Publications by authors named "Elisa D"

2 Publications

  • Page 1 of 1

Hyper-vision of mirror symmetry in patients with macular degenerationreflects parafoveal cortical reorganization.

Restor Neurol Neurosci 2016 ;34(1):67-77

Department of General Psychology, University of Padova, Padova, Italy.

Purpose: This study aims at comparing participants with juvenile macular degeneration (MD) and normally sighted observers in their sensitivity to mirror and translational symmetry.

Methods: We measured in 25 normal sighted and 9 MD participants sensitivity (d') to detect the symmetry of two dot patterns presented at the opposite sides of their central scotoma.

Results: At a large dot patterns separation (13.3 deg), at which detection failed in normally sighted observers, MD patients had high sensitivity to mirror symmetry, whereas translational symmetry was undetected.

Conclusions: The mirror-translational dissociation is not predicted by the well-known phenomenon of shrinking the location of images surrounding the scotoma. Our results indicate higher capacity of MD with respect to normally sighted observers to organize mirror symmetric dot patterns far apart into a unique percept. Our results suggest that MD have acquired the capability to use information only present in mirror symmetry, i.e., the co-aligned position of the centre of low-frequency filters connecting symmetric dot pairs on opposite sides of the scotoma. This relevant functional change in vision of MD patients may find its explanation in a functionally acquired high-level cortical representation of visual input.
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October 2016

Glucocorticoids and estrogens modulate the NF-κB pathway differently in the micro- and macrovasculature.

Med Hypotheses 2013 Dec 18;81(6):1078-82. Epub 2013 Oct 18.

Laboratorio de Respiración Celular Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luıis y Díaz Mirón, México, D.F., Mexico. Electronic address:

Estrogens and glucocorticoids have synergistic effects in the micro and macrovasculature of endothelial cells (ECs), having pro-inflammatory effects in the former and inhibiting the expression of adhesion molecules in the latter. The molecular basis of these effects in the endothelium has not yet been clarified. We postulate that the ECs of the micro- and macrovasculature have different non-genomic mechanisms that regulate levels of preexisting complexes of glucocorticoids and estrogens with their respective receptors. Since these receptors are regulated by NF-κB, their expression could be critical to the activation of a pro- or anti-inflammatory response. In the macrovasculature the synergistic effects of estrogens and glucocorticoids on ECs may be through the inhibition of NF-κB, leading to the inhibition of the expression of inflammatory molecules. It seems likely that glucocorticoid-receptor and estrogen-receptor complexes directly bind to NF-κB proteins in the macrovasculature, resulting in the inhibition of an excessive proinflammatory response. Further insights into these processes may help clarify the role of the endothelial cells of different vascular beds during the inflammatory response and chronic inflammation, and thus contribute to the design of more effective therapeutic strategies for the prevention of diseases related to inflammation, including atherosclerosis, systemic lupus erythematosus and rheumatoid arthritis.
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December 2013