Elizabeth A Shephard

Elizabeth A Shephard

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Elizabeth A Shephard

Elizabeth A Shephard

Publications by authors named "Elizabeth A Shephard"

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Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease.

Xenobiotica 2020 Jan 1;50(1):19-33. Epub 2019 Aug 1.

Research Department of Structural and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1080/00498254.2019.1643515DOI Listing
January 2020

Flavin-containing monooxygenases: new structures from old proteins.

Nat Struct Mol Biol 2020 Jan;27(1):3-4

Department of Structural and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1038/s41594-019-0356-1DOI Listing
January 2020

Recognising laryngeal cancer in primary care: a large case-control study using electronic records.

Br J Gen Pract 2019 Feb 28;69(679):e127-e133. Epub 2019 Jan 28.

University of Exeter Medical School, Exeter.

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http://dx.doi.org/10.3399/bjgp19X700997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355262PMC
February 2019

Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine -oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis.

Drug Metab Dispos 2018 01 25;46(1):20-25. Epub 2017 Oct 25.

Institute of Structural and Molecular Biology (S.V., F.S., D.F., I.R.P., E.A.S.) and Mass Spectrometry Facility, Department of Chemistry (K.K.), University College London, London, United Kingdom; and School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom (I.R.P.)

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http://dx.doi.org/10.1124/dmd.117.077636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733448PMC
January 2018

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria.

Drug Metab Dispos 2017 09 23;45(9):982-989. Epub 2017 Jun 23.

Institute of Structural and Molecular Biology, University College London, London, United Kingdom (F.S., S.G.G.M., B.A.O., D.F., S.V., C.R.C., I.R.P., E.A.S.); and School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom (I.R.P.)

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http://dx.doi.org/10.1124/dmd.117.076612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539585PMC
September 2017

Drug metabolism by flavin-containing monooxygenases of human and mouse.

Expert Opin Drug Metab Toxicol 2017 Feb 29;13(2):167-181. Epub 2016 Sep 29.

a Institute of Structural and Molecular Biology , University College London , London , UK.

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http://dx.doi.org/10.1080/17425255.2017.1239718DOI Listing
February 2017

Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease.

Drug Metab Dispos 2016 11 17;44(11):1839-1850. Epub 2016 May 17.

Institute of Structural and Molecular Biology, University College London (D.F., I.R.P., E.A.S.), and School of Biological and Chemical Sciences, Queen Mary University of London (I.R.P.), London, United Kingdom

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http://dx.doi.org/10.1124/dmd.116.070615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074467PMC
November 2016

Isolation and Culture of Mouse Hepatocytes: Gender-Specific Gene Expression Responses to Chemical Treatments.

Methods Mol Biol 2015 ;1250:3-12

Institute of Structural and Molecular Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.

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http://link.springer.com/10.1007/978-1-4939-2074-7_1
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http://dx.doi.org/10.1007/978-1-4939-2074-7_1DOI Listing
May 2016

A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments.

Comput Struct Biotechnol J 2016 9;14:135-53. Epub 2016 Mar 9.

Medway Metabonomics Research Group, University of Greenwich, Chatham Maritime, Kent ME4 4TB, United Kingdom.

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http://dx.doi.org/10.1016/j.csbj.2016.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821453PMC
April 2016

Clinical utility gene card for: Trimethylaminuria - update 2014.

Eur J Hum Genet 2015 Sep 22;23(9). Epub 2014 Oct 22.

1] Institute of Structural and Molecular Biology, University College London, London, UK [2] School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/ejhg.2014.226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538216PMC
September 2015

The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.

Biochem Pharmacol 2014 Jul 30;90(1):88-95. Epub 2014 Apr 30.

Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.04.007DOI Listing
July 2014

Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.

Br J Clin Pharmacol 2014 May;77(5):839-51

Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.

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http://dx.doi.org/10.1111/bcp.12240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004404PMC
May 2014

Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse.

Pharmaceuticals (Basel) 2012 ;5(11):1147-59

Department of Environmental and Molecular Toxicology, Oregon State University, 1007 ALS Corvallis, OR 97331, USA; (A.L.P.); (V.L.L.); (A.L.).

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http://dx.doi.org/10.3390/ph5111147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621790PMC
November 2013

Public perceptions of the risks, benefits and use of natural remedies, pharmaceutical medicines and personalised medicines.

Complement Ther Med 2013 Oct 20;21(5):487-91. Epub 2013 Aug 20.

Cognitive, Perceptual and Brain Sciences, University College London, Gower Street, London WC1E 6BT, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S09652299130012
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http://dx.doi.org/10.1016/j.ctim.2013.07.007DOI Listing
October 2013

Detection of regulatory polymorphisms: high-throughput capillary DNase I footprinting.

Methods Mol Biol 2013 ;987:269-82

Institute of Structural and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1007/978-1-62703-321-3_23DOI Listing
August 2013

Isolation of mouse hepatocytes.

Methods Mol Biol 2013 ;987:283-93

Institute of Structural and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1007/978-1-62703-321-3_24DOI Listing
August 2013

Clinical features of bladder cancer in primary care.

Br J Gen Pract 2012 Sep;62(602):e598-604

Peninsula College of Medicine and Dentistry, Exeter.

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http://dx.doi.org/10.3399/bjgp12X654560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426598PMC
September 2012

Clinical utility gene card for: trimethylaminuria.

Eur J Hum Genet 2012 Mar 30;20(3). Epub 2011 Nov 30.

Institute of Structural and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1038/ejhg.2011.214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283181PMC
March 2012

The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism.

Expert Opin Drug Metab Toxicol 2010 Sep;6(9):1083-94

University College London, Institute of Structural and Molecular Biology, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1517/17425255.2010.503705DOI Listing
September 2010

Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.

Pharmacogenet Genomics 2009 Apr;19(4):289-99

Department of Biochemical Engineering, Institute of Structural and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1097/FPC.0b013e328328d507DOI Listing
April 2009

Planning the human variome project: the Spain report.

Authors:
Jim Kaput Richard G H Cotton Lauren Hardman Michael Watson Aida I Al Aqeel Jumana Y Al-Aama Fahd Al-Mulla Santos Alonso Stefan Aretz Arleen D Auerbach Bharati Bapat Inge T Bernstein Jong Bhak Stacey L Bleoo Helmut Blöcker Steven E Brenner John Burn Mariona Bustamante Rita Calzone Anne Cambon-Thomsen Michele Cargill Paola Carrera Lawrence Cavedon Yoon Shin Cho Yeun-Jun Chung Mireille Claustres Garry Cutting Raymond Dalgleish Johan T den Dunnen Carlos Díaz Steven Dobrowolski M Rosário N dos Santos Rosemary Ekong Simon B Flanagan Paul Flicek Yoichi Furukawa Maurizio Genuardi Ho Ghang Maria V Golubenko Marc S Greenblatt Ada Hamosh John M Hancock Ross Hardison Terence M Harrison Robert Hoffmann Rania Horaitis Heather J Howard Carol Isaacson Barash Neskuts Izagirre Jongsun Jung Toshio Kojima Sandrine Laradi Yeon-Su Lee Jong-Young Lee Vera L Gil-da-Silva-Lopes Finlay A Macrae Donna Maglott Makia J Marafie Steven G E Marsh Yoichi Matsubara Ludwine M Messiaen Gabriela Möslein Mihai G Netea Melissa L Norton Peter J Oefner William S Oetting James C O'Leary Ana Maria Oller de Ramirez Mark H Paalman Jillian Parboosingh George P Patrinos Giuditta Perozzi Ian R Phillips Sue Povey Suyash Prasad Ming Qi David J Quin Rajkumar S Ramesar C Sue Richards Judith Savige Dagmar G Scheible Rodney J Scott Daniela Seminara Elizabeth A Shephard Rolf H Sijmons Timothy D Smith María-Jesús Sobrido Toshihiro Tanaka Sean V Tavtigian Graham R Taylor Jon Teague Thoralf Töpel Mollie Ullman-Cullere Joji Utsunomiya Henk J van Kranen Mauno Vihinen Elizabeth Webb Thomas K Weber Meredith Yeager Young I Yeom Seon-Hee Yim Hyang-Sook Yoo

Hum Mutat 2009 Apr;30(4):496-510

Division of Personalised Nutrition and Medicine, FDA/National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.

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http://compbio.berkeley.edu/people/brenner/pubs/kaput-2009-h
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http://doi.wiley.com/10.1002/humu.20972
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http://dx.doi.org/10.1002/humu.20972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879779PMC
April 2009

Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.

Drug Metab Dispos 2009 Jan 23;37(1):178-86. Epub 2008 Oct 23.

Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.108.024158
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http://dx.doi.org/10.1124/dmd.108.024158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683658PMC
January 2009

Flavin-containing monooxygenases: mutations, disease and drug response.

Trends Pharmacol Sci 2008 Jun 16;29(6):294-301. Epub 2008 Apr 16.

School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK.

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http://dx.doi.org/10.1016/j.tips.2008.03.004DOI Listing
June 2008

Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3).

Pharmacogenet Genomics 2007 Oct;17(10):827-39

Department of Biochemistry and Molecular Biology, University College London, UK.

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http://dx.doi.org/10.1097/FPC.0b013e328256b198DOI Listing
October 2007

Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse.

Biochem J 2007 Sep;406(3):491-9

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1042/BJ20070523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2049042PMC
September 2007

Mutation, polymorphism and perspectives for the future of human flavin-containing monooxygenase 3.

Mutat Res 2006 Jun 14;612(3):165-71. Epub 2006 Feb 14.

Department of Occupational and Environmental Health, Soochow University, 462# Zhuhui Road, Suzhou 215007, China.

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http://dx.doi.org/10.1016/j.mrrev.2005.09.001DOI Listing
June 2006

Expression of recombinant flavin-containing monooxygenases in a baculovirus/insect cell system.

Methods Mol Biol 2006 ;320:39-59

Department of Biochemistry and Molecular Biology, University College London, UK.

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June 2006

Transfection of primary cultures of rat hepatocytes.

Methods Mol Biol 2006 ;320:273-82

Department of Biochemistry and Molecular Biology, University College London, UK.

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June 2006

Determination of cellular localization of expression of flavin-containing monooxygenase genes in mouse tissues by in situ hybridization.

Methods Mol Biol 2006 ;320:295-305

Department of Biochemistry and Molecular Biology, University College London, UK.

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June 2006

Deletion of genes from the mouse genome using Cre/loxP technology.

Methods Mol Biol 2006 ;320:307-19

Department of Biochemistry and Molecular Biology, University College London, UK.

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June 2006

Characterization of targeted mouse embryonic stem cell chromosomes: karyotyping and fluorescence in situ hybridization of metaphase spreads.

Methods Mol Biol 2006 ;320:321-7

Department of Biochemistry and Molecular Biology, University College London, UK.

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June 2006

Microinjection of targeted embryonic stem cells and establishment of knockout mouse lines for Fmo genes.

Methods Mol Biol 2006 ;320:329-41

Department of Biochemistry and Molecular Biology, University College London, UK.

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June 2006

Transfection of Primary Cultures of Rat Hepatocytes.

Methods Mol Biol 2006;320:273-282

Department of Biochemistry and Molecular Biology, University College London, London, UK.

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http://link.springer.com/10.1385/1-59259-998-2:273
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http://dx.doi.org/10.1385/1-59259-998-2:273DOI Listing
January 2006

Determination of Cellular Localization of Expression of Flavin-Containing Monooxygenase Genes in Mouse Tissues by In Situ Hybridization.

Methods Mol Biol 2006;320:295-305

Department of Biochemistry and Molecular Biology, University College London, London, UK.

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http://link.springer.com/10.1385/1-59259-998-2:295
Publisher Site
http://dx.doi.org/10.1385/1-59259-998-2:295DOI Listing
January 2006

Deletion of Genes From the Mouse Genome Using Cre/loxP Technology.

Methods Mol Biol 2006;320:307-319

Department of Biochemistry and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1385/1-59259-998-2:307DOI Listing
January 2006

Characterization of Targeted Mouse Embryonic Stem Cell Chromosomes : Karyotyping and Fluorescence In Situ Hybridization of Metaphase Spreads.

Methods Mol Biol 2006;320:321-327

School of Biological Sciences, Queen Mary, University of London, London, UK.

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http://dx.doi.org/10.1385/1-59259-998-2:321DOI Listing
January 2006

Microinjection of Targeted Embryonic Stem Cells and Establishment of Knockout Mouse Lines for Fmo Genes.

Methods Mol Biol 2006;320:329-341

Department of Biochemistry and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1385/1-59259-998-2:329DOI Listing
January 2006

Expression of Recombinant Flavin-Containing Monooxygenases in a Baculovirus/Insect Cell System.

Methods Mol Biol 2006;320:39-59

School of Biological Sciences, Queen Mary, University of London, London, UK.

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http://dx.doi.org/10.1385/1-59259-998-2:39DOI Listing
January 2006

Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos).

Biochem Pharmacol 2004 Jul;68(1):73-83

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.bcp.2004.02.036DOI Listing
July 2004

Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters.

Pharmacogenetics 2004 Feb;14(2):117-30

Department of Biochemistry and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1097/00008571-200402000-00006DOI Listing
February 2004

Trimethylaminuria and a human FMO3 mutation database.

Hum Mutat 2003 Sep;22(3):209-13

Department of Biochemistry and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1002/humu.10252DOI Listing
September 2003

Genetic polymorphisms of flavin-containing monooxygenase (FMO).

Drug Metab Rev 2002 Aug;34(3):523-32

Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, USA.

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http://dx.doi.org/10.1081/dmr-120005653DOI Listing
August 2002