Publications by authors named "Eli Pikarsky"

109 Publications

Hepatocellular carcinoma.

Nat Rev Dis Primers 2021 01 21;7(1). Epub 2021 Jan 21.

Department of Oncology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

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January 2021

Excess of the NF-ĸB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1- and chemokines-mediated mechanisms.

Proc Natl Acad Sci U S A 2020 11 9;117(47):29823-29831. Epub 2020 Nov 9.

The Rappaport Faculty of Medicine and Research Institute, and the Rappaport Technion Integrated Cancer Center (R-TICC), Technion-Israel Institute of Technology, 3109601 Haifa, Israel;

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November 2020

Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome.

JCI Insight 2020 Sep 17;5(18). Epub 2020 Sep 17.

Gastroenterology Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

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September 2020

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.

Nature 2020 10 29;586(7827):133-138. Epub 2020 Jul 29.

The Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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October 2020

Chronic expression of p16 in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation.

Nat Commun 2020 06 1;11(1):2711. Epub 2020 Jun 1.

Department of Developmental Biology and Cancer Research, Institute for Medical Research - Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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June 2020

Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice.

Life Sci Alliance 2020 05 10;3(5). Epub 2020 Apr 10.

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel

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May 2020

Activation of Siglec-7 results in inhibition of in vitro and in vivo growth of human mast cell leukemia cells.

Pharmacol Res 2020 08 5;158:104682. Epub 2020 Feb 5.

Pharmacology & Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel. Electronic address:

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August 2020

The microbiota programs DNA methylation to control intestinal homeostasis and inflammation.

Nat Microbiol 2020 04 3;5(4):610-619. Epub 2020 Feb 3.

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel.

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April 2020

Are we ready for targeted therapy combinations in HCC?

Gut 2020 04 8;69(4):613-614. Epub 2020 Jan 8.

The Lautenberg Center for Immunology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Jerusalem, Israel

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April 2020

Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2.

Cancer Res 2019 05 26;79(10):2480-2493. Epub 2019 Mar 26.

Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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May 2019

VICKZ1 enhances tumor progression and metastasis in lung adenocarcinomas in mice.

Oncogene 2019 05 30;38(21):4169-4181. Epub 2019 Jan 30.

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel.

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May 2019

Author Correction: WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.

Cell Death Dis 2018 Nov 23;9(12):1159. Epub 2018 Nov 23.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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November 2018

Vav1 mutations identified in human cancers give rise to different oncogenic phenotypes.

Oncogenesis 2018 Oct 8;7(10):80. Epub 2018 Oct 8.

Developmental Biology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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October 2018

Postnatal DNA demethylation and its role in tissue maturation.

Nat Commun 2018 05 23;9(1):2040. Epub 2018 May 23.

Department of Developmental Biology and Cancer Research, Hebrew University Medical School, P.O.B. 12272, , Jerusalem, 91120, Israel.

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May 2018

WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.

Cell Death Dis 2018 05 1;9(5):511. Epub 2018 May 1.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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May 2018

The immunology of hepatocellular carcinoma.

Nat Immunol 2018 03 29;19(3):222-232. Epub 2018 Jan 29.

Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.

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March 2018

Learning the Roles of the Hepatic Adaptive Immune System in Hepatocellular Carcinoma-Nature's Guide for Successful Cancer Immunotherapy.

Semin Liver Dis 2017 08 28;37(3):210-218. Epub 2017 Aug 28.

The Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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August 2017

Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients.

Medicine (Baltimore) 2017 May;96(20):e6931

Sharett Institute of Oncology Leslie and Michael Gaffin Center for Oncology, Departments of Oncology and Neurology, Hebrew University-Hadassah Medical Center Department of Pediatrics, Hadassah Medical Center, Division of Pediatric Hematology and Oncology Lautenberg Center for Immunology, IMRIC, The Hebrew University-Hadassah Medical School Department of Pathology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.

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May 2017

miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression.

Gut 2018 06 5;67(6):1124-1134. Epub 2017 Apr 5.

The Silberman Institute of Life Sciences and the Edmond and Lily Safra Center for Brain Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, Israel.

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June 2018

Immune defects caused by mutations in the ubiquitin system.

J Allergy Clin Immunol 2017 Mar;139(3):743-753

Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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March 2017