Elizabeth Head

Elizabeth Head

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Neuropathological correlates of amyloid PET imaging in Down syndrome.

Dev Neurobiol 2019 Aug 4. Epub 2019 Aug 4.

Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/dneu.22713DOI Listing
August 2019

Plasma Metabolites Related to Cellular Energy Metabolism Are Altered in Adults with Down Syndrome and Alzheimer's Disease.

Dev Neurobiol 2019 Aug 16. Epub 2019 Aug 16.

Department of Neurology, The University of California, Irvine Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1002/dneu.22716DOI Listing
August 2019

Dementia in Down syndrome: unique insights for Alzheimer disease research.

Nat Rev Neurol 2019 Mar;15(3):135-147

Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1038/s41582-018-0132-6DOI Listing
March 2019

Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease.

Biochim Biophys Acta Mol Basis Dis 2018 10 5;1864(10):3181-3194. Epub 2018 Jul 5.

Department of Biochemical Sciences "A. Rossi-Fanelli", Sapienza University of Rome, Piazzale A. Moro 5, 00185 Roma, Italy; Universidad Autónoma de Chile, Instituto de Ciencias Biomédicas, Facultad de Salud, Avenida Pedro de Valdivia 425, Providencia, Santiago, Chile. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183023
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http://dx.doi.org/10.1016/j.bbadis.2018.07.005DOI Listing
October 2018

Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging.

Theranostics 2017 22;7(14):3573-3584. Epub 2017 Aug 22.

Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.7150/thno.20621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596444PMC
July 2018

Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.

Cell Rep 2018 Jun;23(10):2967-2975

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040810PMC
June 2018

Analysis of shared heritability in common disorders of the brain.

Authors:
Verneri Anttila Brendan Bulik-Sullivan Hilary K Finucane Raymond K Walters Jose Bras Laramie Duncan Valentina Escott-Price Guido J Falcone Padhraig Gormley Rainer Malik Nikolaos A Patsopoulos Stephan Ripke Zhi Wei Dongmei Yu Phil H Lee Patrick Turley Benjamin Grenier-Boley Vincent Chouraki Yoichiro Kamatani Claudine Berr Luc Letenneur Didier Hannequin Philippe Amouyel Anne Boland Jean-François Deleuze Emmanuelle Duron Badri N Vardarajan Christiane Reitz Alison M Goate Matthew J Huentelman M Ilyas Kamboh Eric B Larson Ekaterina Rogaeva Peter St George-Hyslop Hakon Hakonarson Walter A Kukull Lindsay A Farrer Lisa L Barnes Thomas G Beach F Yesim Demirci Elizabeth Head Christine M Hulette Gregory A Jicha John S K Kauwe Jeffrey A Kaye James B Leverenz Allan I Levey Andrew P Lieberman Vernon S Pankratz Wayne W Poon Joseph F Quinn Andrew J Saykin Lon S Schneider Amanda G Smith Joshua A Sonnen Robert A Stern Vivianna M Van Deerlin Linda J Van Eldik Denise Harold Giancarlo Russo David C Rubinsztein Anthony Bayer Magda Tsolaki Petra Proitsi Nick C Fox Harald Hampel Michael J Owen Simon Mead Peter Passmore Kevin Morgan Markus M Nöthen Martin Rossor Michelle K Lupton Per Hoffmann Johannes Kornhuber Brian Lawlor Andrew McQuillin Ammar Al-Chalabi Joshua C Bis Agustin Ruiz Mercè Boada Sudha Seshadri Alexa Beiser Kenneth Rice Sven J van der Lee Philip L De Jager Daniel H Geschwind Matthias Riemenschneider Steffi Riedel-Heller Jerome I Rotter Gerhard Ransmayr Bradley T Hyman Carlos Cruchaga Montserrat Alegret Bendik Winsvold Priit Palta Kai-How Farh Ester Cuenca-Leon Nicholas Furlotte Tobias Kurth Lannie Ligthart Gisela M Terwindt Tobias Freilinger Caroline Ran Scott D Gordon Guntram Borck Hieab H H Adams Terho Lehtimäki Juho Wedenoja Julie E Buring Markus Schürks Maria Hrafnsdottir Jouke-Jan Hottenga Brenda Penninx Ville Artto Mari Kaunisto Salli Vepsäläinen Nicholas G Martin Grant W Montgomery Mitja I Kurki Eija Hämäläinen Hailiang Huang Jie Huang Cynthia Sandor Caleb Webber Bertram Muller-Myhsok Stefan Schreiber Veikko Salomaa Elizabeth Loehrer Hartmut Göbel Alfons Macaya Patricia Pozo-Rosich Thomas Hansen Thomas Werge Jaakko Kaprio Andres Metspalu Christian Kubisch Michel D Ferrari Andrea C Belin Arn M J M van den Maagdenberg John-Anker Zwart Dorret Boomsma Nicholas Eriksson Jes Olesen Daniel I Chasman Dale R Nyholt Andreja Avbersek Larry Baum Samuel Berkovic Jonathan Bradfield Russell J Buono Claudia B Catarino Patrick Cossette Peter De Jonghe Chantal Depondt Dennis Dlugos Thomas N Ferraro Jacqueline French Helle Hjalgrim Jennifer Jamnadas-Khoda Reetta Kälviäinen Wolfram S Kunz Holger Lerche Costin Leu Dick Lindhout Warren Lo Daniel Lowenstein Mark McCormack Rikke S Møller Anne Molloy Ping-Wing Ng Karen Oliver Michael Privitera Rodney Radtke Ann-Kathrin Ruppert Thomas Sander Steven Schachter Christoph Schankin Ingrid Scheffer Susanne Schoch Sanjay M Sisodiya Philip Smith Michael Sperling Pasquale Striano Rainer Surges G Neil Thomas Frank Visscher Christopher D Whelan Federico Zara Erin L Heinzen Anthony Marson Felicitas Becker Hans Stroink Fritz Zimprich Thomas Gasser Raphael Gibbs Peter Heutink Maria Martinez Huw R Morris Manu Sharma Mina Ryten Kin Y Mok Sara Pulit Steve Bevan Elizabeth Holliday John Attia Thomas Battey Giorgio Boncoraglio Vincent Thijs Wei-Min Chen Braxton Mitchell Peter Rothwell Pankaj Sharma Cathie Sudlow Astrid Vicente Hugh Markus Christina Kourkoulis Joana Pera Miriam Raffeld Scott Silliman Vesna Boraska Perica Laura M Thornton Laura M Huckins N William Rayner Cathryn M Lewis Monica Gratacos Filip Rybakowski Anna Keski-Rahkonen Anu Raevuori James I Hudson Ted Reichborn-Kjennerud Palmiero Monteleone Andreas Karwautz Katrin Mannik Jessica H Baker Julie K O'Toole Sara E Trace Oliver S P Davis Sietske G Helder Stefan Ehrlich Beate Herpertz-Dahlmann Unna N Danner Annemarie A van Elburg Maurizio Clementi Monica Forzan Elisa Docampo Jolanta Lissowska Joanna Hauser Alfonso Tortorella Mario Maj Fragiskos Gonidakis Konstantinos Tziouvas Hana Papezova Zeynep Yilmaz Gudrun Wagner Sarah Cohen-Woods Stefan Herms Antonio Julià Raquel Rabionet Danielle M Dick Samuli Ripatti Ole A Andreassen Thomas Espeseth Astri J Lundervold Vidar M Steen Dalila Pinto Stephen W Scherer Harald Aschauer Alexandra Schosser Lars Alfredsson Leonid Padyukov Katherine A Halmi James Mitchell Michael Strober Andrew W Bergen Walter Kaye Jin Peng Szatkiewicz Bru Cormand Josep Antoni Ramos-Quiroga Cristina Sánchez-Mora Marta Ribasés Miguel Casas Amaia Hervas Maria Jesús Arranz Jan Haavik Tetyana Zayats Stefan Johansson Nigel Williams Astrid Dempfle Aribert Rothenberger Jonna Kuntsi Robert D Oades Tobias Banaschewski Barbara Franke Jan K Buitelaar Alejandro Arias Vasquez Alysa E Doyle Andreas Reif Klaus-Peter Lesch Christine Freitag Olga Rivero Haukur Palmason Marcel Romanos Kate Langley Marcella Rietschel Stephanie H Witt Soeren Dalsgaard Anders D Børglum Irwin Waldman Beth Wilmot Nikolas Molly Claiton H D Bau Jennifer Crosbie Russell Schachar Sandra K Loo James J McGough Eugenio H Grevet Sarah E Medland Elise Robinson Lauren A Weiss Elena Bacchelli Anthony Bailey Vanessa Bal Agatino Battaglia Catalina Betancur Patrick Bolton Rita Cantor Patrícia Celestino-Soper Geraldine Dawson Silvia De Rubeis Frederico Duque Andrew Green Sabine M Klauck Marion Leboyer Pat Levitt Elena Maestrini Shrikant Mane Daniel Moreno- De-Luca Jeremy Parr Regina Regan Abraham Reichenberg Sven Sandin Jacob Vorstman Thomas Wassink Ellen Wijsman Edwin Cook Susan Santangelo Richard Delorme Bernadette Rogé Tiago Magalhaes Dan Arking Thomas G Schulze Robert C Thompson Jana Strohmaier Keith Matthews Ingrid Melle Derek Morris Douglas Blackwood Andrew McIntosh Sarah E Bergen Martin Schalling Stéphane Jamain Anna Maaser Sascha B Fischer Céline S Reinbold Janice M Fullerton José Guzman-Parra Fermin Mayoral Peter R Schofield Sven Cichon Thomas W Mühleisen Franziska Degenhardt Johannes Schumacher Michael Bauer Philip B Mitchell Elliot S Gershon John Rice James B Potash Peter P Zandi Nick Craddock I Nicol Ferrier Martin Alda Guy A Rouleau Gustavo Turecki Roel Ophoff Carlos Pato Adebayo Anjorin Eli Stahl Markus Leber Piotr M Czerski Cristiana Cruceanu Ian R Jones Danielle Posthuma Till F M Andlauer Andreas J Forstner Fabian Streit Bernhard T Baune Tracy Air Grant Sinnamon Naomi R Wray Donald J MacIntyre David Porteous Georg Homuth Margarita Rivera Jakob Grove Christel M Middeldorp Ian Hickie Michele Pergadia Divya Mehta Johannes H Smit Rick Jansen Eco de Geus Erin Dunn Qingqin S Li Matthias Nauck Robert A Schoevers Aartjan Tf Beekman James A Knowles Alexander Viktorin Paul Arnold Cathy L Barr Gabriel Bedoya-Berrio O Joseph Bienvenu Helena Brentani Christie Burton Beatriz Camarena Carolina Cappi Danielle Cath Maria Cavallini Daniele Cusi Sabrina Darrow Damiaan Denys Eske M Derks Andrea Dietrich Thomas Fernandez Martijn Figee Nelson Freimer Gloria Gerber Marco Grados Erica Greenberg Gregory L Hanna Andreas Hartmann Matthew E Hirschtritt Pieter J Hoekstra Alden Huang Chaim Huyser Cornelia Illmann Michael Jenike Samuel Kuperman Bennett Leventhal Christine Lochner Gholson J Lyon Fabio Macciardi Marcos Madruga-Garrido Irene A Malaty Athanasios Maras Lauren McGrath Eurípedes C Miguel Pablo Mir Gerald Nestadt Humberto Nicolini Michael S Okun Andrew Pakstis Peristera Paschou John Piacentini Christopher Pittenger Kerstin Plessen Vasily Ramensky Eliana M Ramos Victor Reus Margaret A Richter Mark A Riddle Mary M Robertson Veit Roessner Maria Rosário Jack F Samuels Paul Sandor Dan J Stein Fotis Tsetsos Filip Van Nieuwerburgh Sarah Weatherall Jens R Wendland Tomasz Wolanczyk Yulia Worbe Gwyneth Zai Fernando S Goes Nicole McLaughlin Paul S Nestadt Hans-Jorgen Grabe Christel Depienne Anuar Konkashbaev Nuria Lanzagorta Ana Valencia-Duarte Elvira Bramon Nancy Buccola Wiepke Cahn Murray Cairns Siow A Chong David Cohen Benedicto Crespo-Facorro James Crowley Michael Davidson Lynn DeLisi Timothy Dinan Gary Donohoe Elodie Drapeau Jubao Duan Lieuwe Haan David Hougaard Sena Karachanak-Yankova Andrey Khrunin Janis Klovins Vaidutis Kučinskas Jimmy Lee Chee Keong Svetlana Limborska Carmel Loughland Jouko Lönnqvist Brion Maher Manuel Mattheisen Colm McDonald Kieran C Murphy Igor Nenadic Jim van Os Christos Pantelis Michele Pato Tracey Petryshen Digby Quested Panos Roussos Alan R Sanders Ulrich Schall Sibylle G Schwab Kang Sim Hon-Cheong So Elisabeth Stögmann Mythily Subramaniam Draga Toncheva John Waddington James Walters Mark Weiser Wei Cheng Robert Cloninger David Curtis Pablo V Gejman Frans Henskens Morten Mattingsdal Sang-Yun Oh Rodney Scott Bradley Webb Gerome Breen Claire Churchhouse Cynthia M Bulik Mark Daly Martin Dichgans Stephen V Faraone Rita Guerreiro Peter Holmans Kenneth S Kendler Bobby Koeleman Carol A Mathews Alkes Price Jeremiah Scharf Pamela Sklar Julie Williams Nicholas W Wood Chris Cotsapas Aarno Palotie Jordan W Smoller Patrick Sullivan Jonathan Rosand Aiden Corvin Benjamin M Neale Jonathan M Schott Richard Anney Josephine Elia Maria Grigoroiu-Serbanescu Howard J Edenberg Robin Murray

Science 2018 06;360(6395)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1126/science.aap8757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097237PMC
June 2018

Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis.

Front Aging Neurosci 2018 21;10:191. Epub 2018 Jun 21.

Department of Neurology, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, United States.

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http://dx.doi.org/10.3389/fnagi.2018.00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021507PMC
June 2018

Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines.

Brain Pathol 2018 05;28(3):427-430

Department of Neurology, University of Bonn, 53127 Bonn, Germany.

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http://doi.wiley.com/10.1111/bpa.12573
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http://dx.doi.org/10.1111/bpa.12573DOI Listing
May 2018

Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP.

J Alzheimers Dis 2017 ;56(2):459-470

Department of Pediatrics, University of California, Irvine Medical Center, Orange, CA, USA.

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http://dx.doi.org/10.3233/JAD-160836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662115PMC
February 2018

Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism.

Free Radic Biol Med 2018 01 10;114:84-93. Epub 2017 Jul 10.

Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748256PMC
January 2018

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia.

Free Radic Biol Med 2018 01 12;114:94-101. Epub 2017 Aug 12.

Department of Chemistry and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506 USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748251PMC
January 2018

Down syndrome, beta-amyloid and neuroimaging.

Free Radic Biol Med 2018 01 19;114:102-109. Epub 2017 Sep 19.

University of Kentucky, Sanders-Brown Center on Aging, 800 South Limestone Street, Lexington, KY 40536, United States; University of Kentucky, Department of Neurology, Lexington, KY 40536, United States.

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748259PMC
January 2018

Cerebrovascular pathology in Down syndrome and Alzheimer disease.

Acta Neuropathol Commun 2017 Dec 1;5(1):93. Epub 2017 Dec 1.

Department of Pediatrics, University of California, Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1186/s40478-017-0499-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709935PMC
December 2017

Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease.

Alzheimers Dement 2017 Nov 29;13(11):1251-1260. Epub 2017 Apr 29.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660938PMC
November 2017

HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology.

Free Radic Biol Med 2017 10 10;111:262-269. Epub 2016 Nov 10.

Department of Biochemical Sciences, Sapienza University of Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639937PMC
October 2017

Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan.

Neurobiol Aging 2017 06 14;54:163-169. Epub 2017 Mar 14.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580173007
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http://dx.doi.org/10.1016/j.neurobiolaging.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638297PMC
June 2017

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology.

Curr Alzheimer Res 2016 ;13(1):18-29

Sanders Brown Center on Aging, University of Kentucky, 800 South Limestone Street, Lexington, KY, 40536, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948181PMC
September 2016

Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome.

Biochim Biophys Acta 2016 05 26;1862(5):909-14. Epub 2015 Nov 26.

Department of Pharmacology & Nutritional Sciences, University of Kentucky, Sanders-Brown Center on Aging, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821721PMC
May 2016

Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain.

Aging Dis 2016 May 27;7(3):267-77. Epub 2016 May 27.

1Department of Biological Sciences, Boise State University, Boise, Idaho, 83725, USA.

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http://dx.doi.org/10.14336/AD.2015.1020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898923PMC
May 2016

Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms.

Brain Cogn 2016 Apr 27;104:48-57. Epub 2016 Feb 27.

University of Florida College of Medicine, Department of Neurology, Room L3-100, McKnight Brain Institute, 1149 Newell Drive, Gainesville, FL 32611, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bandc.2016.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801771PMC
April 2016

Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aβ Fibrils.

ACS Chem Neurosci 2016 Feb 30;7(2):171-6. Epub 2015 Dec 30.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States.

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http://dx.doi.org/10.1021/acschemneuro.5b00266DOI Listing
February 2016

Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease.

Neurobiol Aging 2015 Sep 30;36(9):2468-74. Epub 2015 May 30.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Pharmacology and Nutritional Sciences, Lexington, KY, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602365PMC
September 2015

Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease.

J Alzheimers Dis 2014 ;42(3):767-75

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.3233/JAD-140795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392817PMC
August 2015

Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology.

J Alzheimers Dis 2014 ;42(4):1221-7

Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA University of Kentucky Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.3233/JAD-132450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198456PMC
July 2015

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

Authors:
Li-San Wang Adam C Naj Robert R Graham Paul K Crane Brian W Kunkle Carlos Cruchaga Josue D Gonzalez Murcia Lisa Cannon-Albright Clinton T Baldwin Henrik Zetterberg Kaj Blennow Walter A Kukull Kelley M Faber Nicole Schupf Maria C Norton JoAnn T Tschanz Ronald G Munger Christopher D Corcoran Ekaterina Rogaeva Chiao-Feng Lin Beth A Dombroski Laura B Cantwell Amanda Partch Otto Valladares Hakon Hakonarson Peter St George-Hyslop Robert C Green Alison M Goate Tatiana M Foroud Regina M Carney Eric B Larson Timothy W Behrens John S K Kauwe Jonathan L Haines Lindsay A Farrer Margaret A Pericak-Vance Richard Mayeux Gerard D Schellenberg Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Michael Barmada Lisa L Barnes Thomas G Beach James T Becker Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Steven L Carroll Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky F Yesim Demirci Malcolm Dick Dennis W Dickson Ranjan Duara Nilufer Ertekin-Taner Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass Neill R Graff-Radford John H Growdon Ronald L Hamilton Kara L Hamilton-Nelson Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun Gyungah Jun M Ilyas Kamboh Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Gei Li Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Constantine G Lyketsos Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee W Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Jill R Murrell John M Olichney Joseph E Parisi William Perry Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2015 Feb;72(2):209-16

Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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http://dx.doi.org/10.1001/jamaneurol.2014.2157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324097PMC
February 2015

Con: are we ready to translate Alzheimer's disease-modifying therapies to people with down syndrome?

Alzheimers Res Ther 2014 12;6(5-8):61. Epub 2014 Sep 12.

Department of Neurology, Sanders-Brown Center on Aging, University of Kentucky, 203 Sanders-Brown Building, 800 S. Limestone Street, Lexington 40536-0230, KY, USA.

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http://dx.doi.org/10.1186/s13195-014-0061-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255531PMC
December 2014

Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?

J Parkinsons Dis Alzheimers Dis 2014 Dec;1(1)

University of Kentucky, Department of Pharmacology & Nutritional Sciences, Sanders-Brown Center on Aging, Lexington, KY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291017PMC
December 2014

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Authors:
Adam C Naj Gyungah Jun Christiane Reitz Brian W Kunkle William Perry Yo Son Park Gary W Beecham Ruchita A Rajbhandary Kara L Hamilton-Nelson Li-San Wang John S K Kauwe Matthew J Huentelman Amanda J Myers Thomas D Bird Bradley F Boeve Clinton T Baldwin Gail P Jarvik Paul K Crane Ekaterina Rogaeva M Michael Barmada F Yesim Demirci Carlos Cruchaga Patricia L Kramer Nilufer Ertekin-Taner John Hardy Neill R Graff-Radford Robert C Green Eric B Larson Peter H St George-Hyslop Joseph D Buxbaum Denis A Evans Julie A Schneider Kathryn L Lunetta M Ilyas Kamboh Andrew J Saykin Eric M Reiman Philip L De Jager David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Eden R Martin Jonathan L Haines Richard P Mayeux Lindsay A Farrer Gerard D Schellenberg Margaret A Pericak-Vance Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Lisa L Barnes Thomas G Beach James T Becker Duane Beekly Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Minerva M Carrasquillo Steven L Carroll Helena C Chui David G Clark Jason Corneveaux David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky Malcolm Dick Dennis W Dickson Ranjan Duara Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Chiao-Feng Lin Oscar L Lopez Constantine G Lyketsos Wendy J Mack Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Jill R Murrell John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Otto Valladares Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2014 Nov;71(11):1394-404

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamaneurol.2014.1491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314944PMC
November 2014

Aging in the canine and feline brain.

Vet Clin North Am Small Anim Pract 2014 Nov 1;44(6):1113-29. Epub 2014 Nov 1.

Department of Pharmacology & Nutritional Sciences, Sanders-Brown Center on Aging, University of Kentucky, 800 South Limestone Street, 203 Sanders Brown Building, Lexington, KY 40515, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cvsm.2014.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254595PMC
November 2014

Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation.

J Cereb Blood Flow Metab 2014 Oct 23;34(10):1637-45. Epub 2014 Jul 23.

1] Department of Pediatrics, Loma Linda University, Loma Linda, California, USA [2] Department of Physiology, Loma Linda University, Loma Linda, California, USA [3] CNRS UMR 5287, Bordeaux University, Bordeaux, France.

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http://dx.doi.org/10.1038/jcbfm.2014.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269722PMC
October 2014

Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease.

J Alzheimers Dis 2014 ;39(1):191-210

Department of Psychiatry & Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.3233/JAD-131490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376359PMC
September 2014

Frontal white matter integrity in adults with Down syndrome with and without dementia.

Neurobiol Aging 2014 Jul 4;35(7):1562-9. Epub 2014 Feb 4.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.01.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992921PMC
July 2014

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.

Biochim Biophys Acta 2014 Jul 13;1842(7):1144-53. Epub 2014 Apr 13.

Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062876PMC
July 2014

Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges.

Front Pharmacol 2014 21;5:47. Epub 2014 Mar 21.

Sanders-Brown Center on Aging, University of Kentucky Lexington, KY, USA ; Department of Molecular and Biomedical Pharmacology, University of Kentucky Lexington, KY, USA.

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http://dx.doi.org/10.3389/fphar.2014.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968758PMC
June 2014

An outbreak of Candida albicans folliculitis masquerading as Malassezia folliculitis in a prison population.

J Correct Health Care 2014 Apr;20(2):154-62

1University of Texas Medical Branch, Galveston, TX, USA.

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http://dx.doi.org/10.1177/1078345813518636DOI Listing
April 2014

Bathroom injuries in children less than 15 years old.

Inj Prev 2013 Oct 15;19(5):316-9. Epub 2013 Jan 15.

Georgia State University, Institute of Public Health, , Atlanta, Georgia, USA.

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http://dx.doi.org/10.1136/injuryprev-2012-040600DOI Listing
October 2013

A canine model of human aging and Alzheimer's disease.

Authors:
Elizabeth Head

Biochim Biophys Acta 2013 Sep 23;1832(9):1384-9. Epub 2013 Mar 23.

Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1016/j.bbadis.2013.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937962PMC
September 2013

Alzheimer's Disease in Down Syndrome.

Eur J Neurodegener Dis 2012 Dec;1(3):353-364

Department of Neurology, University of Kentucky Lexington, KY, 40356 ; Sanders-Brown Center on Aging, University of Kentucky Lexington, KY, 40356.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184282PMC
December 2012

Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain.

Int J Neuropsychopharmacol 2012 Aug 18;15(7):981-7. Epub 2011 Jul 18.

Department of Chemistry, Center of Membrane Sciences, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506-0055, USA.

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http://dx.doi.org/10.1017/S1461145711001118DOI Listing
August 2012

Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels.

Curr Gerontol Geriatr Res 2012 9;2012:179318. Epub 2012 May 9.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1155/2012/179318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357506PMC
August 2012

Aging and down syndrome.

Curr Gerontol Geriatr Res 2012 11;2012:412536. Epub 2012 Jul 11.

Department of Molecular and Biomedical Pharmacology, Sanders-Brown Center on Aging, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1155/2012/412536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400297PMC
August 2012

Novel late-onset Alzheimer disease loci variants associate with brain gene expression.

Authors:
Mariet Allen Fanggeng Zou High Seng Chai Curtis S Younkin Julia Crook V Shane Pankratz Minerva M Carrasquillo Christopher N Rowley Asha A Nair Sumit Middha Sooraj Maharjan Thuy Nguyen Li Ma Kimberly G Malphrus Ryan Palusak Sarah Lincoln Gina Bisceglio Constantin Georgescu Debra Schultz Fariborz Rakhshan Christopher P Kolbert Jin Jen Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg Ronald C Petersen Neill R Graff-Radford Dennis W Dickson Steven G Younkin Nilüfer Ertekin-Taner Liana G Apostolova Steven E Arnold Clinton T Baldwin Robert Barber Michael M Barmada Thomas Beach Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Jacqueline Buros Joseph D Buxbaum Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Paul K Crane Carlos Cruchaga Jeffrey L Cummings Philip L De Jager Charles DeCarli Steven T DeKosky F Yesim Demirci Ramon Diaz-Arrastia Malcolm Dick Beth A Dombroski Ranjan Duara William D Ellis Denis Evans Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Tatiana M Foroud Matthew Frosch Douglas R Galasko Paul J Gallins Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass Alison M Goate Robert C Green John H Growdon Hakon Hakonarson Ronald L Hamilton John Hardy Lindy E Harrell Elizabeth Head Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun M Ilyas Kamboh Jason Karlawish Anna Karydas John S K Kauwe Jeffrey A Kaye Nancy Kennedy Ronald Kim Edward H Koo Neil W Kowall Patricia Kramer Walter A Kukull James J Lah Eric B Larson Allan I Levey Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Amanda J Myers Adam C Naj Petra Nowotny Joseph E Parisi Daniel P Perl Elaine Peskind Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Ruchita A Rajbhandary Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Peter St George-Hyslop Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Badri Narayan Vardarajan Harry V Vinters Jean Paul Vonsattel Li-San Wang Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer

Neurology 2012 Jul 20;79(3):221-8. Epub 2012 Jun 20.

Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA.

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http://dx.doi.org/10.1212/WNL.0b013e3182605801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398432PMC
July 2012

Antioxidants in the canine model of human aging.

Biochim Biophys Acta 2012 May 8;1822(5):685-9. Epub 2011 Oct 8.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1016/j.bbadis.2011.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291812PMC
May 2012

Frontal cortex neuropathology in dementia pugilistica.

J Neurotrauma 2012 Apr 10;29(6):1054-70. Epub 2012 Apr 10.

Institute for Memory Impairments and Neurological Disorders, University of California-Irvine, Irvine, California, USA.

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http://dx.doi.org/10.1089/neu.2011.1957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325552PMC
April 2012

BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog.

Neurobiol Aging 2012 Mar 5;33(3):546-54. Epub 2010 May 5.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935515PMC
March 2012

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.

Biochim Biophys Acta 2012 Feb 8;1822(2):130-8. Epub 2011 Oct 8.

Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536-0055, USA.

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http://dx.doi.org/10.1016/j.bbadis.2011.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260028PMC
February 2012

Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines.

Neurobiol Aging 2012 Jan 30;33(1):108-20. Epub 2010 Apr 30.

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, United States.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932860PMC
January 2012

Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease.

J Neurochem 2012 Jan 9;120(1):135-46. Epub 2011 Nov 9.

Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40506-0055, USA.

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http://doi.wiley.com/10.1111/j.1471-4159.2011.07538.x
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http://dx.doi.org/10.1111/j.1471-4159.2011.07538.xDOI Listing
January 2012

Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model.

Curr Neuropharmacol 2011 Dec;9(4):651-61

Sanders Brown Center on Aging, University of Kentucky, Lexington KY, USA.

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http://dx.doi.org/10.2174/157015911798376217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263459PMC
December 2011

Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.

Neuroreport 2011 Oct;22(15):767-72

Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1097/WNR.0b013e32834ae348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339866PMC
October 2011

Neurobiology of the aging dog.

Authors:
Elizabeth Head

Age (Dordr) 2011 Sep 16;33(3):485-96. Epub 2010 Sep 16.

Sanders-Brown Center on Aging, Department of Molecular and Biomedical Pharmacology, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1007/s11357-010-9183-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168593PMC
September 2011

Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation.

Am J Med Genet A 2011 Aug 7;155A(8):1939-48. Epub 2011 Jul 7.

Department of Pediatrics, School of Medicine, University of California, Irvine (UCI), Orange, California, USA.

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http://dx.doi.org/10.1002/ajmg.a.34114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410645PMC
August 2011

Coenzyme Q10 and cognition in atorvastatin treated dogs.

Neurosci Lett 2011 Aug 8;501(2):92-5. Epub 2011 Jul 8.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, United States.

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http://dx.doi.org/10.1016/j.neulet.2011.06.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174091PMC
August 2011

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:
Adam C Naj Gyungah Jun Gary W Beecham Li-San Wang Badri Narayan Vardarajan Jacqueline Buros Paul J Gallins Joseph D Buxbaum Gail P Jarvik Paul K Crane Eric B Larson Thomas D Bird Bradley F Boeve Neill R Graff-Radford Philip L De Jager Denis Evans Julie A Schneider Minerva M Carrasquillo Nilufer Ertekin-Taner Steven G Younkin Carlos Cruchaga John S K Kauwe Petra Nowotny Patricia Kramer John Hardy Matthew J Huentelman Amanda J Myers Michael M Barmada F Yesim Demirci Clinton T Baldwin Robert C Green Ekaterina Rogaeva Peter St George-Hyslop Steven E Arnold Robert Barber Thomas Beach Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Jeffrey L Cummings Charles DeCarli Steven T DeKosky Ramon Diaz-Arrastia Malcolm Dick Dennis W Dickson William G Ellis Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Nancy Johnson Jason Karlawish Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall James J Lah Allan I Levey Andrew P Lieberman Oscar L Lopez Wendy J Mack Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Joseph E Parisi Daniel P Perl Elaine Peskind Ronald C Petersen Wayne W Poon Joseph F Quinn Ruchita A Rajbhandary Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Roger N Rosenberg Mary Sano Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer Laura B Cantwell Beth A Dombroski Duane Beekly Kathryn L Lunetta Eden R Martin M Ilyas Kamboh Andrew J Saykin Eric M Reiman David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg

Nat Genet 2011 May 3;43(5):436-41. Epub 2011 Apr 3.

The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.

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http://dx.doi.org/10.1038/ng.801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090745PMC
May 2011

Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease.

Neurobiol Aging 2011 Apr 9;32(4):604-13. Epub 2009 May 9.

Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930132PMC
April 2011

Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy.

Ann N Y Acad Sci 2010 Oct;1207:58-70

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05786.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958685PMC
October 2010

Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines.

J Alzheimers Dis 2010 ;20(2):637-46

Department of Molecular and Biomedical Pharmacology and the Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536-0230, USA.

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http://dx.doi.org/10.3233/JAD-2010-1397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903832PMC
September 2010

Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia.

J Alzheimers Dis 2010 ;20 Suppl 2:S293-310

Mitochondrial and Molecular Medicine and Genetics, University of California Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.3233/JAD-2010-100351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175722PMC
September 2010

Nutrition, brain aging, and neurodegeneration.

J Neurosci 2009 Oct;29(41):12795-801

USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3520-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665319PMC
October 2009

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction.

Neurobiol Dis 2009 Sep 10;35(3):352-8. Epub 2009 Jun 10.

Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697-3900, USA.

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http://dx.doi.org/10.1016/j.nbd.2009.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725199PMC
September 2009

Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines.

Age (Dordr) 2009 Sep 22;31(3):211-20. Epub 2008 Jun 22.

Institute for Brain Aging & Dementia, University of California, 1259 Gillespie NRF, Irvine, CA 92697-4540, USA.

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http://link.springer.com/10.1007/s11357-008-9063-2
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http://dx.doi.org/10.1007/s11357-008-9063-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734239PMC
September 2009