Eleni Aklillu

Eleni Aklillu

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Eleni Aklillu

Publications by authors named "Eleni Aklillu"

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Adverse birth outcomes among mothers who received intermittent preventive treatment with Sulphadoxine-Pyrimethamine in the low malaria transmission region.

BMC Pregnancy Childbirth 2019 Jul 8;19(1):236. Epub 2019 Jul 8.

Clinical Pharmacy and Pharmacology Department, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

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http://dx.doi.org/10.1186/s12884-019-2397-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615266PMC
July 2019

Potential drug-drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals.

Int J Infect Dis 2019 Jun 13;83:98-101. Epub 2019 Apr 13.

Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.ijid.2019.04.009DOI Listing
June 2019

Comparison of malaria treatment outcome of generic and innovator's anti-malarial drugs containing artemether-lumefantrine combination in the management of uncomplicated malaria amongst Tanzanian children.

Malar J 2019 Apr 11;18(1):133. Epub 2019 Apr 11.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital-Huddinge C1:68, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s12936-019-2769-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460845PMC
April 2019

Conference report: pharmacogenomics in special populations at WCP2018.

Br J Clin Pharmacol 2019 03 24;85(3):467-475. Epub 2019 Jan 24.

Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1111/bcp.13828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379283PMC
March 2019

HIV and cART-Associated Dyslipidemia Among HIV-Infected Children.

J Clin Med 2019 Mar 28;8(4). Epub 2019 Mar 28.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.

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https://www.mdpi.com/2077-0383/8/4/430
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http://dx.doi.org/10.3390/jcm8040430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518233PMC
March 2019

Vitamin D Status and Association of Genetic Polymorphism to Risk of Breast Cancer in Ethiopia.

Nutrients 2019 Jan 29;11(2). Epub 2019 Jan 29.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.3390/nu11020289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412905PMC
January 2019

Cigarette smoking and heavy coffee consumption affecting response to olanzapine: the role of genetic polymorphism.

World J Biol Psychiatry 2018 Dec 4:1-53. Epub 2018 Dec 4.

f Division of Clinical Pharmacology, Department of Laboratory Medicine , Karolinska Institutet, Karolinska University Hospital, Huddinge C1:68, SE-141 86 Stockholm , Sweden.

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https://www.tandfonline.com/doi/full/10.1080/15622975.2018.1
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http://dx.doi.org/10.1080/15622975.2018.1548779DOI Listing
December 2018

Neuropsychiatric manifestations among HIV-1 infected African patients receiving efavirenz-based cART with or without tuberculosis treatment containing rifampicin.

Eur J Clin Pharmacol 2018 Nov 12;74(11):1405-1415. Epub 2018 Jul 12.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-018-2499-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182598PMC
November 2018

Long-term efavirenz pharmacokinetics is comparable between Tanzanian HIV and HIV/Tuberculosis patients with the same CYP2B6*6 genotype.

Sci Rep 2018 Nov 5;8(1):16316. Epub 2018 Nov 5.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://www.nature.com/articles/s41598-018-34674-3
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http://dx.doi.org/10.1038/s41598-018-34674-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218524PMC
November 2018

Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations.

Sci Rep 2018 Aug 24;8(1):12726. Epub 2018 Aug 24.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital-Huddinge C1:68, SE-141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-018-31191-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109098PMC
August 2018

N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians.

Eur J Clin Pharmacol 2018 Jul 27;74(7):903-911. Epub 2018 Mar 27.

Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.

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http://link.springer.com/10.1007/s00228-018-2448-y
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http://dx.doi.org/10.1007/s00228-018-2448-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999125PMC
July 2018

Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women.

Malar J 2017 07 3;16(1):267. Epub 2017 Jul 3.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s12936-017-1914-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496343PMC
July 2017

Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back-Looking Forward to Next-Generation Innovation.

OMICS 2017 03 16;21(3):123-131. Epub 2017 Feb 16.

2 Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital , Huddinge C1:68, Karolinska Institutet, Stockholm, Sweden .

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http://dx.doi.org/10.1089/omi.2017.0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346905PMC
March 2017

Allele Is Associated with Concomitant Anti-tuberculosis and Antiretroviral Drugs Induced Liver Toxicity in Ethiopians.

Front Pharmacol 2017 27;8:90. Epub 2017 Feb 27.

Department of Laboratory Medicine, Karolinska Institutet-Karolinska University Hospital Stockholm, Sweden.

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http://journal.frontiersin.org/article/10.3389/fphar.2017.00
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http://dx.doi.org/10.3389/fphar.2017.00090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326775PMC
February 2017

Long-Term Effect of Rifampicin-Based Anti-TB Regimen Coadministration on the Pharmacokinetic Parameters of Efavirenz and 8-Hydroxy-Efavirenz in Ethiopian Patients.

J Clin Pharmacol 2016 12 29;56(12):1538-1549. Epub 2016 May 29.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcph.756DOI Listing
December 2016

Precision Medicine 2.0: The Rise of Glocal Innovation, Superconnectors, and Design Thinking.

OMICS 2016 09;20(9):493-5

12 Faculty of Communications, Gaziantep University , Gaziantep, Turkey .

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http://dx.doi.org/10.1089/omi.2016.0129DOI Listing
September 2016

Conference Report: First Pharmacogenetics and Precision Medicine Conference in Africa (April 7-9, 2016, Cape Town, South Africa).

OMICS 2016 09;20(9):496-7

3 Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet , Stockholm, Sweden .

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http://dx.doi.org/10.1089/omi.2016.0128DOI Listing
September 2016

SLCO1B1 Gene Variations Among Tanzanians, Ethiopians, and Europeans: Relevance for African and Worldwide Precision Medicine.

OMICS 2016 09;20(9):538-45

6 Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg , Heidelberg, Germany .

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http://dx.doi.org/10.1089/omi.2016.0119DOI Listing
September 2016

Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity.

BMC Genomics 2016 Sep 26;17(1):755. Epub 2016 Sep 26.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge C1:68, Karolinska Institutet, SE-141 86, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037629PMC
http://dx.doi.org/10.1186/s12864-016-3078-3DOI Listing
September 2016

Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study.

Medicine (Baltimore) 2016 Aug;95(34):e4631

aDepartment of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden bDepartment of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia cDepartment of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden dDepartment of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/MD.0000000000004631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400328PMC
August 2016

Is there a need to increase the dose of efavirenz during concomitant rifampicin-based antituberculosis therapy in sub-Saharan Africa? The HIV-TB pharmagene study.

Pharmacogenomics 2015 1;16(10):1047-64. Epub 2015 Apr 1.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, C-168, Karolinska Institutet, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs.15.35DOI Listing
June 2016

Malaria prevalence, severity and treatment outcome in relation to day 7 lumefantrine plasma concentration in pregnant women.

Malar J 2016 05 13;15(1):278. Epub 2016 May 13.

Department of Laboratory of Medicine, Division of Clinical Pharmacology, Karolinska Institutet, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s12936-016-1327-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866074PMC
May 2016

CYP2B6 genotype-based efavirenz dose recommendations during rifampicin-based antituberculosis cotreatment for a sub-Saharan Africa population.

Pharmacogenomics 2016 Apr 5;17(6):603-13. Epub 2016 Apr 5.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institutet, SE - 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs.16.7DOI Listing
April 2016

The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans.

J Clin Psychopharmacol 2015 Dec;35(6):694-9

From the *Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; †CICAB Clinical Research Centre, Extremadura University Hospital and Medical School, Badajoz, Spain; and ‡Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital-Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1097/JCP.0000000000000413DOI Listing
December 2015

P450 (Cytochrome) Oxidoreductase Gene (POR) Common Variant (POR*28) Significantly Alters CYP2C9 Activity in Swedish, But Not in Korean Healthy Subjects.

OMICS 2015 Dec;19(12):777-81

1 Department of Laboratory Medicine, Karolinska Institutet, Division of Clinical Pharmacology, Karolinska University Hospital , Huddinge, Sweden .

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http://www.liebertpub.com/doi/10.1089/omi.2015.0159
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http://dx.doi.org/10.1089/omi.2015.0159DOI Listing
December 2015

miRNA-27b levels are associated with CYP3A activity in vitro and in vivo.

Pharmacol Res Perspect 2015 12 27;3(6):e00192. Epub 2015 Oct 27.

Division of Clinical Microbiology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital, Huddinge SE-141 86 Stockholm Sweden; Palliative Home Care and Hospice Ward ASIH Stockholm Södra Långbro Park Bergtallsvägen 12SE-125 59 Älvsjö Sweden.

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http://dx.doi.org/10.1002/prp2.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777245PMC
December 2015

The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles.

Drug Metab Dispos 2015 Aug 28;43(8):1226-35. Epub 2015 May 28.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.115.064428
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http://dx.doi.org/10.1124/dmd.115.064428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518065PMC
August 2015

Differences in CYP2C9 Genotype and Enzyme Activity Between Swedes and Koreans of Relevance for Personalized Medicine: Role of Ethnicity, Genotype, Smoking, Age, and Sex.

OMICS 2015 Jun 15;19(6):346-53. Epub 2015 May 15.

1 Department of Laboratory Medicine, Karolinska Institutet, Division of Clinical Pharmacology, Karolinska University Hospital , Huddinge, Sweden .

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http://dx.doi.org/10.1089/omi.2015.0022DOI Listing
June 2015

The influence of nevirapine and efavirenz-based anti-retroviral therapy on the pharmacokinetics of lumefantrine and anti-malarial dose recommendation in HIV-malaria co-treatment.

Malar J 2015 Apr 25;14:179. Epub 2015 Apr 25.

Unit of Pharmacology and Therapeutics, School of Pharmacy, Muhimbili University of Health and Allied Sciences, PO Box 65013, Dar es Salaam, Tanzania.

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http://dx.doi.org/10.1186/s12936-015-0695-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424554PMC
April 2015

Genesis of EDCTP2.

Lancet Infect Dis 2015 Jan 2;15(1):11-3. Epub 2014 Dec 2.

European and Developing Countries Clinical Trials Partnership (EDCTP), The Hague 2593, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(14)71034-5DOI Listing
January 2015

Pharmacogenetic-based efavirenz dose modification: suggestions for an African population and the different CYP2B6 genotypes.

PLoS One 2014 31;9(1):e86919. Epub 2014 Jan 31.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086919PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909010PMC
October 2014

PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.

Pharmacogenet Genomics 2014 Aug;24(8):409-25

Departments of aGenetics bBioengineering, Stanford University, Palo Alto, California cDepartment of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville, Kentucky, USA dDepartment of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece eDepartment of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/FPC.0000000000000062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109976PMC
August 2014

CYP2B6 genotype, but not rifampicin-based anti-TB cotreatments, explains variability in long-term efavirenz plasma exposure.

Pharmacogenomics 2014 Aug;15(11):1423-35

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, C-168 SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs.14.73DOI Listing
August 2014

Comparisons of CYP2A6 genotype and enzyme activity between Swedes and Koreans.

Drug Metab Pharmacokinet 2013 24;28(2):93-7. Epub 2012 Jul 24.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden.

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July 2014

High CYP2A6 enzyme activity as measured by a caffeine test and unique distribution of CYP2A6 variant alleles in Ethiopian population.

OMICS 2014 Jul 31;18(7):446-53. Epub 2013 Dec 31.

1 Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital , Karolinska Institutet, Stockholm, Sweden .

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http://dx.doi.org/10.1089/omi.2013.0140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086241PMC
July 2014

The VKORC1 Asp36Tyr variant and VKORC1 haplotype diversity in Ashkenazi and Ethiopian populations.

J Appl Genet 2014 May 15;55(2):163-71. Epub 2014 Jan 15.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://link.springer.com/content/pdf/10.1007/s13353-013-0189
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http://link.springer.com/10.1007/s13353-013-0189-2
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http://dx.doi.org/10.1007/s13353-013-0189-2DOI Listing
May 2014

Influence of efavirenz pharmacokinetics and pharmacogenetics on neuropsychological disorders in Ugandan HIV-positive patients with or without tuberculosis: a prospective cohort study.

BMC Infect Dis 2013 Jun 4;13:261. Epub 2013 Jun 4.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, SE- 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1186/1471-2334-13-261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680019PMC
June 2013

Haplotypes in the 5'-untranslated region of the CYP1A2 gene are inversely associated with lung cancer risk but do not correlate with caffeine metabolism.

Environ Mol Mutagen 2013 Mar 9;54(2):124-32. Epub 2012 Nov 9.

Department of Medical & Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.1002/em.21747DOI Listing
March 2013

Comparison of N-acetyltransferase-2 enzyme genotype-phenotype and xanthine oxidase enzyme activity between Swedes and Koreans.

J Clin Pharmacol 2012 Oct 21;52(10):1527-34. Epub 2011 Nov 21.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1177/0091270011420261DOI Listing
October 2012

Risk factors for mortality among HIV-positive patients with and without active tuberculosis in Dar es Salaam, Tanzania.

Antivir Ther 2012 17;17(2):265-74. Epub 2011 Nov 17.

Department of Internal Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania.

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http://dx.doi.org/10.3851/IMP1956DOI Listing
July 2012

Search for the molecular basis of ultra-rapid CYP2C9-catalysed metabolism: relationship between SNP IVS8-109A>T and the losartan metabolism phenotype in Swedes.

Eur J Clin Pharmacol 2012 Jul 1;68(7):1033-42. Epub 2012 Feb 1.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet-Karolinska University Hospital, Huddinge 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-012-1210-0DOI Listing
July 2012

PharmGKB summary: caffeine pathway.

Pharmacogenet Genomics 2012 May;22(5):389-95

Department of Genetics, Stanford University Medical Center, Stanford, California 94305-5120, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283505d5eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381939PMC
May 2012

PharmGKB summary: very important pharmacogene information for CYP1A2.

Pharmacogenet Genomics 2012 Jan;22(1):73-7

Department of Genetics, Stanford University Medical Center, Stanford, California 94305-5120, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32834c6efdDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346273PMC
January 2012

Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method.

Eur J Clin Pharmacol 2011 Nov 1;67(11):1139-45. Epub 2011 Jun 1.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge C-168, Karolinska Institute, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-011-1065-9DOI Listing
November 2011

Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients.

J Antimicrob Chemother 2011 Oct 16;66(10):2350-61. Epub 2011 Aug 16.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge C1:68, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1093/jac/dkr304DOI Listing
October 2011

HIV/AIDS patients display lower relative bioavailability of efavirenz than healthy subjects.

Clin Pharmacokinet 2011 Aug;50(8):531-40

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2165/11592660-000000000-00000DOI Listing
August 2011

N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population.

J Clin Pharmacol 2011 Jul 27;51(7):994-1003. Epub 2010 Aug 27.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1177/0091270010377630DOI Listing
July 2011

CYP2C19 activity comparison between Swedes and Koreans: effect of genotype, sex, oral contraceptive use, and smoking.

Eur J Clin Pharmacol 2010 Sep 25;66(9):871-7. Epub 2010 May 25.

Division of Clinical Pharmacology, Department of Laboratory Medicine at Karolinska Institutet, Karolinska University Hospital-Huddinge C1:68, 14186 Stockholm, Sweden.

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http://link.springer.com/content/pdf/10.1007/s00228-010-0835
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http://link.springer.com/10.1007/s00228-010-0835-0
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http://dx.doi.org/10.1007/s00228-010-0835-0DOI Listing
September 2010

Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 -163C>A polymorphism.

Eur J Clin Pharmacol 2010 Jul;66(7):697-703

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, C1: 68 SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-010-0823-4DOI Listing
July 2010

In vivo evaluation of CYP2A6 and xanthine oxidase enzyme activities in the Serbian population.

Eur J Clin Pharmacol 2010 Jun 13;66(6):571-8. Epub 2010 Feb 13.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, 14186, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-010-0785-6DOI Listing
June 2010

Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans.

Ther Drug Monit 2010 Jun;32(3):346-52

Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1097/FTD.0b013e3181da79d6DOI Listing
June 2010

Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients.

Eur J Clin Pharmacol 2010 May 9;66(5):465-74. Epub 2010 Feb 9.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge-Karolinska Institutet, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-009-0783-8DOI Listing
May 2010

A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans.

Br J Clin Pharmacol 2009 Nov;68(5):690-9

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2125.2009.03516.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791975PMC
November 2009

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers.

Pharmacogenomics J 2009 Jun 10;9(3):208-17. Epub 2009 Mar 10.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://www.nature.com/articles/tpj20094
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http://dx.doi.org/10.1038/tpj.2009.4DOI Listing
June 2009

MAO-A and COMT genotypes as possible regulators of perinatal serotonergic symptoms after in utero exposure to SSRIs.

Eur Neuropsychopharmacol 2009 May 14;19(5):363-70. Epub 2009 Feb 14.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.euroneuro.2009.01.006DOI Listing
May 2009

Association of MAOA gene functional promoter polymorphism with CSF dopamine turnover and atypical depression.

Pharmacogenet Genomics 2009 Apr;19(4):267-75

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/FPC.0b013e328328d4d3DOI Listing
April 2009

Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme.

Hum Mutat 2008 Sep;29(9):1147-53

Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1002/humu.20786DOI Listing
September 2008

Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes.

Eur J Clin Pharmacol 2008 Apr 22;64(4):381-5. Epub 2007 Dec 22.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, C1: 68, SE-14186, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-007-0438-6DOI Listing
April 2008

4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.

Pharmacogenet Genomics 2008 Mar;18(3):201-8

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1097/FPC.0b013e3282f50ee9DOI Listing
March 2008

CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine.

Pharmacogenet Genomics 2007 Nov;17(11):989-93

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/FPC.0b013e3282f01aa3DOI Listing
November 2007

Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression.

Neuropsychopharmacology 2007 Oct 14;32(10):2143-51. Epub 2007 Feb 14.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge,C-168,SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.npp.1301336DOI Listing
October 2007

Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans.

Eur J Clin Pharmacol 2007 Jun 17;63(6):537-46. Epub 2007 Mar 17.

Division of Clinical Pharmacology, Karolinska University Hospital-Huddinge, Karolinska Institutet, C1-68, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-007-0288-2DOI Listing
June 2007

CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population.

Pharmacogenet Genomics 2006 Sep;16(9):637-45

Department of Clinical Toxicology, Central Laboratories & Blood Bank, King Fahad Medical City, Riyadh 11525, Kingdom of Saudi Arabia.

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http://dx.doi.org/10.1097/01.fpc.0000230411.89973.1bDOI Listing
September 2006

Pharmacogenetics for off-patent antipsychotics: reframing the risk for tardive dyskinesia and access to essential medicines.

Expert Opin Pharmacother 2006 Feb;7(2):119-33

VA Long Beach Healthcare System, Southern California Institute for Research and Education, Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, Long Beach, CA 90822, USA.

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http://dx.doi.org/10.1517/14656566.7.2.119DOI Listing
February 2006

A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.

Clin Pharmacol Ther 2006 Jan;79(1):103-13

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm.

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http://dx.doi.org/10.1016/j.clpt.2005.10.002DOI Listing
January 2006

Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene.

Cancer Res 2005 Jun;65(12):5105-11

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0113DOI Listing
June 2005

Xanthine oxidase activity is influenced by environmental factors in Ethiopians.

Eur J Clin Pharmacol 2003 Oct 21;59(7):533-6. Epub 2003 Aug 21.

Division of Molecular Toxicology, IMM, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-003-0653-8DOI Listing
October 2003

Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1.

Mol Pharmacol 2003 Sep;64(3):659-69

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1124/mol.64.3.659DOI Listing
September 2003

Analysis of CYP2C9*5 in Caucasian, Oriental and black-African populations.

Eur J Clin Pharmacol 2002 Nov 1;58(8):555-8. Epub 2002 Nov 1.

Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sewden.

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http://dx.doi.org/10.1007/s00228-002-0518-6DOI Listing
November 2002

Recent Progress in Drug Metabolism Research.

Drug News Perspect 2002 Oct;15(8):528-534

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October 2002

Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population.

Mol Pharmacol 2002 Mar;61(3):586-94

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1124/mol.61.3.586DOI Listing
March 2002