Publications by authors named "Elke Schaeffeler"

100Publications

Optimized protocol for metabolomic and lipidomic profiling in formalin-fixed paraffin-embedded kidney tissue by LC-MS.

Anal Chim Acta 2020 Oct 13;1134:125-135. Epub 2020 Aug 13.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany and University of Tübingen, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2020.08.005DOI Listing
October 2020

The Membrane Transporter OAT7 (SLC22A9) Is Not a Susceptibility Factor for Osteoporosis in Europeans.

Front Endocrinol (Lausanne) 2020 18;11:532. Epub 2020 Aug 18.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.3389/fendo.2020.00532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461822PMC
August 2020

Cell motility and migration as determinants of stem cell efficacy.

EBioMedicine 2020 Sep 10;60:102989. Epub 2020 Sep 10.

Institute of Clinical and Experimental Transfusion Medicine, University Hospital Tübingen, Tübingen, Germany; Institute for Transfusion Medicine and Immunohematology, German Red Cross Blood Donor Service Baden-Württemberg-Hessen gGmbH, Goethe-University Hospital, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.102989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494685PMC
September 2020

Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin.

Sci Rep 2020 Jul 27;10(1):12457. Epub 2020 Jul 27.

Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41598-020-69326-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385621PMC
July 2020

The cytosolic isoform of glutaredoxin 2 promotes cell migration and invasion.

Biochim Biophys Acta Gen Subj 2020 Jul 12;1864(7):129599. Epub 2020 Mar 12.

Institute for Medical Biochemistry and Molecular Biology, University Medicine, University Greifswald, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2020.129599DOI Listing
July 2020

Germline variant burden in multidrug resistance transporters is a therapy-specific predictor of survival in breast cancer patients.

Int J Cancer 2020 05 17;146(9):2475-2487. Epub 2020 Feb 17.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.32898DOI Listing
May 2020

Hypertonicity-Affected Genes Are Differentially Expressed in Clear Cell Renal Cell Carcinoma and Correlate with Cancer-Specific Survival.

Cancers (Basel) 2019 Dec 18;12(1). Epub 2019 Dec 18.

Department of Medicine, Hematology and Oncology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.

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http://dx.doi.org/10.3390/cancers12010006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017076PMC
December 2019

Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression.

Hum Genet 2020 Feb 30;139(2):137-149. Epub 2019 Nov 30.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1007/s00439-019-02093-7DOI Listing
February 2020

A Clinical Drug-Drug Interaction Study Assessing a Novel Drug Transporter Phenotyping Cocktail With Adefovir, Sitagliptin, Metformin, Pitavastatin, and Digoxin.

Clin Pharmacol Ther 2019 12 12;106(6):1398-1407. Epub 2019 Aug 12.

University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, Cologne, Germany.

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http://dx.doi.org/10.1002/cpt.1564DOI Listing
December 2019

Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry.

Genet Med 2019 09 7;21(9):2145-2150. Epub 2019 Feb 7.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1038/s41436-019-0448-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752748PMC
September 2019

Pharmacogene Variation Consortium Gene Introduction: NUDT15.

Clin Pharmacol Ther 2019 05 4;105(5):1091-1094. Epub 2018 Dec 4.

School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.

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http://dx.doi.org/10.1002/cpt.1268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465081PMC
May 2019

Simultaneous Extraction of RNA and Metabolites from Single Kidney Tissue Specimens for Combined Transcriptomic and Metabolomic Profiling.

J Proteome Res 2018 09 23;17(9):3039-3049. Epub 2018 Aug 23.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology , Stuttgart , Germany and University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1021/acs.jproteome.8b00199DOI Listing
September 2018

Influence of Variants on ova Treatment Outcome in Crohn's Disease.

Front Pharmacol 2018 16;9:764. Epub 2018 Jul 16.

Department of Internal Medicine I, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.3389/fphar.2018.00764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054957PMC
July 2018

The fruit fly Drosophila melanogaster as an innovative preclinical ADME model for solute carrier membrane transporters, with consequences for pharmacology and drug therapy.

Drug Discov Today 2018 10 8;23(10):1746-1760. Epub 2018 Jun 8.

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S13596446183008
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http://dx.doi.org/10.1016/j.drudis.2018.06.002DOI Listing
October 2018

Variants of PEAR1 Are Associated With Outcome in Patients With ACS and Stable CAD Undergoing PCI.

Front Pharmacol 2018 15;9:490. Epub 2018 May 15.

Department of Cardiology and Cardiovascular Medicine, University Hospital of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.3389/fphar.2018.00490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962768PMC
May 2018

Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy.

Clin Transl Sci 2018 07 16;11(4):352-364. Epub 2018 Apr 16.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1111/cts.12551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039204PMC
July 2018

Metabolic and Lipidomic Reprogramming in Renal Cell Carcinoma Subtypes Reflects Regions of Tumor Origin.

Eur Urol Focus 2019 07 13;5(4):608-618. Epub 2018 Feb 13.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tuebingen, Tuebingen, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Clinical Pharmacology, University Hospital Tuebingen, Tuebingen, Germany; Department of Pharmacy and Biochemistry, University of Tuebingen, Tuebingen, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054569183001
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http://dx.doi.org/10.1016/j.euf.2018.01.016DOI Listing
July 2019

Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia.

Hepatology 2018 04 2;67(4):1609-1619. Epub 2018 Mar 2.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1002/hep.29599DOI Listing
April 2018

Comment on "Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin".

Sci Transl Med 2017 05;9(391)

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Auerbachstr.112, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.1126/scitranslmed.aal2439DOI Listing
May 2017

The importance of drug transporter characterization to precision medicine.

Expert Opin Drug Metab Toxicol 2017 04 9;13(4):361-365. Epub 2017 Feb 9.

a Dr. Margarete Fischer-Bosch - Institute of Clinical Pharmacology , Stuttgart , Germany.

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http://dx.doi.org/10.1080/17425255.2017.1290083DOI Listing
April 2017

Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors.

Trends Pharmacol Sci 2016 11 19;37(11):904-932. Epub 2016 Sep 19.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Germany.

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http://dx.doi.org/10.1016/j.tips.2016.08.003DOI Listing
November 2016

PDK1 Determines Collagen-Dependent Platelet Ca2+ Signaling and Is Critical to Development of Ischemic Stroke In Vivo.

Arterioscler Thromb Vasc Biol 2016 08 23;36(8):1507-16. Epub 2016 Jun 23.

From the Department of Cardiology and Cardiovascular Medicine (P.M., B.W.-A., S.G., D.R., D.E., T.G., M.G., O.B.), Department of Physiology (B.W.-A., F.L.), Department of Evolutionary Biology of Invertebrates, Institute for Evolution and Ecology (M.M.), Department of Dermatology (M.S.), and Department of Clinical Pharmacology (M.S.), University of Tübingen, Tübingen, Germany; Department of Neurology, University of Würzburg, Würzburg, Germany (E.G., C.K.); Institute for Immunology and Transfusion Medicine, University of Greifswald, Greifswald, Germany (G.H., A.G.); and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany (S.W., E.S., M.S.).

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http://dx.doi.org/10.1161/ATVBAHA.115.307105DOI Listing
August 2016

Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine.

Arch Toxicol 2016 Jul 10;90(7):1555-84. Epub 2016 May 10.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1007/s00204-016-1728-5DOI Listing
July 2016

Pharmacogenetics: Implications for Modern Type 2 Diabetes Therapy.

Rev Diabet Stud 2015 Fall-Winter;12(3-4):363-76. Epub 2016 Feb 10.

Interfaculty Centre for Pharmacogenomics and Pharma Research at the University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1900/RDS.2015.12.363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5275760PMC
July 2018

Enzymatically Modified Low-Density Lipoprotein Is Present in All Stages of Aortic Valve Sclerosis: Implications for Pathogenesis of the Disease.

J Am Heart Assoc 2015 Oct 16;4(10):e002156. Epub 2015 Oct 16.

Department of Laboratory Medicine, Robert-Bosch-Hospital, Stuttgart, Germany (L.T., F.C., M.T.) Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany (F.C., S.W., U.H., E.S., S., M.S., K.S., M.S., M.T.).

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https://www.ahajournals.org/doi/10.1161/JAHA.115.002156
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http://dx.doi.org/10.1161/JAHA.115.002156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845139PMC
October 2015

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics.

Clin Pharmacokinet 2016 May;55(5):507-24

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Room Sp-3458, Wytemaweg 80, PO-box 2060, 3000 CB, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40262-015-0328-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823323PMC
May 2016

Impact of p38 MAP Kinase Inhibitors on LPS-Induced Release of TNF-α in Whole Blood and Primary Cells from Different Species.

Cell Physiol Biochem 2015 24;36(6):2237-49. Epub 2015 Jul 24.

Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University Tuebingen, Tuebingen, Germany.

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https://www.karger.com/Article/FullText/430188
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http://dx.doi.org/10.1159/000430188DOI Listing
May 2016

Survival Prediction of Clear Cell Renal Cell Carcinoma Based on Gene Expression Similarity to the Proximal Tubule of the Nephron.

Eur Urol 2015 Dec 12;68(6):1016-20. Epub 2015 Jun 12.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.eururo.2015.05.045DOI Listing
December 2015

Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Authors:
Tin Aung Mineo Ozaki Takanori Mizoguchi R Rand Allingham Zheng Li Aravind Haripriya Satoko Nakano Steffen Uebe Jeffrey M Harder Anita S Y Chan Mei Chin Lee Kathryn P Burdon Yury S Astakhov Khaled K Abu-Amero Juan C Zenteno Yildirim Nilgün Tomasz Zarnowski Mohammad Pakravan Leen Abu Safieh Liyun Jia Ya Xing Wang Susan Williams Daniela Paoli Patricio G Schlottmann Lulin Huang Kar Seng Sim Jia Nee Foo Masakazu Nakano Yoko Ikeda Rajesh S Kumar Morio Ueno Shin-Ichi Manabe Ken Hayashi Shigeyasu Kazama Ryuichi Ideta Yosai Mori Kazunori Miyata Kazuhisa Sugiyama Tomomi Higashide Etsuo Chihara Kenji Inoue Satoshi Ishiko Akitoshi Yoshida Masahide Yanagi Yoshiaki Kiuchi Makoto Aihara Tsutomu Ohashi Toshiya Sakurai Takako Sugimoto Hideki Chuman Fumihiko Matsuda Kenji Yamashiro Norimoto Gotoh Masahiro Miyake Sergei Y Astakhov Essam A Osman Saleh A Al-Obeidan Ohoud Owaidhah Leyla Al-Jasim Sami Al Shahwan Rhys A Fogarty Paul Leo Yaz Yetkin Çilingir Oğuz Mozhgan Rezaei Kanavi Afsaneh Naderi Beni Shahin Yazdani Evgeny L Akopov Kai-Yee Toh Gareth R Howell Andrew C Orr Yufen Goh Wee Yang Meah Su Qin Peh Ewa Kosior-Jarecka Urszula Lukasik Mandy Krumbiegel Eranga N Vithana Tien Yin Wong Yutao Liu Allison E Ashley Koch Pratap Challa Robyn M Rautenbach David A Mackey Alex W Hewitt Paul Mitchell Jie Jin Wang Ari Ziskind Trevor Carmichael Rangappa Ramakrishnan Kalpana Narendran Rangaraj Venkatesh Saravanan Vijayan Peiquan Zhao Xueyi Chen Dalia Guadarrama-Vallejo Ching Yu Cheng Shamira A Perera Rahat Husain Su-Ling Ho Ulrich-Christoph Welge-Luessen Christian Mardin Ursula Schloetzer-Schrehardt Axel M Hillmer Stefan Herms Susanne Moebus Markus M Nöthen Nicole Weisschuh Rohit Shetty Arkasubhra Ghosh Yik Ying Teo Matthew A Brown Ignacio Lischinsky Jonathan G Crowston Michae Coote Bowen Zhao Jinghong Sang Nihong Zhang Qisheng You Vera Vysochinskaya Panayiota Founti Anthoula Chatzikyriakidou Alexandros Lambropoulos Eleftherios Anastasopoulos Anne L Coleman M Roy Wilson Douglas J Rhee Jae Hee Kang Inna May-Bolchakova Steffen Heegaard Kazuhiko Mori Wallace L M Alward Jost B Jonas Liang Xu Jeffrey M Liebmann Balram Chowbay Elke Schaeffeler Matthias Schwab Fabian Lerner Ningli Wang Zhenglin Yang Paolo Frezzotti Shigeru Kinoshita John H Fingert Masaru Inatani Kei Tashiro André Reis Deepak P Edward Louis R Pasquale Toshiaki Kubota Janey L Wiggs Francesca Pasutto Fotis Topouzis Michael Dubina Jamie E Craig Nagahisa Yoshimura Periasamy Sundaresan Simon W M John Robert Ritch Michael A Hauser Chiea-Chuen Khor

Nat Genet 2015 Jun;47(6):689

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http://dx.doi.org/10.1038/ng0615-689cDOI Listing
June 2015

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.

Clin Pharmacokinet 2015 Jul;54(7):709-35

Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Hoppe-Seyler Strasse 3, 72076, Tübingen, Germany.

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http://link.springer.com/10.1007/s40262-015-0267-1
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http://dx.doi.org/10.1007/s40262-015-0267-1DOI Listing
July 2015

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Authors:
Tin Aung Mineo Ozaki Takanori Mizoguchi R Rand Allingham Zheng Li Aravind Haripriya Satoko Nakano Steffen Uebe Jeffrey M Harder Anita S Y Chan Mei Chin Lee Kathryn P Burdon Yury S Astakhov Khaled K Abu-Amero Juan C Zenteno Yildirim Nilgün Tomasz Zarnowski Mohammad Pakravan Leen Abu Safieh Liyun Jia Ya Xing Wang Susan Williams Daniela Paoli Patricio G Schlottmann Lulin Huang Kar Seng Sim Jia Nee Foo Masakazu Nakano Yoko Ikeda Rajesh S Kumar Morio Ueno Shin-ichi Manabe Ken Hayashi Shigeyasu Kazama Ryuichi Ideta Yosai Mori Kazunori Miyata Kazuhisa Sugiyama Tomomi Higashide Etsuo Chihara Kenji Inoue Satoshi Ishiko Akitoshi Yoshida Masahide Yanagi Yoshiaki Kiuchi Makoto Aihara Tsutomu Ohashi Toshiya Sakurai Takako Sugimoto Hideki Chuman Fumihiko Matsuda Kenji Yamashiro Norimoto Gotoh Masahiro Miyake Sergei Y Astakhov Essam A Osman Saleh A Al-Obeidan Ohoud Owaidhah Leyla Al-Jasim Sami Al Shahwan Rhys A Fogarty Paul Leo Yaz Yetkin Çilingir Oğuz Mozhgan Rezaei Kanavi Afsaneh Nederi Beni Shahin Yazdani Evgeny L Akopov Kai-Yee Toh Gareth R Howell Andrew C Orr Yufen Goh Wee Yang Meah Su Qin Peh Ewa Kosior-Jarecka Urszula Lukasik Mandy Krumbiegel Eranga N Vithana Tien Yin Wong Yutao Liu Allison E Ashley Koch Pratap Challa Robyn M Rautenbach David A Mackey Alex W Hewitt Paul Mitchell Jie Jin Wang Ari Ziskind Trevor Carmichael Rangappa Ramakrishnan Kalpana Narendran Rangaraj Venkatesh Saravanan Vijayan Peiquan Zhao Xueyi Chen Dalia Guadarrama-Vallejo Ching Yu Cheng Shamira A Perera Rahat Husain Su-Ling Ho Ulrich-Christoph Welge-Luessen Christian Mardin Ursula Schloetzer-Schrehardt Axel M Hillmer Stefan Herms Susanne Moebus Markus M Nöthen Nicole Weisschuh Rohit Shetty Arkasubhra Ghosh Yik Ying Teo Matthew A Brown Ignacio Lischinsky Jonathan G Crowston Michael Coote Bowen Zhao Jinghong Sang Nihong Zhang Qisheng You Vera Vysochinskaya Panayiota Founti Anthoula Chatzikyriakidou Alexandros Lambropoulos Eleftherios Anastasopoulos Anne L Coleman M Roy Wilson Douglas J Rhee Jae Hee Kang Inna May-Bolchakova Steffen Heegaard Kazuhiko Mori Wallace L M Alward Jost B Jonas Liang Xu Jeffrey M Liebmann Balram Chowbay Elke Schaeffeler Matthias Schwab Fabian Lerner Ningli Wang Zhenglin Yang Paolo Frezzotti Shigeru Kinoshita John H Fingert Masaru Inatani Kei Tashiro André Reis Deepak P Edward Louis R Pasquale Toshiaki Kubota Janey L Wiggs Francesca Pasutto Fotis Topouzis Michael Dubina Jamie E Craig Nagahisa Yoshimura Periasamy Sundaresan Simon W M John Robert Ritch Michael A Hauser Chiea-Chuen Khor

Nat Genet 2015 Apr 23;47(4):387-92. Epub 2015 Feb 23.

1] Singapore Eye Research Institute, Singapore. [2] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [3] Division of Human Genetics, Genome Institute of Singapore, Singapore.

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http://dx.doi.org/10.1038/ng.3226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605818PMC
April 2015

Differential expression of drug uptake and efflux transporters in Japanese patients with hepatocellular carcinoma.

Drug Metab Dispos 2014 Dec 17;42(12):2033-40. Epub 2014 Sep 17.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany (T.N., E.S., P.F., M.S., A.T.N.); Third Department of Internal Medicine (T.N., H.F., H.Y.) and Department of Surgery (Y.N.), Nara Medical University, Kashihara, Japan; and Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital, Tübingen, Germany (M.S.)

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http://dmd.aspetjournals.org/content/early/2014/09/17/dmd.11
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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.114.059832
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http://dx.doi.org/10.1124/dmd.114.059832DOI Listing
December 2014

Mechanisms and assessment of statin-related muscular adverse effects.

Br J Clin Pharmacol 2014 Sep;78(3):454-66

Division of General Practice, University Hospital Tübingen, Tübingen, D-72074, Germany.

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http://doi.wiley.com/10.1111/bcp.12360
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http://dx.doi.org/10.1111/bcp.12360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243897PMC
September 2014

Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research.

Expert Opin Drug Metab Toxicol 2014 Mar 8;10(3):395-408. Epub 2014 Jan 8.

Margarete Fischer-Bosch-Institute of Clinical Pharmacology , Auerbachstrasse 125, Stuttgart, 70376 , Germany

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http://dx.doi.org/10.1517/17425255.2014.876990DOI Listing
March 2014

Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).

Clin Cancer Res 2014 Feb 18;20(4):985-94. Epub 2013 Dec 18.

Authors' Affiliations: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen; Institute of Pharmacy, Department of Pharmacology, University of Tübingen; Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen; Institute of Experimental and Clinical Pharmacology, Second Medical Department, University Hospital Schleswig-Holstein, Campus Kiel; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany; and Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932302PMC
February 2014

Impact of vitamin D receptor VDR rs2228570 polymorphism in oldest old.

Kidney Blood Press Res 2013 14;37(4-5):311-22. Epub 2013 Sep 14.

Department of Physiology, University of Tuebingen, Germany.

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http://dx.doi.org/10.1159/000350159DOI Listing
August 2014

Functional genomics suggest neurogenesis in the adult human olfactory bulb.

Brain Struct Funct 2014 Nov 9;219(6):1991-2000. Epub 2013 Aug 9.

Institute of Clinical Pharmacology, Goethe-University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany,

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http://dx.doi.org/10.1007/s00429-013-0618-3DOI Listing
November 2014

DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome.

Clin Cancer Res 2013 Sep 23;19(18):5170-81. Epub 2013 Jul 23.

Authors' Affiliations: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tuebingen, Tuebingen, Germany; Department of Urology, University Hospital Tuebingen, Tuebingen, Germany; Institute of Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany; Department of Clinical Pharmacology, University Hospital Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1180DOI Listing
September 2013

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1.

Genome Med 2013 11;5(1). Epub 2013 Jan 11.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376 Stuttgart, Germany, and University of Tübingen.

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http://dx.doi.org/10.1186/gm405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706890PMC
May 2014

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects.

Trends Pharmacol Sci 2013 Feb 29;34(2):126-35. Epub 2012 Dec 29.

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1016/j.tips.2012.11.005DOI Listing
February 2013

Pharmacogenomics: a key component of personalized therapy.

Genome Med 2012 29;4(11):93. Epub 2012 Nov 29.

Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376, Stuttgart, Germany ; Department of Clinical Pharmacology, University Hospital, 72076 Tuebingen, Germany.

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http://dx.doi.org/10.1186/gm394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580426PMC
May 2014

Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs.

Expert Opin Drug Metab Toxicol 2012 Dec 13;8(12):1565-77. Epub 2012 Sep 13.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Auerbachstrasse 112, 70376 Stuttgart, Germany.

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http://www.tandfonline.com/doi/full/10.1517/17425255.2012.72
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http://dx.doi.org/10.1517/17425255.2012.722996DOI Listing
December 2012

Organic anion transporters and their implications in pharmacotherapy.

Pharmacol Rev 2012 Jul 28;64(3):421-49. Epub 2012 Mar 28.

Margarete Fischer-Bosch Institute of Clinical Pharmacology, 70-376 Stuttgart, Auerbachstr. 112, Germany.

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http://dx.doi.org/10.1124/pr.111.004614DOI Listing
July 2012

Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry.

Anal Chem 2012 Feb 25;84(3):1294-301. Epub 2012 Jan 25.

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1021/ac2031699DOI Listing
February 2012

Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics.

Drug Metab Rev 2011 Nov 17;43(4):499-523. Epub 2011 Sep 17.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.3109/03602532.2011.602687DOI Listing
November 2011

Warfarin pharmacogenetics meets clinical use.

Blood 2011 Sep;118(11):2938-9

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-07-36
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http://dx.doi.org/10.1182/blood-2011-07-367763DOI Listing
September 2011

Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs).

PLoS One 2011 14;6(7):e22163. Epub 2011 Jul 14.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022163PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136501PMC
November 2011

Neural correlates of error monitoring modulated by atomoxetine in healthy volunteers.

Biol Psychiatry 2011 May 17;69(9):890-7. Epub 2010 Dec 17.

Department of Psychiatry, Ulm University Hospital, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1016/j.biopsych.2010.10.018DOI Listing
May 2011

A multiplex MALDI-TOF MS approach facilitates genotyping of DNA from formalin-fixed paraffin-embedded tumour specimens.

Pharmacogenet Genomics 2010 Oct;20(10):598-604

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1097/FPC.0b013e32833deb16DOI Listing
October 2010

Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy?

Ther Drug Monit 2010 Apr;32(2):119-28

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1097/FTD.0b013e3181d12f19DOI Listing
April 2010

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation.

Pharmacogenomics 2009 Apr;10(4):579-99

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Auerbachstrasse 112, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.2217/pgs.09.7DOI Listing
April 2009