Ellen E Blaak

Ellen E Blaak

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Ellen E Blaak

Ellen E Blaak

Publications by authors named "Ellen E Blaak"

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Plasma cathepsin D activity is negatively associated with hepatic insulin sensitivity in overweight and obese humans.

Diabetologia 2020 Feb 5;63(2):374-384. Epub 2019 Nov 5.

Department of Molecular Genetics, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-019-05025-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946744PMC
February 2020

Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit.

Am J Physiol Gastrointest Liver Physiol 2020 Feb 23;318(2):G361-G369. Epub 2019 Dec 23.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1152/ajpgi.00283.2019DOI Listing
February 2020

The Relationship between Circulating Acetate and Human Insulin Resistance before and after Weight Loss in the DiOGenes Study.

Nutrients 2020 Jan 28;12(2). Epub 2020 Jan 28.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Universiteitssingel 50, PO Box 616, 6229 ER Maastricht, The Netherlands.

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http://dx.doi.org/10.3390/nu12020339DOI Listing
January 2020

Vitamin D release across abdominal adipose tissue in lean and obese men: The effect of ß-adrenergic stimulation.

Physiol Rep 2019 Dec;7(24):e14308

Department of Human Biology, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.14814/phy2.14308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928243PMC
December 2019

Effects of gut microbiota manipulation on ex vivo lipolysis in human abdominal subcutaneous adipocytes.

Adipocyte 2018 25;7(2):106-112. Epub 2018 Apr 25.

a Department of Human Biology , NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+ , ER Maastricht , The Netherlands.

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http://dx.doi.org/10.1080/21623945.2018.1464366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152497PMC
September 2019

The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans.

Adipocyte 2018 22;7(3):190-196. Epub 2018 May 22.

a Department of Human Biology , NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+ , the Netherlands.

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http://dx.doi.org/10.1080/21623945.2018.1469942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224187PMC
September 2019

Short-Term Microbiota Manipulation and Forearm Substrate Metabolism in Obese Men: A Randomized, Double-Blind, Placebo-Controlled Trial.

Obes Facts 2018 9;11(4):318-326. Epub 2018 Aug 9.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1159/000492114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189533PMC
September 2019

Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes.

Obes Rev 2019 09 26;20(9):1205-1217. Epub 2019 Jun 26.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1111/obr.12862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852205PMC
September 2019

The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity.

Nutrients 2019 Aug 18;11(8). Epub 2019 Aug 18.

Department of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Universiteitssingel 50, P.O. Box 616, 6229 ER Maastricht, The Netherlands.

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http://dx.doi.org/10.3390/nu11081943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723943PMC
August 2019

Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans.

Sci Rep 2019 Aug 29;9(1):12515. Epub 2019 Aug 29.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-48775-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715624PMC
August 2019

Vitamin D deficiency in the aetiology of obesity-related insulin resistance.

Diabetes Metab Res Rev 2019 07 18;35(5):e3146. Epub 2019 Mar 18.

Department of Human Biology, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/dmrr.3146DOI Listing
July 2019

Plasma lipid profiling of tissue-specific insulin resistance in human obesity.

Int J Obes (Lond) 2019 05 21;43(5):989-998. Epub 2018 Sep 21.

Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://www.nature.com/articles/s41366-018-0189-8
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http://dx.doi.org/10.1038/s41366-018-0189-8DOI Listing
May 2019

Gut microbial metabolites in obesity, NAFLD and T2DM.

Nat Rev Endocrinol 2019 05;15(5):261-273

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, Netherlands.

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http://www.nature.com/articles/s41574-019-0156-z
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http://dx.doi.org/10.1038/s41574-019-0156-zDOI Listing
May 2019

Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome.

Eur J Endocrinol 2019 May;180(5):321-328

Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway.

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-19-
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http://dx.doi.org/10.1530/EJE-19-0022DOI Listing
May 2019

Distal versus proximal intestinal short-chain fatty acid release in man.

Gut 2019 04 4;68(4):764-765. Epub 2018 Apr 4.

Department of Surgery, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2018-316161DOI Listing
April 2019

Vitamin D and Tissue-Specific Insulin Sensitivity in Humans With Overweight/Obesity.

J Clin Endocrinol Metab 2019 01;104(1):49-56

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.

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http://dx.doi.org/10.1210/jc.2018-00995DOI Listing
January 2019

Increased circulating choline, L-carnitine and TMAO levels are related to changes in adiposity during weight loss: role of the gut microbiota?

Ann Transl Med 2018 Dec;6(Suppl 2):S92

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://dx.doi.org/10.21037/atm.2018.11.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330612PMC
December 2018

Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity.

J Appl Physiol (1985) 2018 11 13;125(5):1585-1593. Epub 2018 Sep 13.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht , The Netherlands.

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http://dx.doi.org/10.1152/japplphysiol.00496.2018DOI Listing
November 2018

The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men.

Metabolism 2018 10 25;87:25-35. Epub 2018 Jun 25.

Top Institute Food and Nutrition, Wageningen, the Netherlands; Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, 6229 ER Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.06.009DOI Listing
October 2018

Differences in Upper and Lower Body Adipose Tissue Oxygen Tension Contribute to the Adipose Tissue Phenotype in Humans.

J Clin Endocrinol Metab 2018 10;103(10):3688-3697

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands.

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http://dx.doi.org/10.1210/jc.2018-00547DOI Listing
October 2018

Global testing of shifts in metabolic phenotype.

Metabolomics 2018 10 4;14(10):139. Epub 2018 Oct 4.

Laboratory of Biophysics, Wageningen University, Wageningen, The Netherlands.

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http://dx.doi.org/10.1007/s11306-018-1435-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208751PMC
October 2018

Adipose tissue oxygenation is associated with insulin sensitivity independently of adiposity in obese men and women.

Diabetes Obes Metab 2018 09 9;20(9):2286-2290. Epub 2018 May 9.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://doi.wiley.com/10.1111/dom.13329
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http://dx.doi.org/10.1111/dom.13329DOI Listing
September 2018

Ectopic Fat Accumulation in Distinct Insulin Resistant Phenotypes; Targets for Personalized Nutritional Interventions.

Front Nutr 2018 4;5:77. Epub 2018 Sep 4.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, Netherlands.

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http://dx.doi.org/10.3389/fnut.2018.00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131567PMC
September 2018

Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training.

Clin Sci (Lond) 2018 08 14;132(15):1685-1698. Epub 2018 Aug 14.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands

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http://dx.doi.org/10.1042/CS20180453DOI Listing
August 2018

Effect of diet-induced weight loss on angiopoietin-like protein 4 and adipose tissue lipid metabolism in overweight and obese humans.

Physiol Rep 2018 07;6(13):e13735

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands.

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http://dx.doi.org/10.14814/phy2.13735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041698PMC
July 2018

Gastrointestinal Transit Time, Glucose Homeostasis and Metabolic Health: Modulation by Dietary Fibers.

Nutrients 2018 Feb 28;10(3). Epub 2018 Feb 28.

Department of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Universiteitssingel 50, 6229 ER, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.3390/nu10030275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872693PMC
February 2018

Effect of Sacubitril/Valsartan on Exercise-Induced Lipid Metabolism in Patients With Obesity and Hypertension.

Hypertension 2018 01 27;71(1):70-77. Epub 2017 Nov 27.

From the Institute of Clinical Pharmacology (S.E., M.M., S.H., J.J.), Institute of Sports Medicine (U.T.), Hannover Medical School, Germany; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism (R.S., G.H.G., E.E.B.), Division of Endocrinology, Department of Internal Medicine (B.H.), Maastricht University Medical Center, The Netherlands; Profil, Neuss, Germany (T.H., T.J.); Translational Medicine, Novartis Pharma AG, Basel, Switzerland (D.A., T.H.L.); Biostatistical Sciences, Integrated Development Functions and Regions, Novartis Healthcare Pvt. Ltd, Hyderabad, India (P.P.); and Institute of Aerospace Medicine, German Aerospace Center (DLR) and Chair of Aerospace Medicine, University of Cologne, Germany (J.J.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753808PMC
January 2018

Short-Chain Fatty Acids Differentially Affect Intracellular Lipolysis in a Human White Adipocyte Model.

Front Endocrinol (Lausanne) 2017 11;8:372. Epub 2018 Jan 11.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, Netherlands.

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http://journal.frontiersin.org/article/10.3389/fendo.2017.00
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http://dx.doi.org/10.3389/fendo.2017.00372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768634PMC
January 2018

Adipose tissue autophagy related gene expression is associated with glucometabolic status in human obesity.

Adipocyte 2018 01 5;7(1):12-19. Epub 2018 Feb 5.

a Department of Human Biology , NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+ , Maastricht , The Netherlands.

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http://dx.doi.org/10.1080/21623945.2017.1394537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915036PMC
January 2018

Acetate: a diet-derived key metabolite in energy metabolism: good or bad in context of obesity and glucose homeostasis?

Curr Opin Clin Nutr Metab Care 2017 Nov;20(6):477-483

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1097/MCO.0000000000000408DOI Listing
November 2017

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition.

Cell Metab 2017 Oct;26(4):611-619.e6

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; Top Institute of Food and Nutrition, 6700 AN Wageningen, the Netherlands; Department of Internal Medicine, VUMC, Free University, Amsterdam, the Netherlands; Wallenberg Laboratory, Sahlgrenska Hospital, University of Gothenburg, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.09.008DOI Listing
October 2017

Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals.

Gastroenterology 2017 07 8;153(1):87-97.e3. Epub 2017 Apr 8.

Top Institute Food and Nutrition, Wageningen, The Netherlands; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2017.03.051DOI Listing
July 2017

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial.

Sci Rep 2017 05 24;7(1):2360. Epub 2017 May 24.

Department of Human Biology, NUTRIM 'School of Nutrition and Translational Research in Metabolism', Maastricht University Medical Centre, 6229ER, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-02546-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443817PMC
May 2017

Characterisation of fatty acid metabolism in different insulin-resistant phenotypes by means of stable isotopes.

Authors:
Ellen E Blaak

Proc Nutr Soc 2017 Jan 19:1-7. Epub 2017 Jan 19.

Department of Human Biology,Maastricht University,Maastricht,The Netherlands.

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http://dx.doi.org/10.1017/S0029665116003013DOI Listing
January 2017

Altered skeletal muscle fatty acid handling is associated with the degree of insulin resistance in overweight and obese humans.

Diabetologia 2016 12 15;59(12):2686-2696. Epub 2016 Sep 15.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, PO Box 616, 6200 MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-016-4104-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518064PMC
December 2016

Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men.

Clin Sci (Lond) 2016 11 20;130(22):2073-2082. Epub 2016 Jul 20.

Top Institute Food and Nutrition, Wageningen, 6700 AN, The Netherlands Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6229 ER, The Netherlands.

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http://dx.doi.org/10.1042/CS20160263DOI Listing
November 2016

Attenuated atrial natriuretic peptide-mediated lipolysis in subcutaneous adipocytes of obese type 2 diabetic men.

Clin Sci (Lond) 2016 07 4;130(13):1105-14. Epub 2016 Apr 4.

NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht 6200 MD, The Netherlands.

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http://dx.doi.org/10.1042/CS20160220DOI Listing
July 2016

Carbohydrate quantity and quality and cardio-metabolic risk.

Authors:
Ellen E Blaak

Curr Opin Clin Nutr Metab Care 2016 07;19(4):289-93

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1097/MCO.0000000000000290DOI Listing
July 2016

Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial.

Am J Clin Nutr 2016 Jul 18;104(1):215-27. Epub 2016 May 18.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands;

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http://dx.doi.org/10.3945/ajcn.115.122937DOI Listing
July 2016

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial.

Cell Metab 2016 07;24(1):63-74

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, 6229ER Maastricht, The Netherlands; Top Institute Food and Nutrition, 6700AN Wageningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.06.016DOI Listing
July 2016

Angiopoietin-Like Protein 4 and Postprandial Skeletal Muscle Lipid Metabolism in Overweight and Obese Prediabetics.

J Clin Endocrinol Metab 2016 06 24;101(6):2332-9. Epub 2016 Mar 24.

Department of Human Biology (B.W.v.d.K., G.H.G., J.W.J., E.E.B.), NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands; and Nutrition, Metabolism, and Genomics Group (S.K.), Division of Human Nutrition, Wageningen University, 6700 HB Wageningen, The Netherlands.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2015-4285DOI Listing
June 2016

Altered Skeletal Muscle Fatty Acid Handling in Subjects with Impaired Glucose Tolerance as Compared to Impaired Fasting Glucose.

Nutrients 2016 Mar 14;8(3):164. Epub 2016 Mar 14.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht 6200 MD, The Netherlands.

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http://dx.doi.org/10.3390/nu8030164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808892PMC
March 2016

Insulin resistance determines a differential response to changes in dietary fat modification on metabolic syndrome risk factors: the LIPGENE study.

Am J Clin Nutr 2015 Dec 11;102(6):1509-17. Epub 2015 Nov 11.

Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba, Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain; CIBER Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Spain;

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http://dx.doi.org/10.3945/ajcn.115.111286DOI Listing
December 2015

A 3-day EGCG-supplementation reduces interstitial lactate concentration in skeletal muscle of overweight subjects.

Sci Rep 2015 Dec 9;5:17896. Epub 2015 Dec 9.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/srep17896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673403PMC
December 2015

Short-chain fatty acids in control of body weight and insulin sensitivity.

Nat Rev Endocrinol 2015 Oct 11;11(10):577-91. Epub 2015 Aug 11.

Department of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Universiteitssingel 50, 6229 ER, Maastricht, PO Box 616, 6200 MD, Maastricht, Netherlands.

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http://dx.doi.org/10.1038/nrendo.2015.128DOI Listing
October 2015

The role of polydextrose in body weight control and glucose regulation.

Curr Opin Clin Nutr Metab Care 2015 Jul;18(4):395-400

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1097/MCO.0000000000000184DOI Listing
July 2015

Adipose tissue dysfunction and impaired metabolic health in human obesity: a matter of oxygen?

Front Endocrinol (Lausanne) 2015 24;6:55. Epub 2015 Apr 24.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre , Maastricht , Netherlands.

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http://dx.doi.org/10.3389/fendo.2015.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408910PMC
May 2015

Nε-(carboxymethyl)lysine-receptor for advanced glycation end product axis is a key modulator of obesity-induced dysregulation of adipokine expression and insulin resistance.

Arterioscler Thromb Vasc Biol 2014 Jun 10;34(6):1199-208. Epub 2014 Apr 10.

From the Department of Internal Medicine and the Laboratory of Metabolism and Vascular Medicine (K.H.J.G., P.M.N., M.M.v.G., C.J.H.v.d.K., C.D.A.S., C.G.S.), Cardiovascular Research Institute Maastricht (K.H.J.G., P.M.N., M.M.v.G., C.J.H.v.d.K., M.A.v.Z., C.D.A.S., C.G.S.), Department of Human Biology (G.H.G., E.E.B.), NUTRIM School for Nutrition, Toxicology, and Metabolism (G.H.G., S.S.R., W.A.B., J.W.M.G., E.E.B.), Department of General Surgery (S.S.R., W.A.B., J.W.M.G.), and Department of Biomedical Engineering (M.A.v.Z.), Maastricht University Medical Center, Maastricht, The Netherlands; Department of Pathology and Cardiac Surgery, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands (H.W.N.); and Department of Medicine and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany (A.B.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302281DOI Listing
June 2014

Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity.

J Hepatol 2014 Apr 6;60(4):824-31. Epub 2013 Dec 6.

Department of Medicine, Academic Medical Center, Amsterdam, The Netherlands; Department of Vascular Medicine and Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2013.11.034DOI Listing
April 2014

Top single nucleotide polymorphisms affecting carbohydrate metabolism in metabolic syndrome: from the LIPGENE study.

J Clin Endocrinol Metab 2014 Feb 7;99(2):E384-9. Epub 2013 Nov 7.

Lipids and Atherosclerosis Unit (J.D.-L., P.P-M., A.G.-R., A.I.P.-C., A.C., J.L.-M.), Department of Medicine, and Neurosurgery Unit (J.S.), Instituto Maimónedes de Investigación Biomédica de Córdoba/Hospital Universitario Reina Sofía/Universidad de Córdoba, 14004 Cordoba, Spain and Centro de Investigación Biomédica en Red Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, 28029 Madrid, Spain; Department of Food and Nutritional Sciences and Institute for Cardiovascular and Metabolic Research (J.A.L.), University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom; Department of Nutrition (C.A.D.), Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway; Unité Mixte de Recherche, Inserm 1062 (C.D.), Research Unit in Nutrition, Obesity and Risk of Thrombosis, Faculté de Médecine, Aix-Marseille University, F-13385 Marseille, France; Department of Human Biology (E.E.B.), Nutrition and Toxicology Research Institute, Maastricht, 6200 MD Maastricht, The Netherlands; Department of Clinical Biochemistry (A.D.-K.), Jagiellonian University Medical College, 31-008, Krakow, Poland; Clinical Nutrition and Metabolism (U.R.), Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, 753 12 Uppsala, Sweden; Department of Computer Engineering (E.H.-G.), University of Cordoba, 14071 Cordoba, Spain; Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University (J.M.O.), Boston, Massachusetts 20111; and Nutrigenomics Research Group (H.R.), UCD School of Public Health and Population Science, UCD Conway Institute, University College Dublin 2010, Ireland.

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http://dx.doi.org/10.1210/jc.2013-3165DOI Listing
February 2014

Effect of polydextrose and soluble maize fibre on energy metabolism, metabolic profile and appetite control in overweight men and women.

Br J Nutr 2014 Jan 23;111(1):111-21. Epub 2013 Jul 23.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1017/S0007114513002183DOI Listing
January 2014

Adapted dietary inflammatory index and its association with a summary score for low-grade inflammation and markers of glucose metabolism: the Cohort study on Diabetes and Atherosclerosis Maastricht (CODAM) and the Hoorn study.

Am J Clin Nutr 2013 Dec 23;98(6):1533-42. Epub 2013 Oct 23.

Division of Human Nutrition, Wageningen University, Wageningen, Netherlands (GJvW, DT, AK, and EJMF); the CARIM School for Cardiovascular Diseases (IF, MMvG, CJvdK, CGS, and CDAS), the Department of Human Biology (EEB) and the NUTRIM School for Toxicology, Metabolism, and Nutrition (EEB), Maastricht University, Maastricht Netherlands; the Departments of Internal Medicine (IF, MMvG, CJvdK, CGS, and CDAS) and Clinical Epidemiology and Medical Technology Assessment (IF), Maastricht University Medical Center, Maastricht, Netherlands; the National Institute for Public Health and the Environment, Bilthoven, Netherlands (MCO); and the Departments of General Practice (GN) and Epidemiology and Biostatistics (JMD), EMGO Institute for Health and Care Research, Vrije Universiteit University Medical Center, Amsterdam, Netherlands.

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http://dx.doi.org/10.3945/ajcn.112.056333DOI Listing
December 2013

Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance.

Diabetologia 2013 Oct 2;56(10):2255-65. Epub 2013 Aug 2.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre+, PO Box 616, 6200 MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-013-2995-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764323PMC
October 2013

The effects of long-term valsartan treatment on skeletal muscle fatty acid handling in humans with impaired glucose metabolism.

J Clin Endocrinol Metab 2013 May 3;98(5):E891-6. Epub 2013 Apr 3.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2012-4067DOI Listing
May 2013

Obesity and body fat classification in the metabolic syndrome: impact on cardiometabolic risk metabotype.

Obesity (Silver Spring) 2013 Jan;21(1):E154-61

Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1002/oby.20263DOI Listing
January 2013

Impact of dietary fat quantity and quality on skeletal muscle fatty acid metabolism in subjects with the metabolic syndrome.

Metabolism 2012 Nov 1;61(11):1554-65. Epub 2012 Jun 1.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, 6200 MD Maastricht, the Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00260495120012
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http://dx.doi.org/10.1016/j.metabol.2012.04.003DOI Listing
November 2012

Adipose tissue oxygen tension: implications for chronic metabolic and inflammatory diseases.

Curr Opin Clin Nutr Metab Care 2012 Nov;15(6):539-46

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1097/MCO.0b013e328358fa87DOI Listing
November 2012

Reduced glycaemic and insulinaemic responses following trehalose and isomaltulose ingestion: implications for postprandial substrate use in impaired glucose-tolerant subjects.

Br J Nutr 2012 Oct 15;108(7):1210-7. Epub 2011 Dec 15.

Department of Human Biology, Maastricht University Medical Centre, Universiteitssingel 50, Maastricht, The Netherlands.

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http://dx.doi.org/10.1017/S0007114511006714DOI Listing
October 2012

Adipose triglyceride lipase and hormone-sensitive lipase protein expression in subcutaneous adipose tissue is decreased after an isoenergetic low-fat high-complex carbohydrate diet in the metabolic syndrome.

Metabolism 2012 Oct 30;61(10):1404-12. Epub 2012 Apr 30.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.metabol.2012.03.017DOI Listing
October 2012

A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome.

J Nutr 2012 Jul 23;142(7):1213-8. Epub 2012 May 23.

Lipid and Atherosclerosis Unit, Instituto Maimónides de Investigación Biomédica de Córdoba/Reina Sofia University Hospital/University of Cordoba, and Centro de Investigación Biomédica en Red en Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Spain.

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http://jn.nutrition.org/content/early/2012/05/22/jn.111.1569
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http://jn.nutrition.org/cgi/doi/10.3945/jn.111.156968
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July 2012

PUFAs acutely affect triacylglycerol-derived skeletal muscle fatty acid uptake and increase postprandial insulin sensitivity.

Am J Clin Nutr 2012 Apr 15;95(4):825-36. Epub 2012 Feb 15.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, Netherlands.

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https://academic.oup.com/ajcn/article/95/4/825/4576716
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http://dx.doi.org/10.3945/ajcn.111.028787DOI Listing
April 2012

Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans.

Mol Immunol 2012 Mar 8;50(3):142-9. Epub 2012 Feb 8.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology & Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2012.01.005DOI Listing
March 2012

Human plasma complement C3 is independently associated with coronary heart disease, but only in heavy smokers (the CODAM study).

Int J Cardiol 2012 Jan 5;154(2):158-62. Epub 2010 Oct 5.

Laboratory of Metabolism and Vascular Medicine, Cardiovascular Research Institute Maastricht and Department of Internal Medicine, Maastricht University, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S01675273100069
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http://dx.doi.org/10.1016/j.ijcard.2010.09.017DOI Listing
January 2012

Transcriptional metabolic inflexibility in skeletal muscle among individuals with increasing insulin resistance.

Obesity (Silver Spring) 2011 Nov 23;19(11):2158-66. Epub 2011 Jun 23.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre +, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/oby.2011.149DOI Listing
November 2011

Abdominal fat mass is associated with adaptive immune activation: the CODAM Study.

Obesity (Silver Spring) 2011 Aug 20;19(8):1690-8. Epub 2011 Jan 20.

Division of Clinical and Experimental Immunology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/oby.2010.337DOI Listing
August 2011

Skeletal muscle fatty acid handling in insulin resistant men.

Obesity (Silver Spring) 2011 Jul 17;19(7):1350-9. Epub 2011 Feb 17.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://diabetes.diabetesjournals.org/content/59/6/1366.full.
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http://doi.wiley.com/10.1038/oby.2011.10
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July 2011

Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation.

Circulation 2011 Jul 13;124(1):67-76. Epub 2011 Jun 13.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.111.027813DOI Listing
July 2011

Valsartan improves {beta}-cell function and insulin sensitivity in subjects with impaired glucose metabolism: a randomized controlled trial.

Diabetes Care 2011 Apr 17;34(4):845-51. Epub 2011 Feb 17.

Diabetes Center, Department of Internal Medicine, Vrije University Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.2337/dc10-2224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064038PMC
April 2011

Skeletal muscle lipase content and activity in obesity and type 2 diabetes.

J Clin Endocrinol Metab 2010 Dec 15;95(12):5449-53. Epub 2010 Sep 15.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2010-0776DOI Listing
December 2010

Effects of dietary fat modification on oxidative stress and inflammatory markers in the LIPGENE study.

Br J Nutr 2010 Nov 23;104(9):1357-62. Epub 2010 Jun 23.

Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden.

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http://dx.doi.org/10.1017/S000711451000228XDOI Listing
November 2010

Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids.

Am J Physiol Endocrinol Metab 2010 Jul 4;299(1):E14-22. Epub 2010 May 4.

Department of Human Biology, Maastricht University, Nutrition and Toxicology Research Institute Maastricht, Maastricht, The Netherlands.

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http://www.physiology.org/doi/10.1152/ajpendo.00187.2010
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July 2010