Publications by authors named "Eleftherios Kostaras"

9Publications

Inhibitors in AKTion: ATP-competitive vs allosteric.

Authors:
Glorianne Lazaro Eleftherios Kostaras Igor Vivanco

Biochem Soc Trans 2020 06;48(3):933-943

Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd., SM2 5NG London, U.K.

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June 2020

A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.

Authors:
Eleftherios Kostaras Teresa Kaserer Glorianne Lazaro Sara Farrah Heuss Aasia Hussain Pedro Casado Angela Hayes Cihangir Yandim Nicolaos Palaskas Yi Yu Brian Schwartz Florence Raynaud Yuen-Li Chung Pedro R Cutillas Igor Vivanco

Br J Cancer 2020 Aug 22;123(4):542-555. Epub 2020 May 22.

Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, SM2 5NG, London, UK.

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August 2020

Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.

Authors:
Andrew D Jenks Simon Vyse Jocelyn P Wong Eleftherios Kostaras Deborah Keller Thomas Burgoyne Amelia Shoemark Athanasios Tsalikis Maike de la Roche Martin Michaelis Jindrich Cinatl Paul H Huang Barbara E Tanos

Cell Rep 2018 06;23(10):3042-3055

Division of Cancer Therapeutics, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK. Electronic address:

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June 2018

Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models.

Authors:
Victoria L Bridgeman Peter B Vermeulen Shane Foo Agnes Bilecz Frances Daley Eleftherios Kostaras Mark R Nathan Elaine Wan Sophia Frentzas Thomas Schweiger Balazs Hegedus Konrad Hoetzenecker Ferenc Renyi-Vamos Elizabeth A Kuczynski Naveen S Vasudev James Larkin Martin Gore Harold F Dvorak Sandor Paku Robert S Kerbel Balazs Dome Andrew R Reynolds

J Pathol 2017 Feb 29;241(3):362-374. Epub 2016 Dec 29.

Tumour Biology Team, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

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February 2017

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases.

Authors:
Sophia Frentzas Eve Simoneau Victoria L Bridgeman Peter B Vermeulen Shane Foo Eleftherios Kostaras Mark Nathan Andrew Wotherspoon Zu-Hua Gao Yu Shi Gert Van den Eynden Frances Daley Clare Peckitt Xianming Tan Ayat Salman Anthoula Lazaris Patrycja Gazinska Tracy J Berg Zak Eltahir Laila Ritsma Jacco Van Rheenen Alla Khashper Gina Brown Hanna Nystrom Malin Sund Steven Van Laere Evelyne Loyer Luc Dirix David Cunningham Peter Metrakos Andrew R Reynolds

Nat Med 2016 11 17;22(11):1294-1302. Epub 2016 Oct 17.

Tumour Biology Team, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

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November 2016

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis.

Authors:
Cassie J Clarke Tracy J Berg Joanna Birch Darren Ennis Louise Mitchell Catherine Cloix Andrew Campbell David Sumpton Colin Nixon Kirsteen Campbell Victoria L Bridgeman Peter B Vermeulen Shane Foo Eleftherios Kostaras J Louise Jones Linda Haywood Ellie Pulleine Huabing Yin Douglas Strathdee Owen Sansom Karen Blyth Iain McNeish Sara Zanivan Andrew R Reynolds Jim C Norman

Curr Biol 2016 Mar 3;26(6):755-65. Epub 2016 Mar 3.

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address:

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March 2016

Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity.

Authors:
Alexandra Primikyri Maria V Chatziathanasiadou Evdoxia Karali Eleftherios Kostaras Michalis D Mantzaris Eleftheria Hatzimichael Jae-Sun Shin Seung-Wook Chi Evangelos Briasoulis Evangelos Kolettas Ioannis P Gerothanassis Andreas G Tzakos

ACS Chem Biol 2014 Dec 9;9(12):2737-41. Epub 2014 Oct 9.

Section of Organic Chemistry and Biochemistry, Department of Chemistry, ‡Laboratory of Biological Chemistry, School of Medicine, §Cancer Biobank Center, and ⊥Department of Hematology, School of Medicine, ▽Laboratory of Biology, School of Medicine, University of Ioannina , 45110 Ioannina, Greece.

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December 2014

SARA and RNF11 at the crossroads of EGFR signaling and trafficking.

Authors:
Eleftherios Kostaras Nina Marie Pedersen Harald Stenmark Theodore Fotsis Carol Murphy

Methods Enzymol 2014 ;535:225-47

Department of Biomedical Research, Foundation for Research & Technology - Hellas, Institute of Molecular Biology & Biotechnology, University Campus of Ioannina, Ioannina, Greece. Electronic address:

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August 2014

ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN.

Authors:
George Sflomos Eleftherios Kostaras Ekaterini Panopoulou Nikolaos Pappas Athena Kyrkou Anastasia S Politou Theodore Fotsis Carol Murphy

J Cell Sci 2011 Oct 30;124(Pt 19):3209-22. Epub 2011 Aug 30.

Laboratory of Biological Chemistry, Medical School, University of Ioannina, 45110 Ioannina, Greece.

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October 2011