

Metroplex Clinical Research Center, Dallas, Texas.

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http://dx.doi.org/10.1002/art.40388DOI Listing
March 2018

Synovium-Derived MicroRNAs Regulate Bone Pathways in Rheumatoid Arthritis.

J Bone Miner Res 2017 Mar 28;32(3):461-472. Epub 2016 Oct 28.

Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

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http://doi.wiley.com/10.1002/jbmr.3005
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http://dx.doi.org/10.1002/jbmr.3005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340607PMC
March 2017

Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?

J Leukoc Biol 2017 01 16;101(1):121-126. Epub 2016 Aug 16.

Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA;

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http://dx.doi.org/10.1189/jlb.3MR0316-115RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166439PMC
January 2017

RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis.

Arthritis Rheumatol 2016 12;68(12):2889-2900

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/art.39837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125876PMC
December 2016

Differential Effects of Inflammation on Bone and Response to Biologics in Rheumatoid Arthritis and Spondyloarthritis.

Curr Rheumatol Rep 2016 Dec;18(12):72

Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, 55 Lake Ave North, Worcester, MA, 01655, USA.

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http://dx.doi.org/10.1007/s11926-016-0620-xDOI Listing
December 2016

Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts.

Clin Rev Allergy Immunol 2016 Aug;51(1):1-15

Department of Medicine and Division of Rheumatology, University of Massachusetts Medical School, Lazare Research Building Suite 223, 364 Plantation Street, Worcester, MA, 01605, USA.

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http://dx.doi.org/10.1007/s12016-015-8515-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809775PMC
August 2016

IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis.

Arthritis Res Ther 2016 05 10;18(1):104. Epub 2016 May 10.

Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, 364 Plantation Street, Suite 223, Worcester, MA, 01605, USA.

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http://dx.doi.org/10.1186/s13075-016-0998-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863346PMC
May 2016

Brief Report: Development and Validation of a Semiautomated Method to Measure Erosion Volume in Inflammatory Arthritis by Computed Tomography Scanning.

Arthritis Rheumatol 2016 Feb;68(2):332-6

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/art.39459DOI Listing
February 2016

Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.

J Immunol 2016 Feb 4;196(3):1348-54. Epub 2016 Jan 4.

Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605; and

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http://dx.doi.org/10.4049/jimmunol.1502130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724517PMC
February 2016

Mediators of inflammation and bone remodeling in rheumatic disease.

Semin Cell Dev Biol 2016 Jan 19;49:2-10. Epub 2015 Oct 19.

Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2015.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761455PMC
January 2016

An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.

Clin Exp Rheumatol 2015 Jul-Aug;33(4 Suppl 92):S70-3. Epub 2015 Oct 12.

Department of Medicine, University of Massachusetts School of Medicine, Worcester, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731237PMC
December 2015

Gadolinium-based compounds induce NLRP3-dependent IL-1β production and peritoneal inflammation.

Ann Rheum Dis 2015 Nov 9;74(11):2062-9. Epub 2014 Jun 9.

Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1136/annrheumdis-2013-204900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428954PMC
November 2015

Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.

J Immunol 2015 Feb 29;194(3):873-7. Epub 2014 Dec 29.

Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605;

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http://dx.doi.org/10.4049/jimmunol.1402573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299698PMC
February 2015

Impact of inflammation on the osteoblast in rheumatic diseases.

Curr Osteoporos Rep 2014 Mar;12(1):9-16

Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Lazare Research Building, Suite 223, 364 Plantation Street, Worcester, MA, 01605, USA.

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http://dx.doi.org/10.1007/s11914-013-0183-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943531PMC
March 2014

Rheumatoid arthritis: erosion defined: back to basics.

Nat Rev Rheumatol 2013 Jun 23;9(6):323-4. Epub 2013 Apr 23.

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http://dx.doi.org/10.1038/nrrheum.2013.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140649PMC
June 2013

Assessment of control of rheumatoid arthritis disease activity.

Best Pract Res Clin Rheumatol 2011 Aug;25(4):497-507

University of Massachusetts Medical School, Rheumatology Center, UMass Memorial Medical Center, Worcester, USA.

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http://dx.doi.org/10.1016/j.berh.2011.10.007DOI Listing
August 2011

Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention.

Rheum Dis Clin North Am 2010 May;36(2):385-404

Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, UMass Memorial Medical Center, Lazare Research Building, Suite 223, 364 Plantation Street, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1016/j.rdc.2010.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905601PMC
May 2010

Bone remodeling in rheumatic disease: a question of balance.

Immunol Rev 2010 Jan;233(1):301-12

Bone, Joint, Cancer Unit, St Vincent's Institute, Fitzroy, Victoria, Australia.

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http://dx.doi.org/10.1111/j.0105-2896.2009.00857.xDOI Listing
January 2010

Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis.

J Bone Miner Res 2009 Sep;24(9):1572-85

Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1359/jbmr.090320DOI Listing
September 2009

The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis.

Arthritis Res Ther 2006 13;8(3):R70. Epub 2006 Apr 13.

New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1186/ar1938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526628PMC
August 2006

Rheumatic diseases: the effects of inflammation on bone.

Immunol Rev 2005 Dec;208:228-51

Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, MA 02115, USA.

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http://dx.doi.org/10.1111/j.0105-2896.2005.00338.xDOI Listing
December 2005

The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes.

FEBS J 2005 Apr;272(7):1676-87

New England Baptist Bone and Joint Institute and BIDMC Genomics Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2005.04592.xDOI Listing
April 2005

Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis.

Arthritis Rheum 2004 Aug;50(8):2685-94

Joslin Diabetes Center, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1002/art.20381DOI Listing
August 2004

Bone loss in inflammatory arthritis: mechanisms and treatment strategies.

Curr Opin Rheumatol 2004 Jul;16(4):419-27

Division of Rheumatology and Metabolic Bone Disease, Beth Israel Deaconess Medical Center and New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1097/01.bor.0000127824.42507.68DOI Listing
July 2004

Bisphosphonates: environmental protection for the joint?

Arthritis Rheum 2004 Jul;50(7):2044-7

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http://dx.doi.org/10.1002/art.20383DOI Listing
July 2004

ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation.

J Biol Chem 2004 Mar 8;279(13):12794-803. Epub 2004 Jan 8.

Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA.

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http://dx.doi.org/10.1074/jbc.M308593200DOI Listing
March 2004

Osteopontin: a bridge between bone and the immune system.

J Clin Invest 2003 Jul;112(2):147-9

Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 241, 4 Blackfan Circle, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI19190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164297PMC
July 2003

Pathogenesis of bone lesions in rheumatoid arthritis.

Curr Rheumatol Rep 2002 Jun;4(3):226-31

Harvard Institutes of Medicine, Room 241, 4 Blackfan Circle, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s11926-002-0069-yDOI Listing
June 2002

Etanercept in the treatment of adult patients with Still's disease.

Arthritis Rheum 2002 May;46(5):1171-6

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/art.10231DOI Listing
May 2002