Elisabet Viayna

Elisabet Viayna

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Elisabet Viayna

Elisabet Viayna

Publications by authors named "Elisabet Viayna"

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20Publications

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Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AβPPswe/PS-1 Mice of Different Ages.

Curr Alzheimer Res 2016 ;13(9):1017-29

CARE Biomedical Center, P. Catholic University of Chile, Postal code 8331150, PO Box 114-D, Santiago, Chile.

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http://dx.doi.org/10.2174/1567205012666151027141542DOI Listing
October 2017

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.

Bioorg Med Chem 2016 11 22;24(21):5162-5171. Epub 2016 Aug 22.

Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.08.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080452PMC
November 2016

Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.

Bioorg Med Chem 2016 10 28;24(20):4835-4854. Epub 2016 Jun 28.

Department of Nutrition, Food Science and Gastronomy, Faculty of Pharmacy and Institute of Biomedicine (IBUB), University of Barcelona, Av. Prat de la Riba 171, E-08921 Santa Coloma de Gramenet, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.06.045DOI Listing
October 2016

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.

Eur J Med Chem 2015 Nov 19;105:120-37. Epub 2015 Oct 19.

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, E-08028, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638191PMC
November 2015

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.

Bioorg Med Chem 2015 Aug 24;23(16):5156-67. Epub 2015 Jan 24.

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.01.031DOI Listing
August 2015

Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound.

Molecules 2015 Mar 10;20(3):4492-515. Epub 2015 Mar 10.

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona E-08028, Spain.

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http://dx.doi.org/10.3390/molecules20034492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272704PMC
March 2015

Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.

Bioorg Med Chem 2014 Oct 7;22(19):5298-307. Epub 2014 Aug 7.

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.07.053DOI Listing
October 2014

Dual inhibitors of β-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates.

Curr Top Med Chem 2013 ;13(15):1820-42

Laboratori de Química Farmacèutica, Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028-Barcelona, Spain.

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http://dx.doi.org/10.2174/15680266113139990139DOI Listing
March 2014

Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

J Med Chem 2014 Mar 10;57(6):2549-67. Epub 2014 Mar 10.

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, Universitat de Barcelona , Av. Joan XXIII 27-31, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1021/jm401824wDOI Listing
March 2014

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.

Eur J Med Chem 2014 Feb 18;73:141-52. Epub 2013 Dec 18.

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII 27-31, E-08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2013.12.008DOI Listing
February 2014

Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents.

Neurodegener Dis 2012 6;10(1-4):96-9. Epub 2012 Jan 6.

Laboratori de Química Farmacèutica, Unitat Associada al CSIC, Facultat de Farmàcia, and Institut de Biomedicina, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1159/000333225DOI Listing
August 2012

Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents.

Curr Pharm Des 2010 ;16(25):2818-36

Laboratori de Química Farmacèutica and Departament de Fisicoquímica, Facultat de Farmàcia, and Institut de Biomedicina, Universitat de Barcelona, Av. Diagonal 643, E-08028, Barcelona, Spain.

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http://dx.doi.org/10.2174/138161210793176536DOI Listing
February 2011

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.

Chem Biol Interact 2010 Sep 16;187(1-3):411-5. Epub 2010 Feb 16.

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Diagonal 643, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.cbi.2010.02.013DOI Listing
September 2010