Elina Ikonen

Elina Ikonen

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Elina Ikonen

Elina Ikonen

Publications by authors named "Elina Ikonen"

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An efficient auxin-inducible degron system with low basal degradation in human cells.

Nat Methods 2019 Sep 26;16(9):866-869. Epub 2019 Aug 26.

Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41592-019-0512-xDOI Listing
September 2019

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact.

Dev Cell 2019 Aug 6;50(4):478-493.e9. Epub 2019 Jun 6.

Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.05.016DOI Listing
August 2019

Shuttling HDL Cholesterol to the Membrane via Metastable Receptor Multimers.

Dev Cell 2019 Aug;50(3):257-258

Faculty of Medicine, Department of Anatomy and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.devcel.2019.07.018DOI Listing
August 2019

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo.

Mol Metab 2019 Jul 6. Epub 2019 Jul 6.

Department of Anatomy, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8 00290 Helsinki, Finland; Minerva Foundation Institute for Medical Research, Tukholmankatu 8, 00290 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.07.005DOI Listing
July 2019

Moving out but keeping in touch: contacts between endoplasmic reticulum and lipid droplets.

Curr Opin Cell Biol 2019 Apr 23;57:64-70. Epub 2018 Nov 23.

Faculty of Medicine, Dept. of Anatomy and HiLIFE, Univ. of Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ceb.2018.11.002DOI Listing
April 2019

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol.

Biochimie 2019 Mar 24;158:90-101. Epub 2018 Dec 24.

Minerva Foundation Institute for Medical Research, Biomedicum 2U, FI-00290, Helsinki, Finland; Department of Anatomy, Faculty of Medicine, FI-00014, University of Helsinki, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03009084183035
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http://dx.doi.org/10.1016/j.biochi.2018.12.013DOI Listing
March 2019

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases.

Elife 2019 Feb 18;8. Epub 2019 Feb 18.

Institute of Cellular Biochemistry, University Medical Center Goettingen, Goettingen, Germany.

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http://dx.doi.org/10.7554/eLife.39598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379092PMC
February 2019

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.

Cell 2018 10 13;175(2):514-529.e20. Epub 2018 Sep 13.

Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.08.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469685PMC
October 2018

Mechanisms of cellular cholesterol compartmentalization: recent insights.

Authors:
Elina Ikonen

Curr Opin Cell Biol 2018 08 28;53:77-83. Epub 2018 Jun 28.

Faculty of Medicine, Dept. of Anatomy and HiLIFE, University of Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2018.06.002DOI Listing
August 2018

Association of tamoxifen resistance and lipid reprogramming in breast cancer.

BMC Cancer 2018 Aug 24;18(1):850. Epub 2018 Aug 24.

Institute for Molecular Medicine Finland, FIMM, Helsinki Institute for Life Sciences (HiLIFE), University of Helsinki, Helsinki, Finland.

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4757-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109356PMC
August 2018

Concerted regulation of npc2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin.

PLoS Comput Biol 2017 Oct 30;13(10):e1005831. Epub 2017 Oct 30.

Laboratory of Physics, Tampere University of Technology, Tampere, Finland.

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http://dx.doi.org/10.1371/journal.pcbi.1005831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679659PMC
October 2017

Language-Agnostic Reproducible Data Analysis Using Literate Programming.

PLoS One 2016 6;11(10):e0164023. Epub 2016 Oct 6.

Research Programs Unit, Genome-Scale Biology, University of Helsinki, Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053501PMC
June 2017

Plant sterols, cholesterol precursors and oxysterols: Minute concentrations-Major physiological effects.

J Steroid Biochem Mol Biol 2017 05 28;169:4-9. Epub 2015 Dec 28.

Minerva Foundation Institute for Medical Research, Biomedicum 2U, FI-00290 Helsinki, Finland; Department of Anatomy, Faculty of Medicine, FI-00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jsbmb.2015.12.026DOI Listing
May 2017

Introducing inducible fluorescent split cholesterol oxidase to mammalian cells.

J Biol Chem 2017 05 7;292(21):8811-8822. Epub 2017 Apr 7.

From the Department of Biochemistry and Developmental Biology and

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http://dx.doi.org/10.1074/jbc.M116.761718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448107PMC
May 2017

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.

Nat Commun 2017 03 31;8:14858. Epub 2017 Mar 31.

Department of Anatomy and Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki 00290, Finland.

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http://dx.doi.org/10.1038/ncomms14858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380971PMC
March 2017

Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation.

Traffic 2016 09 13;17(9):1054-7. Epub 2016 Jun 13.

Faculty of Medicine, Department of Anatomy, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1111/tra.12414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988379PMC
September 2016

D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage.

J Biomed Opt 2016 Jun;21(6):61003

University of California, Irvine, Department of Chemistry, Irvine, California 92697, United States.

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http://dx.doi.org/10.1117/1.JBO.21.6.061003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681884PMC
June 2016

LDL-cholesterol transport to the endoplasmic reticulum: current concepts.

Curr Opin Lipidol 2016 06;27(3):282-7

Department of Anatomy and Research Programs Unit, Faculty of Medicine, University of Helsinki, Finland and Minerva Foundation Institute for Medical Research, Helsinki, Finland.

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http://dx.doi.org/10.1097/MOL.0000000000000292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888931PMC
June 2016

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity.

Atherosclerosis 2016 06 11;249:140-7. Epub 2016 Apr 11.

Department of Anatomy, Faculty of Medicine, University of Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.04.005DOI Listing
June 2016

Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism.

Biol Open 2016 May 15;5(5):584-95. Epub 2016 May 15.

Folkhälsan Institute of Genetics, FI-00290 Helsinki, Finland Research Programs Unit, Molecular Neurology, University of Helsinki, FI-00290 Helsinki, Finland Neuroscience Center, University of Helsinki, FI-00790 Helsinki, Finland

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http://dx.doi.org/10.1242/bio.016246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874348PMC
May 2016

Lipoprotein-mediated delivery of BODIPY-labeled sterol and sphingolipid analogs reveals lipid transport mechanisms in mammalian cells.

Chem Phys Lipids 2016 Jan 4;194:29-36. Epub 2015 Sep 4.

Dept of Anatomy, Faculty of Medicine, University of Helsinki and Minerva Foundation Institute for Medical Research, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.chemphyslip.2015.08.013DOI Listing
January 2016

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways.

Nat Chem Biol 2015 Oct 17;11(10):799-806. Epub 2015 Aug 17.

Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/nchembio.1889DOI Listing
October 2015

Lipid transport takes the 'omics' highway.

Curr Opin Lipidol 2015 Aug;26(4):348-9

aDepartment of Anatomy, Faculty of Medicine, University of Helsinki bMinerva Institute for Medical Research, Helsinki, Finland.

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http://dx.doi.org/10.1097/MOL.0000000000000201DOI Listing
August 2015

The impact of low-frequency and rare variants on lipid levels.

Nat Genet 2015 Jun 11;47(6):589-97. Epub 2015 May 11.

1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] Department of Public Health, University of Helsinki, Helsinki, Finland. [3] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757735PMC
June 2015

Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes.

PLoS One 2014 26;9(8):e103743. Epub 2014 Aug 26.

Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103743PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144813PMC
May 2015

Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers.

Am J Pathol 2015 Apr 12;185(4):987-1000. Epub 2015 Feb 12.

Faculty of Medicine, Department of Anatomy, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.12.018DOI Listing
April 2015

Cholesterol precursors: more than mere markers of biosynthesis.

Curr Opin Lipidol 2014 Apr;25(2):133-9

aSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia bInstitute of Biomedicine, Anatomy, University of Helsinki cMinerva Foundation Institute for Medical Research, Helsinki, Finland.

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http://dx.doi.org/10.1097/MOL.0000000000000038DOI Listing
April 2014

PNPLA3 mediates hepatocyte triacylglycerol remodeling.

J Lipid Res 2014 Apr 7;55(4):739-46. Epub 2014 Feb 7.

Minerva Foundation Institute for Medical Research, Biomedicum 2U, FI-00290 Helsinki, Finland.

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http://www.jlr.org/content/55/4/739.full.pdf
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http://www.jlr.org/cgi/doi/10.1194/jlr.M046607
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http://dx.doi.org/10.1194/jlr.M046607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966707PMC
April 2014

Amyloid precursor protein α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2.

FASEB J 2014 Feb 18;28(2):849-60. Epub 2013 Nov 18.

2Institute of Biomedicine, Haartmaninkatu 8, FI-00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1096/fj.13-239301DOI Listing
February 2014

LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route.

Dev Cell 2013 Nov 24;27(3):249-62. Epub 2013 Oct 24.

Institute of Biomedicine, Anatomy, University of Helsinki, FI-00014 Helsinki, Finland; Minerva Foundation Institute for Medical Research, FI-00290 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.devcel.2013.09.016DOI Listing
November 2013

Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.

Prog Lipid Res 2013 Oct 2;52(4):666-80. Epub 2013 Oct 2.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.plipres.2013.09.002DOI Listing
October 2013

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.

J Cell Sci 2013 Sep 26;126(Pt 17):3961-71. Epub 2013 Jun 26.

Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1242/jcs.128132DOI Listing
September 2013

What dictates the accumulation of desmosterol in the developing brain?

FASEB J 2013 Mar 10;27(3):865-70. Epub 2012 Dec 10.

Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland.

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http://www.fasebj.org/content/early/2012/12/07/fj.12-211235.
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http://www.fasebj.org/cgi/doi/10.1096/fj.12-211235
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http://dx.doi.org/10.1096/fj.12-211235DOI Listing
March 2013

Alleviation of seipinopathy-related ER stress by triglyceride storage.

Hum Mol Genet 2013 Mar 18;22(6):1157-66. Epub 2012 Dec 18.

Institute of Biomedicine, Anatomy, University of Helsinki, 00014 Helsinki, Finland.

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http://hmg.oxfordjournals.org/content/early/2013/01/07/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/dds523
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http://dx.doi.org/10.1093/hmg/dds523DOI Listing
March 2013

ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion.

Biochim Biophys Acta 2012 Dec 11;1821(12):1472-84. Epub 2012 Aug 11.

Institute of Biomedicine, Anatomy, PO Box 63, FI-00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.bbalip.2012.08.004DOI Listing
December 2012

Lipid-protein interactions: finding the perfect match.

Curr Opin Lipidol 2012 Dec;23(6):581-3

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http://dx.doi.org/10.1097/MOL.0b013e32835a4166DOI Listing
December 2012

Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case.

Traffic 2012 Sep 11;13(9):1234-43. Epub 2012 Jun 11.

Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/j.1600-0854.2012.01379.xDOI Listing
September 2012

Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism.

Neurobiol Dis 2012 Apr 13;46(1):19-29. Epub 2011 Dec 13.

National Institute for Health and Welfare (THL), Public Health Genomics Unit, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.nbd.2011.12.009DOI Listing
April 2012

Endosomal actin remodeling by coronin-1A controls lipoprotein uptake and degradation in macrophages.

Circ Res 2012 Feb 5;110(3):450-5. Epub 2012 Jan 5.

Institute of Biomedicine/Anatomy, University of Helsinki, Finland.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.111.25684
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http://dx.doi.org/10.1161/CIRCRESAHA.111.256842DOI Listing
February 2012

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Neuron 2011 Oct 21;72(2):257-68. Epub 2011 Sep 21.

Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200438PMC
October 2011

Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters?

Chem Phys Lipids 2011 Sep 17;164(6):443-50. Epub 2011 Mar 17.

Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.chemphyslip.2011.03.002DOI Listing
September 2011

Synthesis and biosynthetic trafficking of membrane lipids.

Cold Spring Harb Perspect Biol 2011 Aug 1;3(8):a004713. Epub 2011 Aug 1.

Institute of Biomedicine, Department of Anatomy, University of Helsinki, FIN-00014 Finland.

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http://dx.doi.org/10.1101/cshperspect.a004713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140686PMC
August 2011

Sterol binding by OSBP-related protein 1L regulates late endosome motility and function.

Cell Mol Life Sci 2011 Feb 6;68(3):537-51. Epub 2010 Aug 6.

Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Tukholmankatu 8, 00290 Helsinki, Finland.

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http://dx.doi.org/10.1007/s00018-010-0470-zDOI Listing
February 2011

Automatic FRAP analysis with inhomogeneous fluorescence distribution and movement compensation.

Adv Exp Med Biol 2010 ;680:717-24

Department of Signal Processing, Tampere University of Technology, Korkeakoulunkatu 10, 33720 Tampere, Finland.

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http://dx.doi.org/10.1007/978-1-4419-5913-3_80DOI Listing
February 2011

[Finnish disease heritage].

Duodecim 2010 ;126(19):2311-20

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December 2010

Zebrafish: gaining popularity in lipid research.

Biochem J 2010 Jul;429(2):235-42

Institute of Biomedicine/Anatomy, Haartmaninkatu 8, 00140 University of Helsinki, Finland.

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http://dx.doi.org/10.1042/BJ20100293DOI Listing
July 2010

Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages.

Arterioscler Thromb Vasc Biol 2009 Jun 19;29(6):883-8. Epub 2009 Mar 19.

Institute of Biomedicine/Anatomy, Haartmaninkatu 8, 00014 University of Helsinki, Finland.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.108.179481
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http://dx.doi.org/10.1161/ATVBAHA.108.179481DOI Listing
June 2009

Role of lysosomal acid lipase in the intracellular metabolism of LDL-transported dehydroepiandrosterone-fatty acyl esters.

Am J Physiol Endocrinol Metab 2008 Dec 16;295(6):E1455-61. Epub 2008 Sep 16.

Dept. of Medicine, Helsinki Univ. Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland.

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http://dx.doi.org/10.1152/ajpendo.90527.2008DOI Listing
December 2008

BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms.

Traffic 2008 Nov 19;9(11):1839-49. Epub 2008 Jul 19.

Institute of Biomedicine/Anatomy, Haartmaninkatu 8, University of Helsinki, Helsinki 00014, Finland.

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http://dx.doi.org/10.1111/j.1600-0854.2008.00801.xDOI Listing
November 2008

Cellular sterol trafficking and metabolism: spotlight on structure.

Curr Opin Cell Biol 2008 Aug 24;20(4):371-7. Epub 2008 May 24.

Institute of Biomedicine/Anatomy, Haartmaninkatu 8, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ceb.2008.03.017DOI Listing
August 2008

Cholesterol substitution increases the structural heterogeneity of caveolae.

J Biol Chem 2008 May 19;283(21):14610-8. Epub 2008 Mar 19.

Institute of Biomedicine/Anatomy, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1074/jbc.M710355200DOI Listing
May 2008

Cellular cholesterol trafficking and compartmentalization.

Authors:
Elina Ikonen

Nat Rev Mol Cell Biol 2008 Feb;9(2):125-38

Institute of Biomedicine/Anatomy, University of Helsinki, Haartmaninkatu 8, University of Helsinki, Helsinki FI-00014, Finland.

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http://dx.doi.org/10.1038/nrm2336DOI Listing
February 2008

Endocytic trafficking of sphingomyelin depends on its acyl chain length.

Mol Biol Cell 2007 Dec 17;18(12):5113-23. Epub 2007 Oct 17.

Institute of Biomedicine/Anatomy and Institute of Biomedicine/Biochemistry, University of Helsinki, FIN-00014, Helsinki, Finland.

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http://dx.doi.org/10.1091/mbc.e07-04-0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096594PMC
December 2007

Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction.

Neurobiol Dis 2007 Oct 23;28(1):52-64. Epub 2007 Jun 23.

National Public Health Institute, Department of Molecular Medicine, Biomedicum Helsinki, PO Box 104, 00251 Helsinki, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S096999610700133
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http://dx.doi.org/10.1016/j.nbd.2007.06.012DOI Listing
October 2007

Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells.

Mol Biol Cell 2007 Jan 18;18(1):47-56. Epub 2006 Oct 18.

Institute of Biomedicine/Anatomy, University of Helsinki, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1091/mbc.e06-07-0575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751315PMC
January 2007

When intracellular logistics fails--genetic defects in membrane trafficking.

J Cell Sci 2006 Dec;119(Pt 24):5031-45

Department of Molecular Medicine, National Public Health Institute (KTL), Biomedicum, POBox 104, FI-00251 Helsinki, Finland.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.03303
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http://dx.doi.org/10.1242/jcs.03303DOI Listing
December 2006

Mechanisms for cellular cholesterol transport: defects and human disease.

Authors:
Elina Ikonen

Physiol Rev 2006 Oct;86(4):1237-61

Institute of Biomedicine/Anatomy, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1152/physrev.00022.2005DOI Listing
October 2006

Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts.

J Biol Chem 2006 Jan 25;281(1):348-55. Epub 2005 Oct 25.

Institute of Biomedicine/Anatomy, University of Helsinki, Helsinki FI-00014, Finland.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M509530200
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http://dx.doi.org/10.1074/jbc.M509530200DOI Listing
January 2006

Genetics and molecular biology.

Authors:
Elina Ikonen

Curr Opin Lipidol 2005 Dec;16(6):695-7

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December 2005

MLN64 is involved in actin-mediated dynamics of late endocytic organelles.

Mol Biol Cell 2005 Aug 1;16(8):3873-86. Epub 2005 Jun 1.

Institute of Biomedicine, University of Helsinki, 00014 Helsinki, Finland.

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http://www.molbiolcell.org/doi/10.1091/mbc.e04-12-1105
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http://dx.doi.org/10.1091/mbc.e04-12-1105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182323PMC
August 2005

Introduction: new aspects of cellular sterol metabolism and transport.

Authors:
Elina Ikonen

Semin Cell Dev Biol 2005 Apr;16(2):151-3

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http://dx.doi.org/10.1016/j.semcdb.2005.02.016DOI Listing
April 2005

Lipid microdomains and insulin resistance: is there a connection?

Sci STKE 2005 Jan 25;2005(268):pe3. Epub 2005 Jan 25.

Institute of Biotechnology, Viikinkaari 9, 00014 University of Helsinki, and National Public Health Institute, Helsinki, Finland.

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http://dx.doi.org/10.1126/stke.2682005pe3DOI Listing
January 2005

Secretion of sterols and the NPC2 protein from primary astrocytes.

J Biol Chem 2004 Nov 7;279(47):48654-62. Epub 2004 Sep 7.

Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1074/jbc.M405345200DOI Listing
November 2004

Cellular pathology of Niemann-Pick type C disease.

Semin Cell Dev Biol 2004 Aug;15(4):445-54

Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.semcdb.2004.03.001DOI Listing
August 2004

Genetics and molecular biology.

Authors:
Elina Ikonen

Curr Opin Lipidol 2004 Apr;15(2):219-21

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April 2004

Macrophage cholesterol transport: a critical player in foam cell formation.

Ann Med 2003 ;35(3):146-55

Department of Molecular Medicine, National Public Health Institute, Biomedicum Helsinki, Haartmaninkatu 8, Fl-00251 Helsinki, Finland.

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October 2003

Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells.

J Biol Chem 2003 May 25;278(22):19844-51. Epub 2003 Mar 25.

Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland.

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http://dx.doi.org/10.1074/jbc.M212503200DOI Listing
May 2003

Genetics and molecular biology.

Authors:
Elina Ikonen

Curr Opin Lipidol 2003 Apr;14(2):219-21

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http://dx.doi.org/10.1097/01.mol.0000064052.08840.b9DOI Listing
April 2003

Defective endocytic trafficking of NPC1 and NPC2 underlying infantile Niemann-Pick type C disease.

Hum Mol Genet 2003 Feb;12(3):257-72

Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland.

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http://dx.doi.org/10.1093/hmg/ddg025DOI Listing
February 2003

Modulation of cellular cholesterol transport and homeostasis by Rab11.

Mol Biol Cell 2002 Sep;13(9):3107-22

Department of Molecular Medicine, National Public Health Institute, Biomedicum Helsinki, Finland.

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http://dx.doi.org/10.1091/mbc.e02-01-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124146PMC
September 2002

Genetics and molecular biology.

Authors:
Elina Ikonen

Curr Opin Lipidol 2002 Aug;13(4):441-3

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August 2002

Cognitive deficit and development of motor impairment in a mouse model of Niemann-Pick type C disease.

Behav Brain Res 2002 Apr;132(1):1-10

Laboratory of Molecular Neurobiology, Institute of Biotechnology and Department of Biosciences, PO Box 56, Viikinkaari 5, FIN-00014 University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/s0166-4328(01)00380-1DOI Listing
April 2002

ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism.

J Lipid Res 2002 Feb;43(2):245-55

Department of Molecular Medicine, National Public Health Institute, Biomedicum, P.O. Box 104, FIN-00251 Helsinki, Finland.

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February 2002