Elizabeth J Cartwright

Elizabeth J Cartwright

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Elizabeth J Cartwright

Elizabeth J Cartwright

Publications by authors named "Elizabeth J Cartwright"

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Cardiomyocyte damage control in heart failure and the role of the sarcolemma.

J Muscle Res Cell Motil 2019 12 13;40(3-4):319-333. Epub 2019 Sep 13.

Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, AV Hill, Dover Street, Manchester, M13 9PL, UK.

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http://dx.doi.org/10.1007/s10974-019-09539-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831538PMC
December 2019

Pharmacological inhibition of Hippo pathway, with the novel kinase inhibitor XMU-MP-1, protects the heart against adverse effects during pressure overload.

Br J Pharmacol 2019 Oct 8;176(20):3956-3971. Epub 2019 Oct 8.

Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1111/bph.14795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811740PMC
October 2019

TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.

J Cell Sci 2019 Aug 8;132(15). Epub 2019 Aug 8.

Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK

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http://dx.doi.org/10.1242/jcs.234948DOI Listing
August 2019

Acute inhibition of PMCA4, but not global ablation, reduces blood pressure and arterial contractility via a nNOS-dependent mechanism.

J Cell Mol Med 2018 02 30;22(2):861-872. Epub 2017 Nov 30.

Faculty of Biology, Medicine and Health, Division of Cardiovascular Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1111/jcmm.13371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783868PMC
February 2018

Plasma membrane Ca -ATPase 1 is required for maintaining atrial Ca homeostasis and electrophysiological stability in the mouse.

J Physiol 2017 12 9;595(24):7383-7398. Epub 2017 Nov 9.

Department of Pharmacology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1113/JP274110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730856PMC
December 2017

Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide.

FEBS Open Bio 2017 11 26;7(11):1672-1685. Epub 2017 Sep 26.

Division of Cardiovascular Sciences The University of Manchester, Manchester Academic Health Science Centre UK.

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http://doi.wiley.com/10.1002/2211-5463.12284
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http://dx.doi.org/10.1002/2211-5463.12284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666397PMC
November 2017

Reduced expression of PMCA1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries.

Aging Cell 2017 10 9;16(5):1104-1113. Epub 2017 Aug 9.

Division of Cardiovascular Sciences, Manchester Academic Health Science Centre, The University of Manchester, AV Hill Building, Manchester, M13 9PT, UK.

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http://doi.wiley.com/10.1111/acel.12637
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http://dx.doi.org/10.1111/acel.12637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595685PMC
October 2017

Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia.

Circ Res 2017 Oct 17;121(9):1058-1068. Epub 2017 Aug 17.

From the Division of Cardiovascular Sciences, University of Manchester, United Kingdom (A.D., C.M.P., Y.W., S.N., S.J.R.J.L., C.C., H.B., Y.Z., J.E., A.R., A.K., E.J.C., O.M., H.D., D.O., G.M.M., M.R.B.); K.G. Jebsen Center for Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway (A.B.J., U.W.); Faculty of Health Sciences, NNF Center for Protein Research, University of Copenhagen, Denmark (N.L., P.C.P., A.L.); School of Healthcare Science, Manchester Metropolitan University, United Kingdom (J.C., J.M.); Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Netherlands (P.A.d.C.M.); and School of Human Movement & Nutrition Sciences, University of Queensland, Australia (U.W.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.31160
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http://dx.doi.org/10.1161/CIRCRESAHA.117.311607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636198PMC
October 2017

The Plasma Membrane Calcium ATPases and Their Role as Major New Players in Human Disease.

Physiol Rev 2017 07;97(3):1089-1125

Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1152/physrev.00028.2016DOI Listing
July 2017

Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival.

Stem Cell Res 2017 04 27;20:42-49. Epub 2017 Feb 27.

Division of Cardiovascular Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2017.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376382PMC
April 2017

Calcium Extrusion Pump PMCA4: A New Player in Renal Calcium Handling?

PLoS One 2016 21;11(4):e0153483. Epub 2016 Apr 21.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153483PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839660PMC
February 2017

Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention.

Circulation 2017 02 29;135(7):683-699. Epub 2016 Nov 29.

From Faculty of Biology, Medicine and Health (S.K.C., W.L., M.Z., Y.L., S.W., H.T., S.P., C.B.M., M.R.B., E.J.C., H.A.S., X.W.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; Atherosclerosis Research Centre, Nanjing Medical University, Jiangsu, China (Y.J.); Institute of Molecular Medicine, Peking University, Beijing, China (X.Z., R.X.); Case Cardiovascular Research Institute, Case Western Reserve University, Cleveland, OH (R.Z., X.L., M.K.J.); Department of Pharmacology, University of Oxford, United Kingdom (M.L.); and Department of Cardiology and Pneumology, University Medical Center Göttingen, Germany (L.C., K.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022941DOI Listing
February 2017

Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness.

Crit Care Med 2016 May;44(5):e278-88

1Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom. 2Institute of Cardiovascular Sciences, Centre for Cardiac Research, University of Manchester, Manchester, United Kingdom. 3Department of Musculoskeletal Biology II, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom. 4Intensive Care Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom. 5Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Liverpool, United Kingdom.

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http://dx.doi.org/10.1097/CCM.0000000000001413DOI Listing
May 2016

Plasma membrane calcium ATPases (PMCAs) as potential targets for the treatment of essential hypertension.

Pharmacol Ther 2016 Mar 25;159:23-34. Epub 2016 Jan 25.

Faculty of Health and Social Care, Edge Hill University, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.01.013DOI Listing
March 2016

Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32.

Hypertension 2015 Dec 19;66(6):1176-83. Epub 2015 Oct 19.

From the Faculty of Life Sciences (H.T, S.W., S.K.C., W.L., X.W.) and Faculty of Medical and Human Sciences (M.Z., S.P., E.J.C.), University of Manchester, Manchester, United Kingdom; Department of Biomedical Sciences, New York Institute of Technology, NY (Q.L.); and Department of Pharmacology, University of Oxford, Oxford, United Kingdom (M.L.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06068DOI Listing
December 2015

Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3.

Biochem Biophys Res Commun 2015 Nov 21;467(1):152-6. Epub 2015 Sep 21.

Nephrology Research, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.09.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772868PMC
November 2015

Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin.

Arterioscler Thromb Vasc Biol 2014 Oct 21;34(10):2310-20. Epub 2014 Aug 21.

From the Molecular Pharmacology Group, School of Pharmacy (R.R.B., S.K., A.L.A.), Brain Tumor UK Neuro-oncology Research Centre (F.B.R.), and Oncology Group (W.W.), Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, United Kingdom; Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain (A.A., D.L.-M., A.E., J.O., B.C.O., P.G.-d.A., S.M.-M., J.M.R.); Human Genetics Department, Institute for Rare Diseases Research, Carlos III Health Institute, Madrid, Spain (A.A.); Institute of Cardiovascular Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom (T.M.A.M., D.O., E.J.C., L.N.); Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt (T.M.A.M.); Aston Research Centre for Healthy Ageing, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom (J.E.B.); Department of Molecular Biology, Universidad Autónoma de Madrid, Madrid, Spain (P.G.-d.A.); and University of Luxembourg, Walferdange, Luxembourg (L.N.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304363DOI Listing
October 2014

Pak1 is required to maintain ventricular Ca²⁺ homeostasis and electrophysiological stability through SERCA2a regulation in mice.

Circ Arrhythm Electrophysiol 2014 Oct 12;7(5):938-48. Epub 2014 Sep 12.

From the Department of Pharmacology, University of Oxford, Oxford, United Kingdom (Y.W., D.A.T., M.L.); Institute of Cardiovascular Sciences, Faculty of Medicine and Human Sciences (Y.W., H.T., Y.L., L.D., E.J.C., L.V., M.L.), Faculty of Life Science (X.W.), School of Physics and Astronomy (H.Z.), University of Manchester, Manchester, United Kingdom; Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago (Y.K., R.J.S.); Department of Cardiovascular Diseases, Union Hospital, Huazhong University of Science and Technology, Wuhan, People's Republic of China (Y.S., M.L.); Physiological Laboratory, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom (C.L.-H.H.).

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http://dx.doi.org/10.1161/CIRCEP.113.001198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213946PMC
October 2014

The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy.

J Biol Chem 2014 Aug 17;289(35):24275-88. Epub 2014 Jul 17.

From the Institute of Cardiovascular Sciences, University of Manchester and Manchester Academic Health Science Centre, Manchester M13 9PT, United Kingdom,

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http://dx.doi.org/10.1074/jbc.M114.562405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148857PMC
August 2014

Development and characterization of a novel fluorescent indicator protein PMCA4-GCaMP2 in cardiomyocytes.

J Mol Cell Cardiol 2013 Oct 21;63:57-68. Epub 2013 Jul 21.

Institute of Cardiovascular Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK; Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

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http://dx.doi.org/10.1016/j.yjmcc.2013.07.007DOI Listing
October 2013

Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells.

Carcinogenesis 2012 Dec 7;33(12):2362-8. Epub 2012 Sep 7.

Molecular Pharmacology Group, Research Institute in Healthcare Sciences, Dept. of Pharmacy, School of Applied Sciences, University of Wolverhampton, Wolverhampton, WV1 1SB, UK.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgs282DOI Listing
December 2012

Calcium signaling dysfunction in heart disease.

Biofactors 2011 May-Jun;37(3):175-81. Epub 2011 Jun 14.

Cardiovascular Medicine Research Group, Manchester Academic Health Science Centre, University of Manchester, UK.

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http://dx.doi.org/10.1002/biof.149DOI Listing
October 2011

Ca2+ signalling in cardiovascular disease: the role of the plasma membrane calcium pumps.

Sci China Life Sci 2011 Aug 24;54(8):691-8. Epub 2011 Jul 24.

Cardiovascular Medicine Research Group, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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http://link.springer.com/10.1007/s11427-011-4199-1
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http://dx.doi.org/10.1007/s11427-011-4199-1DOI Listing
August 2011

Local signals with global impacts and clinical implications: lessons from the plasma membrane calcium pump (PMCA4).

Biochim Biophys Acta 2011 May 15;1813(5):974-8. Epub 2010 Dec 15.

The Cardiovascular Medicine Research Group, School of Biomedicine, University of Manchester Academic Health Science Centre, UK.

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http://dx.doi.org/10.1016/j.bbamcr.2010.12.007DOI Listing
May 2011

Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload.

J Mol Cell Cardiol 2011 Apr 31;50(4):702-11. Epub 2011 Jan 31.

Faculty of Life Sciences, The University of Manchester, Manchester, M13 9NT, UK.

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http://dx.doi.org/10.1016/j.yjmcc.2011.01.013DOI Listing
April 2011

Evaluation of plasma membrane calcium/calmodulin-dependent ATPase isoform 4 as a potential target for fertility control.

Handb Exp Pharmacol 2010 (198):79-95

Cardiovascular Medicine, University of Manchester, Room 1.302 Stopford Building, Oxford Road, Manchester, UK.

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http://dx.doi.org/10.1007/978-3-642-02062-9_6DOI Listing
November 2010

Ras-association domain family member 1A (RASSF1A)-where the heart and cancer meet.

Trends Cardiovasc Med 2009 Nov;19(8):262-7

The Cardiovascular Medicine Research Group, School of Biomedicine, University of Manchester, Manchester Academic Health Science Center, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.tcm.2010.02.008DOI Listing
November 2009

Large-scale mouse mutagenesis.

Methods Mol Biol 2009 ;561:275-83

Cardiovascular Medicine, University of Manchester, Oxford Road, Manchester, UK.

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http://dx.doi.org/10.1007/978-1-60327-019-9_18DOI Listing
September 2009

Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.

Circulation 2009 Aug 3;120(7):607-16. Epub 2009 Aug 3.

Cardiovascular Medicine Research Group, School of Clinical and Laboratory Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.868554DOI Listing
August 2009

Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium.

J Biol Chem 2009 May 10;284(18):12091-8. Epub 2009 Mar 10.

Department of Cardiology, University of Manchester and Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester, Lancashire M13 9PT, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M809112200
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http://dx.doi.org/10.1074/jbc.M809112200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673278PMC
May 2009

Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.

Circ Res 2009 Apr 5;104(7):905-14. Epub 2009 Mar 5.

Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.188292DOI Listing
April 2009

Physiological implications of the interaction between the plasma membrane calcium pump and nNOS.

Pflugers Arch 2009 Jan 29;457(3):665-71. Epub 2008 Jan 29.

Cardiovascular Medicine Research Group, University of Manchester, Room 1.302 Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

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http://link.springer.com/10.1007/s00424-008-0455-z
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http://dx.doi.org/10.1007/s00424-008-0455-zDOI Listing
January 2009

Plasma membrane calcium ATPase and its relationship to nitric oxide signaling in the heart.

Ann N Y Acad Sci 2007 Mar;1099:247-53

Division of Cardiovascular and Endocrine Sciences, University of Manchester, Oxford Road, Manchester, UK, M13 9PT.

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http://dx.doi.org/10.1196/annals.1387.007DOI Listing
March 2007

Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b.

Circulation 2007 Jan 22;115(4):483-92. Epub 2007 Jan 22.

Division of Cardiovascular and Endocrine Sciences, University of Manchester, Oxford Rd, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.643791DOI Listing
January 2007

The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex.

J Biol Chem 2006 Aug 30;281(33):23341-8. Epub 2006 May 30.

Division of Cardiology, Room 1.302 Stopford Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M513341200DOI Listing
August 2006

Sperm phenotype of mice carrying a gene deletion for the plasma membrane calcium/calmodulin dependent ATPase 4.

Mol Cell Endocrinol 2006 May 27;250(1-2):93-7. Epub 2006 Jan 27.

Division of Cardiology, University of Manchester, Room 1.302 Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.mce.2005.12.028DOI Listing
May 2006

The emergence of plasma membrane calcium pump as a novel therapeutic target for heart disease.

Mini Rev Med Chem 2006 May;6(5):583-8

Division of Cardiology, The University of Manchester, 1.302 Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.2174/138955706776876177DOI Listing
May 2006

Calcium transport in cardiovascular health and disease--the sarcolemmal calcium pump enters the stage.

J Mol Cell Cardiol 2005 Sep;39(3):403-6

Division of Cardiology, University of Manchester, UK.

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http://dx.doi.org/10.1016/j.yjmcc.2005.04.007DOI Listing
September 2005

Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.

J Biol Chem 2004 Jul 12;279(27):28220-6. Epub 2004 Apr 12.

Institute for Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Josef-Schneider-Strasse 2, D-97080 Wuerzburg, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M312599200
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http://dx.doi.org/10.1074/jbc.M312599200DOI Listing
July 2004