Elena K Schneider-Futschik

Multiple Reaction Monitoring Mass Spectrometry for the Drug Monitoring of Ivacaftor, Tezacaftor, and Elexacaftor Treatment Response in Cystic Fibrosis: A High-Throughput Method.

Authors:

Felisa Reyes-Ortega Fiona Qiu Elena K Schneider-Futschik

ACS Pharmacol Transl Sci 2020 Oct 11;3(5):987-996. Epub 2020 Sep 11.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.

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October 2020

The Balance between the Safety of Mother, Fetus, and Newborn Undergoing Cystic Fibrosis Transmembrane Conductance Regulator Treatments during Pregnancy.

Authors:

Fiona Qiu Mark Habgood Elena K Schneider-Futschik

ACS Pharmacol Transl Sci 2020 Oct 19;3(5):835-843. Epub 2020 Aug 19.

Department of Pharmacology & Therapeutics, Lung Health Research Centre, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.

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October 2020

Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens.

Authors:

Maytham Hussein Xiaohan Hu Olivia K A Paulin Simon Crawford Qi Tony Zhou Mark Baker Elena K Schneider-Futschik Yan Zhu Jian Li Tony Velkov

Comput Struct Biotechnol J 2020 21;18:2247-2258. Epub 2020 Aug 21.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.

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August 2020

Polymyxins Bind to the Cell Surface of Unculturable and Cause Unique Dependent Resistance.

Adv Sci (Weinh) 2020 Aug 8;7(15):2000704. Epub 2020 Jun 8.

Infection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.

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August 2020

Metabolomic Description of Ivacaftor Elevating Polymyxin B Mediated Antibacterial Activity in Cystic Fibrosis .

Authors:

Rafah Allobawi Drishti P Ghelani Elena K Schneider-Futschik

ACS Pharmacol Transl Sci 2020 Jun 27;3(3):433-443. Epub 2020 Apr 27.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.

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June 2020

The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study.

Authors:

Maytham Hussein John A Karas Elena K Schneider-Futschik Fan Chen James Swarbrick Olivia K A Paulin Daniel Hoyer Mark Baker Yan Zhu Jian Li Tony Velkov

mSystems 2020 May 26;5(3). Epub 2020 May 26.

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia

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May 2020

Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline.

Authors:

Maytham Hussein Elena K Schneider-Futschik Olivia K A Paulin Rafah Allobawi Simon Crawford Qi Tony Zhou Adil Hanif Mark Baker Yan Zhu Jian Li Tony Velkov

ACS Infect Dis 2020 06 25;6(6):1436-1450. Epub 2020 May 25.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.

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June 2020

Emerging Cystic Fibrosis Transmembrane Conductance Regulator Modulators as New Drugs for Cystic Fibrosis: A Portrait of Pharmacology and Clinical Translation.

Authors:

Drishti P Ghelani Elena K Schneider-Futschik

ACS Pharmacol Transl Sci 2020 Feb 2;3(1):4-10. Epub 2019 Oct 2.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.

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February 2020

Health impacts of bushfire smoke exposure in Australia.

Authors:

Clare M Walter Elena K Schneider-Futschik Luke D Knibbs Louis B Irving

Respirology 2020 May 17;25(5):495-501. Epub 2020 Mar 17.

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC, Australia.

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May 2020

Synthesis and structure-activity relationships of teixobactin.

Authors:

John A Karas Fan Chen Elena K Schneider-Futschik Zhisen Kang Maytham Hussein James Swarbrick Daniel Hoyer Andrew M Giltrap Richard J Payne Jian Li Tony Velkov

Ann N Y Acad Sci 2020 01 2;1459(1):86-105. Epub 2019 Dec 2.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, the University of Melbourne, Parkville, Victoria, Australia.

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January 2020

The impact of backbone N-methylation on the structure-activity relationship of Leu -teixobactin.

Authors:

Tony Velkov James D Swarbrick Maytham H Hussein Elena K Schneider-Futschik Daniel Hoyer Jian Li John A Karas

J Pept Sci 2019 Sep 6;25(9):e3206. Epub 2019 Aug 6.

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia.

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September 2019

Beyond cystic fibrosis transmembrane conductance regulator therapy: a perspective on gene therapy and small molecule treatment for cystic fibrosis.

Authors:

Elena K Schneider-Futschik

Gene Ther 2019 09 12;26(9):354-362. Epub 2019 Jul 12.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.

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September 2019

Predictive factors for lumacaftor/ivacaftor clinical response.

Authors:

Alexandra Masson Elena K Schneider-Futschik Nesrine Baatallah Thao Nguyen-Khoa Emmanuelle Girodon Aurélie Hatton Thomas Flament Muriel Le Bourgeois Frederique Chedevergne Céline Bailly Sylvia Kyrilli Diane Achimastos Alexandre Hinzpeter Aleksander Edelman Isabelle Sermet-Gaudelus

J Cyst Fibros 2019 05 28;18(3):368-374. Epub 2018 Dec 28.

Centre Maladie Rare Mucoviscidose, Hôpital Necker-Enfants Malades, Assistance-Publique Hôpitaux de Paris, 149 rue de sèvres, 75015 Paris, France; Institut Necker-Enfants Malades, INSERM U1151, 149 rue de Sèvres, 75015 Paris, France; Université Paris Sorbonne, 75005 Paris, France. Electronic address:

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May 2019

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR .

Authors:

Maytham Hussein Mei-Ling Han Yan Zhu Elena K Schneider-Futschik Xiaohan Hu Qi Tony Zhou Yu-Wei Lin Dovile Anderson Darren J Creek Daniel Hoyer Jian Li Tony Velkov

Comput Struct Biotechnol J 2018 10;16:587-599. Epub 2018 Nov 10.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville 3010, VIC, Australia.

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November 2018

Contemporary Anti-Ebola Drug Discovery Approaches and Platforms.

Authors:

Elena K Schneider-Futschik Daniel Hoyer Alexander A Khromykh Jonathan B Baell Glenn A Marsh Mark A Baker Jian Li Tony Velkov

ACS Infect Dis 2019 01 20;5(1):35-48. Epub 2018 Dec 20.

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences , The University of Melbourne , Parkville , Victoria 3010 , Australia.

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January 2019

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention.

Authors:

Chongshan Dai Xilong Xiao Jichang Li Giuseppe D Ciccotosto Roberto Cappai Shusheng Tang Elena K Schneider-Futschik Daniel Hoyer Tony Velkov Jianzhong Shen

ACS Chem Neurosci 2019 01 7;10(1):120-131. Epub 2018 Nov 7.

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine , China Agricultural University , No. 2 Yuanmingyuan West Road , Beijing 100193 , P. R. China.

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January 2019