Elizabeth R Lawlor

Elizabeth R Lawlor

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Elizabeth R Lawlor

Elizabeth R Lawlor

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Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma.

Neoplasia 2019 Sep 12;21(10):1063-1072. Epub 2019 Sep 12.

Department of Pediatrics, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 15224. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586193016
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http://dx.doi.org/10.1016/j.neo.2019.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745492PMC
September 2019

Tissue-directed Implantation Using Ultrasound Visualization for Development of Biologically Relevant Metastatic Tumor Xenografts.

In Vivo 2017 Sep-Oct;31(5):779-791

Department of Surgery, C.S Mott Children's and Women's Hospital, Mott Solid Tumor Oncology Program, The University of Michigan Medical School, Ann Arbor, MI, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656850PMC
May 2018

Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States.

Cancer Res 2016 09 30;76(17):5040-53. Epub 2016 Jun 30.

Translational Oncology Program, The University of Michigan, Ann Arbor, Michigan. Department of Pediatrics, and Communicable Diseases, The University of Michigan, Ann Arbor, Michigan. Department of Pathology, The University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010452PMC
September 2016

Micro-Environmental Stress Induces Src-Dependent Activation of Invadopodia and Cell Migration in Ewing Sarcoma.

Neoplasia 2016 08;18(8):480-8

University of Michigan, Department of Pediatrics, Ann Arbor, MI, 48109, USA; University of Michigan, Department of Pathology, Ann Arbor, MI, 48109, USA; University of Michigan, Department of Translational Oncology Program, Ann Arbor, MI, 48109, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586163009
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http://dx.doi.org/10.1016/j.neo.2016.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018098PMC
August 2016

The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma.

Oncotarget 2016 Jul;7(27):41767-41780

Laboratory for Functional Genomics and Transplantation Biology, Children's Cancer Research Center and Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich Comprehensive Cancer Center (CCCM), and German Translational Cancer Research Consortium (DKTK), Munich, Germany.

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http://dx.doi.org/10.18632/oncotarget.9702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173095PMC
July 2016

Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?

Crit Rev Oncog 2015 ;20(3-4):155-71

Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671490PMC
June 2016

Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.

PLoS One 2015 30;10(4):e0120348. Epub 2015 Apr 30.

Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland; Departments of Pathology and Department of Biochemistry and Biophysics, University of California San Francisco (UCSF), San Francisco, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120348PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415914PMC
April 2016

Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation.

Mol Cancer Res 2016 Jan 16;14(1):26-34. Epub 2015 Nov 16.

Translational Oncology Program, University of Michigan, Ann Arbor, Michigan. Department of Pediatrics, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716008PMC
January 2016

Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group.

PLoS One 2014 5;9(8):e104378. Epub 2014 Aug 5.

Sarcoma Services, Department of Orthopedic Surgery, University of Utah, Salt Lake City, Utah, United States of America; Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America; Division of Pediatric Hematology/Oncology, University of Utah, Salt Lake City, Utah, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104378PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122435PMC
November 2015

Systemic levels of neuropeptide Y and dipeptidyl peptidase activity in patients with Ewing sarcoma--associations with tumor phenotype and survival.

Cancer 2015 Mar 11;121(5):697-707. Epub 2014 Nov 11.

Department of Nursing, School of Nursing and Health Studies, Georgetown University, Washington, District of Columbia; Department of Human Science, School of Nursing and Health Studies, Georgetown University, Washington, District of Columbia.

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http://dx.doi.org/10.1002/cncr.29090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339539PMC
March 2015

Differentially expressed miRNAs in Ewing sarcoma compared to mesenchymal stem cells: low miR-31 expression with effects on proliferation and invasion.

PLoS One 2014 25;9(3):e93067. Epub 2014 Mar 25.

Gerhard-Domagk-Institute for Pathology, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany; Department of Pathology, Justus-Liebig-University, Giessen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093067PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965523PMC
November 2014

Comparative evaluation of strategies for quantifying signaling pathway proteins in Ewing sarcoma.

Appl Immunohistochem Mol Morphol 2014 Sep;22(8):593-9

*Department of Pediatrics, University of Chicago, Chicago, IL Departments of ¶Pediatrics §Pathology, San Francisco School of Medicine, University of California, San Francisco, CA Departments of †Pathology ∥Pediatrics, University of Michigan Medical School, Ann Arbor, MI ‡OncoPlex Diagnostics, Rockville, MD.

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http://dx.doi.org/10.1097/PAI.0b013e3182a8d4bbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148473PMC
September 2014

Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines.

PLoS One 2013 2;8(12):e80060. Epub 2013 Dec 2.

Childrens Center for Cancer and Blood Diseases, Childrens Hospital Los Angeles, Los Angeles, California, United States of America ; Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, United States of America ; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080060PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846563PMC
August 2014

Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma.

Mol Cancer Res 2014 Jun 20;12(6):953-64. Epub 2014 Mar 20.

Authors' Affiliations: Departments of Pediatrics and Communicable Diseases, Pathology, University of Michigan, Ann Arbor, Michigan

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058379PMC
June 2014

LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/β-Catenin Signaling.

Front Oncol 2013 15;3:81. Epub 2013 Apr 15.

Keck School of Medicine, University Southern California Los Angeles, CA, USA ; Department of Pediatrics, University of Michigan Ann Arbor, MI, USA.

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http://dx.doi.org/10.3389/fonc.2013.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625903PMC
April 2013

Ewing sarcoma of the kidney: case series and literature review of an often overlooked entity in the diagnosis of primary renal tumors.

Urology 2013 Feb;81(2):347-53

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-5848, USA.

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http://dx.doi.org/10.1016/j.urology.2012.10.016DOI Listing
February 2013

Epigenetic changes in pediatric solid tumors: promising new targets.

Clin Cancer Res 2012 May;18(10):2768-79

Department of Pediatrics and Pathology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691809PMC
May 2012

Modeling initiation of Ewing sarcoma in human neural crest cells.

PLoS One 2011 Apr 29;6(4):e19305. Epub 2011 Apr 29.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019305PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084816PMC
April 2011

Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma.

Clin Cancer Res 2010 Jul 4;16(14):3769-78. Epub 2010 Jun 4.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905506PMC
July 2010

GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors.

PLoS One 2009 Oct 27;4(10):e7608. Epub 2009 Oct 27.

Division of Hematology-Oncology, Department of Pediatrics, Childrens Hospital Los Angeles and the Saban Research Institute, University of Southern California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007608PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763206PMC
October 2009

Isolation and characterization of neural crest stem cells derived from in vitro-differentiated human embryonic stem cells.

Stem Cells Dev 2009 Sep;18(7):1059-70

Divisions of Hematology-Oncology, The Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California 90027, USA.

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https://www.liebertpub.com/doi/10.1089/scd.2008.0362
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http://dx.doi.org/10.1089/scd.2008.0362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606969PMC
September 2009

EWS-FLI1 causes neuroepithelial defects and abrogates emigration of neural crest stem cells.

Stem Cells 2008 Sep 12;26(9):2237-44. Epub 2008 Jun 12.

Division of Biology M/C 139-74, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1634/stemcells.2008-0133DOI Listing
September 2008

Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Bone Tumor Committee.

Pediatr Blood Cancer 2008 Aug;51(2):163-70

Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1002/pbc.21596DOI Listing
August 2008

Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors.

Nat Med 2007 Oct 30;13(10):1211-8. Epub 2007 Sep 30.

Cancer Research Institute and Department of Pathology, University of California San Francisco, 2340 Sutter Street, San Francisco, California 94143-0875, USA.

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http://dx.doi.org/10.1038/nm1649DOI Listing
October 2007

The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.

Genes Dev 2006 Sep;20(18):2527-38

Cancer Research Institute and Department of Cellular and Molecular Pharmacology, University of California at San Francisco Comprehensive Cancer Center, 94143, USA.

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http://dx.doi.org/10.1101/gad.1455706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1578676PMC
September 2006

Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis.

Cancer Res 2006 May;66(9):4591-601

Cancer Research Institute, University of California San Francisco Comprehensive Cancer Center, San Francisco, California 94143, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-3826DOI Listing
May 2006

Temporal dissection of p53 function in vitro and in vivo.

Nat Genet 2005 Jul 29;37(7):718-26. Epub 2005 May 29.

Cancer Research Institute, University of California San Francisco Comprehensive Cancer Center, San Francisco, California 94143-0875, USA.

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http://dx.doi.org/10.1038/ng1572DOI Listing
July 2005

Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions.

Cancer Res 2002 Aug;62(16):4704-10

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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August 2002

Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors.

Oncogene 2002 Jan;21(2):307-18

Department of Pediatrics, Children's and Women's Health Centre of British Columbia, and the University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

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http://www.nature.com/articles/1205053
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http://dx.doi.org/10.1038/sj.onc.1205053DOI Listing
January 2002