Publications by authors named "Elena B Pasquale"

100Publications

Ligand bias in receptor tyrosine kinase signaling.

J Biol Chem 2020 10 29. Epub 2020 Oct 29.

Dept. of Materials Science and Engineering, Johns Hopkins University, United States.

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http://dx.doi.org/10.1074/jbc.REV120.015190DOI Listing
October 2020

Noncanonical EphA2 Signaling Is a Driver of Tumor-Endothelial Cell Interactions and Metastatic Dissemination in BRAF Inhibitor‒Resistant Melanoma.

J Invest Dermatol 2020 Sep 2. Epub 2020 Sep 2.

The Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA; The Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.

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http://dx.doi.org/10.1016/j.jid.2020.08.012DOI Listing
September 2020

Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.

J Neurosci 2020 Jul 29;40(31):5908-5921. Epub 2020 Jun 29.

Neuroscience Initiative, and Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037

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http://dx.doi.org/10.1523/JNEUROSCI.0723-20.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392511PMC
July 2020

Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex.

Dev Cell 2020 Aug 22;54(3):302-316.e7. Epub 2020 Jun 22.

Department of Pharmacology, University of California, San Diego, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Moores Cancer Center, Department of Pediatrics, University of California, San Diego, San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423770PMC
August 2020

Protein kinase C phosphorylates the EphA2 receptor on serine 892 in the regulatory linker connecting the kinase and SAM domains.

Cell Signal 2020 Sep 13;73:109668. Epub 2020 May 13.

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2020.109668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668293PMC
September 2020

A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors.

J Biol Chem 2020 02 17;295(9):2601-2613. Epub 2020 Jan 17.

Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037

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http://dx.doi.org/10.1074/jbc.RA119.010838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049970PMC
February 2020

Eph receptors and ephrins engage in cellular cannibalism.

Authors:
Elena B Pasquale

J Cell Biol 2019 10 19;218(10):3168-3170. Epub 2019 Sep 19.

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

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http://dx.doi.org/10.1083/jcb.201908074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781436PMC
October 2019

Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.

J Biol Chem 2019 05 23;294(22):8791-8805. Epub 2019 Apr 23.

From the Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037 and

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http://dx.doi.org/10.1074/jbc.RA119.008213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552433PMC
May 2019

Genetically Encoded FRET Biosensor for Visualizing EphA4 Activity in Different Compartments of the Plasma Membrane.

ACS Sens 2019 02 16;4(2):294-300. Epub 2019 Jan 16.

Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.

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http://dx.doi.org/10.1021/acssensors.8b00465DOI Listing
February 2019

Erratum: Author Correction: The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures.

Commun Biol 2018 19;1:40. Epub 2018 Apr 19.

Department of Materials Science and Engineering, Johns Hopkins University, 3400 Charles Street, Baltimore, MD, 21218, USA.

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http://www.nature.com/articles/s42003-018-0044-4
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http://dx.doi.org/10.1038/s42003-018-0044-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123739PMC
April 2018

The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures.

Commun Biol 2018 22;1:15. Epub 2018 Feb 22.

Department of Materials Science and Engineering, Johns Hopkins University, 3400 Charles Street, Baltimore, MD, 21218, USA.

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http://www.nature.com/articles/s42003-018-0017-7
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http://dx.doi.org/10.1038/s42003-018-0017-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123813PMC
February 2018

SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.

J Exp Med 2017 Dec 7;214(12):3669-3685. Epub 2017 Nov 7.

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

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http://dx.doi.org/10.1084/jem.20171413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716044PMC
December 2017

Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.

ACS Med Chem Lett 2017 Jul 12;8(7):726-731. Epub 2017 Jun 12.

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512124PMC
July 2017

The SAM domain inhibits EphA2 interactions in the plasma membrane.

Biochim Biophys Acta Mol Cell Res 2017 Jan 21;1864(1):31-38. Epub 2016 Oct 21.

Department of Materials Science and Engineering, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, United States; Program in Molecular Biophysics, Johns Hopkins University, 3400 Charles street, Baltimore, MD 21218, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148718PMC
January 2017

Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability.

ACS Med Chem Lett 2016 Sep 25;7(9):841-6. Epub 2016 Jun 25.

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States; Pathology Department, University of California, San Diego, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018863PMC
September 2016

Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation.

Mol Biol Cell 2016 09 6;27(17):2757-70. Epub 2016 Jul 6.

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037 Pathology Department, University of California, San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1091/mbc.E16-01-0048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007095PMC
September 2016

Exosomes expand the sphere of influence of Eph receptors and ephrins.

Authors:
Elena B Pasquale

J Cell Biol 2016 07 27;214(1):5-7. Epub 2016 Jun 27.

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037

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http://dx.doi.org/10.1083/jcb.201606074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932377PMC
July 2016

A small peptide promotes EphA2 kinase-dependent signaling by stabilizing EphA2 dimers.

Biochim Biophys Acta 2016 09 6;1860(9):1922-8. Epub 2016 Jun 6.

Department of Materials Science and Engineering, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2016.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950921PMC
September 2016

Regional expression and ultrastructural localization of EphA7 in the hippocampus and cerebellum of adult rat.

J Comp Neurol 2016 08 26;524(12):2462-78. Epub 2016 Feb 26.

Département de neurosciences and Groupe de recherche sur le système nerveux central (GRSNC), Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1002/cne.23962DOI Listing
August 2016

EphA2 Receptor Unliganded Dimers Suppress EphA2 Pro-tumorigenic Signaling.

J Biol Chem 2015 Nov 11;290(45):27271-9. Epub 2015 Sep 11.

From the Department of Materials Science and Engineering and Program in Molecular Biophysics, The Johns Hopkins University, Baltimore, Maryland 21218 and

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http://dx.doi.org/10.1074/jbc.M115.676866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646390PMC
November 2015

Unliganded EphA3 dimerization promoted by the SAM domain.

Biochem J 2015 Oct 31;471(1):101-9. Epub 2015 Jul 31.

Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21212, U.S.A. Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD 21212, U.S.A.

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http://www.biochemj.org/content/ppbiochemj/471/1/101.full.pd
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http://www.biochemj.org/content/ppbiochemj/early/2015/07/31/
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http://biochemj.org/cgi/doi/10.1042/BJ20150433
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http://dx.doi.org/10.1042/BJ20150433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692061PMC
October 2015

Targeting the Eph System with Peptides and Peptide Conjugates.

Curr Drug Targets 2015 ;16(10):1031-47

Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861043PMC
http://dx.doi.org/10.2174/1389450116666150727115934DOI Listing
July 2016

Eph receptors and ephrins: therapeutic opportunities.

Annu Rev Pharmacol Toxicol 2015 3;55:465-87. Epub 2014 Oct 3.

Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037; email: ,

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http://dx.doi.org/10.1146/annurev-pharmtox-011112-140226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388660PMC
September 2015

Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor.

ACS Chem Biol 2014 Dec 14;9(12):2787-95. Epub 2014 Oct 14.

Cancer Center, Sanford-Burnham Medical Research Institute , 10901 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/cb500677xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273976PMC
December 2014

Design, synthesis and bioevaluation of an EphA2 receptor-based targeted delivery system.

ChemMedChem 2014 Jul 26;9(7):1403-12. Epub 2014 Mar 26.

Cancer Research Center, Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037 (USA).

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http://dx.doi.org/10.1002/cmdc.201400067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082471PMC
July 2014

EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers.

PLoS One 2014 21;9(3):e92309. Epub 2014 Mar 21.

Departamento de Biología Celular y Molecular, Laboratorio de Señalización Celular, Facultad de Ciencias Biológicas, P. Universidad Católica de Chile, Santiago, Chile.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092309PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962387PMC
January 2015

Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance.

J Biol Chem 2014 Apr 28;289(15):10431-44. Epub 2014 Feb 28.

From the Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and.

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http://dx.doi.org/10.1074/jbc.M113.541839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036165PMC
April 2014

Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands.

PLoS One 2013 29;8(11):e81445. Epub 2013 Nov 29.

Sanford-Burnham Medical Research Institute, San Diego, California, United States of America ; Department of Pathology, University of California San Diego, San Diego, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081445PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857839PMC
July 2014

Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor.

ACS Med Chem Lett 2013 Feb;4(3)

SUNY Upstate Cancer Research Institute, Department of Pharmacology, State University of New York, Syracuse, New York 13210, USA.

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http://dx.doi.org/10.1021/ml3004523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807576PMC
February 2013

Eph receptor signaling and ephrins.

Cold Spring Harb Perspect Biol 2013 Sep 1;5(9). Epub 2013 Sep 1.

Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1101/cshperspect.a009159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753714PMC
September 2013

Ephrin-A1/EphA4-mediated adhesion of monocytes to endothelial cells.

Biochim Biophys Acta 2013 Oct 23;1833(10):2201-11. Epub 2013 May 23.

Department of Internal Medicine and Cardiology, Dresden University of Technology, Dresden, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2013.05.017DOI Listing
October 2013

Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.

Nat Commun 2013 ;4:1681

Program in Apoptosis and Cell Death Research, Cancer Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/ncomms2687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640864PMC
October 2013

Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4.

Biochem Pharmacol 2013 Feb 17;85(4):507-13. Epub 2012 Dec 17.

SUNY Upstate Cancer Research Institute, Department of Pharmacology, State University of New York, Syracuse, NY 13210, USA.

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http://dx.doi.org/10.1016/j.bcp.2012.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807243PMC
February 2013

NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer.

Genes Cancer 2012 May;3(5-6):382-93

Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1177/1947601912460050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513790PMC
May 2012

Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols.

Pharmacol Res 2012 Oct 28;66(4):363-73. Epub 2012 Jun 28.

Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.phrs.2012.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677025PMC
October 2012

Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach.

Cell Adh Migr 2012 Mar-Apr;6(2):102-12. Epub 2012 Mar 1.

Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.4161/cam.19620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499309PMC
November 2012

Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells.

J Med Chem 2012 Mar 27;55(5):2427-36. Epub 2012 Feb 27.

Cancer Research Center, Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/jm201743sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299084PMC
March 2012

Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms.

Biochemistry 2012 Feb 8;51(7):1464-75. Epub 2012 Feb 8.

Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://pubs.acs.org/doi/10.1021/bi2014079
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http://dx.doi.org/10.1021/bi2014079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471792PMC
February 2012

NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.

Nat Struct Mol Biol 2011 Nov 13;18(12):1381-7. Epub 2011 Nov 13.

Program of Apoptosis and Cell Death Research, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nsmb.2152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230775PMC
November 2011

Targeting Eph receptors with peptides and small molecules: progress and challenges.

Semin Cell Dev Biol 2012 Feb 25;23(1):51-7. Epub 2011 Oct 25.

Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10849521110021
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http://dx.doi.org/10.1016/j.semcdb.2011.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319464PMC
February 2012

Complementary expression and repulsive signaling suggest that EphB receptors and ephrin-B ligands control cell positioning in the gastric epithelium.

Histochem Cell Biol 2011 Dec 30;136(6):617-36. Epub 2011 Sep 30.

Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-Ourai-Kita, Izumisano, Osaka 598-8531, Japan.

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http://link.springer.com/10.1007/s00418-011-0867-2
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http://dx.doi.org/10.1007/s00418-011-0867-2DOI Listing
December 2011

EphB signaling inhibits gap junctional intercellular communication and synchronized contraction in cultured cardiomyocytes.

Basic Res Cardiol 2011 Nov 3;106(6):1057-68. Epub 2011 Sep 3.

Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-Ourai-Kita, Izumisano, Osaka 598-8531, Japan.

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http://link.springer.com/10.1007/s00395-011-0219-3
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http://dx.doi.org/10.1007/s00395-011-0219-3DOI Listing
November 2011

Eph receptors and ephrins in neuron-astrocyte communication at synapses.

Glia 2011 Nov 17;59(11):1567-78. Epub 2011 Aug 17.

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Canada.

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http://dx.doi.org/10.1002/glia.21226DOI Listing
November 2011

Restraining stem cell niche plasticity: a new talent of Eph receptors.

Cell Stem Cell 2010 Dec;7(6):647-8

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, QC, Canada.

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http://dx.doi.org/10.1016/j.stem.2010.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040214PMC
December 2010

SHEP1 partners with CasL to promote marginal zone B-cell maturation.

Proc Natl Acad Sci U S A 2010 Nov 18;107(44):18944-9. Epub 2010 Oct 18.

Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1007558107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973925PMC
November 2010

Structure-activity relationship analysis of peptides targeting the EphA2 receptor.

Biochemistry 2010 Aug;49(31):6687-95

Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/bi1006223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932750PMC
August 2010

The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas.

Cell Signal 2010 Nov 24;22(11):1745-52. Epub 2010 Jul 24.

Sanford-Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.cellsig.2010.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948029PMC
November 2010

Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse.

Dev Biol 2010 Aug 27;344(2):1035-46. Epub 2010 Jun 27.

Sanford-Burnham Medical Research Institute, Cancer Center, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.ydbio.2010.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197744PMC
August 2010

Eph receptors and ephrins in cancer: bidirectional signalling and beyond.

Authors:
Elena B Pasquale

Nat Rev Cancer 2010 Mar;10(3):165-80

Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://www.nature.com/articles/nrc2806
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http://dx.doi.org/10.1038/nrc2806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921274PMC
March 2010

EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain.

J Neurochem 2010 Apr 12;113(1):153-65. Epub 2010 Jan 12.

Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06582.xDOI Listing
April 2010

Tsc2-Rheb signaling regulates EphA-mediated axon guidance.

Nat Neurosci 2010 Feb 10;13(2):163-72. Epub 2010 Jan 10.

The F.M. Kirby Neurobiology Center, Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nn.2477
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http://dx.doi.org/10.1038/nn.2477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812631PMC
February 2010

Proliferation and tumor suppression: not mutually exclusive for Eph receptors.

Cancer Cell 2009 Dec;16(6):452-4

Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.11.008DOI Listing
December 2009

Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity.

J Biol Chem 2010 Jan 29;285(1):644-54. Epub 2009 Oct 29.

Department of Biological Sciences, Faculty of Science, National University of Singapore, 10 Kent Ridge Crescent, Singapore.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.064824
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http://dx.doi.org/10.1074/jbc.M109.064824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804212PMC
January 2010

Journal club. A biologist is gratified to find reconciliation for a conflicted receptor.

Authors:
Elena B Pasquale

Nature 2009 Sep;461(7261):149

Burnham Institute for Medical Research, La Jolla, California, USA.

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http://dx.doi.org/10.1038/461149eDOI Listing
September 2009

Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport.

Proc Natl Acad Sci U S A 2009 Jul 10;106(30):12524-9. Epub 2009 Jul 10.

Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0903328106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718351PMC
July 2009

Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor.

Biochem J 2009 Aug 27;422(3):433-42. Epub 2009 Aug 27.

The Burnham Institute for Medical Research, La Jolla, CA 92037, U.S.A.

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http://dx.doi.org/10.1042/BJ20090014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866036PMC
August 2009

Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus.

J Comp Neurol 2009 Feb;512(6):798-813

Département de Pathologie et Biologie Cellulaire, Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montréal, Québec, Canada.

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http://doi.wiley.com/10.1002/cne.21922
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February 2009

Heparan sulfate regulates ephrin-A3/EphA receptor signaling.

Proc Natl Acad Sci U S A 2008 Aug 20;105(34):12307-12. Epub 2008 Aug 20.

Sanford Children's Health Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0801302105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527907PMC
August 2008

Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor.

J Biol Chem 2008 Oct 14;283(43):29473-84. Epub 2008 Aug 14.

Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 11926.

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http://dx.doi.org/10.1074/jbc.M804114200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662028PMC
October 2008

Protein kinase D is a positive regulator of Bit1 apoptotic function.

J Biol Chem 2008 Oct 14;283(42):28029-37. Epub 2008 Aug 14.

Burnham Institute for Medical Research at the University of California Santa Barbara, University of California, Santa Barbara, California 93106-9610, USA.

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http://dx.doi.org/10.1074/jbc.M803139200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568913PMC
October 2008

Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain.

J Neurochem 2008 Jul 12;106(2):682-95. Epub 2008 Apr 12.

Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central (GRSNC), Université de Montréal, Montréal, Quebéc, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05416.xDOI Listing
July 2008

Neuroscience. Axons seek neighborly advice.

Science 2008 Apr;320(5873):185-6

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada.

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http://dx.doi.org/10.1126/science.1157605DOI Listing
April 2008

Eph-ephrin bidirectional signaling in physiology and disease.

Authors:
Elena B Pasquale

Cell 2008 Apr;133(1):38-52

Burnham Institute for Medical Research, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740800386
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http://dx.doi.org/10.1016/j.cell.2008.03.011DOI Listing
April 2008

A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature.

Transgenic Res 2008 Jun 20;17(3):403-15. Epub 2007 Nov 20.

Burnham Institute for Medical Research, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

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http://link.springer.com/content/pdf/10.1007/s11248-007-9156
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June 2008

The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies.

Biopolymers 2008 Jan;89(1):86-92

Cancer Center and Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/bip.20862DOI Listing
January 2008

Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.

J Biol Chem 2007 Dec 26;282(50):36505-13. Epub 2007 Sep 26.

Department of Cellular Biology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M706340200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370777PMC
December 2007

The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways.

J Cell Biol 2007 Sep 17;178(7):1295-307. Epub 2007 Sep 17.

Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1083/jcb.200610139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064660PMC
September 2007

Paradoxes of the EphB4 receptor in cancer.

Cancer Res 2007 May;67(9):3994-7

Burnham Institute for Medical Research and Pathology Department, University of California San Diego, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0525DOI Listing
May 2007

Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus.

J Comp Neurol 2007 Apr;501(5):691-702

Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1002/cne.21263DOI Listing
April 2007

Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia.

Development 2006 Dec 15;133(24):4839-47. Epub 2006 Nov 15.

Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

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http://dx.doi.org/10.1242/dev.02662DOI Listing
December 2006

The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization.

J Biol Chem 2006 Oct 31;281(43):32574-86. Epub 2006 Aug 31.

Division of Biomedical Sciences, University of California-Riverside, Riverside, CA 92521, USA.

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http://dx.doi.org/10.1074/jbc.M604338200DOI Listing
October 2006

The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway.

Nat Cell Biol 2006 Aug 23;8(8):815-25. Epub 2006 Jul 23.

Burnham Institute for Medical Research, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/ncb1438DOI Listing
August 2006

Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion.

J Cell Sci 2006 Apr 7;119(Pt 7):1244-54. Epub 2006 Mar 7.

The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1242/jcs.02842DOI Listing
April 2006

EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases.

J Cell Sci 2006 Feb;119(Pt 3):559-70

Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.

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http://dx.doi.org/10.1242/jcs.02777DOI Listing
February 2006