Publications by authors named "Elham Karimi"

34 Publications

Effects of greater occipital nerve block with local anesthetic and triamcinolone for treatment of medication overuse headache: an open-label, parallel, randomized, controlled clinical trial.

Neurol Sci 2021 May 4. Epub 2021 May 4.

Isfahan Neurosciences Research Center, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Aim: There is a paucity of evidence and consensus on exactly how to carry out the detoxification process. To examine the effect of a greater occipital nerve block (GONB) in the detoxification process, we conducted an open-label, parallel, randomized, controlled clinical trial.

Materials And Methods: In order to conduct this study, 54 medication-overuse headache (MOH) patients were recruited and allocated randomly to group A (n = 27) or B (n = 27). In both groups, patients underwent detoxification processes without any acute migraine medication or analgesics. During the run-in period, all patients in both groups received the same education, managed by a neurologist and nutritionist. All patients were offered maximally 300 mL of promethazine syrup (5 mg/5 mL) to be taken 10 mg every 8 h during the first 10 days of the study. A 2-mL syringe containing 1 mL of lidocaine 2% and 1 mL of triamcinolone 40 mg/mL was prepared for each patient of group A for conducting GONB. Characteristics of headache attacks, including headache severity, frequency, and duration, were assessed at baseline and after 3 months of intervention.

Results: Twenty-six patients in group A (96.3%) and twenty-three in group B (85.2%) completed detoxification, and were thus cured of MOH (P = 0.351). The present study revealed that GONB with local anesthetic and triamcinolone significantly improved the characteristics of headache, including frequency (- 13.66 in group A and - 7.55 in group B), duration (- 7.92 in group A and - 5.88 in group B), and severity (- 3.44 in group A vs. - 1.33 in group B) in group A compared to control (all P value < 0.05).

Conclusions: Although both detoxification programs were effective, detoxification with GONB resulted in better outcomes.

Trial Registration: Iranian Registry of Clinical Trials (registration number; IRCT20150906023922N2).
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http://dx.doi.org/10.1007/s10072-021-05295-yDOI Listing
May 2021

Mothers and their children's health (MATCH): a study protocol for a population-based longitudinal cohort.

BMC Pregnancy Childbirth 2021 Apr 12;21(1):297. Epub 2021 Apr 12.

Department of Biostatistics and Epidemiology, School of Public Health, Babol University of Medical Sciences, Babol, Iran.

Background: The quality of prenatal care is critical for the prevention of adverse pregnancy outcomes. However, according to the World Health Organization (WHO), only 64 % of women worldwide have access to over four sessions of prenatal care throughout their pregnancy. Thus, studies that address factors affecting maternal and child health status before and after pregnancy are of immense importance. The primary aim of the mothers and their children's health (MATCH) cohort study is to evaluate the effect of nutrition, sleep quality, and lifestyle on maternal and neonatal outcomes.

Methods: A prospective cohort of > 2500 pregnant women in the first trimester (before 12 weeks' gestation) will be recruited at Arash Women's Hospital in Tehran, Iran between February 2020 and August 2021. All eligible pregnant women will be followed from their first trimester of pregnancy until delivery at four time points and assessed through a series of in-person visits with interviewer-administered questionnaires and telephone interviews. Detailed data will be collected on maternal demographics, lifestyle, medical history, reproductive history, obstetric history, dietary intake, sleep pattern, blood specimens, and anthropometric measurements, alongside paternal demographics, lifestyle, and family history. The outcomes will include antenatal, peripartum, and postnatal maternal complications and infant growth and neurodevelopment.

Discussion: The results of the MATCH cohort study will support the development of contextual interventions that can enhance antenatal, peripartum, and postnatal status, neonatal outcomes, and longevity mother and child.
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http://dx.doi.org/10.1186/s12884-021-03732-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042918PMC
April 2021

The Effect of Saffron Consumption on Liver Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

Complement Med Res 2021 Mar 18:1-10. Epub 2021 Mar 18.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran,

Background And Aims: The present systematic review and meta-analysis of randomized controlled trials aimed to determine the effects of saffron supplementation on liver function tests among adults.

Methods: Electronic databases including PubMed, ISI Web of Science, and Scopus were searched up to January 2021. The risk of bias in individual studies was assessed using the Cochrane Collaboration tool. The overall estimates and their 95% CIs were calculated using random-effects models. Egger's test and Begg's rank-correlation were run to assess the presence of publication bias. p < 0.05 was considered statistically significant.

Results: A total of 12 trials involving 608 participants were included in this systematic review and meta-analysis. Saffron supplementation had no significant effect on liver function tests including aspartate transaminase (AST) (weighted mean difference [WMD] = 0.23 U/L; 95% CI -2.22 to 2.69; p = 0.851; I2 = 74.0%), alanine aminotransferase (ALT) (WMD = -1.49 U/L; 95% CI -3.84 to 0.86; p = 0.213; I2 = 60.2%), and alkaline phosphatase (ALP) (WMD = -0.70 U/L; 95% CI -11.35 to 9.95; p = 0.898; I2 = 40.8%) compared to placebo.

Conclusion: Based on what was discussed, it seems that saffron supplementation could not improve liver function tests including AST, ALT, and ALP among the adult population. Further clinical trials with larger sample size, longer duration, and higher doses of saffron should be conducted exclusively among patients with liver dysfunction to elucidate the beneficial role of saffron consumption on liver function.
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http://dx.doi.org/10.1159/000515003DOI Listing
March 2021

Is phase angle a valuable prognostic tool in cancer patients' survival? A systematic review and meta-analysis of available literature.

Clin Nutr 2021 Jan 27. Epub 2021 Jan 27.

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background & Aims: The phase angle (PA), expressed via bioelectrical impedance, is an indicator of cell membrane health and integrity, hydration, and nutritional status, and may have further application as a prognostic marker in cancer survival. However, the associations between PA and cancer survival are inconsistent and unclear. The present systematic review and meta-analysis investigated the relationship between PA and survival among adult patients diagnosed with cancer.

Methods: A systematic search of observational studies up to November 2020 was conducted through PubMed, Scopus, and ISI Web of Science. The critical appraisal of the eligible studies was performed using the Newcastle-Ottawa Quality Assessment Scale. Statistical analyses were performed using STATA 11.2 software. A P-value <0.05 was considered statistically significant.

Results: A total of 14 studies covering 2625 participants were included in this study. There was a positive and significant correlation between PA and cancer survival (Fisher's Z: 0.30; 95% CI, 0.21-0.40; P < 0.001; I = 0.0%). Also, there was a significant prognostic role for PA on patients' survival (HR 0.77; 95% CI, 0.74-0.81; P < 0.001; I = 0.0%). In other words, patients with low values of PA were 23% less likely to survive than patients with high values of PA.

Conclusions: Given that predicting survival in advanced cancer patients remains a challenge, the findings of this systematic review and meta-analysis suggest that phase angle may be an important prognostic factor of survival in this population.
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http://dx.doi.org/10.1016/j.clnu.2021.01.027DOI Listing
January 2021

Effects of L-arginine supplementation on biomarkers of glycemic control: a systematic review and meta-analysis of randomised clinical trials.

Arch Physiol Biochem 2021 Jan 10:1-11. Epub 2021 Jan 10.

Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

The present meta-analysis aimed to determine the effectiveness of L-arginine supplementation in improving biomarkers of glycemic control in adults. Electronic databases including PubMed, ISI Web of Science, Scopus, and the Cochrane Collaboration Library were searched up to January 2020. The meta-analysis of twelve randomised clinical trials indicated that L-arginine had no significant effect on serum fasting blood sugar (FBS) (weighted mean difference [WMD]: -3.38 mg/dl, 95% CI: -6.79 to 0.04,  = .53), serum insulin (WMD: -0.12 Hedges' g 95% CI: -0.33 to 0.09,  = .27), glycated haemoglobin A1c (HbA1c; WMD: -0.04%, 95% CI: -0.25 to 0.17,  = .71), and homeostasis model assessment for insulin resistance (WMD: -0.48, 95% CI: -1.15 to 0.19,  = .15). Although several animal studies have proposed that L-arginine supplementation might improve blood glucose control, the present study could not confirm this benefit in humans.
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http://dx.doi.org/10.1080/13813455.2020.1863991DOI Listing
January 2021

Effects of resveratrol supplementation on liver enzymes: A systematic review and meta-analysis of randomised controlled trials.

Int J Clin Pract 2021 Mar 24;75(3):e13692. Epub 2020 Sep 24.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The available evidence regarding the possible effects of resveratrol on liver function is inconsistent. Therefore, the present meta-analysis was performed to investigate the overall effects of resveratrol supplementation on liver enzymes in adults.

Methods: A systematic and comprehensive search of the online medical databases including PubMed, Scupos, Web of Science and Cochran Library was performed up to February 2020. All RCTs using resveratrol supplements in adults were included in this systematic review and meta-analysis. The overall effect was presented as weighted mean difference (WMD) and 95% confidence interval (CI) in a random-effects meta-analysis model.

Results: Finally, 15 randomised trials including 714 participants were selected for the present meta-analysis. Pooled analysis did not show any significant changes in alanine aminotransferase (ALT) (WMD: 0 IU/L, 95% CI: -3.17 to 3.17, P = .99; I = 74.2%), aspartate aminotransferase (AST) (WMD: -2.40 IU/L, 95% CI: -5.45 to 0.65, P = .11; I = 82.9%), gamma-glutamyl transferase (GGT) (WMD: -1.26 IU/L, 95% CI: -4.64 to 2.13, P = .64; I = 23.7%), alkaline phosphatase (ALP) (WMD: 3.80 IU/L, 95% CI: -4.65 to 12.25, P = .37; I = 29.9%) and bilirubin (WMD: 0.13 IU/L, 95% CI: -0.43 to 0.17, P = .39; I = 8.9%) after supplementation with resveratrol.

Conclusion: Overall, in our study, resveratrol does not affect liver enzyme levels significantly, but subgroup analysis indicates that these results may be influenced by resveratrol dose, duration of the study and population status, so future high-quality studies are necessary to get definitive results.
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http://dx.doi.org/10.1111/ijcp.13692DOI Listing
March 2021

The association between serum omentin level and bodyweight: A systematic review and meta-analysis of observational studies.

Clin Nutr ESPEN 2020 10 12;39:22-29. Epub 2020 Jul 12.

Department of Epidemiology and Biostatistics, Health School, and Infectious Disease and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background And Aims: A number of studies have examined the association between omentin and body weight, but the findings have been inconclusive. Here in, we systematically reviewed available observational studies to elucidate the overall relationship between omentin and body weight, by comparison of serum omentin level in overweight/obese and normal weight subjects.

Methods: PubMed, Science direct, Scopus and ISI web of science databases were searched for all available literature until January 2020 for studies assessing the association between omentin and body weight. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of each study.

Results: A total of 27 articles met the inclusion criteria and were included in our systematic review and meta-analysis. There was a significant association between omentin serum level and body weight (Standard Mean Difference (SMD) -0.43; 95% CI, -0.70 to -0.15; P = 0.002; I = 93.2%). In order to find the probable source of heterogeneity subgroup analysis based on the participants' age (adolescent, adult), gender (male, female, both gender), health status (healthy, unhealthy), geographical location (Asian, non-Asian countries), study quality (low, medium, high), study design (case-control, cross-sectional), participants' health status (healthy, unhealthy) and BMI (obese, overweight) was carried out.

Conclusion: According to what was discussed, we found that serum omentin level is significantly lower in overweight subjects but not obese ones. This finding should be interpreted cautiously because of significant heterogeneity among included studies.
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http://dx.doi.org/10.1016/j.clnesp.2020.06.014DOI Listing
October 2020

Anthropometric Measurements of Distal Femur to Design the Femoral Component of Total Knee Arthroplasty for the Iranian Population.

Arch Bone Jt Surg 2020 May;8(3):400-406

Department of Biology and Anatomical Sciences, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Acquiring knowledge about anatomic and geometric quantities of bones is among the most vital parameters in orthopedic surgery that has a significant effect on the treatment of various disorders and subsequent outcomes. The aim of this study was to obtain anthropometric information for distal femur in order to compare with similar dimensions of prosthesis used in total knee arthroplasty (TKA) surgery and to design more suitable and optimal components.

Methods: Morphological data of distal femur were measured in 132 knees (81 males and 51 females) using magnetic resonance imaging (MRI). The data included anterior-posterior (AP) length, medial-lateral (ML) width, medial AP (MAP), lateral AP (LAP), MAP to LAP distance in the anterior distal femur namely anterior medial lateral (AML) width, medial and lateral condyle width, and intercondylar notch. The aspect ratio (ML/AP) was also calculated and the results were compared with similar dimensions of currently used knee implants.

Results: Our data showed that men are significantly larger in all dimensions than women. In the distal femur with similar AP lengths in both sexes, women had a smaller ML width than men (). Comparison between the distal femur and studied prostheses showed no high correlation and similarity between the femoral component and femoral condyle prostheses in the resected surface of the bone.

Conclusion: The results of this study can provide the data needed to design prostheses suitable for the Iranian population.
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http://dx.doi.org/10.22038/abjs.2018.32420.1861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358243PMC
May 2020

The expanding role of CDR1-AS in the regulation and development of cancer and human diseases.

J Cell Physiol 2021 Feb 22;236(2):771-790. Epub 2020 Jul 22.

Department of Medical Genetics, Faculty of Medicine Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

CircRNAs are a superabundant and highly conserved group of noncoding RNAs (ncRNAs) that are characterized by their high stability and integrity compared with linear forms of ncRNAs. Recently, their critical role in gene expression regulation has been shown; thus, it is not far-fetched to believe that their abnormal expression can be a cause of different kinds of diseases such as cancer, neurodegenerative, and autoimmune diseases. They can have a function in variety of biological processes such as microRNA (miRNA) sponging, interacting with RNA-binding proteins, or even an ability to translate to proteins. A huge challenge in finding diagnostic biomarkers is finding noninvasive biomarkers that can be detected in human fluids, especially blood samples. CircRNAs are becoming candidate biomarkers for diagnosis and prognosis of these diseases through their ability to transverse from the blood-brain barrier and their broad presence in circulating exosomes. The circRNA for miRNA-7 (ciRS-7) is newly recognized, and acknowledged to being related to human pathology and cancer progression. In this review, we first briefly summarize the latest studies about their characteristics, biogenesis, and their mechanisms of action in the regulation and development of human diseases. Finally, we provide a list of diseases that are linked to one member of this novel class of ncRNAs called ciRS-7.
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http://dx.doi.org/10.1002/jcp.29950DOI Listing
February 2021

lncRNA ZEB2-AS1: A promising biomarker in human cancers.

IUBMB Life 2020 09 20;72(9):1891-1899. Epub 2020 Jul 20.

Department of Medical Genetics, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Long non-coding RNAs (lncRNAs) are one of the ncRNAs that transcript with length more than 200 nt that are not translated into protein. Studies have shown that lncRNAs have regulatory function in human disease especially cancers. lncRNA dysfunction causes altered cellular behavior including proliferation, invasion, and migration, and also it can inhibit apoptosis. Long non-coding zinc finger E-box binding homeobox 2 antisense RNA1 (lnZEB2-AS1) is one of the lncRNAs that plays the oncogenic role in different cancers. Dysregulation of lncZEB2-AS1 can lead to tumorigenesis and cancer progression. lncZEB2-AS1 may be introduced as a diagnostic marker or therapeutic target for human cancers. In this review, we describe briefly the mechanism of ZEB2-AS1 in cells and its function in cancer progression.
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http://dx.doi.org/10.1002/iub.2338DOI Listing
September 2020

The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trial.

Lipids Health Dis 2020 Apr 6;19(1):60. Epub 2020 Apr 6.

Department of Biostatistics and Epidemiology, School of Public Health, Babol University of Medical Sciences, Babol, Iran.

Background: Different therapies have been suggested for polycystic ovary syndrome (PCOS), but changes in lifestyle and diet have been considered. Diet and dietary factors can be very effective in modifying the disease. The positive effects of probiotic and synbiotics supplementation on improving lipid profiles and anthropometric indices have been examined in various diseases. This study was conducted to evaluate the effects of synbiotics supplementation on lipid and anthropometric profiles in infertile women with PCOS.

Methods: PCOS patients aged 19-37 years old were randomized to receive either synbiotics supplement (n = 50) or placebo (n = 49) for 12 weeks.

Results: Consumption of synbiotics compared to the placebo, resulted in a significant decrease in Low-density lipoprotein cholesterol (LDL) value (Change Mean Difference (CMD): 4.66, 95%CI: 0.20, 9.13) and a significant increase in high-density lipoprotein cholesterol (HDL) (CMD: 1.80, 95%CI: 0.34, 3.26). Although we failed to find a significant effect of synbiotics consumption on total cholesterol (TC) and triglyceride (TG) levels. We did not find differences in anthropometric indices between groups.

Conclusions: Overall, 12 weeks of synbiotics supplementation among PCOS women resulted in beneficial effects on LDL and HDL, although it is not yet clear how much our findings are clinically significant and more clinical studies with larger sample sizes are still needed.

Trial Registration: Iranian Registry of clinical Trial, IRCT.ir, ID: IRCT2014110515536N2. Registered on 19 December 2015.
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http://dx.doi.org/10.1186/s12944-020-01244-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132870PMC
April 2020

Automatic tongue surface extraction from three-dimensional ultrasound vocal tract images.

J Acoust Soc Am 2020 03;147(3):1623

Department of Electrical Engineering, École de technologie supérieure, Montréal, Québec, Canada.

Three-dimensional (3D/4D) ultrasound (US) imaging of the tongue has emerged as a useful instrument for articulatory studies. However, extracting quantitative measurements of the shape of the tongue surface remains challenging and time-consuming. In response to these challenges, this paper documents and evaluates the first automated method for extracting tongue surfaces from 3D/4D US data. The method draws on established methods in computer vision, and combines image phase symmetry measurements, eigen-analysis of the image Hessian matrix, and a fast marching method for surface evolution towards the automatic detection of the sheet-like surface of the tongue amidst noisy US data. The method was tested on US recordings from eight speakers and the resulting automatically extracted tongue surfaces were generally found to lie within 1 to 2 mm from their corresponding manually delineated surfaces in terms of mean-sum-of-distances error. Further experiments demonstrate that the accuracy of 2D midsagittal tongue contour extraction is also improved using 3D data and methods. This is likely because the additional information afforded by 3D US compared to 2D US images strongly constrains the possible location of the midsagittal contour. Thus, the proposed method seems appropriate for immediate practical use in the analysis of 3D/4D US recordings of the tongue.
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http://dx.doi.org/10.1121/10.0000891DOI Listing
March 2020

Genome Sequences of 72 Bacterial Strains Isolated from Ectocarpus subulatus: A Resource for Algal Microbiology.

Genome Biol Evol 2020 01;12(1):3647-3655

Sorbonne Université/CNRS, Station Biologique de Roscoff, UMR 8227, Integrative Biology of Marine Models, Roscoff, France.

Brown algae are important primary producers and ecosystem engineers in the ocean, and Ectocarpus has been established as a laboratory model for this lineage. Like most multicellular organisms, Ectocarpus is associated with a community of microorganisms, a partnership frequently referred to as holobiont due to the tight interconnections between the components. Although genomic resources for the algal host are well established, its associated microbiome is poorly characterized from a genomic point of view, limiting the possibilities of using these types of data to study host-microbe interactions. To address this gap in knowledge, we present the annotated draft genome sequences of seventy-two cultivable Ectocarpus-associated bacteria. A screening of gene clusters related to the production of secondary metabolites revealed terpene, bacteriocin, NRPS, PKS-t3, siderophore, PKS-t1, and homoserine lactone clusters to be abundant among the sequenced genomes. These compounds may be used by the bacteria to communicate with the host and other microbes. Moreover, detoxification and provision of vitamin B pathways have been observed in most sequenced genomes, highlighting potential contributions of the bacterial metabolism toward host fitness and survival. The genomes sequenced in this study form a valuable resource for comparative genomic analyses and evolutionary surveys of alga-associated bacteria. They help establish Ectocarpus as a model for brown algal holobionts and will enable the research community to produce testable hypotheses about the molecular interactions within this complex system.
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http://dx.doi.org/10.1093/gbe/evz278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948157PMC
January 2020

Correlation of Anthropometric Measurements of Proximal Tibia in Iranian Knees with Size of Current Tibial Implants.

Arch Bone Jt Surg 2019 Jul;7(4):339-345

Department of biology and anatomical sciences, faculty of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The results of clinical studies have reported that Asian knee anatomical aspects are smaller than those of the Caucasian population. The purpose of this study was to investigate the morphometry of the proximal tibia in the standard resected surface of total knee arthroplasty (TKA).

Methods: In this descriptive study, the anthropometric data of the proximal tibia were measured in 132 knees (80 males and 52 females) using magnetic resonance imaging in 2015. The collected data included anteroposterior (AP) length, mediolateral (ML) width, medial AP, lateral AP, and aspect ratio (ML/AP). The medial and lateral AP distance to bone center was calculated for symmetry analysis. The morphometric data were also compared with the same dimensions of four current tibial implants.

Results: The mean age of the subjects was 38.26±11.45 year (age range: 20-60 years). The mean AP length and mean ML width in the resected surface of the bone, as well as the mean aspect ratio (ML/AP) of tibial bone in all the subjects, were 46.53±4.05 mm, 73.36±6.86 mm, and 1.58±0.11, respectively. The mean values of medial and lateral AP distance up to bone center were 13.40±6.17 and 17.09±6.83 mm, respectively, indicating asymmetric proximal tibia in the study population.

Conclusion: The measurements of anatomic shapes and dimensions of the proximal tibia revealed that women have smaller dimensions than their male counterparts. Prostheses with smaller AP size tended to be undersized and larger AP size had a tendency towards overhang in the mediolateral dimension. The data and obtained results of this study can be used as guidance on designing tibial implant components suitable for TKA in the Iranian population.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686072PMC
July 2019

Fully-automated tongue detection in ultrasound images.

Comput Biol Med 2019 08 27;111:103335. Epub 2019 Jun 27.

Department of Electrical Engineering, École de technologie supérieure, 1100 Rue Notre-Dame O, Montréal, QC, H3C 1K3, Canada; Sainte-Justine University Hospital Research Centre, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, QC, H3T 1C4, Canada. Electronic address:

Tracking the tongue in ultrasound images provides information about its shape and kinematics during speech. Current methods for detecting/tracking the tongue require manual initialization or training using large amounts of labeled images. In this article, we propose a solution to convert a semi-automatic tongue contour tracking system to a fully-automatic one. This work introduces a new method for extracting tongue contours in ultrasound images that requires no training nor manual intervention. The method consists in an image enhancement step based on phase symmetry, followed by skeletonization and clustering steps, leading to a set of candidate points that can be used to fit an active contour to the image and subsequently initialize a tracking algorithm. Two novel quality measures were also developed that predict the reliability of the segmentation result so that an image with a reliable contour can be chosen to confidently initialize fully automated tongue tracking. This is achieved by automatically generating and choosing a set of points that can replace the manually segmented points for a semi-automated tracking approach. This paper also improves the accuracy of tracking by incorporating two criteria to reset the tracking algorithm from time to time. Experiments show that fully automated and semi-automated methods result in very similar mean sum of distances errors, respectively, indicating that the proposed automatic initialization does not significantly alter accuracy. Moreover, further results show that tracking accuracy is improved when using the new segmentation technique within the proposed re-initialization scheme.
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http://dx.doi.org/10.1016/j.compbiomed.2019.103335DOI Listing
August 2019

Genomic blueprints of sponge-prokaryote symbiosis are shared by low abundant and cultivatable Alphaproteobacteria.

Sci Rep 2019 02 13;9(1):1999. Epub 2019 Feb 13.

Centre of Marine Sciences, Algarve University, Gambelas, 8005-139, Faro, Portugal.

Marine sponges are early-branching, filter-feeding metazoans that usually host complex microbiomes comprised of several, currently uncultivatable symbiotic lineages. Here, we use a low-carbon based strategy to cultivate low-abundance bacteria from Spongia officinalis. This approach favoured the growth of Alphaproteobacteria strains in the genera Anderseniella, Erythrobacter, Labrenzia, Loktanella, Ruegeria, Sphingorhabdus, Tateyamaria and Pseudovibrio, besides two likely new genera in the Rhodobacteraceae family. Mapping of complete genomes against the metagenomes of S. officinalis, seawater, and sediments confirmed the rare status of all the above-mentioned lineages in the marine realm. Remarkably, this community of low-abundance Alphaproteobacteria possesses several genomic attributes common to dominant, presently uncultivatable sponge symbionts, potentially contributing to host fitness through detoxification mechanisms (e.g. heavy metal and metabolic waste removal, degradation of aromatic compounds), provision of essential vitamins (e.g. B6 and B12 biosynthesis), nutritional exchange (especially regarding the processing of organic sulphur and nitrogen) and chemical defence (e.g. polyketide and terpenoid biosynthesis). None of the studied taxa displayed signs of genome reduction, indicative of obligate mutualism. Instead, versatile nutrient metabolisms along with motility, chemotaxis, and tight-adherence capacities - also known to confer environmental hardiness - were inferred, underlying dual host-associated and free-living life strategies adopted by these diverse sponge-associated Alphaproteobacteria.
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http://dx.doi.org/10.1038/s41598-019-38737-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374434PMC
February 2019

Metagenomic binning reveals versatile nutrient cycling and distinct adaptive features in alphaproteobacterial symbionts of marine sponges.

FEMS Microbiol Ecol 2018 06;94(6)

Centre of Marine Sciences (CCMAR), Faculty of Science and Technology (FCT), Algarve University, 8005-139 Faro, Portugal.

Marine sponges are early-branched metazoans known to harbor dense and diverse microbial communities. Yet the role of the so far uncultivable alphaproteobacterial lineages that populate these sessile invertebrates remains unclear. We applied a sequence composition-dependent binning approach to assemble one Rhodospirillaceae genome from the Spongia officinalis microbial metagenome and contrast its functional features with those of closely related sponge-associated and free-living genomes. Both symbiotic and free-living Rhodospirillaceae shared a suite of common features, possessing versatile carbon, nitrogen, sulfur and phosphorus metabolisms. Symbiotic genomes could be distinguished from their free-living counterparts by the lack of chemotaxis and motility traits, enrichment of genes required for the uptake and utilization of organic sulfur compounds-particularly taurine-, higher diversity and abundance of ABC transporters, and a distinct repertoire of genes involved in natural product biosynthesis, plasmid stability, cell detoxification and oxidative stress remediation. These sessile symbionts may more effectively contribute to host fitness via nutrient exchange, and also host detoxification and chemical defense. Considering the worldwide occurrence and high diversity of sponge-associated Rhodospirillaceae verified here using a tailored in silico approach, we suggest that these organisms are not only relevant to holobiont homeostasis but also to nutrient cycling in benthic ecosystems.
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http://dx.doi.org/10.1093/femsec/fiy074DOI Listing
June 2018

Effects of synbiotic supplementation on metabolic parameters and apelin in women with polycystic ovary syndrome: a randomised double-blind placebo-controlled trial.

Br J Nutr 2018 02;119(4):398-406

1Department of Clinical Nutrition,School of Nutritional Sciences and Dietetics,Tehran University of Medical Sciences,no. 44,Hojjatdoost Street,Naderi Avenue,Keshavarz Boulevard,Tehran, 14166-43931,Iran.

Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in women of reproductive age. Insulin resistance is a main pathophysiologic feature in these patients. According to some studies, the intake of probiotic bacteria may improve glucose homoeostasis. The aim of this study was to investigate the effect of synbiotics on metabolic parameters and apelin in PCOS patients. This randomised double-blind placebo-controlled trial was conducted on eighty-eight PCOS women aged 19-37 years old. The participants were randomly assigned to two groups receiving (1) synbiotic supplement (n 44), and (2) placebo (n 44) for 12 weeks. Fasting blood samples were taken at baseline and after 12 weeks. The two groups showed no difference in fasting blood sugar (adjusted mean difference: 0·60; 95 % CI -3·80, 5·00, P=0·727), plasma glucose fasting 2-h (adjusted mean difference 2·09; 95 % CI -9·96, 14·15, P=0·134), HbA1c (adjusted mean difference 0·06; 95 % CI -0·09, 0·22, P=0·959), homoeostatic model assessment-insulin resistance (HOMA-IR) (adjusted mean difference: 0·02; 95 % CI -0·99, 1·03, P=0·837), quantitative insulin sensitivity check index (QUICKI) (adjusted mean difference: -0·02; 95 % CI -0·33, 0·29, P=0·940) and C-reactive protein (CRP) (adjusted mean difference: 0·24; 95 % CI -1·61, 2·08, P=0·141) by the end of the intervention. A significant difference was observed in the mean apelin 36 before and after the intervention between synbiotic and placebo groups (adjusted mean difference: -4·05; 95 % CI -7·15, -0·96, P=0·004). A 12-week synbiotic supplementation has no significant beneficial effects on HOMA-IR and CRP in PCOS patients, whereas the level of apelin 36 significantly decreased.
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http://dx.doi.org/10.1017/S0007114517003920DOI Listing
February 2018

Comparative Metagenomics Reveals the Distinctive Adaptive Features of the Endosymbiotic Consortium.

Front Microbiol 2017 14;8:2499. Epub 2017 Dec 14.

Microbial Ecology and Evolution Research Group, Centre of Marine Sciences, University of Algarve, Faro, Portugal.

Current knowledge of sponge microbiome functioning derives mostly from comparative analyses with bacterioplankton communities. We employed a metagenomics-centered approach to unveil the distinct features of the endosymbiotic consortium in the context of its two primary environmental vicinities. Microbial metagenomic DNA samples ( = 10) from sponges, seawater, and sediments were subjected to Hiseq Illumina sequencing ( 15 million 100 bp reads per sample). Totals of 10,272 InterPro (IPR) predicted protein entries and 784 rRNA gene operational taxonomic units (OTUs, 97% cut-off) were uncovered from all metagenomes. Despite the large divergence in microbial community assembly between the surveyed biotopes, the symbiotic community shared slightly greater similarity ( < 0.05), in terms of both taxonomy and function, to sediment than to seawater communities. The vast majority of the dominant symbionts (i.e., OTUs), representing several, so-far uncultivable lineages in diverse bacterial phyla, displayed higher residual abundances in sediments than in seawater. CRISPR-Cas proteins and restriction endonucleases presented much higher frequencies (accompanied by lower viral abundances) in sponges than in the environment. However, several genomic features sharply enriched in the sponge specimens, including eukaryotic-like repeat motifs (ankyrins, tetratricopeptides, WD-40, and leucine-rich repeats), and genes encoding for plasmids, sulfatases, polyketide synthases, type IV secretion proteins, and terpene/terpenoid synthases presented, to varying degrees, higher frequencies in sediments than in seawater. In contrast, much higher abundances of motility and chemotaxis genes were found in sediments and seawater than in sponges. Higher cell and surface densities, sponge cell shedding and particle uptake, and putative chemical signaling processes favoring symbiont persistence in particulate matrices all may act as mechanisms underlying the observed degrees of taxonomic connectivity and functional convergence between sponges and sediments. The reduced frequency of motility and chemotaxis genes in the sponge microbiome reinforces the notion of a prevalent mutualistic mode of living inside the host. This study highlights the "endosymbiome" as a distinct consortium of uncultured prokaryotes displaying a likely "sit-and-wait" strategy to nutrient foraging coupled to sophisticated anti-viral defenses, unique natural product biosynthesis, nutrient utilization and detoxification capacities, and both microbe-microbe and host-microbe gene transfer amenability.
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http://dx.doi.org/10.3389/fmicb.2017.02499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735121PMC
December 2017

Measurement of Posterior Tibial Slope Using Magnetic Resonance Imaging.

Arch Bone Jt Surg 2017 Nov;5(6):435-439

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Posterior tibial slope (PTS) is an important factor in the knee joint biomechanics and one of the bone features, which affects knee joint stability. Posterior tibial slope has impact on flexion gap, knee joint stability and posterior femoral rollback that are related to wide range of knee motion. During high tibial osteotomy and total knee arthroplasty (TKA) surgery, proper retaining the mechanical and anatomical axis is important. The aim of this study was to evaluate the value of posterior tibial slope in medial and lateral compartments of tibial plateau and to assess the relationship among the slope with age, gender and other variables of tibial plateau surface.

Methods: This descriptive study was conducted on 132 healthy knees (80 males and 52 females) with a mean age of 38.26±11.45 (20-60 years) at Imam Reza hospital in Mashhad, Iran. All patients, selected and enrolled for MRI in this study, were admitted for knee pain with uncertain clinical history. According to initial physical knee examinations the study subjects were reported healthy.

Results: The mean posterior tibial slope was 7.78± 2.48 degrees in the medial compartment and 6.85± 2.24 degrees in lateral compartment. No significant correlation was found between age and gender with posterior tibial slope (≥0.05), but there was significant relationship among PTS with mediolateral width, plateau area and medial plateau.

Conclusion: Comparison of different studies revealed that the PTS value in our study is different from other communities, which can be associated with genetic and racial factors. The results of our study are useful to PTS reconstruction in surgeries.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736893PMC
November 2017

Survey on the effects of electron beam irradiation on chemical quality and sensory properties on quail meat.

Food Chem Toxicol 2018 Feb 14;112:416-420. Epub 2017 Dec 14.

Environmental and Food Hygiene Laboratories (LIAA) of Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Italy. Electronic address:

Introduction: Irradiation is one of the intervention strategies for effective control of food-borne pathogen microorganisms, which reduces microbial load and extends the meat shelf life.

Materials And Methods: This experimental study was carried out on quail meat. Quail meat samples were treated with electron beam irradiation at doses of 0.5, 1, and 3 kGy and stored at 4 ± 1 °C for 15 days. Five days after irradiation, the chemical and organoleptic changes in the quail meat were evaluated for 15 days. Total volatile basic nitrogen and TBA were also measured to investigate chemical changes.

Results: Irradiation significantly reduced the amount of total volatile basic nitrogen in irradiated samples. Furthermore, the increase of TBA level was significant in irradiated samples, which had a direct correlation with irradiation dose and storage/shelf life duration. Despite the increase of thiobarbituric acid, irradiation had no significant effect on the sensory properties of quail meat.

Conclusion: Irradiation of quilt meat resulted in extension of the meat shelf life to at least two weeks at refrigeration temperature by decreasing the corrosion-causing microorganisms and improving microbial quality, while the sensory properties of meat were preserved. Regarding the increase in the oxidation level at high doses of the electron beam and the absence of significant differences in the studied dosages in reducing the total amount of total volatile basic nitrogen, it is recommended to apply electron beam irradiation at doses of 1.5 and 3 kGy to extend the meat shelf life and preserve the quality/health of the quail meat.
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http://dx.doi.org/10.1016/j.fct.2017.12.015DOI Listing
February 2018

Draft Genome Sequence of Microbacterium sp. Strain Alg239_V18, an Actinobacterium Retrieved from the Marine Sponge Spongia sp.

Genome Announc 2017 Jan 19;5(3). Epub 2017 Jan 19.

Institute for Bioengineering and Biosciences (IBB), Department of Bioengineering, IST, Universidade de Lisboa, Lisbon, Portugal

Here, we describe the draft genome sequence of Microbacterium sp. strain Alg239_V18, an actinobacterium retrieved from the marine sponge Spongia sp. Genome annotation revealed a vast gene repertoire involved in antibiotic and heavy metal-resistance, and a versatile carbohydrate assimilation metabolism with potential for chitin utilization.
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http://dx.doi.org/10.1128/genomeA.01457-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255927PMC
January 2017

DBT desulfurization by decorating IGTS8 using magnetic FeO nanoparticles in a bioreactor.

Eng Life Sci 2017 May 21;17(5):528-535. Epub 2016 Dec 21.

Department of Life Science Engineering, Faculty of New Sciences and Technologies University of Tehran Tehran Iran.

Today, crude oil is an important source of energy and environmental contamination due to the continued use of petroleum products is a matter or urgent concern. In this work, two technological platforms, namely, the use of a robust desulfurizing bacteria and the use of nanotechnology to decorate the surface of the bacteria with nanoparticles (NP), were combined to enhance biodesulfurization (BDS). BDS is an ecologically friendly method for desulfurizing petroleum products while avoiding damage to the hydrocarbons due to the high temperatures normally associated with physical desulfurization methods. First, a bacterium known to be a good organism for desulfurization ( IGTS8) was employed in cell culture to remove a recalcitrant sulfur molecule from a common sulfur-containing compound found in crude petroleum products (dibenzothiophene). 2-Hydroxybiphenyl (2-HBP) produced as a consequence of the BDS of dibenzothiophene was determined using Gibbs' assay. The synthesized NP were characterized by field emission scanning electron microscope, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction spectroscopy, and vibrating sample magnetometer. The field emission scanning electron microscope and transmission electron microscopy images showed the size of the NP is 7-8 nm. The decorated cells had a long lag phase, but the growth continued until 148 h (at OD = 3.408) while the noncoated bacteria grow until 96 h before entering the stationary phase at OD = 2.547. Gibbs' assay results showed that production of 2-HBP by decorated cells was 0.210 mM at = 148 h, while 2-HBP production by nondecorated cells was 0.182 mM at = 96 h. Finally, the experiments were repeated in a fermenter.
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http://dx.doi.org/10.1002/elsc.201600080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999300PMC
May 2017

Bacillus amyloliquefaciens SB14 from rhizosphere alleviates Rhizoctonia damping-off disease on sugar beet.

Microbiol Res 2016 Nov 30;192:221-230. Epub 2016 Jul 30.

Sugar Beet Seed Research Institute, Karaj, Iran.

The use of biocontrol strains recently has become a popular alternative to conventional chemical treatments. A set of bacteria isolated from sugar beet rhizosphere and from roots and shoots of apple and walnut were evaluated for their potential to control sugar beet seedling damping-off caused by R. solani AG-4 and AG2-2.The results of in vitro assays concluded that three isolates, SB6, SB14, SB15, obtained from rhizosphere of sugar beet and five isolates, AP2, AP4, AP6, AP7, AP8, obtained from shoots and roots of apple were the most effective antagonists that inhibited the mycelial growth of both R. solani isolates. Combination of several biochemical tests and partial sequencing of 16S rRNA and gyrBgenes revealed that eight efficient bacterial isolates could be assigned to the genus Bacillus and all could tolerate high temperatures and salt concentrations in their vegetative growth. The potential biocontrol activity of the eight bacterial antagonists were tested in greenhouse condition. The results indicated that four strains,B. amyloliquefaciens SB14, B. pumilus SB6,B. siamensis AP2 and B. siamensisAP8 exerted a significant influence on controlling of seedling damping-off and performed significantly better than others.However, the treatment of the seeds with bacteria was most effective when the isolate SB14 was used, which significantly controlled damping-off disease by 58% caused by R. solani AG-4 and by 52.5% caused by R. solani AG-2-2. This indicates that the use of beneficial bacterial native to the host plant may increase the success rate in screening biocontrols, because these microbes are likely to be better adapted to their host and its associated environmental conditions than are strains isolated from other plant species grown in different environmental conditions. We can infer from the results reported here that sugar beet plantsmay recruitbeneficial microbes to the rhizosphere to help them solve context-specific challenges.
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http://dx.doi.org/10.1016/j.micres.2016.06.011DOI Listing
November 2016

Spatial traffic noise pollution assessment - A case study.

Int J Occup Med Environ Health 2015 ;28(3):625-34

Islamic Azad University, Tehran, Iran (Department of Environmental Science, Faculty of Environment and Energy, Science and Research Branch).

Objectives: Spatial assessment of traffic noise pollution intensity will provide urban planners with approximate estimation of citizens exposure to impermissible sound levels. They could identify critical noise pollution areas wherein noise barriers should be embedded. The present study aims at using the Geographic Information System (GIS) to assess spatial changes in traffic noise pollution in Tehran, the capital of Iran, and the largest city in the Middle East.

Material And Methods: For this purpose, while measuring equivalent sound levels at different time periods of a day and different days of a week in District 14 of Tehran, wherein there are highways and busy streets, the geographic coordination of the measurement points was recorded at the stations. The obtained results indicated that the equivalent sound level did not show a statistically significant difference between weekdays, and morning, afternoon and evening hours as well as time intervals of 10 min, 15 min and 30 min. Then, 91 stations were selected in the target area and equivalent sound level was measured for each station on 3 occasions of the morning (7:00-9:00 a.m.), afternoon (12.00-3:00 p.m.) and evening (5:00-8:00 p.m.) on Saturdays to Wednesdays.

Results: As the results suggest, the maximum equivalent sound level (Leq) was reported from Basij Highway, which is a very important connecting thoroughfare in the district, and was equal to 84.2 dB(A), while the minimum equivalent sound level (Leq), measured in the Fajr Hospital, was equal to 59.9 dB(A).

Conclusions: The average equivalent sound level was higher than the national standard limit at all stations. The use of sound walls in Highways Basij and Mahallati as well as widening the Streets 17th Shahrivar, Pirouzi and Khavaran, benchmarked on a map, were recommended as the most effective mitigation measures. Additionally, the research findings confirm the outstanding applicability of the Geographic Information System in handling noise pollution data towards depicting noise pollution intensity caused by traffic.
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http://dx.doi.org/10.13075/ijomeh.1896.00103DOI Listing
December 2016

In vivo SPECT imaging of tumors by 198,199Au-labeled graphene oxide nanostructures.

Mater Sci Eng C Mater Biol Appl 2014 Dec 16;45:196-204. Epub 2014 Sep 16.

Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 31485-498, Karaj, Iran.

Graphene oxide (GO) sheets functionalized by aminopropylsilyl groups (8.0 wt.%) were labeled by (198,199)Au nanoparticle radioisotopes (obtained through reduction of HAuCl4 in sodium citrate solution followed by thermal neutron irradiation) for fast in vivo targeting and SPECT imaging (high purity germanium-spectrometry) of tumors. Using instant thin layer chromatography method, the physicochemical properties of the amino-functionalized GO sheets labeled by (198,199)Au NPs ((198,199)Au@AF-GO) were found to be highly stable enough in organic phases, e.g. a human serum, to be reliably used in bioapplications. In vivo biodistribution of the (198,199)Au@AF-GO composite was investigated in rats bearing fibrosarcoma tumor after various post-injection periods of time. The (198,199)Au@AF-GO nanostructure exhibited a rapid as well as high tumor uptake (with uptake ratio of tumor to muscle of 167 after 4h intravenous injection) that resulted in an efficient tumor targeting/imaging. Meantime, the low lipophilicity of the (198,199)Au@AF-GO caused to its fast excretion (~24 h) throughout the body by the kidneys (as also confirmed by the urinary tract). Because of the short half-life of (198,199)Au radioisotopes, the (198,199)Au@AF-GO with an excellent tumor targeting/imaging and fast washing out from the body can be suggested as one of the most effective and promising nanomaterials in nanotechnology-based cancer diagnosis and therapy.
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http://dx.doi.org/10.1016/j.msec.2014.09.019DOI Listing
December 2014

Redundancy among phospholipase D isoforms in resistance triggered by recognition of the Pseudomonas syringae effector AvrRpm1 in Arabidopsis thaliana.

Front Plant Sci 2014 13;5:639. Epub 2014 Nov 13.

Department of Biology and Environmental Sciences, University of Gothenburg Gothenburg, Sweden.

Plants possess a highly sophisticated system for defense against microorganisms. So called MAMP (microbe-associated molecular patterns) triggered immunity (MTI) prevents the majority of non-adapted pathogens from causing disease. Adapted plant pathogens use secreted effector proteins to interfere with such signaling. Recognition of microbial effectors or their activity by plant resistance (R)-proteins triggers a second line of defense resulting in effector triggered immunity (ETI). The latter usually comprises the hypersensitive response (HR) which includes programmed cell death at the site of infection. Phospholipase D (PLD) mediated production of phosphatidic acid (PA) has been linked to both MTI and ETI in plants. Inhibition of PLD activity has been shown to attenuate MTI as well as ETI. In this study, we systematically tested single and double knockouts in all 12 genes encoding PLDs in Arabidopsis thaliana for effects on ETI and MTI. No single PLD could be linked to ETI triggered by recognition of effectors secreted by the bacterium Pseudomonas syringae. However, repression of PLD dependent PA production by n-butanol strongly inhibited the HR following Pseudomonas syringae effector recognition. In addition some pld mutants were more sensitive to n-butanol than wild type. Thus, the effect of mutations of PLDs could become detectable, and the corresponding genes can be proposed to be involved in the HR. Only knockout of PLDδ caused a loss of MTI-induced cell wall based defense against the non-host powdery mildew Erysiphe pisi. This is thus in stark contrast to the involvement of a multitude of PLD isoforms in the HR triggered by AvrRpm1 recognition.
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http://dx.doi.org/10.3389/fpls.2014.00639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230166PMC
November 2014

Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris.

Int J Dermatol 2013 Aug 20;52(8):999-1004. Epub 2013 Jun 20.

Department of Dermatology, Sina Hospital, Tabriz, Iran.

Nicotinamide and clindamycin gels are two popular topical medications for acne vulgaris. This study aimed to compare efficacy of the topical 4% nicotinamide and 1% clindamycin gels in these patients. In this randomized, double-blind clinical trial, patients with moderate inflammatory facial acne vulgaris were randomly allocated to receive either topical 4% nicotinamide (n = 40) or 1% clindamycin gels (n = 40) twice daily. In each group, they were further categorized in two subgroups with oily and non-oily types of facial skin. The Cook's acne grade was determined at baseline and at weeks 4 and 8 post treatment. Acne grade decreased from an average of 5.93 ± 0.83 at baseline to 4.03 ± 1.33 at week 4 and 2.08 ± 1.59 at week 8 in nicotinamide receivers, and from an average of 5.70 ± 0.94 at baseline to 3.85 ± 1.66 at week 4 and 2.03 ± 1.53 at week 8 in the clindamycin group (within-group P < 0.001, between-group P > 0.05). Comparing with each other, nicotinamide and clindamycin gels were significantly more efficacious in oily and non-oily skin types, respectively. No major side effect was encountered by any patient. Skin type is a significant factor in choosing between topical nicotinamide and clindamycin in patients with acne vulgaris.
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http://dx.doi.org/10.1111/ijd.12002DOI Listing
August 2013

Dosimetric comparison of 90Y, 32P, and 186Re radiocolloids in craniopharyngioma treatments.

Med Phys 2009 Nov;36(11):5022-6

Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, P.O. Box 31485/498, Karaj, Iran.

Purpose: In the radionuclide treatment of some forms of brain tumors such as craniopharyngiomas, the selection of the appropriate radionuclide for therapy is a key element in treatment planning. The aim was to study the influence by considering the beta-emitter radionuclide dose rate in an intracranial cyst.

Methods: Dosimetry was performed using the MCNP4C radiation transport code. Analytical dosimetry was additionally performed using the Loevinger and the Berger formulas in the MATLAB software. Each result was compared under identical conditions. The advantages and disadvantages of using 90Y versus 32P and 186Re were investigated.

Results: The dose rate at the inner surface of the cyst wall was estimated to be 400 mGy/h for a 1 MBq/ml concentration of 90Y. Under identical conditions of treatment, the corresponding dose rates were 300 mGy/h for 32P and 160 mGy/h for 186Re. For a well-defined cyst radius and identical wall thickness, higher dose rates resulted for 90Y.

Conclusions: To achieve the same radiological burden, the required amount of physical activity of injectable solution is lower for 32P. This is found to be a consequence of both the radionuclide physical half-life and the pattern of energy deposition from the emitted radiation. According to the half-life and dose-rate results, 90Y would be a good substitute for 32P.
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http://dx.doi.org/10.1118/1.3243085DOI Listing
November 2009