Eleanor N Fish

Eleanor N Fish

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Eleanor N Fish

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Amanda E. I. Proudfoot 1949-2019.

Authors:
Eleanor N Fish

Nat Immunol 2020 03;21(3):241

Department of Immunology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41590-020-0603-yDOI Listing
March 2020

Global virus outbreaks: Interferons as 1st responders.

Semin Immunol 2019 06;43:101300

Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, ON M5G 2M1, Canada; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2019.101300DOI Listing
June 2019

IFN-γ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5.

Sci Signal 2018 11 20;11(557). Epub 2018 Nov 20.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1126/scisignal.aap9921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684240PMC
November 2018

Chemokines in breast cancer: Regulating metabolism.

Cytokine 2018 09;109:57-64

Dept. Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Bldg., Toronto, Ontario M5S 1A8, Canada; Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, Ontario M5G 2M1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.02.010DOI Listing
September 2018

CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis.

BMC Cancer 2017 12 8;17(1):834. Epub 2017 Dec 8.

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1186/s12885-017-3817-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721608PMC
December 2017

Interferon-β regulates dendritic cell activation and migration in experimental autoimmune encephalomyelitis.

Immunology 2017 11 21;152(3):439-450. Epub 2017 Jul 21.

Toronto General Research Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/imm.12781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629448PMC
November 2017

Cutting Edge: Endogenous IFN-β Regulates Survival and Development of Transitional B Cells.

J Immunol 2017 10 13;199(8):2618-2623. Epub 2017 Sep 13.

Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294;

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http://dx.doi.org/10.4049/jimmunol.1700888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636672PMC
October 2017

Interleukin-34 Promotes Fibrocyte Proliferation.

J Interferon Cytokine Res 2017 10 3;37(10):440-448. Epub 2017 Oct 3.

1 Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network , Toronto, Canada .

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http://dx.doi.org/10.1089/jir.2017.0063DOI Listing
October 2017

Interactions Between NS1 of Influenza A Viruses and Interferon-α/β: Determinants for Vaccine Development.

J Interferon Cytokine Res 2017 08 17;37(8):331-341. Epub 2017 May 17.

1 Toronto General Hospital Research Institute, University Health Network , Toronto, Ontario, Canada .

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http://dx.doi.org/10.1089/jir.2017.0032DOI Listing
August 2017

Residues F103 and M106 within the influenza A virus NS1 CPSF4-binding region regulate interferon-stimulated gene translation initiation.

Virology 2017 08 26;508:170-179. Epub 2017 May 26.

Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8; Toronto General Hospital Research Institute, University Health Network, 67 College Street, Room 424, Toronto, Ontario, Canada M5G 2M1. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2017.05.009DOI Listing
August 2017

A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection.

Viruses 2017 05 12;9(5). Epub 2017 May 12.

Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, ON M5G 2M1, Canada.

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http://dx.doi.org/10.3390/v9050107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454420PMC
May 2017

Interferon-Stimulated Gene Expression as a Preferred Biomarker for Disease Activity in Aicardi-Goutières Syndrome.

J Interferon Cytokine Res 2017 04 17;37(4):147-152. Epub 2017 Feb 17.

1 Toronto General Research Institute, University Health Network , Toronto, Ontario, Canada .

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http://dx.doi.org/10.1089/jir.2016.0117DOI Listing
April 2017

CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells.

Open Biol 2016 06;6(6)

Toronto General Research Institute, University Health Network, Toronto, Canada Department of Immunology, University of Toronto, Toronto, Canada

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http://rsob.royalsocietypublishing.org/content/royopenbio/6/
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http://dx.doi.org/10.1098/rsob.160122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929946PMC
June 2016

Fibrocyte and T cell interactions promote disease pathogenesis in rheumatoid arthritis.

J Autoimmun 2016 May 3;69:38-50. Epub 2016 Mar 3.

Toronto General Research Institute, University Health Network, Toronto, Canada; Department of Immunology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.02.008DOI Listing
May 2016

Small Molecule Agonists for the Type I Interferon Receptor: An In Silico Approach.

J Interferon Cytokine Res 2016 Mar 24;36(3):180-91. Epub 2015 Dec 24.

2 Toronto General Research Institute, University Health Network , Toronto, Canada .

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http://dx.doi.org/10.1089/jir.2015.0123DOI Listing
March 2016

Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses.

J Biol Chem 2016 Jan 8;291(5):2389-96. Epub 2015 Dec 8.

From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612,

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http://dx.doi.org/10.1074/jbc.M115.664995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732221PMC
January 2016

Central role of ULK1 in type I interferon signaling.

Cell Rep 2015 Apr 16;11(4):605-17. Epub 2015 Apr 16.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477687PMC
April 2015

Sex-based differences in immune function and responses to vaccination.

Trans R Soc Trop Med Hyg 2015 Jan;109(1):9-15

Department of Immunology, University of Toronto, Canada Toronto General Research Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1093/trstmh/tru167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447843PMC
January 2015

Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.

Mol Cancer Res 2014 Dec 12;12(12):1691-703. Epub 2014 Sep 12.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School and Jesse Brown VA Medical Center, Chicago, Illinois.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-14
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http://dx.doi.org/10.1158/1541-7786.MCR-14-0450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272667PMC
December 2014

Regulatory effects of SKAR in interferon α signaling and its role in the generation of type I IFN responses.

Proc Natl Acad Sci U S A 2014 Aug 21;111(31):11377-82. Epub 2014 Jul 21.

Robert H. Lurie Comprehensive Cancer Center andDivision of Hematology/Oncology, Northwestern University Medical School, Chicago, IL 60611;Division of Hematology/Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612;

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http://dx.doi.org/10.1073/pnas.1405250111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128135PMC
August 2014

Immunoregulatory effects of interferon-β in suppression of Th17 cells.

J Interferon Cytokine Res 2014 May 31;34(5):330-41. Epub 2013 Oct 31.

1 Toronto General Research Institute, University Health Network , Toronto, Canada .

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http://dx.doi.org/10.1089/jir.2013.0088DOI Listing
May 2014

Small molecule mimetics of an interferon-α receptor interacting domain.

Bioorg Med Chem 2014 Feb 2;22(3):978-85. Epub 2014 Jan 2.

Center for Molecular Design and Preformulations, University Health Network, Toronto, Ontario M5G 1L7, Canada; Toronto General Research Institute, Toronto, Ontario M5G 2M1, Canada; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; McLaughlin Center for Molecular Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.12.049DOI Listing
February 2014

STAT activation in malignancies: roles in tumor progression and in the generation of antineoplastic effects of IFNs.

J Interferon Cytokine Res 2013 Apr;33(4):181-8

Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/jir.2012.0154DOI Listing
April 2013

The schlafen family of proteins and their regulation by interferons.

J Interferon Cytokine Res 2013 Apr;33(4):206-10

Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1089/jir.2012.0133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624771PMC
April 2013

The role of circulating fibrocytes in inflammation and autoimmunity.

J Leukoc Biol 2013 Jan 19;93(1):45-50. Epub 2012 Sep 19.

University Health Network, 67 College St., Toronto, Ontario, Canada.

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http://dx.doi.org/10.1189/jlb.0712365DOI Listing
January 2013

Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses.

J Biol Chem 2012 Dec 16;287(50):42352-60. Epub 2012 Oct 16.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M112.400721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516778PMC
December 2012

Circulating fibrocytes contribute to the pathogenesis of collagen antibody-induced arthritis.

Arthritis Rheum 2012 Nov;64(11):3583-93

Toronto General Research Institute, University Health Network, Ontario, Canada.

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http://dx.doi.org/10.1002/art.34589DOI Listing
November 2012

WFDC1/ps20: a host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection.

Antiviral Res 2012 Nov 6;96(2):158-68. Epub 2012 Sep 6.

Toronto General Research Institute, Division of Cell and Molecular Biology, University Health Network, 67 College Street, Toronto, Ontario, Canada M5G 2M1.

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http://dx.doi.org/10.1016/j.antiviral.2012.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114264PMC
November 2012

LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection.

J Exp Med 2012 Sep 17;209(10):1853-67. Epub 2012 Sep 17.

Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20112256
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http://dx.doi.org/10.1084/jem.20112256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457726PMC
September 2012

The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis.

J Biol Chem 2012 Aug 10;287(35):29406-16. Epub 2012 Jul 10.

Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.348946
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http://dx.doi.org/10.1074/jbc.M112.348946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436201PMC
August 2012

Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses.

Mol Cell Biol 2012 Jul 14;32(14):2809-22. Epub 2012 May 14.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1128/MCB.00310-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416205PMC
July 2012

Sex affects immunity.

J Autoimmun 2012 May 4;38(2-3):J282-91. Epub 2012 Jan 4.

Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S08968411110012
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http://dx.doi.org/10.1016/j.jaut.2011.11.013DOI Listing
May 2012

Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses.

Proc Natl Acad Sci U S A 2012 May 1;109(20):7723-8. Epub 2012 May 1.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, Chicago, IL 60611, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1118122109
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http://dx.doi.org/10.1073/pnas.1118122109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356630PMC
May 2012

The yin and yang of viruses and interferons.

Trends Immunol 2012 Apr 7;33(4):190-7. Epub 2012 Feb 7.

University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.it.2012.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106503PMC
April 2012

Glomulin: a permissivity factor for vaccinia virus infection.

J Interferon Cytokine Res 2012 Mar 26;32(3):127-37. Epub 2012 Jan 26.

Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/jir.2011.0100DOI Listing
March 2012

Antiviral effects of interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3.

Antivir Ther 2011 ;16(4):577-84

Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.3851/IMP1752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142995PMC
October 2011

Interferon: current status and future prospects in cancer therapy.

J Interferon Cytokine Res 2011 Jul 16;31(7):545-52. Epub 2011 Feb 16.

Department of Immunology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1089/jir.2010.0158DOI Listing
July 2011

Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis.

J Biol Chem 2011 Feb 13;286(8):6017-26. Epub 2010 Dec 13.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M110.197921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057839PMC
February 2011

Regulatory effects of ribosomal S6 kinase 1 (RSK1) in IFNλ signaling.

J Biol Chem 2011 Jan 12;286(2):1147-56. Epub 2010 Nov 12.

Division of Hematology-Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60611, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.183566
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http://dx.doi.org/10.1074/jbc.M110.183566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020721PMC
January 2011

Interferon-β modulates type 1 immunity during influenza virus infection.

Antiviral Res 2010 Oct 24;88(1):64-71. Epub 2010 Jul 24.

Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1016/j.antiviral.2010.07.006DOI Listing
October 2010

Identification of a novel antigen-presenting cell population modulating antiinfluenza type 2 immunity.

J Exp Med 2010 Jul 14;207(7):1435-51. Epub 2010 Jun 14.

Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada.

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http://www.jem.org/lookup/doi/10.1084/jem.20091373
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http://dx.doi.org/10.1084/jem.20091373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901068PMC
July 2010

Fibrocyte activation in rheumatoid arthritis.

Rheumatology (Oxford) 2010 Apr 25;49(4):640-51. Epub 2009 Oct 25.

Toronto General Research Institute, University Health Network, 67 College Street, 4-424, Toronto, Ontario M5G 2M1, Canada.

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http://dx.doi.org/10.1093/rheumatology/kep265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909797PMC
April 2010

Role of Schlafen 2 (SLFN2) in the generation of interferon alpha-induced growth inhibitory responses.

J Biol Chem 2009 Sep 10;284(37):25051-64. Epub 2009 Jul 10.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M109.030445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757209PMC
September 2009

CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation.

Biochem Biophys Res Commun 2009 Sep 14;387(2):381-6. Epub 2009 Jul 14.

Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Ont, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0901381
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http://dx.doi.org/10.1016/j.bbrc.2009.07.035DOI Listing
September 2009

Dynamic accumulation of plasmacytoid dendritic cells in lymph nodes is regulated by interferon-beta.

Blood 2009 Sep 3;114(13):2623-31. Epub 2009 Aug 3.

Department of Immunology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2008-10-183301DOI Listing
September 2009

Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses.

Proc Natl Acad Sci U S A 2009 Jul 2;106(29):12097-102. Epub 2009 Jul 2.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology- Oncology, Northwestern University Medical School, and Jesse Brown Veterans Administration Medical Center, Chicago, IL 60611, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0900562106
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http://dx.doi.org/10.1073/pnas.0900562106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715502PMC
July 2009

Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals.

Mol Cell Biol 2009 May 16;29(10):2865-75. Epub 2009 Mar 16.

Robert H. Lurie Comprehensive Cancer Center and and Division of Hematology-Oncology, Northwestern University Medical School, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/MCB.01537-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682034PMC
May 2009

Activation of protein kinase C{eta} by type I interferons.

J Biol Chem 2009 Apr 11;284(16):10301-14. Epub 2009 Feb 11.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology/Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M807254200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667717PMC
April 2009

Role for CCR5 in dissemination of vaccinia virus in vivo.

J Virol 2009 Mar 10;83(5):2226-36. Epub 2008 Dec 10.

Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01655-08
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http://dx.doi.org/10.1128/JVI.01655-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643720PMC
March 2009

Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling.

J Immunol 2008 Nov;181(10):7316-23

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, Chicago, IL 60611, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597572PMC
http://dx.doi.org/10.4049/jimmunol.181.10.7316DOI Listing
November 2008

The X-files in immunity: sex-based differences predispose immune responses.

Authors:
Eleanor N Fish

Nat Rev Immunol 2008 Sep;8(9):737-44

Toronto General Research Institute, University Health Network, Department of Immunology, University of Toronto, Women's College Research Institute, Ontario, Canada.

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http://dx.doi.org/10.1038/nri2394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097214PMC
September 2008

The role of consensus interferon in the current treatment of chronic hepatitis C viral infection.

Gastroenterol Hepatol (N Y) 2008 Sep;4(9 18):1-12

Eleanor N. Fish, PhD Division of Cellular & Molecular Biology Toronto General Research Institute.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394503PMC
September 2008

Distinct signature type I interferon responses are determined by the infecting virus and the target cell.

Antivir Ther 2008 ;13(3):409-22

Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network & Department of Immunology, University of Toronto, Toronto, Canada.

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July 2008

CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1.

Blood 2008 May 12;111(10):4892-901. Epub 2008 Mar 12.

Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, ON, Canada.

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http://www.bloodjournal.org/content/111/10/4892.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-11-12
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http://dx.doi.org/10.1182/blood-2007-11-125039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2384123PMC
May 2008

De novo design of nonpeptidic compounds targeting the interactions between interferon-alpha and its cognate cell surface receptor.

J Med Chem 2008 May 5;51(9):2734-43. Epub 2008 Apr 5.

Center for Molecular Design and Preformulations, Toronto General Research Institute, Toronto General Hospital, Toronto, ON M5G 2C4, Canada.

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http://pubs.acs.org/doi/abs/10.1021/jm701182y
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http://dx.doi.org/10.1021/jm701182yDOI Listing
May 2008

Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells.

J Biol Chem 2008 Apr 20;283(16):10793-803. Epub 2008 Feb 20.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M706816200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447623PMC
April 2008

Role of the Akt pathway in mRNA translation of interferon-stimulated genes.

Proc Natl Acad Sci U S A 2008 Mar 13;105(12):4808-13. Epub 2008 Mar 13.

Division of Hematology-Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, IL 60611, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0710907105
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http://dx.doi.org/10.1073/pnas.0710907105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290753PMC
March 2008

A structural basis for interferon-alpha-receptor interactions.

FASEB J 2007 Oct 21;21(12):3288-96. Epub 2007 May 21.

Division of Cell and Molecular Biology, Toronto General Research Institute, Toronto, ON M5G 2M1 Canada.

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http://dx.doi.org/10.1096/fj.07-8585comDOI Listing
October 2007

Interferon-inducible Stat2 activation of JUND and CLDN4: mediators of IFN responses.

J Interferon Cytokine Res 2007 Jul;27(7):559-65

Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Department of Immunology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1089/jir.2007.0014DOI Listing
July 2007

Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling.

J Biol Chem 2007 Jan 17;282(3):1757-68. Epub 2006 Nov 17.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M607365200DOI Listing
January 2007

Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide.

J Biol Chem 2006 Oct 15;281(41):31119-30. Epub 2006 Aug 15.

Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21201, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M604958200
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October 2006

CCL5-CCR5-mediated apoptosis in T cells: Requirement for glycosaminoglycan binding and CCL5 aggregation.

J Biol Chem 2006 Sep 28;281(35):25184-94. Epub 2006 Jun 28.

Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Department of Immunology, University of Toronto, Toronto, Ontario, M5G 2M1, Canada.

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September 2006

Identification of GAS-dependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent.

FEBS J 2006 Apr;273(7):1569-81

Department of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, ON, Canada.

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http://doi.wiley.com/10.1111/j.1742-4658.2006.05176.x
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April 2006

Stats: multifaceted regulators of transcription.

J Interferon Cytokine Res 2005 Dec;25(12):733-44

Division of Cell & Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario M5G 2M1, Canada.

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http://www.liebertpub.com/doi/10.1089/jir.2005.25.733
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December 2005

Chemokines and cancer.

Cancer Treat Res 2005 ;126:15-44

University of Toronto, Department of Immunology & Toronto General Research Institute, University of Health Network, Toronto, ON.

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http://dx.doi.org/10.1007/0-387-24361-5_2DOI Listing
November 2005

Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells.

Blood 2005 Oct 24;106(7):2436-43. Epub 2005 Mar 24.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, Lakeside Veterans Administration Medical Center, Section of Hematology-Oncology, University of Chicago, IL, USA.

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http://dx.doi.org/10.1182/blood-2004-10-4003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895266PMC
October 2005

Genomic DNA affinity chromatography: a technique to isolate interferon-inducible DNA binding factors.

Methods Mol Med 2005 ;116:57-67

Department of Immunology, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1385/1-59259-939-7:057DOI Listing
September 2005

Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells.

Exp Hematol 2005 May;33(5):550-7

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, Ill. 60611, USA.

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http://dx.doi.org/10.1016/j.exphem.2005.01.014DOI Listing
May 2005

Functional relevance of the conserved DNA-binding domain of STAT2.

J Biol Chem 2005 Apr 24;280(13):13029-36. Epub 2005 Jan 24.

Division of Cell & Molecular Biology, Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M500426200
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April 2005

Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons.

J Biol Chem 2005 Mar 11;280(11):10001-10. Epub 2005 Jan 11.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, 710 North Fairbanks St., Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M410972200DOI Listing
March 2005

Protective role for interferon-beta in coxsackievirus B3 infection.

Circulation 2004 Dec 12;110(23):3540-3. Epub 2004 Jul 12.

Toronto General Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/01.CIR.0000136824.73458.20DOI Listing
December 2004

Diversity and relatedness among the type I interferons.

J Interferon Cytokine Res 2004 Dec;24(12):687-98

Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/jir.2004.24.687DOI Listing
December 2004

Engagement of protein kinase C-theta in interferon signaling in T-cells.

J Biol Chem 2004 Jul 18;279(29):29911-20. Epub 2004 May 18.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M401997200DOI Listing
July 2004

Role of the p38 mitogen-activated protein kinase pathway in the generation of the effects of imatinib mesylate (STI571) in BCR-ABL-expressing cells.

J Biol Chem 2004 Jun 31;279(24):25345-52. Epub 2004 Mar 31.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M400590200DOI Listing
June 2004

Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein.

Exp Cell Res 2004 Apr;295(1):173-82

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.yexcr.2003.12.021DOI Listing
April 2004

Role of p38alpha Map kinase in Type I interferon signaling.

J Biol Chem 2004 Jan 24;279(2):970-9. Epub 2003 Oct 24.

Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M309927200DOI Listing
January 2004

Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha.

Proc Natl Acad Sci U S A 2003 Nov 3;100(23):13453-8. Epub 2003 Nov 3.

Toronto General Research Institute, University Health Network, Toronto, ON, Canada MG5 2M1.

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http://www.pnas.org/cgi/doi/10.1073/pnas.2230460100
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC263835PMC
November 2003

Activation of protein kinase C delta by all-trans-retinoic acid.

J Biol Chem 2003 Aug 12;278(35):32544-51. Epub 2003 Jun 12.

Robert H. Lurie Comprehensive Cancer Center and the Division of Hematology-Oncology, Northwestern University Feinberg School of Medicine and Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M301523200DOI Listing
August 2003

Role of Stat5 in type I interferon-signaling and transcriptional regulation.

Biochem Biophys Res Commun 2003 Aug;308(2):325-30

Section of Hematology-Oncology, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/s0006-291x(03)01382-2DOI Listing
August 2003

Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons.

J Biol Chem 2003 Jul 20;278(30):27772-80. Epub 2003 May 20.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M301364200DOI Listing
July 2003

Activation of protein kinase C delta by IFN-gamma.

J Immunol 2003 Jul;171(1):267-73

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, Chicago, IL 60611, USA.

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http://dx.doi.org/10.4049/jimmunol.171.1.267DOI Listing
July 2003

Therapeutic implications for interferon-alpha in arthritis: a pilot study.

J Rheumatol 2003 May;30(5):934-40

Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.

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May 2003

Chemokines: attractive mediators of the immune response.

Semin Immunol 2003 Feb;15(1):5-14

Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1016/s1044-5323(02)00123-9DOI Listing
February 2003