Publications by authors named "Elias Silva dos Santos"

4 Publications

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Screening and testing potential inhibitors of sulphide gas production by sulphate-reducing bacteria.

J Mol Model 2021 May 27;27(6):189. Epub 2021 May 27.

Instituto de Ciências da Saúde, Universidade Federal da Bahia, Av. Reitor Miguel Calmon, s/n - Vale do Canela, Salvador, BA, 40.231-300, Brazil.

Sulphate-reducing bacteria are commonly associated with biological causes of oil well souring. Biosulphetogenesis can directly affect oil quality and storage due to the accumulation of sulphides. In addition, these microorganisms can create bio-incrustation that can clog pipes. Sulphite reductase (SIR) is the enzyme responsible for converting ion sulphite into sulphide and several substances may interfere or control such activity. This interference can hinder growth of the sulphate-reducing bacteria and, consequently, it reduces sulphide accumulation in situ. This work focuses on molecular modelling techniques along with in vitro experiments in order to investigate the potential of two essential oils and one vegetable oil as main inhibitors of sulphite reductase activity. Docking simulation identified several substances present in Rosmarinus officinalis, Tea tree and Neem extractable oils as potential inhibitors of SIR. Substances present in Neem vegetable oil are the most potent inhibitors, followed by Rosmarinus officinalis and Tea tree essential oils. The Neem oil mixture showed a superior effectiveness in intracellular SIR inhibitory effects.
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http://dx.doi.org/10.1007/s00894-021-04801-5DOI Listing
May 2021

Comparison of early cardiovascular risk among Brazilian and African university students.

Clin Biochem 2020 Jan 1;75:7-14. Epub 2019 Nov 1.

Department of Clinical and Toxicological Analysis, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Cardiovascular diseases are among the main causes of mortality worldwide, and dyslipidemia is a principal factor risk. Hence the study of biochemical markers is necessary for early diagnosis.

Objectives: Evaluate biomarkers to diagnose the risks of cardiovascular diseases in healthy Brazilian and African young adults.

Design & Methods: Weight, height, waist circumference, percentage of body fat and systemic blood pressure were measured; and fasting blood samples were taken for biochemical analysis. Triglycerides, total cholesterol, HDL-c, and apolipoproteins A-I and B were measured on automated equipment using commercially available kits, in addition to the tests of antioxidant capacity of HDL and the enzymatic activity of Paraoxonase 1.

Results: After statistical analysis, it was found that BMI, WC, fat (%), triglycerides, ApoB/ApoA-I ratio and Vmax were higher in Brazilians, while HDL-c, ApoA-I, Lag Time, Vmax and PON1 activity were higher in Africans. In Brazilians, the ApoB/ApoA-I ratio was related to obesity factors and lipid profile, but in Africans it was related only to lipids. The antioxidant capacity of HDL and PON1 activity was better in Africans. Through independence testing, we observed an association with moderate risk of myocardial infarction with gender in Africans. In the binary logistic regression analysis, it was found that men in general - and particularly African men - have higher risk of myocardial infarction than women; Odds Ratio 2144 (CI: 1343-3424) and 2281 (CI: 1082-4811), respectively.

Conclusions: The anthropometric and biochemical parameters of Brazilians, especially men, predispose them to greater risks of cardiovascular diseases.
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http://dx.doi.org/10.1016/j.clinbiochem.2019.09.007DOI Listing
January 2020

Souring control in fluid samples of oil industry using a multiple ligand simultaneous docking (MLSD) strategy.

J Biomol Struct Dyn 2015 22;33(6):1176-84. Epub 2014 Jul 22.

a Instituto de Física, Universidade Federal da Bahia , Rua Barão de Geremoabo s/n, Ondina, Salvador , BA , Brazil.

We have used docking techniques in order to propose potential inhibitors to the enzymes adenosine phosphosulfate reductase and adenosine triphosphate sulfurylase that are responsible, among other deleterious effects, for causing souring of oil and gas reservoirs. Three candidates selected through molecular docking revealed new and improved polar and hydrophobic interactions with the above-mentioned enzymes. Microbiological laboratory assays performed subsequently corroborated the results of computer modelling that the three compounds can efficiently control the biogenic sulfide production.
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http://dx.doi.org/10.1080/07391102.2014.937461DOI Listing
December 2015

Novel potential inhibitors for adenylylsulfate reductase to control souring of water in oil industries.

J Biomol Struct Dyn 2014 13;32(11):1780-92. Epub 2013 Sep 13.

a Instituto de Física, Universidade Federal da Bahia , Rua Barão de Geremoabo s/n - Ondina, Salvador , BA , 40.300-000 , Brasil .

The biogenic production of hydrogen sulfide gas by sulfate-reducing bacteria (SRB) causes serious economic problems for natural gas and oil industry. One of the key enzymes important in this biologic process is adenosine phosphosulfate reductase (APSr). Using virtual screening technique we have discovered 15 compounds that are novel potential APSr inhibitors. Three of them have been selected for molecular docking and microbiological studies which have shown good inhibition of SRB in the produced water from the oil industry.
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http://dx.doi.org/10.1080/07391102.2013.834850DOI Listing
May 2015
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