Elizabeth A Winzeler

Elizabeth A Winzeler

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Elizabeth A Winzeler

Publications by authors named "Elizabeth A Winzeler"

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Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections.

Genome Med 2019 10 22;11(1):63. Epub 2019 Oct 22.

Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, Gilman Drive, La Jolla, CA, 92093, USA.

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https://genomemedicine.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13073-019-0673-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805675PMC
October 2019

The genomic architecture of antimalarial drug resistance.

Brief Funct Genomics 2019 09;18(5):314-328

Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, Gilman Dr., La Jolla, CA, USA.

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http://dx.doi.org/10.1093/bfgp/elz008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859814PMC
September 2019

A roadmap for malaria research.

Science 2019 08;365(6455):753-754

Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1126/science.aay5963DOI Listing
August 2019

The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa.

Proc Natl Acad Sci U S A 2019 May 13;116(21):10198-10200. Epub 2019 May 13.

Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093.

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http://dx.doi.org/10.1073/pnas.1904694116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534972PMC
May 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

8-Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual-Stage Antiplasmodial Activity.

ChemMedChem 2019 02 14;14(4):501-511. Epub 2019 Jan 14.

Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1002/cmdc.201800691DOI Listing
February 2019

An improbable journey: Creativity helped me make the transition from art to curing malaria.

J Biol Chem 2019 01 6;294(2):405-409. Epub 2018 Nov 6.

From the Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California 92093

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http://www.jbc.org/lookup/doi/10.1074/jbc.AW118.005229
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http://dx.doi.org/10.1074/jbc.AW118.005229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333892PMC
January 2019

One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.

Eur J Med Chem 2018 Oct 7;158:801-813. Epub 2018 Sep 7.

Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany; Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Medical Faculty, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195125PMC
October 2018

Exploration of Plasmodium vivax transmission dynamics and recurrent infections in the Peruvian Amazon using whole genome sequencing.

Genome Med 2018 07 4;10(1):52. Epub 2018 Jul 4.

Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1186/s13073-018-0563-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032790PMC
July 2018

Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon.

ACS Infect Dis 2018 04 15;4(4):541-548. Epub 2018 Mar 15.

Division of Infectious Diseases, Department of Medicine, School of Medicine , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.7b00195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902790PMC
April 2018

Developing Plasmodium vivax Resources for Liver Stage Study in the Peruvian Amazon Region.

ACS Infect Dis 2018 04 15;4(4):531-540. Epub 2018 Mar 15.

Division of Host-Microbe Systems and Therapeutics, Health Sciences Center for Immunology, Infection and Inflammation, Department of Pediatrics, School of Medicine , University of California, San Diego , 9500 Gilman Drive #0760 , La Jolla , California 92093-0760 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.7b00198DOI Listing
April 2018

Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.

ACS Infect Dis 2018 03 21;4(3):301-314. Epub 2018 Feb 21.

Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics , University of California San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.7b00276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848146PMC
March 2018

A Sleeping Area of Malaria Research Awakes.

Cell Host Microbe 2018 03;23(3):292-295

School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.02.008DOI Listing
March 2018

Antimalarial drug discovery - approaches and progress towards new medicines.

Nat Rev Microbiol 2017 09 24;15(9):572. Epub 2017 Jul 24.

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http://dx.doi.org/10.1038/nrmicro.2017.88DOI Listing
September 2017

Glycophorin alleles link to malaria protection.

Science 2017 06;356(6343):1122-1123

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92030-0761, USA.

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http://dx.doi.org/10.1126/science.aan4184DOI Listing
June 2017

Longitudinal study of Plasmodium pathogens identifies new loci associated with artemisinin resistance.

Genome Biol 2017 04 28;18(1):79. Epub 2017 Apr 28.

Department of Pediatrics, University of California, San Diego, La Jolla, California, 92093, USA.

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http://dx.doi.org/10.1186/s13059-017-1219-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410039PMC
April 2017

Esterase mutation is a mechanism of resistance to antimalarial compounds.

Nat Commun 2017 01 20;8:14240. Epub 2017 Jan 20.

Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/ncomms14240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263872PMC
January 2017

Phenotypic Screens in Antimalarial Drug Discovery.

Trends Parasitol 2016 09 27;32(9):697-707. Epub 2016 May 27.

School of Medicine, Department of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California, San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2016.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007148PMC
September 2016

Systems analysis of host-parasite interactions.

Wiley Interdiscip Rev Syst Biol Med 2015 Nov-Dec;7(6):381-400. Epub 2015 Aug 26.

Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/wsbm.1311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679367PMC
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class.

J Am Chem Soc 2016 06 31;138(23):7268-71. Epub 2016 May 31.

Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/jacs.6b03899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851774PMC
June 2016

High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.

ACS Infect Dis 2016 Apr 10;2(4):281-293. Epub 2016 Feb 10.

School of Medicine, Department of Pediatrics, Pharmacology & Drug Discovery, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acsinfecdis.5b00143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890880PMC
April 2016

Kalkipyrone B, a marine cyanobacterial γ-pyrone possessing cytotoxic and anti-fungal activities.

Phytochemistry 2016 Feb 26;122:113-118. Epub 2015 Nov 26.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, 8615 Kennel Way, La Jolla, CA 92037, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724546PMC
February 2016

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.

Cell Host Microbe 2016 Jan 31;19(1):114-26. Epub 2015 Dec 31.

Division of Pharmacology and Drug Discovery, Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723716PMC
January 2016

Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials.

ACS Chem Biol 2015 Feb 5;10(2):413-20. Epub 2014 Nov 5.

Division of Pharmacology and Drug Discovery, Department of Pediatrics, ‡Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine , La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/cb500616xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340351PMC
February 2015

Targeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacity.

J Biol Chem 2014 Dec 23;289(49):34408-21. Epub 2014 Oct 23.

From the Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033,

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http://dx.doi.org/10.1074/jbc.M114.615393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256368PMC
December 2014

A high resolution case study of a patient with recurrent Plasmodium vivax infections shows that relapses were caused by meiotic siblings.

PLoS Negl Trop Dis 2014 Jun 5;8(6):e2882. Epub 2014 Jun 5.

Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0002882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046966PMC
June 2014

Identification of pathogen genomic variants through an integrated pipeline.

BMC Bioinformatics 2014 Mar 3;15:63. Epub 2014 Mar 3.

Department of Pediatrics, University of California, San Diego, School of Medicine, 9500 Gilman Drive 0741, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1186/1471-2105-15-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945619PMC
March 2014

Antimalarial drug discovery - approaches and progress towards new medicines.

Nat Rev Microbiol 2013 Dec 11;11(12):849-62. Epub 2013 Nov 11.

Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive 0741, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nrmicro3138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941073PMC
December 2013

Using genetic methods to define the targets of compounds with antimalarial activity.

J Med Chem 2013 Oct 6;56(20):7761-71. Epub 2013 Sep 6.

Department of Pediatrics, University of California, San Diego, School of Medicine , 9500 Gilman Drive 0741, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/jm400325jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880619PMC
October 2013

Epidemiology: resistance mapping in malaria.

Nature 2013 Jun;498(7455):446-7

School of Medicine, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/498446bDOI Listing
June 2013

A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor.

ACS Chem Biol 2011 Nov 8;6(11):1214-22. Epub 2011 Sep 8.

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/cb200105dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220786PMC
November 2011

Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites.

Vaccine 2011 Oct 30;29(43):7335-42. Epub 2011 Jul 30.

Michael Heidelberger Division, Department of Pathology, New York University School of Medicine, NY 10016, United States.

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http://dx.doi.org/10.1016/j.vaccine.2011.07.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603353PMC
October 2011

Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites.

Antimicrob Agents Chemother 2011 Aug 16;55(8):3908-16. Epub 2011 May 16.

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

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http://aac.asm.org/lookup/doi/10.1128/AAC.01793-10
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http://dx.doi.org/10.1128/AAC.01793-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147642PMC
August 2011

Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum.

BMC Biol 2011 Jul 19;9:50. Epub 2011 Jul 19.

Biomedical Sciences Program, University of California, San Diego, La Jolla, 92093, USA.

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http://dx.doi.org/10.1186/1741-7007-9-50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141604PMC
July 2011

Target identification and validation of novel antimalarials.

Future Microbiol 2011 Jun;6(6):693-704

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.2217/fmb.11.45DOI Listing
June 2011

Validation of isoleucine utilization targets in Plasmodium falciparum.

Proc Natl Acad Sci U S A 2011 Jan 4;108(4):1627-32. Epub 2011 Jan 4.

Department of Medicine and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.1011560108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029723PMC
January 2011