Publications by authors named "Elizaveta Trush"

6 Publications

  • Page 1 of 1

Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial.

Probiotics Antimicrob Proteins 2021 Oct 13. Epub 2021 Oct 13.

Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Moscow, Russian Federation.

The treatment of coronavirus disease (COVID-19) and COVID-19-associated diarrhea remains challenging. This study aimed to evaluate the efficacy of a multi-strain probiotic in the treatment of COVID-19. This was a randomized, controlled, single-center, open-label trial (NCT04854941). Inpatients with confirmed COVID-19 and pneumonia were randomly assigned to a group that received a multi-strain probiotic (PRO group) or to the control group (CON group). There were 99 and 101 patients in the PRO and CON groups, respectively. No significant differences in mortality, total duration of disease and hospital stay, incidence of intensive care unit admission, need for mechanical ventilation or oxygen support, liver injury development, and changes in inflammatory biomarker levels were observed between the PRO and CON groups among all included patients as well as among subgroups delineated based on age younger or older than 65 years, and subgroups with chronic cardiovascular diseases and diabetes. Diarrhea on admission was observed in 11.5% of patients; it resolved earlier in the PRO group than in the CON group (2 [1-4] vs. 4 [3-6] days; p = 0.049). Hospital-acquired diarrhea developed less frequently in the PRO group than in the CON group among patients who received a single antibiotic (0% vs. 12.5%; p = 0.023) unlike among those who received > 1 antibiotic (10.5% vs. 13.3%; p = 0.696). The studied probiotic had no significant effect on mortality and changes in most biomarkers in COVID-19. However, it was effective in treating diarrhea associated with COVID-19 and in preventing hospital-acquired diarrhea in patients who received a single antibiotic.
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http://dx.doi.org/10.1007/s12602-021-09858-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512595PMC
October 2021

The Evolution of Human Probiotics: Challenges and Prospects.

Probiotics Antimicrob Proteins 2020 12;12(4):1291-1299

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

In recent years, the intestinal microbiota has been found to greatly influence a number of biological processes important for human health and longevity. Microbial composition changes easily in response to external factors, such as an unbalanced diet, lack of physical activity, and smoking. Probiotics are a key factor in maintaining the optimal composition of the intestinal microbiota. However, a number of important questions related to probiotics, such as indication for prescription, comparative efficacy of monostrain and multistrain probiotics, methods of delivery, and shelf life, remain unresolved. The aim of this review is to highlight existing issues regarding probiotic production and their prescription. The review presents the most recent findings regarding advantages and efficacy of monostrain and multistrain probiotics, preservation of probiotic strains in capsules and microcapsules, production of probiotics in the form of biofilms for improved efficacy and survival, and results of clinical studies evaluating the benefits of probiotics against different pathologies. We believe that this work will be of interest to physicians and researchers alike and will promote the development of new probiotics and ensuing regimens aimed at the treatment of various diseases.
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http://dx.doi.org/10.1007/s12602-019-09628-4DOI Listing
December 2020

Tetra-methyl-ammonium dimethyl (phenyl-sulfonyl-amido)phosphate(1-).

Acta Crystallogr Sect E Struct Rep Online 2012 Feb 7;68(Pt 2):o273. Epub 2012 Jan 7.

The title compound, C(4)H(12)N(+)·C(8)H(11)NO(5)PS(-), was obtained from tetra-methyl-ammonium hydroxide and dimeth-yl(phenyl-sulfon-yl)amido-phosphate. The tetra-methyl-ammonium cation has a slightly distorted tetra-hedral configuration and the N-C bond lengths lie in the range 1.457 (3)-1.492 (3) Å. In the crystal, no classical hydrogen bonds are observed between the cation and the anion.
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http://dx.doi.org/10.1107/S1600536811055024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274970PMC
February 2012

cis-Diaqua-bis-[dimethyl (phenyl-sulfonyl-imino)-phospho-nato]cobalt(II).

Acta Crystallogr Sect E Struct Rep Online 2011 Feb 23;67(Pt 3):m369-70. Epub 2011 Feb 23.

In the title diaqua-cobalt complex, [Co(C(8)H(11)NO(5)PS)(2)(H(2)O)(2)], the Co(II) atom is surrounded by six O atoms belonging to the phosphoryl and sulfonyl groups of two deprotonated chelate ligands and two additional O atoms from water mol-ecules which are in cis positions with respect to one another. The coordination environment of cobalt can be described as a distorted octa-hedron. O-H⋯O hydrogen bonds between the water and sulfonyl O atoms of neighboring mol-ecules form chains running parallel to [010]. Two methoxy groups attached to one phosphorus are disordered over two sets of sites in a 0.6:0.4 ratio.
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http://dx.doi.org/10.1107/S1600536811006027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051992PMC
February 2011

N-[Bis(dimethyl-amino)phosphinoyl]-2,2,2-trichloro-acetamide.

Acta Crystallogr Sect E Struct Rep Online 2010 Apr 17;66(Pt 5):o1102. Epub 2010 Apr 17.

Kyiv National Taras Shevchenko University, Department of Chemistry, Volodymyrska str. 64, 01601 Kyiv, Ukraine.

In the title compound, C(6)H(13)Cl(3)N(3)O(2)P or CCl(3)C(O)NHP(O)(N(CH(3))(2)), the phosphinoyl group is synclinal to the carbonyl group and acts as an acceptor for an inter-molecular N-H⋯O hydrogen bond from the amide group as the donor.
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http://dx.doi.org/10.1107/S1600536810013589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979112PMC
April 2010

catena-Poly[calcium-bis-[μ-N-(dimethyl-phosphino-yl)benzene-sulfonamidato]].

Acta Crystallogr Sect E Struct Rep Online 2009 Sep 19;65(Pt 10):m1231. Epub 2009 Sep 19.

The crystal structure of the title calcium complex, [Ca(C(8)H(11)NO(5)PS)(2)](n), is composed of a polymeric chain, which is formed due to two bridging sulfonyl groups linking Ca(II) ions in a O-S-O-Ca manner. Thus, the coordination environment of the Ca(II) ions is composed of six O atoms belonging to the phosphoryl and sulfonyl groups of two chelate rings and two additional O atoms of two bridging sulfonyl groups. The coordination polyhedron of the central atom (2 symmetry) has a distorted octa-hedral geometry.
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http://dx.doi.org/10.1107/S1600536809032875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970174PMC
September 2009
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