Publications by authors named "Elham Akbari"

5 Publications

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Introducing the risk aggregation problem to aquifers exposed to impacts of anthropogenic and geogenic origins on a modular basis using 'risk cells'.

J Environ Manage 2018 Jul 10;217:654-667. Epub 2018 Apr 10.

Department of Geology, Faculty of Sciences, University of Urmia, Urmia, West Azerbaijan, Iran. Electronic address:

Proof-of-concept is presented in this paper to a methodology formulated for indexing risks to groundwater aquifers exposed to impacts of diffuse contaminations from anthropogenic and geogenic origins. The methodology is for mapping/indexing, which refers to relative values but not their absolute values. The innovations include: (i) making use of the Origins-Source-Pathways-Receptors-Consequences (OSPRC) framework; and (ii) dividing a study area into modular Risk (OSPRC) Cells to capture their idiosyncrasies with different origins. Field measurements are often sparse and comprise pollutants and water table, which are often costly; whereas supplementary data are general-purpose data, which are widely available. Risk mapping for each OSPRC cell is processed by dividing a study area into pixels and for each pixel, the risk from both anthropogenic and geogenic origins are indexed by using algorithms related to: (i) Vulnerability Indices (VI), which identify the potential for risk exposures at each pixel; and (ii) velocity gradient, which expresses the potency to risk exposures across the risk cell. The paper uses DRASTIC for anthropogenic VI but introduces a new framework for geogenic VI. The methodology has a generic architecture and is flexible to modularise risks involving any idiosyncrasies in a generic way in any site exposed to environmental pollution risks. Its application to a real study area provides evidence for the proof-of-concept for the methodology by a set of results that are fit-for-purpose and provides an insight into the study area together with the identification of its hotspots.
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http://dx.doi.org/10.1016/j.jenvman.2018.04.011DOI Listing
July 2018

Health risk assessment of heavy metal intake due to fish consumption in the Sistan region, Iran.

Environ Monit Assess 2017 Oct 25;189(11):583. Epub 2017 Oct 25.

Department of Environmental Health Engineering, Gonabad University of Medical Sciences, Gonabad, Iran.

The heavy metal (Pb, Cd, Cr, and Ni) content of a fish species consumed by the Sistan population and its associated health risk factors were investigated. The mean concentrations of Pb, Cd, and Cr were slightly higher than the standard levels. The Ni content of fish was below the maximum guideline proposed by the US Food and Drug Administration (USFDA). The average estimated weekly intake was significantly below the provisional tolerable intake based on the FAO and WHO standards for all studied metals. The target hazard quotients (THQ) of all metals were below 1, showing an absence of health hazard for the population of Sistan. The combined target hazard quotient for the considered metals was 26.94 × 10. The cancer risk factor for Pb (1.57 × 10) was below the acceptable lifetime carcinogenic risk (10). The results of this study reveal an almost safe level of Pb, Cd, Cr, and Ni contents in the fish consumed by the Sistan population. Graphical abstract ᅟ.
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http://dx.doi.org/10.1007/s10661-017-6286-7DOI Listing
October 2017

Fertility outcome after laparoscopic treatment of advanced endometriosis in two groups of infertile patients with and without ovarian endometrioma.

Eur J Obstet Gynecol Reprod Biol 2016 Jun 12;201:46-50. Epub 2016 Mar 12.

Independent Research Consultant, FACOG, Iran; Avicenna Research Institute, ACECR, Reproductive Biotechnology Research Center, Tehran, Iran.

Objective: To evaluate the result of laparoscopic endometrioma excision in fertility outcome of advanced endometriosis patients.

Study Design: The study was designated as historical cohort, in a private referral center of advance laparoscopy. 111 infertile patients, diagnosed as endometriosis, were divided in two groups: DIE (deep infiltrative endometriosis) and endometrioma (case group), and patients with only DIE (without endometrioma ((control group). All patients underwent global laparoscopic resection of DIE lesion (both groups) and laparoscopic excisional cystectomy of endometrioma (case groups). Patients were followed for fertility outcomes and data were analyzed by Kaplan-Meier test and COX regression using SPSS software.

Results: After adjusting covariates, the Kaplan-Meier analysis of cumulative pregnancy rates (CPR) did not show any statistical significance between cases (35.6%) and controls (39.5%) (Log-rank P-value=0.959). The COX regression analysis of covariates showed there is no significant relationship between cystectomy and fertility outcome. It showed statistical significance effect of age (hazard ratio [HR]=0.772), years of infertility (HR=0.224), and previous endometrioma surgery (HR=0.180), on fertility chance.

Conclusion: In advanced endometriosis with DIE and infertility, fine excision and stripping of the endometrioma along with radical resection of DIE improves fecundity without any significant adverse effect in comparison with patients with intact ovaries.
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http://dx.doi.org/10.1016/j.ejogrb.2016.03.009DOI Listing
June 2016

Premenstrual syndrome and quality of life in Iranian medical students.

Sex Reprod Healthc 2015 Mar 30;6(1):23-7. Epub 2014 Jun 30.

Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran.

Purpose Of Study: The purpose of this research was to investigate the prevalence of premenstrual syndrome (PMS) in medical students and to evaluate the hypothesis that PMS may result in a decrease in quality of life.

Methods: In a cross-sectional study, 142 female medical students who study at Urmia University of Medical Sciences were included. The data were compiled using a PMS questionnaire based on the fourth version (DSM-IV) criteria, the questionnaire of "Premenstrual Syndrome Scale" as well as the "World Health Organization's Quality of Life (WHOQOL-BREF)" questionnaire.

Findings: In total, 56 out of 142 (39.4%) female medical students met the DSM-IV criteria for PMS. In the PMS group, more than half of the girls, i.e. 60.6% had mild, 25.1% had moderate and 14.2% had severe PMS. PMS was found to be significantly high in students who have positive history of PMS in their first degree relatives and who have used drugs to relieve PMS symptoms (P<0.05). Life quality score was low in more than half of the medical students, especially in psychological and social components (P>0.05). However, the quality of life score means in mental health (P=0.02) and environmental health (P=0.002) decreases as the PMS score average increases.

Conclusion: The results of premenstrual syndrome prevalence and their severity suggest that PMS is common in medical students and this adversely affects some domains of the quality of life. Improving the life quality of female medical students needs some interventions related to the PMS and also other interventions not related to PMS.
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http://dx.doi.org/10.1016/j.srhc.2014.06.009DOI Listing
March 2015

Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior.

Fertil Steril 2013 Sep 28;100(3):761-9. Epub 2013 May 28.

Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: To study immunophenotype, differential proliferation capacity, invasiveness, adhesion, and cytokine production in ectopic and eutopic endometrial stromal cells (EESCs and EuESCs) from patients with endometriosis.

Design: In vitro study.

Setting: Academic research center.

Patient(s): Patients with ovarian endometriosis (endometrioma) and nonendometriotic controls.

Intervention(s): None.

Main Outcome Measure(s): EESCs and EuESCs from 25 patients with endometrioma and ESCs from 20 nonendometriotic controls (CESCs) were isolated, and their immunophenotype, proliferation, invasion, adhesion, and cytokine production were assessed and compared.

Result(s): Isolated ESCs from all three sources expressed markers specific for cells of mesenchymal origin but were negative for hematopoietic markers. EESCs exhibited a significantly lower proliferation rate in fibronectin-coated plates and less invasive capacity compared with CESCs or EuESCs. Among all stromal cell groups studied, EuESCs showed the highest invasive behavior. EESCs adhered more firmly to extracellular matrix than EuESCs or CESCs in all time intervals examined. The levels of interleukin (IL) -6 and IL-8 production by EESCs were significantly higher compared with those of EuESCs or CESCs.

Conclusion(s): The results of the present study demonstrated that retrograde menstruation alone does not account for the pathogenesis of endometriosis as eutopic and ectopic counterparts of ESCs from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior.
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http://dx.doi.org/10.1016/j.fertnstert.2013.04.041DOI Listing
September 2013