Elif A Oral

Elif A Oral

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Elif A Oral

Elif A Oral

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Long-term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy.

Endocrine 2019 Jun 25;64(3):500-511. Epub 2019 Feb 25.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s12020-019-01862-8DOI Listing
June 2019

Clinical utility of genomic analysis in adults with idiopathic liver disease.

J Hepatol 2019 Jun 15;70(6):1214-1221. Epub 2019 Apr 15.

Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193011
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http://dx.doi.org/10.1016/j.jhep.2019.01.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526061PMC
June 2019

Diagnosis of acquired generalized lipodystrophy in a single patient with T-cell lymphoma and no exposure to Metreleptin.

Clin Diabetes Endocrinol 2019 14;5. Epub 2019 Mar 14.

1Division of Metabolism Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan and Brehm Center for Diabetes, 1000 Wall Street, Room 5313, Ann Arbor, MI 48105 USA.

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http://dx.doi.org/10.1186/s40842-019-0076-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419468PMC
March 2019

Metabolic Parameters, Weight Loss, and Comorbidities 4 Years After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy.

Obes Surg 2018 Nov;28(11):3415-3423

Division of Metabolism, Endocrinology, and Diabetes, Brehm Center for Diabetes, Michigan Medicine, 24 Frank Lloyd Wright Drive, Domino's Farm, Lobby C, Ann Arbor, MI, 48106, USA.

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http://dx.doi.org/10.1007/s11695-018-3346-1DOI Listing
November 2018

"Fat Shadows" From DXA for the Qualitative Assessment of Lipodystrophy: When a Picture Is Worth a Thousand Numbers.

Diabetes Care 2018 10;41(10):2255-2258

Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI

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http://dx.doi.org/10.2337/dc18-0978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150431PMC
October 2018

Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.

Endocrine 2018 06 12;60(3):479-489. Epub 2018 Apr 12.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s12020-018-1589-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936645PMC
June 2018

Lamin A/C Maintains Exocrine Pancreas Homeostasis by Regulating Stability of RB and Activity of E2F.

Gastroenterology 2018 05 31;154(6):1625-1629.e8. Epub 2018 Jan 31.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; Åbo Akademi University, Turku, Finland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927841PMC
May 2018

Potential association of LMNA-associated generalized lipodystrophy with juvenile dermatomyositis.

Clin Diabetes Endocrinol 2018 27;4. Epub 2018 Mar 27.

2Metabolism Endocrinology and Diabetes Division, Department of Internal Medicine, University of Michigan and Brehm Center for Diabetes, 1000 Wall Street, Room 5313, Ann Arbor, MI MI48105 USA.

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http://dx.doi.org/10.1186/s40842-018-0058-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870259PMC
March 2018

Roux-en-Y gastric bypass versus sleeve gastrectomy: risks and benefits.

Minerva Chir 2017 Dec 26;72(6):505-519. Epub 2017 Jul 26.

Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA -

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http://dx.doi.org/10.23736/S0026-4733.17.07441-7DOI Listing
December 2017

Estimating the prevalence of generalized and partial lipodystrophy: findings and challenges.

Diabetes Metab Syndr Obes 2017 13;10:375-383. Epub 2017 Sep 13.

Complete HEOR Solutions (CHEORS), North Wales, PA, USA.

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http://dx.doi.org/10.2147/DMSO.S130810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604558PMC
September 2017

Milestone Weight Loss Goals (Weight Normalization and Remission of Obesity) after Gastric Bypass Surgery: Long-Term Results from the University of Michigan.

Obes Surg 2017 07;27(7):1659-1666

Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Health Systems, Brehm Center for Diabetes, 1000 Wall Street, Room 5313, Ann Arbor, MI, 48105, USA.

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http://link.springer.com/10.1007/s11695-016-2533-1
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http://dx.doi.org/10.1007/s11695-016-2533-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491351PMC
July 2017

Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.

Cell Metab 2017 Jul;26(1):157-170.e7

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Departments of Medicine and Pharmacology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA; Institute of Diabetes and Metabolic Health, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0757, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663294PMC
July 2017

Roux-En-Y Gastric Bypass Vs. Sleeve Gastrectomy: Balancing the Risks of Surgery with the Benefits of Weight Loss.

Obes Surg 2017 01;27(1):154-161

Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes (MEND), University of Michigan, 1000 Wall Street, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1007/s11695-016-2265-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187368PMC
January 2017

The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline.

J Clin Endocrinol Metab 2016 12 6;101(12):4500-4511. Epub 2016 Oct 6.

National Institute of Diabetes and Digestive and Kidney Diseases (R.J.B., K.I.R.), National Institutes of Health, Bethesda, Maryland 20892; Department of Medicine (D.A.-V.), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; Department of Paediatrics and Adolescent Medicine (P.T.C.), The University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Paediatrics (D.D.), University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Metabolic Research Laboratories Wellcome Trust (D.D.), Medical Research Council (MRC) Institute of Metabolic Science, National Institute for Health Research Cambridge Comprehensive Biomedical Research Centre, MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Division of Nutrition and Metabolic Diseases (A.G.), Department of Internal Medicine and the Center for Human Nutrition, UT Southwestern Medical Center, Dallas, Texas 75390; Royal North Shore Hospital (M.J.), Northern Clinical School, University of Sydney, St Leonards, NSW 2126, Australia; Department of Paediatrics and Child Health (L.M.), University of Nairobi, 00100 Nairobi, Kenya; Brehm Center for Diabetes and Division of Metabolism, Endocrinology, and Diabetes (E.A.O.), Department of Internal Medicine, University of Michigan Medical School and Health Systems, Ann Arbor, Michigan 48109; Division of Pediatric Endocrinology (N.P.), Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas 75390; Division of Pediatric Endocrinology and Diabetes (J.v.S., M.W.), Department of Pediatrics and Adolescent Medicine, University of Ulm, 89075 Ulm, Germany; Clamp Technologies Laboratory (E.S.), Endocrinology Research Center, and Laboratory of Molecular Endocrinology of Medical Scientific Educational Centre of Lomonosov, Moscow State University, Moscow 119991, Russia; Pediatric Endocrine Unit and Program in Nutritional Metabolism (T.S.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115; Sorbonne Universities (C.V.), l'université Pierre et Marie Curie, University of Paris VI, Inserm Unité Mixte de Recherche en Santé 938, St-Antoine Research Center, Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, St-Antoine Hospital, Molecular Biology and Genetics Department, 75012 Paris, France; Department of Paediatric Endocrinology (R.W.), Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, United Kingdom; and Division of Pediatric Endocrinology and Metabolism (T.Y.), Children's Medical Center, Osaka City General Hospital, Osaka City 534-0021, Japan.

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http://dx.doi.org/10.1210/jc.2016-2466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155679PMC
December 2016

Closing the knowledge gap on cardiovascular disease in type 2 diabetes: the EMPA-REG OUTCOME trial and beyond.

Authors:
Elif A Oral

Drugs Context 2016 2;5:212299. Epub 2016 Sep 2.

Division of Metabolism, Endocrinology and Diabetes (MEND), Brehm Center for Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.7573/dic.212299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017828PMC
September 2016

Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy.

Clin Endocrinol (Oxf) 2016 07 2;85(1):137-49. Epub 2016 Feb 2.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/cen.12980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875885PMC
July 2016

Assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome.

Diabetes Metab Syndr Obes 2016 1;9:177-84. Epub 2016 Jun 1.

Division of Cardiovascular Medicine, Cardiovascular Medicine at Domino's Farms, University of Michigan Health System, Ann Arbor, MI, USA.

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http://dx.doi.org/10.2147/DMSO.S94772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898037PMC
June 2016

Efficacy and Safety of Metreleptin in Patients with Partial Lipodystrophy: Lessons from an Expanded Access Program.

J Diabetes Metab 2016 Mar 23;7(3). Epub 2016 Mar 23.

Brehm Center for Diabetes Research and Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.4172/2155-6156.1000659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026130PMC
March 2016

A Report of Three Cases With Acquired Generalized Lipodystrophy With Distinct Autoimmune Conditions Treated With Metreleptin.

J Clin Endocrinol Metab 2015 Nov 21;100(11):3967-70. Epub 2015 Sep 21.

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan 48109.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2015-2589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702455PMC
November 2015

Leptin for type 1 diabetes: coming onto stage to be (or not?).

Authors:
Elif A Oral

Pediatr Diabetes 2012 Feb 14;13(1):68-73. Epub 2011 Sep 14.

Metabolism, Endocrine and Diabetes Division (MEND), University of Michigan, Ann Arbor, MI, USA.

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http://doi.wiley.com/10.1111/j.1399-5448.2011.00797.x
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http://dx.doi.org/10.1111/j.1399-5448.2011.00797.xDOI Listing
February 2012

The metabolic fitness program: lifestyle modification for the metabolic syndrome using the resources of cardiac rehabilitation.

J Cardiopulm Rehabil Prev 2011 Sep-Oct;31(5):282-9

Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1097/HCR.0b013e318220a7ebDOI Listing
January 2012

Insufficient sensitivity of hemoglobin A(₁C) determination in diagnosis or screening of early diabetic states.

Metabolism 2011 Jan 17;60(1):86-91. Epub 2010 Aug 17.

Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Health System, Ann Arbor, MI 48106, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002604951000204
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http://dx.doi.org/10.1016/j.metabol.2010.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998594PMC
January 2011

Rationale for leptin-replacement therapy for severe lipodystrophy.

Endocr Pract 2010 Mar-Apr;16(2):324-33

University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.4158/EP09155.RADOI Listing
June 2010

Clinical classification and treatment of congenital and acquired lipodystrophy.

Endocr Pract 2010 Mar-Apr;16(2):310-23

Amylin Pharmaceuticals, Inc., San Diego, California, USA.

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http://dx.doi.org/10.4158/EP09154.RADOI Listing
June 2010

Leptin and insulin resistance: good, bad, or still unclear?

Am J Physiol Endocrinol Metab 2009 Feb;296(2):E394-5, author reply E396

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http://dx.doi.org/10.1152/ajpendo.90914.2008DOI Listing
February 2009

Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency.

J Clin Endocrinol Metab 2004 Sep;89(9):4258-63

Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA.

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http://dx.doi.org/10.1210/jc.2003-031868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266890PMC
September 2004