Publications by authors named "Elaine Holmes"

100Publications

Differences in amino acid and lipid metabolism distinguish Crohn's from idiopathic/cryptoglandular perianal fistulas by tissue metabonomic profiling and may offer clues to underlying pathogenesis.

Eur J Gastroenterol Hepatol 2020 Dec 18;Publish Ahead of Print. Epub 2020 Dec 18.

Robin Phillips Fistula Research Unit, St Mark's Hospital and Academic Institute, Harrow, Middlesex Department of Surgery and Cancer Computational Systems Division, Imperial College London, South Kensington Campus, London, UK Department of Gastroenterology, St Vincent's Hospital, Melbourne, Australia.

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December 2020

A simultaneous exploratory and quantitative amino acid and biogenic amine metabolic profiling platform for rapid disease phenotyping via UPLC-QToF-MS.

Talanta 2021 Feb 7;223(Pt 2):121872. Epub 2020 Nov 7.

Australian National Phenome Centre, Health Futures Institute, Murdoch University, Harry Perkins South Building, Perth, WA, 6150, Australia; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Murdoch Perth, WA, 6150, Australia; The Perron Institute for Neurological and Translational Science, Nedlands, WA, 6009, Australia. Electronic address:

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February 2021

Metabolomic Analysis in Inflammatory Bowel Disease: A Systematic Review.

J Crohns Colitis 2020 Nov 11. Epub 2020 Nov 11.

Department of Metabolism Digestion and Reproduction, Imperial College London, United Kingdom.

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November 2020

Nutriome-metabolome relationships provide insights into dietary intake and metabolism.

Nat Food 2020 Jul 22;1(7):426-436. Epub 2020 Jun 22.

Division of Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia.

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July 2020

Improved Spatial Resolution of Metabolites in Tissue Biopsies Using High-Resolution Magic-Angle-Spinning Slice Localization NMR Spectroscopy.

Anal Chem 2020 09 20;92(17):11516-11519. Epub 2020 Aug 20.

Section of Nutrition Research, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, United Kingdom.

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September 2020

Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection.

J Proteome Res 2020 11 14;19(11):4442-4454. Epub 2020 Sep 14.

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.

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November 2020

Identifying unknown metabolites using NMR-based metabolic profiling techniques.

Nat Protoc 2020 08 17;15(8):2538-2567. Epub 2020 Jul 17.

The Australian National Phenome Center, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.

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August 2020

Performance of metabonomic serum analysis for diagnostics in paediatric tuberculosis.

Sci Rep 2020 04 29;10(1):7302. Epub 2020 Apr 29.

Centre for International Child Health, Department of Paediatrics, Imperial College London, St. Mary's Hospital, Praed Street, London, W2 1NY, United Kingdom.

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April 2020

Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery.

Gut 2020 Aug 21;69(8):1452-1459. Epub 2020 Jan 21.

Obstetrics & Gynaecology, Chelsea and Westminster Hospital, Institute of Reproductive Developmental Biology, Department of Metabolism, Digestion & Reproduction, Faculty of Medicine, Imperial College London, London, UK.

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August 2020

Clinical and molecular evidence of accelerated ageing following very preterm birth.

Pediatr Res 2020 05 7;87(6):1005-1010. Epub 2019 Dec 7.

Section of Neonatal Medicine, Department of Medicine, Chelsea and Westminster Campus, Imperial College London, 369 Fulham Road, London, SW10 9NH, UK.

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May 2020

Mass Spectrometry: A Guide for the Clinician.

J Clin Exp Hepatol 2019 Sep-Oct;9(5):597-606. Epub 2019 May 9.

Division of Surgery and Cancer, Imperial College London, London, W2 INY, United Kingdom.

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May 2019

Metabolic Phenotyping in Venous Disease: The Need for Standardization.

J Proteome Res 2019 11 16;18(11):3809-3820. Epub 2019 Oct 16.

Academic Section of Vascular Surgery, Department of Surgery and Cancer , Imperial College London , Floor 4 East, Charing Cross Hospital, Fulham Palace Road , London W6 8RF , U.K.

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November 2019

A Unified Conceptual Framework for Metabolic Phenotyping in Diagnosis and Prognosis.

Trends Pharmacol Sci 2019 10 9;40(10):763-773. Epub 2019 Sep 9.

Division of Computational and Systems Medicine and Medical Research Council (MRC) National Institute for Health Research (NIHR) National Phenome Centre, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK. Electronic address:

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October 2019

Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.

Nutrients 2019 Apr 16;11(4). Epub 2019 Apr 16.

Section for Nutrition Research, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.

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April 2019

Obesity and Cage Environment Modulate Metabolism in the Zucker Rat: A Multiple Biological Matrix Approach to Characterizing Metabolic Phenomena.

J Proteome Res 2019 05 18;18(5):2160-2174. Epub 2019 Apr 18.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine , Imperial College London , London , SW7 2AZ , United Kingdom.

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May 2019

The metabolic fate and effects of 2-Bromophenol in male Sprague-Dawley rats.

Xenobiotica 2019 Nov 22;49(11):1352-1359. Epub 2019 Feb 22.

Department of Surgery and Cancer Faculty of Medicine, Imperial College London, South Kensington Campus, London, United Kingdom.

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November 2019

Profiling inflammatory markers in patients with pneumonia on intensive care.

Sci Rep 2018 10 3;8(1):14736. Epub 2018 Oct 3.

Section of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK.

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October 2018

Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by H NMR Spectroscopy in a Multilaboratory Trial.

Anal Chem 2018 10 27;90(20):11962-11971. Epub 2018 Sep 27.

The Imperial Clinical Phenotyping Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer , QEQM Building, Saint Mary's Hospital , London W2 1NY , United Kingdom.

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October 2018

Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Direct Infusion-High-Resolution Mass Spectrometry for Combined Exploratory and Targeted Metabolic Profiling of Human Urine.

J Proteome Res 2018 10 19;17(10):3492-3502. Epub 2018 Sep 19.

Division of Integrative Systems and Digestive Medicine, Department of Surgery and Cancer , Imperial College London , Sir Alexander Fleming Building, South Kensington Campus , London SW7 2AZ , United Kingdom.

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October 2018

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism.

J Proteome Res 2018 10 20;17(10):3565-3573. Epub 2018 Sep 20.

Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine , Imperial College London , South Kensington Campus , London SW7 2AZ , United Kingdom.

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October 2018

Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota.

Gastroenterology 2018 11 17;155(5):1495-1507.e15. Epub 2018 Jul 17.

Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom; School of Biosciences, Cardiff University, Cardiff, United Kingdom. Electronic address:

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November 2018

The effect of L-rhamnose on intestinal transit time, short chain fatty acids and appetite regulation: a pilot human study using combined CO/H breath tests.

J Breath Res 2018 08 6;12(4):046006. Epub 2018 Aug 6.

Nutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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August 2018

Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model.

Eur J Vasc Endovasc Surg 2018 05 8;55(5):703-713. Epub 2018 Mar 8.

Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, UK. Electronic address:

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May 2018

Optimized Phenotypic Biomarker Discovery and Confounder Elimination via Covariate-Adjusted Projection to Latent Structures from Metabolic Spectroscopy Data.

J Proteome Res 2018 04 27;17(4):1586-1595. Epub 2018 Feb 27.

Department of Preventive Medicine, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States.

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April 2018

Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin.

BMC Med 2018 01 24;16(1). Epub 2018 Jan 24.

Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London, W12 0NN, UK.

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January 2018

Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms.

J Proteome Res 2017 11 4;16(11):4208-4216. Epub 2017 Oct 4.

Department of Urogynaecology, St. Mary's Hospital, Imperial College Healthcare NHS Trust , London W2 1NY, U.K.

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November 2017

Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense Infection.

J Infect Dis 2017 12;216(10):1273-1280

Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, United Kingdom.

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December 2017

Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment.

Sci Rep 2017 07 13;7(1):5310. Epub 2017 Jul 13.

Infection and Immunity, Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, North Somerset, BS40 5DU, UK.

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July 2017

The Plasma and Serum Metabotyping of Hepatocellular Carcinoma in a Nigerian and Egyptian Cohort using Proton Nuclear Magnetic Resonance Spectroscopy.

J Clin Exp Hepatol 2017 Jun 15;7(2):83-92. Epub 2017 Mar 15.

Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary's Campus, South Wharf Road, London W2 1NY, United Kingdom.

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June 2017

Deep learning and 3D-DESI imaging reveal the hidden metabolic heterogeneity of cancer.

Chem Sci 2017 May 21;8(5):3500-3511. Epub 2017 Feb 21.

Department of Surgery and Cancer - Division of Computational and Systems Medicine , Imperial College London , London , UK . Email: ; Email: ; Email:

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May 2017

Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery.

J Transl Med 2017 04 26;15(1):83. Epub 2017 Apr 26.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, UK.

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April 2017

Metabolic Profiling in Patients with Pneumonia on Intensive Care.

EBioMedicine 2017 Apr 29;18:244-253. Epub 2017 Mar 29.

Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK. Electronic address:

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April 2017

Lessons from Metabonomics on the Neurobiology of Stroke.

Neuroscientist 2017 08 24;23(4):374-382. Epub 2016 Oct 24.

1 Section of Vascular Surgery, Imperial College London, Charing Cross Hospital, London, UK.

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August 2017

Application of Metabolic Profiling to Abdominal Aortic Aneurysm Research.

J Proteome Res 2017 07 19;16(7):2325-2332. Epub 2017 Jun 19.

Section of Vascular Surgery, Imperial College London , 4 North, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom.

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July 2017

Optimization and Application of Direct Infusion Nanoelectrospray HRMS Method for Large-Scale Urinary Metabolic Phenotyping in Molecular Epidemiology.

J Proteome Res 2017 04 14;16(4):1646-1658. Epub 2017 Mar 14.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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April 2017

Integrated Analytical and Statistical Two-Dimensional Spectroscopy Strategy for Metabolite Identification: Application to Dietary Biomarkers.

Anal Chem 2017 03 10;89(6):3300-3309. Epub 2017 Mar 10.

Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, South Kensington Campus, Imperial College London , London SW7 2AZ, United Kingdom.

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March 2017

Medical Swab Analysis Using Desorption Electrospray Ionization Mass Spectrometry: A Noninvasive Approach for Mucosal Diagnostics.

Anal Chem 2017 02 11;89(3):1540-1550. Epub 2017 Jan 11.

Computational and Systems Medicine, Imperial College London , South Kensington Campus, London, SW7 2AZ, United Kingdom.

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February 2017

The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk.

Microbiome 2017 01 19;5(1). Epub 2017 Jan 19.

Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Hammersmith Campus, London, W12 0NN, UK.

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January 2017

Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial.

Lancet Diabetes Endocrinol 2017 03 13;5(3):184-195. Epub 2017 Jan 13.

Nutrition and Dietetic Research Group, Division of Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK. Electronic address:

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March 2017

Metabolic Phenotype of Obesity in a Saudi Population.

J Proteome Res 2017 02 20;16(2):635-644. Epub 2017 Jan 20.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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February 2017

Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using Proton Nuclear Magnetic Resonance Spectroscopy.

J Clin Exp Hepatol 2016 Sep 20;6(3):186-194. Epub 2016 Apr 20.

Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary's Campus, South Wharf Road, London W2 1NY, United Kingdom.

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September 2016

New technologies - new insights into the pathogenesis of hepatic encephalopathy.

Metab Brain Dis 2016 12 30;31(6):1259-1267. Epub 2016 Sep 30.

Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA.

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December 2016

Role of human milk oligosaccharides in Group B Streptococcus colonisation.

Clin Transl Immunology 2016 Aug 26;5(8):e99. Epub 2016 Aug 26.

Department of Paediatrics, Centre for International Child Health, Imperial College London, St Mary's Hospital, London, UK; Wellcome Trust Centre for Global Health Research, London, UK.

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August 2016

Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage.

Sci Transl Med 2016 08;8(350):350ra102

Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK. Queen Charlotte's Hospital, Imperial College Healthcare National Health Service (NHS) Trust, London W12 0HS, UK.

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August 2016

Development of a Pipeline for Exploratory Metabolic Profiling of Infant Urine.

J Proteome Res 2016 09 23;15(9):3432-40. Epub 2016 Aug 23.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London , South Kensington Campus, London SW7 2AZ, United Kingdom.

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September 2016

Automatic Spectroscopic Data Categorization by Clustering Analysis (ASCLAN): A Data-Driven Approach for Distinguishing Discriminatory Metabolites for Phenotypic Subclasses.

Anal Chem 2016 06 13;88(11):5670-9. Epub 2016 May 13.

Medway Metabonomics Research Group, Medway School of Pharmacy, Universities of Kent and Greenwich , Chatham Maritime, Kent, ME4 4TB, U.K.

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June 2016

Power Analysis and Sample Size Determination in Metabolic Phenotyping.

Anal Chem 2016 05 6;88(10):5179-88. Epub 2016 May 6.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , London SW7 2AZ, U.K.

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May 2016

Systemic Characterization of an Obese Phenotype in the Zucker Rat Model Defining Metabolic Axes of Energy Metabolism and Host-Microbial Interactions.

J Proteome Res 2016 06 3;15(6):1897-906. Epub 2016 May 3.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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June 2016

Optimized Sample Handling Strategy for Metabolic Profiling of Human Feces.

Anal Chem 2016 05 21;88(9):4661-8. Epub 2016 Apr 21.

Center for Digestive and Gut Health, Institute of Global Health Innovation, Imperial College London , South Kensington, London SW7 2AZ, U.K.

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May 2016