Publications by authors named "Elie Besserer-Offroy"

22Publications

Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog.

Eur J Pharmacol 2020 Sep 10;882:173174. Epub 2020 Jun 10.

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12thAvenue North, Sherbrooke, Québec, J1H5N4, Canada; Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12thAvenue North, Sherbrooke, Québec, J1H5N4, Canada; Institut de pharmacologie de Sherbrooke, Université de Sherbrooke, 3001 12thAvenue North, Sherbrooke, Québec, J1H 5N4, Canada; Centre de recherche du Centre hospitalier universitaire de Sherbrooke, CIUSSS de l'Estrie - CHUS, 3001 12thAvenue North, Sherbrooke, Québec, J1H5N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2020.173174DOI Listing
September 2020

Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain.

Pharmacol Res 2020 05 6;155:104750. Epub 2020 Mar 6.

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada; Institut de pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2020.104750DOI Listing
May 2020

Apelin-13 Regulates Vasopressin-Induced Aquaporin-2 Expression and Trafficking in Kidney Collecting Duct Cells.

Cell Physiol Biochem 2019 ;53(4):687-700

Department of Pharmacology & Physiology, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC, Canada.

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http://dx.doi.org/10.33594/000000165DOI Listing
November 2019

Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13).

J Med Chem 2018 08 13;61(16):7103-7115. Epub 2018 Aug 13.

Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke , Université de Sherbrooke , 3001 12e Avenue Nord , Sherbrooke , Quebec J1H 5N4 , Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00175DOI Listing
August 2018

Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses.

Pharmacol Res 2018 10 28;136:108-120. Epub 2018 Jun 28.

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada; Institut de pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.06.027DOI Listing
October 2018

Angiotensin II cyclic analogs as tools to investigate ATR biased signaling mechanisms.

Biochem Pharmacol 2018 08 20;154:104-117. Epub 2018 Apr 20.

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.04.021DOI Listing
August 2018

In Search of the Optimal Macrocyclization Site for Neurotensin.

ACS Med Chem Lett 2018 Mar 29;9(3):227-232. Epub 2018 Jan 29.

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846049PMC
March 2018

The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment.

Pharmacol Res 2018 05 9;131:7-16. Epub 2018 Mar 9.

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada; Institut de pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.02.032DOI Listing
May 2018

Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues.

J Med Chem 2017 04 10;60(8):3303-3313. Epub 2017 Apr 10.

Institut des Biomolécules Max Mousseron, IBMM, UMR-5247, CNRS, Université Montpellier, ENSCM , Place Eugène Bataillon, 34095 Montpellier cedex 5, France.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01848DOI Listing
April 2017

The signaling signature of the neurotensin type 1 receptor with endogenous ligands.

Eur J Pharmacol 2017 Jun 22;805:1-13. Epub 2017 Mar 22.

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2017.03.046DOI Listing
June 2017

Structure-activity relationship of novel macrocyclic biased apelin receptor agonists.

Org Biomol Chem 2017 Jan;15(2):449-458

Département de Pharmacologie-Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada. and Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.

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http://dx.doi.org/10.1039/c6ob02247bDOI Listing
January 2017

Design, synthesis, and biological evaluation of CXCR4 ligands.

Org Biomol Chem 2016 Nov;14(43):10298-10311

Department of Pharmacology-Physiology, Université de Sherbrooke, Sherbrooke, QC, Canada and Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.

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http://dx.doi.org/10.1039/c6ob01484dDOI Listing
November 2016

Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists.

J Med Chem 2016 08 11;59(16):7512-24. Epub 2016 Aug 11.

Department of Pharmacology-Physiology, Université de Sherbrooke , Sherbrooke, QC J1H 5N4, Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00566DOI Listing
August 2016

Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions.

J Med Chem 2016 Apr 30;59(7):2962-72. Epub 2016 Mar 30.

Département de Pharmacologie et Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke , Sherbrooke, J1H 5N4 Québec, Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01549DOI Listing
April 2016

Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues.

J Med Chem 2015 Oct 16;58(19):7785-95. Epub 2015 Sep 16.

Institut des Biomolécules Max Mousseron, IBMM, UMR-5247, CNRS, Université Montpellier, ENSCM, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00841DOI Listing
October 2015

C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action.

J Med Chem 2015 Mar 24;58(5):2431-40. Epub 2015 Feb 24.

Département de Pharmacologie et Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke , Sherbrooke J1H 5N4, Québec Canada.

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http://dx.doi.org/10.1021/jm501916kDOI Listing
March 2015

Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability.

ChemMedChem 2012 Feb 13;7(2):318-25. Epub 2011 Dec 13.

Département de Pharmacologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, 3001 12eAvenue Nord, Sherbrooke, QC, J1H 5N4, Canada.

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http://dx.doi.org/10.1002/cmdc.201100492DOI Listing
February 2012