Publications by authors named "Elisa de Stanchina"

99Publications

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.

Cell 2020 Apr 31;181(2):424-441.e21. Epub 2020 Mar 31.

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2020.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278897PMC
April 2020

Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation.

Cancer Cell 2020 Apr 26;37(4):584-598.e11. Epub 2020 Mar 26.

Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292228PMC
April 2020

Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition.

Nature 2020 01 8;577(7790):421-425. Epub 2020 Jan 8.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1884-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308074PMC
January 2020

Positron-Emission Tomographic Imaging of a Fluorine 18-Radiolabeled Poly(ADP-Ribose) Polymerase 1 Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in SCLC Patient-Derived Xenografts.

J Thorac Oncol 2019 10 11;14(10):1743-1752. Epub 2019 Jun 11.

Molecular Pharmacology Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtho.2019.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764879PMC
October 2019

Phosphorylation state of Ser in α-tubulin is a toggle switch that controls proliferating human breast tumors.

Cell Signal 2018 12 1;52:74-82. Epub 2018 Sep 1.

Department of Chemistry & Biochemistry, Queens College, USA; Graduate Center of The City University of New York, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2018.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765385PMC
December 2018

BET Inhibition-Induced GSK3β Feedback Enhances Lymphoma Vulnerability to PI3K Inhibitors.

Cell Rep 2018 08;24(8):2155-2166

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247183115
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2018.07.055DOI Listing
August 2018

Talazoparib Is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts.

Clin Cancer Res 2018 10 26;24(20):5143-5152. Epub 2018 Jun 26.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-18-0401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742772PMC
October 2018

Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models.

Front Oncol 2018 19;8:19. Epub 2018 Feb 19.

Antitumor Assessment Core Facility, Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2018.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825907PMC
February 2018

Pazopanib radio-sensitization of human sarcoma tumors.

Oncotarget 2018 Feb 20;9(10):9311-9324. Epub 2018 Jan 20.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.24281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823639PMC
February 2018

CryoPause: A New Method to Immediately Initiate Experiments after Cryopreservation of Pluripotent Stem Cells.

Stem Cell Reports 2017 07 8;9(1):355-365. Epub 2017 Jun 8.

The SKI Stem Cell Research Facility, The Center for Stem Cell Biology and Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2017.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511100PMC
July 2017

Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses Loss-Driven Tumorigenesis.

Mol Cancer Ther 2017 08 3;16(8):1693-1704. Epub 2017 May 3.

Department of Cancer Biology and David H. Koch Center for Applied Research of Genitourinary Cancers, University of Texas MD Anderson Cancer Center, Houston, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-16-0821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929164PMC
August 2017

Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis.

Cancer Cell 2017 02;31(2):286-299

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2017.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313262PMC
February 2017

DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy.

Mol Cancer Res 2017 03 10;15(3):269-280. Epub 2017 Jan 10.

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-16-0227-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334281PMC
March 2017

Tumor Inhibition by Enzalutamide in a Xenograft Model of Ovarian Cancer.

Cancer Invest 2016 Nov 8;34(10):517-520. Epub 2016 Nov 8.

b Department of Medicine , Gynecologic Medical Oncology Service, Memorial Sloan-Kettering Cancer Center, and Weill Cornell Medical College , New York , New York , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07357907.2016.1242598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546102PMC
November 2016

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.

Cancer Discov 2016 10 17;6(10):1166-1181. Epub 2016 Aug 17.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-16-0237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584808PMC
October 2016

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.

Nature 2016 06 18;534(7606):272-6. Epub 2016 May 18.

Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nature17963
Publisher Site
http://dx.doi.org/10.1038/nature17963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902179PMC
June 2016

BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition.

Cancer Cell 2015 Sep 3;28(3):370-83. Epub 2015 Sep 3.

Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Mechanism Based Therapeutics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894664PMC
September 2015

Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma.

Clin Cancer Res 2016 Jan 4;22(2):426-35. Epub 2015 Sep 4.

Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut. Department of Pathology, Yale University School of Medicine, New Haven, Connecticut. Department of Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-15-0620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715986PMC
January 2016

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.

Cancer Cell 2015 Apr;27(4):502-15

Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2015.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518555PMC
April 2015

Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ.

Cancer Cell 2015 Jan 24;27(1):109-22. Epub 2014 Dec 24.

Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2014.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293347PMC
January 2015

Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL.

Blood 2015 Feb 12;125(9):1444-51. Epub 2014 Dec 12.

Cancer Biology & Genetics Program, and Howard Hughes Medical Institute, and Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-09-601062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342356PMC
February 2015

Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer.

Mol Cancer Ther 2015 Feb 4;14(2):542-52. Epub 2014 Dec 4.

Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee. Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-14-0723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338015PMC
February 2015

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.

Nature 2014 Dec 22;516(7531):423-7. Epub 2014 Oct 22.

Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature13902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270925PMC
December 2014

Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer.

Cell Rep 2014 Aug 14;8(4):1077-92. Epub 2014 Aug 14.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346175PMC
August 2014

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.

Genes Dev 2014 Aug;28(16):1800-14

Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA; Cell and Developmental Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, New York 10065, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.244368.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197965PMC
August 2014

Frequent disruption of the RB pathway in indolent follicular lymphoma suggests a new combination therapy.

J Exp Med 2014 Jun 9;211(7):1379-91. Epub 2014 Jun 9.

Cancer Biology & Genetics Program, Computational Biology Program, Department of Medicine, Human Oncology and Pathogenesis Program, Genomics Core Facility, Molecular Pharmacology Program, Department of Pathology, Department of Epidemiology and Biostatistics, and Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20132120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076578PMC
June 2014

Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1.

Cell Rep 2014 May 9;7(4):999-1008. Epub 2014 May 9.

Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074596PMC
May 2014

Sustained inhibition of receptor tyrosine kinases and macrophage depletion by PLX3397 and rapamycin as a potential new approach for the treatment of MPNSTs.

Clin Cancer Res 2014 Jun 9;20(12):3146-58. Epub 2014 Apr 9.

Authors' Affiliations: Jennifer Goodman Linn Laboratory of New Drug Development, Department of Medicine, Department of Molecular Pharmacology and Chemistry, Department of Surgery, Memorial Sloan Kettering Cancer Center; and Division of Hematology/Oncology, Columbia University Medical Center, New York, New York.

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/content/20/12/3146.ful
Web Search
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-13-2576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060793PMC
June 2014

The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells.

Mol Cancer Ther 2014 May 21;13(5):1044-53. Epub 2014 Feb 21.

Authors' Affiliation: Jennifer Goodman Linn Laboratory of New Drug Development in Sarcoma and Rare Cancers, Memorial Sloan-Kettering Cancer Center, New York, New York.

View Article

Download full-text PDF

Source
http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-13
Publisher Site
http://dx.doi.org/10.1158/1535-7163.MCT-13-0550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146424PMC
May 2014

Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling.

Cancer Discov 2014 Mar 16;4(3):334-47. Epub 2014 Jan 16.

1Program in Molecular Pharmacology; 2Human Oncology and Pathogenesis Program; 3Program in Cell Biology, Memorial Sloan-Kettering Cancer Center; 4Weill Cornell Medical College, New York, New York; and 5Bayer HealthCare, Global Drug Discovery, Berlin, Germany.

View Article

Download full-text PDF

Source
http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
Publisher Site
http://dx.doi.org/10.1158/2159-8290.CD-13-0611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049524PMC
March 2014

Infrastructure needs for translational integration of mouse and human trials.

Cold Spring Harb Protoc 2013 Dec 1;2013(12):1109-14. Epub 2013 Dec 1.

Preclinical Murine Pharmacogenetics Facility, Division of Genetics, Department of Medicine, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts 02215;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/pdb.top078782DOI Listing
December 2013

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids.

Proc Natl Acad Sci U S A 2013 May 13;110(22):8882-7. Epub 2013 May 13.

Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1307237110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670379PMC
May 2013

Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET.

J Nucl Med 2013 Jun 11;54(6):936-43. Epub 2013 Apr 11.

Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2967/jnumed.112.110239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967936PMC
June 2013

Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death.

Mol Cancer Ther 2013 May 26;12(5):768-76. Epub 2013 Feb 26.

Laboratory of New Drug Development, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-12-1020DOI Listing
May 2013

β4 Integrin signaling induces expansion of prostate tumor progenitors.

J Clin Invest 2013 Feb 25;123(2):682-99. Epub 2013 Jan 25.

Cell Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, New York, USA.

View Article

Download full-text PDF

Source
http://www.jci.org/articles/view/60720
Publisher Site
http://dx.doi.org/10.1172/JCI60720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561800PMC
February 2013

Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype.

PLoS One 2012 10;7(7):e40439. Epub 2012 Jul 10.

Laboratory of New Drug Development, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040439PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393714PMC
March 2013