Publications by authors named "Elias Hobeika"

41Publications

LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking.

Front Immunol 2019 18;10:497. Epub 2019 Mar 18.

Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431647PMC
September 2020

Conditional Selection of B Cells in Mice With an Inducible B Cell Development.

Front Immunol 2018 6;9:1806. Epub 2018 Aug 6.

Centre for Biological Signaling Studies (BIOSS), Biology III, Faculty of Biology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01806
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http://dx.doi.org/10.3389/fimmu.2018.01806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087743PMC
October 2019

PI3K-Mediated Blimp-1 Activation Controls B Cell Selection and Homeostasis.

Cell Rep 2018 07;24(2):391-405

Institute of Immunology, University Medical Center Ulm, 89081 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057491PMC
July 2018

CXCR4 signaling and function require the expression of the IgD-class B-cell antigen receptor.

Proc Natl Acad Sci U S A 2017 05 1;114(20):5231-5236. Epub 2017 May 1.

BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany;

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http://dx.doi.org/10.1073/pnas.1621512114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441763PMC
May 2017

Molecular requirements of the B-cell antigen receptor for sensing monovalent antigens.

EMBO J 2016 11 15;35(21):2371-2381. Epub 2016 Sep 15.

BIOSS Centre for Biological Signalling Studies, Department of Molecular Immunology, Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany

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http://dx.doi.org/10.15252/embj.201694177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090217PMC
November 2016

Control of B Cell Responsiveness by Isotype and Structural Elements of the Antigen Receptor.

Trends Immunol 2016 05 1;37(5):310-320. Epub 2016 Apr 1.

Institute of Immunology, University Hospital Ulm, 89081 Ulm, Germany; Department of Molecular Immunology, Faculty of Biology, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.it.2016.03.004DOI Listing
May 2016

Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.

J Immunol 2016 Mar 3;196(5):2348-60. Epub 2016 Feb 3.

Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; Centre for Biological Signaling Studies, University of Freiburg, 79104 Freiburg, Germany; Institute of Immunology, University Hospital Ulm, 89081 Ulm, Germany

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http://dx.doi.org/10.4049/jimmunol.1501707DOI Listing
March 2016

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.

J Exp Med 2015 Sep 31;212(10):1693-708. Epub 2015 Aug 31.

Department of Molecular Immunology, BioIII, Faculty of Biology, University of Freiburg and Max Planck Institute of Immunobiology and Epigenetics, 79104 Freiburg, Germany Centre for Biological Signaling Studies (BIOSS), Spemann Graduate School of Biology and Medicine (SGBM), Centre of Chronic Immunodeficiency (CCI), Department of Dermatology, Center for Biological Systems Analysis (ZBSA), Institute of Molecular Medicine and Cell Research, Comprehensive Cancer Centre Freiburg, and Institute of Pathology, University Medical Center Freiburg, University of Freiburg, 79104 Freiburg, Germany Centre for Biological Signaling Studies (BIOSS), Spemann Graduate School of Biology and Medicine (SGBM), Centre of Chronic Immunodeficiency (CCI), Department of Dermatology, Center for Biological Systems Analysis (ZBSA), Institute of Molecular Medicine and Cell Research, Comprehensive Cancer Centre Freiburg, and Institute of Pathology, University Medical Center Freiburg, University of Freiburg, 79104 Freiburg, Germany

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http://dx.doi.org/10.1084/jem.20141271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577850PMC
September 2015

CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk.

EMBO J 2015 Apr 28;34(7):925-39. Epub 2015 Jan 28.

Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany Department of Molecular Immunology, BioIII, Faculty of Biology, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany BIOSS, Centre For Biological Signaling Studies, University of Freiburg, Freiburg, Germany

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http://dx.doi.org/10.15252/embj.201489732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388600PMC
April 2015

Signaling mechanisms regulating B-lymphocyte activation and tolerance.

J Mol Med (Berl) 2015 Feb 29;93(2):143-58. Epub 2015 Jan 29.

BIOSS Centre of Biological Signalling Studies, University of Freiburg and Department for Molecular Immunology, Faculty of Biology, University of Freiburg, 79104, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00109-015-1252-8DOI Listing
February 2015

Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms.

Eur J Immunol 2015 Feb 2;45(2):603-11. Epub 2014 Dec 2.

Max Planck Institute for Molecular Biomedicine, Mammalian Cell Signaling Laboratory, Münster, Germany.

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http://dx.doi.org/10.1002/eji.201444538DOI Listing
February 2015

The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells.

J Exp Med 2014 Oct 6;211(11):2199-212. Epub 2014 Oct 6.

Division of Molecular Immunology, Nikolaus Fiebiger Center, Department of Internal Medicine III, Department of Radiation Oncology, Division of Ophthalmology, Department Kopfklinik, University of Erlangen-Nuremberg, D91054 Erlangen, Germany Institute for Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, D20246 Hamburg, Germany

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http://jem.rupress.org/content/211/11/2199.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20130795
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http://dx.doi.org/10.1084/jem.20130795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203943PMC
October 2014

Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE.

Eur J Immunol 2014 Oct 19;44(10):3093-108. Epub 2014 Aug 19.

Graduate Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA; Department of Integrative Physiology and Pathobiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1002/eji.201344282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197127PMC
October 2014

PDK1 regulates B cell differentiation and homeostasis.

Proc Natl Acad Sci U S A 2014 Jul 16;111(26):9573-8. Epub 2014 Jun 16.

Program on Immunity and Pathogenesis, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037; and

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http://dx.doi.org/10.1073/pnas.1314562111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084446PMC
July 2014

B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.

Elife 2014 Jun 24;3:e02069. Epub 2014 Jun 24.

BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany Department of Molecular Immunology, Biology III, Faculty of Biology, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067077PMC
http://dx.doi.org/10.7554/eLife.02069DOI Listing
June 2014

The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling.

J Immunol 2014 Jul 4;193(1):268-76. Epub 2014 Jun 4.

Department of Molecular Immunology, Max-Planck-Institut of Immunobiology and Epigenetics, Freiburg 79108, Germany; Biology III, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg 79108, Germany Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-University Freiburg, Freiburg 79108, Germany; and BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Freiburg 79108, Germany

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http://dx.doi.org/10.4049/jimmunol.1203040DOI Listing
July 2014

MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling.

J Immunol 2014 Jun 23;192(11):5273-84. Epub 2014 Apr 23.

Institute of Biochemistry and Molecular Cell Biology, Rheinisch-Westfälisch Technical University (RWTH) Aachen, D-52074 Aachen, Germany;

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http://dx.doi.org/10.4049/jimmunol.1302209DOI Listing
June 2014

The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity.

J Exp Med 2014 Mar 3;211(3):427-40. Epub 2014 Mar 3.

BIOSS Centre for Biological Signalling Studies; and 2 Department of Molecular Immunology, Institute of Biology III, Faculty of Biology; University of Freiburg, D-79104 Freiburg, Germany.

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http://jem.rupress.org/content/211/3/427.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20131196
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http://dx.doi.org/10.1084/jem.20131196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949573PMC
March 2014

Immunoglobulins drive terminal maturation of splenic dendritic cells.

Proc Natl Acad Sci U S A 2013 Feb 23;110(6):2282-7. Epub 2013 Jan 23.

Department of Molecular Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1073/pnas.1210654110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568358PMC
February 2013

Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles.

Science 2011 Dec 27;334(6062):1561-5. Epub 2011 Oct 27.

Institute of Medical Microbiology and Hygiene, University of Freiburg Medical Center, Freiburg, Germany.

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http://dx.doi.org/10.1126/science.1214914DOI Listing
December 2011

B cells that produce immunoglobulin E mediate colitis in BALB/c mice.

Gastroenterology 2012 Jan 6;142(1):96-108. Epub 2011 Oct 6.

International Centre for Genetic Engineering and Biotechnology and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1053/j.gastro.2011.09.044DOI Listing
January 2012

The dynamics of T cells during persistent Staphylococcus aureus infection: from antigen-reactivity to in vivo anergy.

EMBO Mol Med 2011 Nov 2;3(11):652-66. Epub 2011 Sep 2.

Infection Immunology Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.

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http://dx.doi.org/10.1002/emmm.201100173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377109PMC
November 2011

B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):710-5. Epub 2010 Dec 27.

Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-Nürnberg, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1073/pnas.1012858108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021026PMC
January 2011

Role of PI3K in the generation and survival of B cells.

Immunol Rev 2010 Sep;237(1):55-71

Faculty of Biology, Department of Molecular Immunology, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/j.1600-065X.2010.00934.xDOI Listing
September 2010

Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.

Blood 2009 Dec 7;114(24):4960-7. Epub 2009 Oct 7.

Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, D-38124 Braunschweig, Germany.

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http://dx.doi.org/10.1182/blood-2009-04-218156DOI Listing
December 2009

Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells.

Immunity 2008 Dec 11;29(6):912-21. Epub 2008 Dec 11.

Department of Molecular Immunology, Faculty of Biology and Centre for Biological Signalling Studies (bioss), Albert-Ludwigs-University and Max-Planck-Institute for Immunobiology, 79108 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.immuni.2008.10.013DOI Listing
December 2008

The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.

EMBO J 2008 May 27;27(9):1333-44. Epub 2008 Mar 27.

Faculty of Biology, Max-Planck Institute for Immunobiology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/emboj.2008.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374840PMC
May 2008

Recombinant Sendai virus induces T cell immunity against respiratory syncytial virus that is protective in the absence of antibodies.

Cell Immunol 2007 Jun 29;247(2):85-94. Epub 2007 Sep 29.

Institut für Virologie, Stiftung Tierärztliche Hochschule Hannover, Bünteweg 17, 30559 Hannover, Germany.

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http://dx.doi.org/10.1016/j.cellimm.2007.07.005DOI Listing
June 2007

Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation.

Immunity 2006 Jun;24(6):729-39

The CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.immuni.2006.04.005DOI Listing
June 2006

Identification of a pre-BCR lacking surrogate light chain.

J Exp Med 2003 Dec 24;198(11):1699-706. Epub 2003 Nov 24.

Institute for Biology III, Albert-Ludwigs University of Freiburg, Max Planck Institute for Immunobiology, Freiburg, Germany.

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http://dx.doi.org/10.1084/jem.20031428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194143PMC
December 2003

B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta.

J Immunol 2002 Jul;169(2):865-72

Biologie III, University of Freiburg and Max-Planck-Institute for Immunobiology, Freiburg, Germany.

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http://dx.doi.org/10.4049/jimmunol.169.2.865DOI Listing
July 2002

Cre recombinase-controlled expression of the mb-1 allele.

Genesis 2002 Feb;32(2):154-7

National Jewish Medical and Research Center, Denver, Colorado 80206, USA.

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http://dx.doi.org/10.1002/gene.10070DOI Listing
February 2002