Elizabeth M Simpson

Elizabeth M Simpson

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Elizabeth M Simpson

Elizabeth M Simpson

Publications by authors named "Elizabeth M Simpson"

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Ferroportin-mediated iron export from vascular endothelial cells in retina and brain.

Exp Eye Res 2019 10 16;187:107728. Epub 2019 Jul 16.

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, 305 Stellar-Chance Laboratory, 422 Curie Blvd, Philadelphia, PA, 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2019.107728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759385PMC
October 2019

Correction: Epistasis between Pax6 and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials.

Gene Ther 2019 04;26(3-4):133

Centre for Molecular Medicine and Therapeutics at BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/s41434-018-0054-3DOI Listing
April 2019

How do genes that escape from X-chromosome inactivation contribute to Turner syndrome?

Am J Med Genet C Semin Med Genet 2019 03 19;181(1):28-35. Epub 2019 Feb 19.

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/ajmg.c.31672DOI Listing
March 2019

Epistasis between Pax6 and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials.

Gene Ther 2018 12 26;25(8):524-537. Epub 2018 Sep 26.

Centre for Molecular Medicine and Therapeutics at BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/s41434-018-0043-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335240PMC
December 2018

Human cis-acting elements regulating escape from X-chromosome inactivation function in mouse.

Hum Mol Genet 2018 04;27(7):1252-1262

Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

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https://academic.oup.com/hmg/article/27/7/1252/4833562
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http://dx.doi.org/10.1093/hmg/ddy039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159535PMC
April 2018

Co-activator candidate interactions for orphan nuclear receptor NR2E1.

BMC Genomics 2016 10 26;17(1):832. Epub 2016 Oct 26.

Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada.

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http://dx.doi.org/10.1186/s12864-016-3173-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080790PMC
October 2016

PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina.

Mol Ther Methods Clin Dev 2016 10;3:16051. Epub 2016 Aug 10.

Centre for Molecular Medicine and Therapeutics at the BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/mtm.2016.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980111PMC
August 2016

Nr2e1 regulates retinal lamination and the development of Müller glia, S-cones, and glycineric amacrine cells during retinogenesis.

Mol Brain 2015 Jun 20;8:37. Epub 2015 Jun 20.

Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, University of British Columbia, 950 W 28 Ave, Vancouver, V5Z 4H4, BC, Canada.

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http://link.springer.com/content/pdf/10.1186%2Fs13041-015-01
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http://www.molecularbrain.com/content/8/1/37
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http://dx.doi.org/10.1186/s13041-015-0126-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475312PMC
June 2015

Targeted CNS Delivery Using Human MiniPromoters and Demonstrated Compatibility with Adeno-Associated Viral Vectors.

Mol Ther Methods Clin Dev 2014 Jan;1

Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4 ; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4 ; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada V6T 2A1.

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http://dx.doi.org/10.1038/mtm.2013.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992516PMC
January 2014

Absence of NR2E1 mutations in patients with aniridia.

Mol Vis 2012 22;18:2770-82. Epub 2012 Nov 22.

Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513187PMC
May 2013

Targeting of >1.5 Mb of human DNA into the mouse X chromosome reveals presence of cis-acting regulators of epigenetic silencing.

Genetics 2012 Dec 28;192(4):1281-93. Epub 2012 Sep 28.

Department of Medical Genetics, Molecular Epigenetics Group, Life Sciences Institute, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

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http://dx.doi.org/10.1534/genetics.112.143743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512139PMC
December 2012

Beyond knockouts: cre resources for conditional mutagenesis.

Mamm Genome 2012 Oct 29;23(9-10):587-99. Epub 2012 Aug 29.

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

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http://dx.doi.org/10.1007/s00335-012-9430-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655717PMC
October 2012

The mammalian gene function resource: the International Knockout Mouse Consortium.

Mamm Genome 2012 Oct 12;23(9-10):580-6. Epub 2012 Sep 12.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1007/s00335-012-9422-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463800PMC
October 2012

Modelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencing.

PLoS Genet 2012 1;8(3):e1002544. Epub 2012 Mar 1.

Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1002544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291530PMC
September 2012

The transcription factor encyclopedia.

Authors:
Dimas Yusuf Stefanie L Butland Magdalena I Swanson Eugene Bolotin Amy Ticoll Warren A Cheung Xiao Yu Cindy Zhang Christopher T D Dickman Debra L Fulton Jonathan S Lim Jake M Schnabl Oscar H P Ramos Mireille Vasseur-Cognet Charles N de Leeuw Elizabeth M Simpson Gerhart U Ryffel Eric W-F Lam Ralf Kist Miranda S C Wilson Raquel Marco-Ferreres Jan J Brosens Leonardo L Beccari Paola Bovolenta Bérénice A Benayoun Lara J Monteiro Helma D C Schwenen Lars Grontved Elizabeth Wederell Susanne Mandrup Reiner A Veitia Harini Chakravarthy Pamela A Hoodless M Michela Mancarelli Bruce E Torbett Alison H Banham Sekhar P Reddy Rebecca L Cullum Michaela Liedtke Mario P Tschan Michelle Vaz Angie Rizzino Mariastella Zannini Seth Frietze Peggy J Farnham Astrid Eijkelenboom Philip J Brown David Laperrière Dominique Leprince Tiziana de Cristofaro Kelly L Prince Marrit Putker Luis del Peso Gieri Camenisch Roland H Wenger Michal Mikula Marieke Rozendaal Sylvie Mader Jerzy Ostrowski Simon J Rhodes Capucine Van Rechem Gaylor Boulay Sam W Z Olechnowicz Mary B Breslin Michael S Lan Kyster K Nanan Michael Wegner Juan Hou Rachel D Mullen Stephanie C Colvin Peter John Noy Carol F Webb Matthew E Witek Scott Ferrell Juliet M Daniel Jason Park Scott A Waldman Daniel J Peet Michael Taggart Padma-Sheela Jayaraman Julien J Karrich Bianca Blom Farhad Vesuna Henriette O'Geen Yunfu Sun Richard M Gronostajski Mark W Woodcroft Margaret R Hough Edwin Chen G Nicholas Europe-Finner Magdalena Karolczak-Bayatti Jarrod Bailey Oliver Hankinson Venu Raman David P LeBrun Shyam Biswal Christopher J Harvey Jason P DeBruyne John B Hogenesch Robert F Hevner Christophe Héligon Xin M Luo Marissa Cathleen Blank Kathleen Joyce Millen David S Sharlin Douglas Forrest Karin Dahlman-Wright Chunyan Zhao Yuriko Mishima Satrajit Sinha Rumela Chakrabarti Elodie Portales-Casamar Frances M Sladek Philip H Bradley Wyeth W Wasserman

Genome Biol 2012 ;13(3):R24

Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada.

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http://digital.csic.es/bitstream/10261/53044/2/gb-2012-13-3-
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http://genomebiology.com/2012/13/3/R24
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http://dx.doi.org/10.1186/gb-2012-13-3-r24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439975PMC
September 2012

A rare cause of ear pain in a young boy.

J Pediatr 2012 Feb 13;160(2):350. Epub 2011 Oct 13.

Department of Medicine, Section of Rheumatology, Allergy and Adult Immunology, Georgia Health Sciences University Augusta, Georgia, USA.

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http://dx.doi.org/10.1016/j.jpeds.2011.08.030DOI Listing
February 2012

Laboratory Animal Management Assistant (LAMA): a LIMS for active research colonies.

Mamm Genome 2010 Jun 22;21(5-6):224-30. Epub 2010 Apr 22.

Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047758PMC
http://dx.doi.org/10.1007/s00335-010-9258-6DOI Listing
June 2010

Expression analysis of novel striatal-enriched genes in Huntington disease.

Hum Mol Genet 2010 Feb 23;19(4):609-22. Epub 2009 Nov 23.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada

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http://dx.doi.org/10.1093/hmg/ddp527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807369PMC
February 2010

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.

Nature 2009 Jan 10;457(7229):599-602. Epub 2008 Dec 10.

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T1Z3, Canada.

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http://dx.doi.org/10.1038/nature07586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696133PMC
January 2009

Multicentric reticulohistiocytosis: diagnosis at the nailbeds.

J Rheumatol 2008 Nov;35(11):2272-3

Department of Medicine, Section of Rheumatology, Medical College of Georgia, Augusta, Georgia 30912, USA.

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http://dx.doi.org/10.3899/jrheum.080423DOI Listing
November 2008

Absence of mutations in NR2E1 and SNX3 in five patients with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and related phenotypes.

BMC Med Genet 2007 Jul 26;8:48. Epub 2007 Jul 26.

Centre for Molecular Medicine and Therapeutics, Child & Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28th Ave, Vancouver, V5Z 4H4, Canada.

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http://dx.doi.org/10.1186/1471-2350-8-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950490PMC
July 2007

SAGE2Splice: unmapped SAGE tags reveal novel splice junctions.

PLoS Comput Biol 2006 Apr 28;2(4):e34. Epub 2006 Apr 28.

Genetics Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1371/journal.pcbi.0020034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447652PMC
April 2006

Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1.

J Neurosci 2005 Jul;25(27):6263-70

Graduate Program in Neuroscience, British Columbia Research Institute for Children's and Women's Health, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.4757-04.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725287PMC
July 2005

Engineering embryonic stem cell derived glia for adenosine delivery.

Neurosci Lett 2004 Nov;370(2-3):160-5

Institute of Pharmacology and Toxicology, University of Zürich, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.neulet.2004.08.031DOI Listing
November 2004

Unexpected embryonic stem (ES) cell mutations represent a concern in gene targeting: lessons from "fierce" mice.

Genesis 2004 Feb;38(2):51-7

Doctorate Program in Medical Genetics, University of British Columbia, Vancouver, British Columbia, V5Z 4H4 Canada.

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http://doi.wiley.com/10.1002/gene.20001
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http://dx.doi.org/10.1002/gene.20001DOI Listing
February 2004

Retroposon compensatory mechanism hypothesis not supported: Zfa knockout mice are fertile.

Genomics 2003 Sep;82(3):254-60

Centre for Molecular Medicine and Therapeutics, British Columbia Research Institute for Children's and Women's Health, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4.

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http://dx.doi.org/10.1016/s0888-7543(03)00155-1DOI Listing
September 2003

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.

Hum Mol Genet 2003 Jul;12(13):1555-67

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4.

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http://dx.doi.org/10.1093/hmg/ddg169DOI Listing
July 2003

Metaphase FISHing of transgenic mice recommended: FISH and SKY define BAC-mediated balanced translocation.

Genesis 2003 Jul;36(3):134-41

Graduate Program in Neuroscience, Department of Medical Genetics, University of Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/gene.10205DOI Listing
July 2003

Novel vertebrate genes and putative regulatory elements identified at kidney disease and NR2E1/fierce loci.

Genomics 2002 Jul;80(1):45-53

Centre for Molecular Medicine & Therapeutics, British Columbia Research Institute for Children's and Women's Health, and Department of Medical Genetics, University of British Columbia, 980 West 28(th) Avenue, Vancouver, British Columbia, V5Z 4H4, Canada.

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http://dx.doi.org/10.1006/geno.2002.6795DOI Listing
July 2002

Novel Sxr(a) ES cell line offers hope for Y chromosome gene-targeted mice.

Genesis 2002 Jun;33(2):62-6

Centre for Molecular Medicine and Therapeutics, British Columbia Research Institute for Children's and Women's Health, and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/gene.10093DOI Listing
June 2002