Publications by authors named "Elaine Holmes"

100Publications

NMR Spectroscopic Windows on the Systemic Effects of SARS-CoV-2 Infection on Plasma Lipoproteins and Metabolites in Relation to Circulating Cytokines.

Authors:
Samantha Lodge Philipp Nitschke Torben Kimhofer Jerome D Coudert Sofina Begum Sze-How Bong Toby Richards Dale Edgar Edward Raby Manfred Spraul Hartmut Schaefer John C Lindon Ruey Leng Loo Elaine Holmes Jeremy K Nicholson

J Proteome Res 2021 Jan 11. Epub 2021 Jan 11.

Australian National Phenome Centre, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.

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January 2021

Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease.

Authors:
Luke Whiley Katie E Chappell Ellie D'Hondt Matthew R Lewis Beatriz Jiménez Stuart G Snowden Hilkka Soininen Iwona Kłoszewska Patrizia Mecocci Magda Tsolaki Bruno Vellas Jonathan R Swann Abdul Hye Simon Lovestone Cristina Legido-Quigley Elaine Holmes

Alzheimers Res Ther 2021 Jan 9;13(1):20. Epub 2021 Jan 9.

UK Dementia Research Institute, Imperial College London, Hammersmith Hospital, London, W12 0NN, UK.

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January 2021

Differences in amino acid and lipid metabolism distinguish Crohn's from idiopathic/cryptoglandular perianal fistulas by tissue metabonomic profiling and may offer clues to underlying pathogenesis.

Authors:
Samuel O Adegbola Magali Sarafian Kapil Sahnan Nik S Ding Omar D Faiz Janindra Warusavitarne Robin K S Phillips Phil J Tozer Elaine Holmes Ailsa L Hart

Eur J Gastroenterol Hepatol 2020 Dec 18;Publish Ahead of Print. Epub 2020 Dec 18.

Robin Phillips Fistula Research Unit, St Mark's Hospital and Academic Institute, Harrow, Middlesex Department of Surgery and Cancer Computational Systems Division, Imperial College London, South Kensington Campus, London, UK Department of Gastroenterology, St Vincent's Hospital, Melbourne, Australia.

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December 2020

Urinary metabolic phenotyping for Alzheimer's disease.

Authors:
Natalja Kurbatova Manik Garg Luke Whiley Elena Chekmeneva Beatriz Jiménez María Gómez-Romero Jake Pearce Torben Kimhofer Ellie D'Hondt Hilkka Soininen Iwona Kłoszewska Patrizia Mecocci Magda Tsolaki Bruno Vellas Dag Aarsland Alejo Nevado-Holgado Benjamine Liu Stuart Snowden Petroula Proitsi Nicholas J Ashton Abdul Hye Cristina Legido-Quigley Matthew R Lewis Jeremy K Nicholson Elaine Holmes Alvis Brazma Simon Lovestone

Sci Rep 2020 12 10;10(1):21745. Epub 2020 Dec 10.

Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.

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December 2020

A simultaneous exploratory and quantitative amino acid and biogenic amine metabolic profiling platform for rapid disease phenotyping via UPLC-QToF-MS.

Authors:
Nicola Gray Nathan G Lawler Rongchang Yang Aude-Claire Morillon Melvin C L Gay Sze-How Bong Elaine Holmes Jeremy K Nicholson Luke Whiley

Talanta 2021 Feb 7;223(Pt 2):121872. Epub 2020 Nov 7.

Australian National Phenome Centre, Health Futures Institute, Murdoch University, Harry Perkins South Building, Perth, WA, 6150, Australia; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Murdoch Perth, WA, 6150, Australia; The Perron Institute for Neurological and Translational Science, Nedlands, WA, 6009, Australia. Electronic address:

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February 2021

Metabolic Signatures of Gestational Weight Gain and Postpartum Weight Loss in a Lifestyle Intervention Study of Overweight and Obese Women.

Authors:
Chung-Ho E Lau Victoria Taylor-Bateman Panagiotis A Vorkas Gonçalo Graça Thanh-Huyen T Vu Lifang Hou Elena Chekmeneva Timothy M D Ebbels Queenie Chan Linda Van Horn Elaine Holmes

Metabolites 2020 Dec 4;10(12). Epub 2020 Dec 4.

Section of Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.

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December 2020

Metabolomic Analysis in Inflammatory Bowel Disease: A Systematic Review.

Authors:
Kate Gallagher Alexandra Catesson Julian L Griffin Elaine Holmes Horace R T Williams

J Crohns Colitis 2020 Nov 11. Epub 2020 Nov 11.

Department of Metabolism Digestion and Reproduction, Imperial College London, United Kingdom.

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November 2020

Author Correction: Metabolism of the predominant human milk oligosaccharide fucosyllactose by an infant gut commensal.

Authors:
Kieran James Francesca Bottacini Jose Ivan Serrano Contreras Mariane Vigoureux Muireann Egan Mary O'connell Motherway Elaine Holmes Douwe van Sinderen

Sci Rep 2020 Oct 9;10(1):17265. Epub 2020 Oct 9.

APC Microbiome Ireland, University College Cork, Western Road, Cork, Ireland.

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October 2020

Nutriome-metabolome relationships provide insights into dietary intake and metabolism.

Authors:
Joram M Posma Isabel Garcia-Perez Gary Frost Ghadeer S Aljuraiban Queenie Chan Linda Van Horn Martha Daviglus Jeremiah Stamler Elaine Holmes Paul Elliott Jeremy K Nicholson

Nat Food 2020 Jul 22;1(7):426-436. Epub 2020 Jun 22.

Division of Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia.

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July 2020

Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent infection and beyond: the contribution of gut microbial-derived metabolites.

Authors:
Laura Martinez-Gili Julie A K McDonald Zhigang Liu Dina Kao Jessica R Allegretti Tanya M Monaghan Grace F Barker Jesús Miguéns Blanco Horace R T Williams Elaine Holmes Mark R Thursz Julian R Marchesi Benjamin H Mullish

Gut Microbes 2020 Nov;12(1):1810531

Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London , London, UK.

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November 2020

Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytical Artifact Minimization with Special Reference to COVID-19/SARS-CoV-2 Samples.

Authors:
Ruey Leng Loo Samantha Lodge Torben Kimhofer Sze-How Bong Sofina Begum Luke Whiley Nicola Gray John C Lindon Philipp Nitschke Nathan G Lawler Hartmut Schäfer Manfred Spraul Toby Richards Jeremy K Nicholson Elaine Holmes

J Proteome Res 2020 11 16;19(11):4428-4441. Epub 2020 Oct 16.

Australian National Phenome Centre, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.

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November 2020

Improved Spatial Resolution of Metabolites in Tissue Biopsies Using High-Resolution Magic-Angle-Spinning Slice Localization NMR Spectroscopy.

Authors:
Elisabeth V Vonhof Martial Piotto Elaine Holmes John C Lindon Jeremy K Nicholson Jia V Li

Anal Chem 2020 09 20;92(17):11516-11519. Epub 2020 Aug 20.

Section of Nutrition Research, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, United Kingdom.

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September 2020

Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection.

Authors:
Torben Kimhofer Samantha Lodge Luke Whiley Nicola Gray Ruey Leng Loo Nathan G Lawler Philipp Nitschke Sze-How Bong David L Morrison Sofina Begum Toby Richards Bu B Yeap Chris Smith Kenneth G C Smith Elaine Holmes Jeremy K Nicholson

J Proteome Res 2020 11 14;19(11):4442-4454. Epub 2020 Sep 14.

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.

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November 2020

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study.

Authors:
Rebeca Eriksen Isabel Garcia Perez Joram M Posma Mark Haid Sapna Sharma Cornelia Prehn Louise E Thomas Robert W Koivula Roberto Bizzotto Cornelia Prehn Andrea Mari Giuseppe N Giordano Imre Pavo Jochen M Schwenk Federico De Masi Konstantinos D Tsirigos Søren Brunak Ana Viñuela Anubha Mahajan Timothy J McDonald Tarja Kokkola Femke Rutter Harriet Teare Tue H Hansen Juan Fernandez Angus Jones Chris Jennison Mark Walker Mark I McCarthy Oluf Pedersen Hartmut Ruetten Ian Forgie Jimmy D Bell Ewan R Pearson Paul W Franks Jerzy Adamski Elaine Holmes Gary Frost

EBioMedicine 2020 Aug 4;58:102932. Epub 2020 Aug 4.

Section for Nutrition Research, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, United Kingdom; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom. Electronic address:

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August 2020

Manuscript Strategy for improved characterisation of human metabolic phenotypes using a COmbined Multiblock Principal components Analysis with Statistical Spectroscopy (COMPASS).

Authors:
Ruey Leng Loo Queenie Chan Henrik Antti Jia V Li H Ashrafian Paul Elliott Jeremiah Stamler Jeremy K Nicholson Elaine Holmes Julien Wist

Bioinformatics 2020 Jul 21. Epub 2020 Jul 21.

Chemistry department, Universidad del Valle, Cali, Colombia.

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July 2020

Identifying unknown metabolites using NMR-based metabolic profiling techniques.

Authors:
Isabel Garcia-Perez Joram M Posma Jose Ivan Serrano-Contreras Claire L Boulangé Queenie Chan Gary Frost Jeremiah Stamler Paul Elliott John C Lindon Elaine Holmes Jeremy K Nicholson

Nat Protoc 2020 08 17;15(8):2538-2567. Epub 2020 Jul 17.

The Australian National Phenome Center, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.

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August 2020

Performance of metabonomic serum analysis for diagnostics in paediatric tuberculosis.

Authors:
Nicholas J Andreas Robindra Basu Roy Maria Gomez-Romero Verena Horneffer-van der Sluis Matthew R Lewis Stephane S M Camuzeaux Beatriz Jiménez Joram M Posma Leopold Tientcheu Uzochukwu Egere Abdou Sillah Toyin Togun Elaine Holmes Beate Kampmann

Sci Rep 2020 04 29;10(1):7302. Epub 2020 Apr 29.

Centre for International Child Health, Department of Paediatrics, Imperial College London, St. Mary's Hospital, Praed Street, London, W2 1NY, United Kingdom.

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April 2020

Characterisation of the Serum Metabolic Signature of Cholangiocarcinoma in a United Kingdom Cohort.

Authors:
Munirah Alsaleh Zoe Leftley Thomas A Barbera Larry K Koomson Abigail Zabron Mary M E Crossey Helen L Reeves Matthew Cramp Stephen Ryder Shaun Greer Martin Prince Paiboon Sithithaworn Mohamed Shariff Narong Khuntikeo Watcharin Loilome Puangrat Yongvanit Yi-Liang Shen I Jane Cox Roger Williams Christopher A Wadsworth Elaine Holmes Kathryn Nash Simon D Taylor-Robinson

J Clin Exp Hepatol 2020 Jan-Feb;10(1):17-29. Epub 2019 Jun 15.

Division of Surgery and Cancer, Imperial College London, London, W2 INY, United Kingdom.

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June 2019

Exploring Metabolic Consequences of and Dysregulation in Hepatocellular Carcinoma by Network Reconstruction.

Authors:
Ozbil E Dumenci Abellona Mr U Shahid A Khan Elaine Holmes Simon D Taylor-Robinson

J Hepatocell Carcinoma 2020 7;7:1-9. Epub 2020 Jan 7.

Imperial College London, London, UK.

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January 2020

Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery.

Authors:
Kiana Ashley West Chidimma Kanu Tanya Maric Julie Anne Kathryn McDonald Jeremy K Nicholson Jia V Li Mark R Johnson Elaine Holmes Makrina D Savvidou

Gut 2020 Aug 21;69(8):1452-1459. Epub 2020 Jan 21.

Obstetrics & Gynaecology, Chelsea and Westminster Hospital, Institute of Reproductive Developmental Biology, Department of Metabolism, Digestion & Reproduction, Faculty of Medicine, Imperial College London, London, UK.

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August 2020

Characterisation of the Urinary Metabolic Profile of Liver Fluke-Associated Cholangiocarcinoma.

Authors:
Munirah Alsaleh Paiboon Sithithaworn Narong Khuntikeo Watcharin Loilome Puangrat Yongvanit Nittaya Chamadol Thomas Hughes Thomas O'Connor Ross H Andrews Elaine Holmes Simon D Taylor-Robinson

J Clin Exp Hepatol 2019 Nov-Dec;9(6):657-675. Epub 2019 Jul 31.

Division of Surgery and Cancer, Imperial College London, London, United Kingdom.

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July 2019

Clinical and molecular evidence of accelerated ageing following very preterm birth.

Authors:
James R C Parkinson Robby Emsley Jane L Tarry Adkins Nick Longford Susan E Ozanne Elaine Holmes Neena Modi

Pediatr Res 2020 05 7;87(6):1005-1010. Epub 2019 Dec 7.

Section of Neonatal Medicine, Department of Medicine, Chelsea and Westminster Campus, Imperial College London, 369 Fulham Road, London, SW10 9NH, UK.

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May 2020

The association of fish consumption and its urinary metabolites with cardiovascular risk factors: the International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP).

Authors:
Rachel Gibson Chung-Ho E Lau Ruey Leng Loo Timothy M D Ebbels Elena Chekmeneva Alan R Dyer Katsuyuki Miura Hirotsugu Ueshima Liancheng Zhao Martha L Daviglus Jeremiah Stamler Linda Van Horn Paul Elliott Elaine Holmes Queenie Chan

Am J Clin Nutr 2020 02;111(2):280-290

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.

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February 2020

Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice.

Authors:
Parag Kundu Hae Ung Lee Isabel Garcia-Perez Emmy Xue Yun Tay Hyejin Kim Llanto Elma Faylon Katherine A Martin Rikky Purbojati Daniela I Drautz-Moses Sujoy Ghosh Jeremy K Nicholson Stephan Schuster Elaine Holmes Sven Pettersson

Sci Transl Med 2019 11;11(518)

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.

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November 2019

Mass Spectrometry: A Guide for the Clinician.

Authors:
Munirah Alsaleh Thomas A Barbera Ross H Andrews Paiboon Sithithaworn Narong Khuntikeo Watcharin Loilome Puangrat Yongvanit Isobel J Cox Richard R A Syms Elaine Holmes Simon D Taylor-Robinson

J Clin Exp Hepatol 2019 Sep-Oct;9(5):597-606. Epub 2019 May 9.

Division of Surgery and Cancer, Imperial College London, London, W2 INY, United Kingdom.

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May 2019

Metabolism of the predominant human milk oligosaccharide fucosyllactose by an infant gut commensal.

Authors:
Kieran James Francesca Bottacini Jose Ivan Serrano Contreras Mariane Vigoureux Muireann Egan Mary O'connell Motherway Elaine Holmes Douwe van Sinderen

Sci Rep 2019 10 28;9(1):15427. Epub 2019 Oct 28.

APC Microbiome Ireland, University College Cork, Western Road, Cork, Ireland.

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October 2019

Metabolic Phenotyping in Venous Disease: The Need for Standardization.

Authors:
Sarah Onida Matthew K H Tan Marina Kafeza Richmond T Bergner Joseph Shalhoub Elaine Holmes Alun H Davies

J Proteome Res 2019 11 16;18(11):3809-3820. Epub 2019 Oct 16.

Academic Section of Vascular Surgery, Department of Surgery and Cancer , Imperial College London , Floor 4 East, Charing Cross Hospital, Fulham Palace Road , London W6 8RF , U.K.

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November 2019

Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China.

Authors:
Wei Jie Seow Xiao-Ou Shu Jeremy K Nicholson Elaine Holmes Douglas I Walker Wei Hu Qiuyin Cai Yu-Tang Gao Yong-Bing Xiang Steven C Moore Bryan A Bassig Jason Y Y Wong Jinming Zhang Bu-Tian Ji Claire L Boulangé Manuja Kaluarachchi Anisha Wijeyesekera Wei Zheng Paul Elliott Nathaniel Rothman Qing Lan

JAMA Netw Open 2019 09 4;2(9):e1911970. Epub 2019 Sep 4.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.

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September 2019

A Unified Conceptual Framework for Metabolic Phenotyping in Diagnosis and Prognosis.

Authors:
Jeremy R Everett Elaine Holmes Kirill A Veselkov John C Lindon Jeremy K Nicholson

Trends Pharmacol Sci 2019 10 9;40(10):763-773. Epub 2019 Sep 9.

Division of Computational and Systems Medicine and Medical Research Council (MRC) National Institute for Health Research (NIHR) National Phenome Centre, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK. Electronic address:

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October 2019

The gut microbiota influences skeletal muscle mass and function in mice.

Authors:
Shawon Lahiri Hyejin Kim Isabel Garcia-Perez Musarrat Maisha Reza Katherine A Martin Parag Kundu Laura M Cox Joel Selkrig Joram M Posma Hongbo Zhang Parasuraman Padmanabhan Catherine Moret Balázs Gulyás Martin J Blaser Johan Auwerx Elaine Holmes Jeremy Nicholson Walter Wahli Sven Pettersson

Sci Transl Med 2019 07;11(502)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

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July 2019

Spot and Cumulative Urine Samples Are Suitable Replacements for 24-Hour Urine Collections for Objective Measures of Dietary Exposure in Adults Using Metabolite Biomarkers.

Authors:
Thomas Wilson Isabel Garcia-Perez Joram M Posma Amanda J Lloyd Edward S Chambers Kathleen Tailliart Hassan Zubair Manfred Beckmann John C Mathers Elaine Holmes Gary Frost John Draper

J Nutr 2019 10;149(10):1692-1700

Institute of Biological, Environmental, and Rural Sciences, Aberystwyth University, Aberystwyth, United Kingdom.

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October 2019

Multi-Compartment Profiling of Bacterial and Host Metabolites Identifies Intestinal Dysbiosis and Its Functional Consequences in the Critically Ill Child.

Authors:
Anisha Wijeyesekera Josef Wagner Marcus De Goffau Sarah Thurston Adilson Rodrigues Sabino Sara Zaher Deborah White Jenna Ridout Mark J Peters Padmanabhan Ramnarayan Ricardo G Branco M Estee Torok Frederic Valla Rosan Meyer Nigel Klein Gary Frost Julian Parkhill Elaine Holmes Nazima Pathan

Crit Care Med 2019 09;47(9):e727-e734

Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.

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September 2019

Bariatric Surgery Modulates Urinary Levels of MicroRNAs Involved in the Regulation of Renal Function.

Authors:
Abdullah Alkandari Hutan Ashrafian Thozhukat Sathyapalan Ara Darzi Elaine Holmes Thanos Athanasiou Stephen L Atkin Nigel J Gooderham

Front Endocrinol (Lausanne) 2019 21;10:319. Epub 2019 May 21.

Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

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May 2019

Characterization of the urinary metabolic profile of cholangiocarcinoma in a United Kingdom population.

Authors:
Munirah Alsaleh Thomas A Barbera Helen L Reeves Matthew E Cramp Stephen Ryder Hani Gabra Kathryn Nash Yi-Liang Shen Elaine Holmes Roger Williams Simon D Taylor-Robinson

Hepat Med 2019 3;11:47-67. Epub 2019 May 3.

Division of Surgery and Cancer, Imperial College London, London.

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May 2019

Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease.

Authors:
Ioanna Tzoulaki Raphaële Castagné Claire L Boulangé Ibrahim Karaman Elena Chekmeneva Evangelos Evangelou Timothy M D Ebbels Manuja R Kaluarachchi Marc Chadeau-Hyam David Mosen Abbas Dehghan Alireza Moayyeri Diana L Santos Ferreira Xiuqing Guo Jerome I Rotter Kent D Taylor Maryam Kavousi Paul S de Vries Benjamin Lehne Marie Loh Albert Hofman Jeremy K Nicholson John Chambers Christian Gieger Elaine Holmes Russell Tracy Jaspal Kooner Philip Greenland Oscar H Franco David Herrington John C Lindon Paul Elliott

Eur Heart J 2019 09;40(34):2883-2896

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, UK.

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September 2019

Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.

Authors:
Claire S Byrne Edward S Chambers Tom Preston Catriona Tedford Jerusa Brignardello Isabel Garcia-Perez Elaine Holmes Gareth A Wallis Douglas J Morrison Gary S Frost

Nutrients 2019 Apr 16;11(4). Epub 2019 Apr 16.

Section for Nutrition Research, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.

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April 2019

Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis.

Authors:
Caroline Ovadia Alvaro Perdones-Montero Konstantina Spagou Ann Smith Magali H Sarafian Maria Gomez-Romero Elena Bellafante Louise C D Clarke Fouzia Sadiq Vanya Nikolova Alice Mitchell Peter H Dixon Natalie Santa-Pinter Annika Wahlström Shadi Abu-Hayyeh Julian R F Walters Hanns-Ulrich Marschall Elaine Holmes Julian R Marchesi Catherine Williamson

Hepatology 2019 07 21;70(1):276-293. Epub 2019 May 21.

Division of Women and Children's Health, King's College London, London, United Kingdom.

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July 2019

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.

Authors:
Edward S Chambers Claire S Byrne Douglas J Morrison Kevin G Murphy Tom Preston Catriona Tedford Isabel Garcia-Perez Sofia Fountana Jose Ivan Serrano-Contreras Elaine Holmes Catherine J Reynolds Jordie F Roberts Rosemary J Boyton Daniel M Altmann Julie A K McDonald Julian R Marchesi Arne N Akbar Natalie E Riddell Gareth A Wallis Gary S Frost

Gut 2019 08 10;68(8):1430-1438. Epub 2019 Apr 10.

Section for Nutrition Research, Department of Medicine, Imperial College London, London, UK.

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August 2019

Obesity and Cage Environment Modulate Metabolism in the Zucker Rat: A Multiple Biological Matrix Approach to Characterizing Metabolic Phenomena.

Authors:
Hannah J Lees Jonathan R Swann Simon Poucher Elaine Holmes Ian D Wilson Jeremy K Nicholson

J Proteome Res 2019 05 18;18(5):2160-2174. Epub 2019 Apr 18.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine , Imperial College London , London , SW7 2AZ , United Kingdom.

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May 2019

Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry with Electrospray Ionization Quantification of Tryptophan Metabolites and Markers of Gut Health in Serum and Plasma-Application to Clinical and Epidemiology Cohorts.

Authors:
Luke Whiley Leanne C Nye Isobelle Grant Nick Andreas Katie E Chappell Magali H Sarafian Ravi Misra Robert S Plumb Matthew R Lewis Jeremy K Nicholson Elaine Holmes Jonathan R Swann Ian D Wilson

Anal Chem 2019 04 25;91(8):5207-5216. Epub 2019 Mar 25.

Division of Integrative Systems and Digestive Medicine, Department of Surgery and Cancer , Imperial College London , Sir Alexander Fleming Building, South Kensington Campus , London SW7 2AZ , United Kingdom.

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April 2019

Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent infection.

Authors:
Benjamin H Mullish Julie A K McDonald Alexandros Pechlivanis Jessica R Allegretti Dina Kao Grace F Barker Diya Kapila Elaine O Petrof Susan A Joyce Cormac G M Gahan Izabela Glegola-Madejska Horace R T Williams Elaine Holmes Thomas B Clarke Mark R Thursz Julian R Marchesi

Gut 2019 10 11;68(10):1791-1800. Epub 2019 Feb 11.

Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

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October 2019

Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus.

Authors:
Vinod S Hegade Alexandros Pechlivanis Julie A K McDonald Douglas Rees Margaret Corrigan Gideon M Hirschfield Simon D Taylor-Robinson Elaine Holmes Julian R Marchesi Stuart Kendrick David E Jones

Liver Int 2019 05 25;39(5):967-975. Epub 2019 Feb 25.

Institute of Cellular Medicine and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.

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May 2019

NMR and MS urinary metabolic phenotyping in kidney diseases is fit-for-purpose in the presence of a protease inhibitor.

Authors:
Claire L Boulangé Ilse M Rood Joram M Posma John C Lindon Elaine Holmes Jack F M Wetzels Jeroen K J Deegens Manuja R Kaluarachchi

Mol Omics 2019 02;15(1):39-49

Metabometrix Ltd, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

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February 2019

The metabolic fate and effects of 2-Bromophenol in male Sprague-Dawley rats.

Authors:
Kyrillos N Adesina-Georgiadis Nicola Gray Robert S Plumb David F Thompson Elaine Holmes Jeremy K Nicholson Ian D Wilson

Xenobiotica 2019 Nov 22;49(11):1352-1359. Epub 2019 Feb 22.

Department of Surgery and Cancer Faculty of Medicine, Imperial College London, South Kensington Campus, London, United Kingdom.

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November 2019

odifying ntestinal Integrity and icro iome in Severe Malnutrition with gume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial.

Authors:
Kevin Walsh Nuala Calder Peter Olupot-Olupot Tonny Ssenyondo William Okiror Charles Bernard Okalebo Rita Muhindo Ayub Mpoya Elaine Holmes Julian Marchesi Gael Delamare de la Villenaise de Chenevarin Gary Frost Kathryn Maitland

Wellcome Open Res 2018 2;3:95. Epub 2018 Aug 2.

Department of Paediatrics, Imperial College, London, W2 1PG, UK.

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August 2018

Profiling inflammatory markers in patients with pneumonia on intensive care.

Authors:
David B Antcliffe Arnaud M Wolfer Kieran P O'Dea Masao Takata Elaine Holmes Anthony C Gordon

Sci Rep 2018 10 3;8(1):14736. Epub 2018 Oct 3.

Section of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK.

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October 2018

Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by H NMR Spectroscopy in a Multilaboratory Trial.

Authors:
Beatriz Jiménez Elaine Holmes Clement Heude Rose F Tolson Nikita Harvey Samantha L Lodge Andrew J Chetwynd Claire Cannet Fang Fang Jake T M Pearce Matthew R Lewis Mark R Viant John C Lindon Manfred Spraul Hartmut Schäfer Jeremy K Nicholson

Anal Chem 2018 10 27;90(20):11962-11971. Epub 2018 Sep 27.

The Imperial Clinical Phenotyping Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer , QEQM Building, Saint Mary's Hospital , London W2 1NY , United Kingdom.

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October 2018

Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Direct Infusion-High-Resolution Mass Spectrometry for Combined Exploratory and Targeted Metabolic Profiling of Human Urine.

Authors:
Elena Chekmeneva Gonçalo Dos Santos Correia María Gómez-Romero Jeremiah Stamler Queenie Chan Paul Elliott Jeremy K Nicholson Elaine Holmes

J Proteome Res 2018 10 19;17(10):3492-3502. Epub 2018 Sep 19.

Division of Integrative Systems and Digestive Medicine, Department of Surgery and Cancer , Imperial College London , Sir Alexander Fleming Building, South Kensington Campus , London SW7 2AZ , United Kingdom.

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October 2018

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism.

Authors:
Zhigang Liu Bing Xia Jasmina Saric Jürg Utzinger Elaine Holmes Jennifer Keiser Jia V Li

J Proteome Res 2018 10 20;17(10):3565-3573. Epub 2018 Sep 20.

Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine , Imperial College London , South Kensington Campus , London SW7 2AZ , United Kingdom.

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October 2018

Publisher Correction: Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women.

Authors:
Lesley Hoyles José-Manuel Fernández-Real Massimo Federici Matteo Serino James Abbott Julie Charpentier Christophe Heymes Jèssica Latorre Luque Elodie Anthony Richard H Barton Julien Chilloux Antonis Myridakis Laura Martinez-Gili José Maria Moreno-Navarrete Fadila Benhamed Vincent Azalbert Vincent Blasco-Baque Josep Puig Gemma Xifra Wifredo Ricart Christopher Tomlinson Mark Woodbridge Marina Cardellini Francesca Davato Iris Cardolini Ottavia Porzio Paolo Gentileschi Frédéric Lopez Fabienne Foufelle Sarah A Butcher Elaine Holmes Jeremy K Nicholson Catherine Postic Rémy Burcelin Marc-Emmanuel Dumas

Nat Med 2018 Oct;24(10):1628

Division of Integrative Systems Medicine and Digestive Diseases, Department of Surgery and Cancer, Imperial College London, London, UK.

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October 2018

Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota.

Authors:
Julie A K McDonald Benjamin H Mullish Alexandros Pechlivanis Zhigang Liu Jerusa Brignardello Dina Kao Elaine Holmes Jia V Li Thomas B Clarke Mark R Thursz Julian R Marchesi

Gastroenterology 2018 11 17;155(5):1495-1507.e15. Epub 2018 Jul 17.

Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom; School of Biosciences, Cardiff University, Cardiff, United Kingdom. Electronic address:

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November 2018

The effect of L-rhamnose on intestinal transit time, short chain fatty acids and appetite regulation: a pilot human study using combined CO/H breath tests.

Authors:
Claire S Byrne Tom Preston Jerusa Brignardello Isabel Garcia-Perez Elaine Holmes Gary S Frost Douglas J Morrison

J Breath Res 2018 08 6;12(4):046006. Epub 2018 Aug 6.

Nutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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August 2018

Metabolic phenotype of skeletal muscle in early critical illness.

Authors:
Zudin A Puthucheary Ronan Astin Mark J W Mcphail Saima Saeed Yasmin Pasha Danielle E Bear Despina Constantin Cristiana Velloso Sean Manning Lori Calvert Mervyn Singer Rachel L Batterham Maria Gomez-Romero Elaine Holmes Michael C Steiner Philip J Atherton Paul Greenhaff Lindsay M Edwards Kenneth Smith Stephen D Harridge Nicholas Hart Hugh E Montgomery

Thorax 2018 10 6;73(10):926-935. Epub 2018 Jul 6.

Institute for Sport, Exercise and Health, University College London, London, UK.

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October 2018

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.

Authors:
Chioma Izzi-Engbeaya Alexander N Comninos Sophie A Clarke Anne Jomard Lisa Yang Sophie Jones Ali Abbara Shakunthala Narayanaswamy Pei Chia Eng Deborah Papadopoulou Julia K Prague Paul Bech Ian F Godsland Paul Bassett Caroline Sands Stephane Camuzeaux Maria Gomez-Romero Jake T M Pearce Matthew R Lewis Elaine Holmes Jeremy K Nicholson Tricia Tan Risheka Ratnasabapathy Ming Hu Gaelle Carrat Lorenzo Piemonti Marco Bugliani Piero Marchetti Paul R Johnson Stephen J Hughes A M James Shapiro Guy A Rutter Waljit S Dhillo

Diabetes Obes Metab 2018 12 16;20(12):2800-2810. Epub 2018 Aug 16.

Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.

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December 2018

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women.

Authors:
Lesley Hoyles José-Manuel Fernández-Real Massimo Federici Matteo Serino James Abbott Julie Charpentier Christophe Heymes Jèssica Latorre Luque Elodie Anthony Richard H Barton Julien Chilloux Antonis Myridakis Laura Martinez-Gili José Maria Moreno-Navarrete Fadila Benhamed Vincent Azalbert Vincent Blasco-Baque Josep Puig Gemma Xifra Wifredo Ricart Christopher Tomlinson Mark Woodbridge Marina Cardellini Francesca Davato Iris Cardolini Ottavia Porzio Paolo Gentileschi Frédéric Lopez Fabienne Foufelle Sarah A Butcher Elaine Holmes Jeremy K Nicholson Catherine Postic Rémy Burcelin Marc-Emmanuel Dumas

Nat Med 2018 07 25;24(7):1070-1080. Epub 2018 Jun 25.

Division of Integrative Systems Medicine and Digestive Diseases, Department of Surgery and Cancer, Imperial College London, London, UK.

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July 2018

Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: a longitudinal study in humans.

Authors:
Abdullah Alkandari Hutan Ashrafian Thozhukat Sathyapalan Peter Sedman Ara Darzi Elaine Holmes Thanos Athanasiou Stephen L Atkin Nigel J Gooderham

BMC Obes 2018 31;5:20. Epub 2018 May 31.

1Department of Surgery and Cancer, Imperial College London, London, UK.

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May 2018

A Prospective Metagenomic and Metabolomic Analysis of the Impact of Exercise and/or Whey Protein Supplementation on the Gut Microbiome of Sedentary Adults.

Authors:
Owen Cronin Wiley Barton Peter Skuse Nicholas C Penney Isabel Garcia-Perez Eileen F Murphy Trevor Woods Helena Nugent Aine Fanning Silvia Melgar Eanna C Falvey Elaine Holmes Paul D Cotter Orla O'Sullivan Michael G Molloy Fergus Shanahan

mSystems 2018 May-Jun;3(3). Epub 2018 Apr 24.

APC Microbiome Ireland, National University of Ireland, Cork, Ireland.

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April 2018

Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial.

Authors:
James R C Parkinson Anisha D Wijeyesekera Matthew J Hyde Atul Singhal Alan Lucas Elaine Holmes Neena Modi

BMJ Paediatr Open 2017 1;1(1):e000192. Epub 2017 Nov 1.

Section of Neonatal Medicine, Imperial College London, London, UK.

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November 2017

Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model.

Authors:
Yeji Sung Konstantina Spagou Marina Kafeza Michael Kyriakides Brahman Dharmarajah Joseph Shalhoub Jose A Diaz Thomas W Wakefield Elaine Holmes Alun H Davies

Eur J Vasc Endovasc Surg 2018 05 8;55(5):703-713. Epub 2018 Mar 8.

Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, UK. Electronic address:

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May 2018

Characterization of metabolic responses to healthy diets and association with blood pressure: application to the Optimal Macronutrient Intake Trial for Heart Health (OmniHeart), a randomized controlled study.

Authors:
Ruey Leng Loo Xin Zou Lawrence J Appel Jeremy K Nicholson Elaine Holmes

Am J Clin Nutr 2018 03;107(3):323-334

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

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March 2018

Optimized Phenotypic Biomarker Discovery and Confounder Elimination via Covariate-Adjusted Projection to Latent Structures from Metabolic Spectroscopy Data.

Authors:
Joram M Posma Isabel Garcia-Perez Timothy M D Ebbels John C Lindon Jeremiah Stamler Paul Elliott Elaine Holmes Jeremy K Nicholson

J Proteome Res 2018 04 27;17(4):1586-1595. Epub 2018 Feb 27.

Department of Preventive Medicine, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States.

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April 2018

Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin.

Authors:
Richard G Brown Julian R Marchesi Yun S Lee Ann Smith Benjamin Lehne Lindsay M Kindinger Vasso Terzidou Elaine Holmes Jeremy K Nicholson Phillip R Bennett David A MacIntyre

BMC Med 2018 01 24;16(1). Epub 2018 Jan 24.

Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London, W12 0NN, UK.

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January 2018

Metabolomics as a tool to identify biomarkers to predict and improve outcomes in reproductive medicine: a systematic review.

Authors:
Timothy Bracewell-Milnes Srdjan Saso Hossam Abdalla Dimitrios Nikolau Julian Norman-Taylor Mark Johnson Elaine Holmes Meen-Yau Thum

Hum Reprod Update 2017 11;23(6):723-736

The Lister Fertility Clinic, Chelsea Bridge Road, London, UK.

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November 2017

The C6H6 NMR repository: An integral solution to control the flow of your data from the magnet to the public.

Authors:
Luc Patiny Michaël Zasso Daniel Kostro Andrés Bernal Andrés M Castillo Alejandro Bolaños Miguel A Asencio Norman Pellet Matthew Todd Nils Schloerer Stefan Kuhn Elaine Holmes Sacha Javor Julien Wist

Magn Reson Chem 2018 06 3;56(6):520-528. Epub 2017 Nov 3.

Chemistry Department, Universidad del Valle, Cali, Valle, Colombia.

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June 2018

Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms.

Authors:
Rhiannon Bray Stefano Cacciatore Beatriz Jiménez Rufus Cartwright Alex Digesu Ruwan Fernando Elaine Holmes Jeremy K Nicholson Phillip R Bennett David A MacIntyre Vik Khullar

J Proteome Res 2017 11 4;16(11):4208-4216. Epub 2017 Oct 4.

Department of Urogynaecology, St. Mary's Hospital, Imperial College Healthcare NHS Trust , London W2 1NY, U.K.

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November 2017

Ethnicity and skin autofluorescence-based risk-engines for cardiovascular disease and diabetes mellitus.

Authors:
Muhammad Saeed Ahmad Torben Kimhofer Sultan Ahmad Mohammed Nabil AlAma Hala Hisham Mosli Salwa Ibrahim Hindawi Dennis O Mook-Kanamori Katarína Šebeková Zoheir Abdullah Damanhouri Elaine Holmes

PLoS One 2017 20;12(9):e0185175. Epub 2017 Sep 20.

Drug Metabolism Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.

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October 2017

Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense Infection.

Authors:
Sabrina D Lamour Vincent P Alibu Elaine Holmes Jeremy M Sternberg

J Infect Dis 2017 12;216(10):1273-1280

Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, United Kingdom.

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December 2017

Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism.

Authors:
Agata Korecka Anthony Dona Shawon Lahiri Adrian James Tett Maha Al-Asmakh Viorica Braniste Rossana D'Arienzo Afrouz Abbaspour Nicole Reichardt Yoshiaki Fujii-Kuriyama Joseph Rafter Arjan Narbad Elaine Holmes Jeremy Nicholson Velmurugesan Arulampalam Sven Pettersson

NPJ Biofilms Microbiomes 2016 24;2:16014. Epub 2016 Aug 24.

Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

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August 2016

Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment.

Authors:
Marie C Lewis Claire A Merrifield Bernard Berger Olivier Cloarec Swantje Duncker Annick Mercenier Jeremy K Nicholson Elaine Holmes Mick Bailey

Sci Rep 2017 07 13;7(1):5310. Epub 2017 Jul 13.

Infection and Immunity, Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, North Somerset, BS40 5DU, UK.

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July 2017

The Plasma and Serum Metabotyping of Hepatocellular Carcinoma in a Nigerian and Egyptian Cohort using Proton Nuclear Magnetic Resonance Spectroscopy.

Authors:
Mohamed I F Shariff Jin Un Kim Nimzing G Ladep Asmaa I Gomaa Mary M E Crossey Edith Okeke Edmund Banwat Imam Waked I Jane Cox Roger Williams Elaine Holmes Simon D Taylor-Robinson

J Clin Exp Hepatol 2017 Jun 15;7(2):83-92. Epub 2017 Mar 15.

Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary's Campus, South Wharf Road, London W2 1NY, United Kingdom.

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June 2017

A comprehensive characterisation of the metabolic profile of varicose veins; implications in elaborating plausible cellular pathways for disease pathogenesis.

Authors:
Muzaffar A Anwar Kyrillos N Adesina-Georgiadis K Spagou P A Vorkas J V Li Joseph Shalhoub Elaine Holmes Alun H Davies

Sci Rep 2017 06 7;7(1):2989. Epub 2017 Jun 7.

Academic Section of Vascular Surgery, Imperial College, London, UK.

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June 2017

Corrigendum: A new gender-specific model for skin autofluorescence risk stratification.

Authors:
Muhammad S Ahmad Zoheir A Damanhouri Torben Kimhofer Hala H Mosli Elaine Holmes

Sci Rep 2017 05 31;7:46832. Epub 2017 May 31.

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May 2017

Deep learning and 3D-DESI imaging reveal the hidden metabolic heterogeneity of cancer.

Authors:
Paolo Inglese James S McKenzie Anna Mroz James Kinross Kirill Veselkov Elaine Holmes Zoltan Takats Jeremy K Nicholson Robert C Glen

Chem Sci 2017 May 21;8(5):3500-3511. Epub 2017 Feb 21.

Department of Surgery and Cancer - Division of Computational and Systems Medicine , Imperial College London , London , UK . Email: ; Email: ; Email:

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May 2017

Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery.

Authors:
Arnaud M Wolfer Alasdair J Scott Claudia Rueb Mathieu Gaudin Ara Darzi Jeremy K Nicholson Elaine Holmes James M Kinross

J Transl Med 2017 04 26;15(1):83. Epub 2017 Apr 26.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, UK.

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April 2017

Rifaximin in non-alcoholic steatohepatitis: An open-label pilot study.

Authors:
Jeremy F L Cobbold Stephen Atkinson Julian R Marchesi Ann Smith Sann N Wai Julie Stove Fariba Shojaee-Moradie Nicola Jackson A Margot Umpleby Julie Fitzpatrick E Louise Thomas Jimmy D Bell Elaine Holmes Simon D Taylor-Robinson Robert D Goldin Michael S Yee Quentin M Anstee Mark R Thursz

Hepatol Res 2018 Jan 31;48(1):69-77. Epub 2017 May 31.

Department of Medicine, Imperial College London, London, UK.

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January 2018

Metabolic Profiling in Patients with Pneumonia on Intensive Care.

Authors:
David Antcliffe Beatriz Jiménez Kirill Veselkov Elaine Holmes Anthony C Gordon

EBioMedicine 2017 Apr 29;18:244-253. Epub 2017 Mar 29.

Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK. Electronic address:

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April 2017

The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level.

Authors:
Wiley Barton Nicholas C Penney Owen Cronin Isabel Garcia-Perez Michael G Molloy Elaine Holmes Fergus Shanahan Paul D Cotter Orla O'Sullivan

Gut 2018 04 30;67(4):625-633. Epub 2017 Mar 30.

Alimentary Pharmabiotic Centre Microbiome Institute, University College Cork, National University of Ireland, Cork, Ireland.

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April 2018

Lessons from Metabonomics on the Neurobiology of Stroke.

Authors:
Mahim I Qureshi Panagiotis A Vorkas Alexander P Coupland I Harri Jenkins Elaine Holmes Alun H Davies

Neuroscientist 2017 08 24;23(4):374-382. Epub 2016 Oct 24.

1 Section of Vascular Surgery, Imperial College London, Charing Cross Hospital, London, UK.

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August 2017

Application of Metabolic Profiling to Abdominal Aortic Aneurysm Research.

Authors:
Mahim I Qureshi Michele Greco Panagiotis A Vorkas Elaine Holmes Alun H Davies

J Proteome Res 2017 07 19;16(7):2325-2332. Epub 2017 Jun 19.

Section of Vascular Surgery, Imperial College London , 4 North, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom.

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July 2017

Optimization and Application of Direct Infusion Nanoelectrospray HRMS Method for Large-Scale Urinary Metabolic Phenotyping in Molecular Epidemiology.

Authors:
Elena Chekmeneva Gonçalo Dos Santos Correia Queenie Chan Anisha Wijeyesekera Adrienne Tin Jeffery Hunter Young Paul Elliott Jeremy K Nicholson Elaine Holmes

J Proteome Res 2017 04 14;16(4):1646-1658. Epub 2017 Mar 14.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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April 2017

Integrated Analytical and Statistical Two-Dimensional Spectroscopy Strategy for Metabolite Identification: Application to Dietary Biomarkers.

Authors:
Joram M Posma Isabel Garcia-Perez James C Heaton Paula Burdisso John C Mathers John Draper Matt Lewis John C Lindon Gary Frost Elaine Holmes Jeremy K Nicholson

Anal Chem 2017 03 10;89(6):3300-3309. Epub 2017 Mar 10.

Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, South Kensington Campus, Imperial College London , London SW7 2AZ, United Kingdom.

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March 2017

Medical Swab Analysis Using Desorption Electrospray Ionization Mass Spectrometry: A Noninvasive Approach for Mucosal Diagnostics.

Authors:
Pamela Pruski David A MacIntyre Holly V Lewis Paolo Inglese Gonçalo D S Correia Trevor T Hansel Phillip R Bennett Elaine Holmes Zoltan Takats

Anal Chem 2017 02 11;89(3):1540-1550. Epub 2017 Jan 11.

Computational and Systems Medicine, Imperial College London , South Kensington Campus, London, SW7 2AZ, United Kingdom.

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February 2017

The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk.

Authors:
Lindsay M Kindinger Phillip R Bennett Yun S Lee Julian R Marchesi Ann Smith Stefano Cacciatore Elaine Holmes Jeremy K Nicholson T G Teoh David A MacIntyre

Microbiome 2017 01 19;5(1). Epub 2017 Jan 19.

Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Hammersmith Campus, London, W12 0NN, UK.

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January 2017

Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial.

Authors:
Isabel Garcia-Perez Joram M Posma Rachel Gibson Edward S Chambers Tue H Hansen Henrik Vestergaard Torben Hansen Manfred Beckmann Oluf Pedersen Paul Elliott Jeremiah Stamler Jeremy K Nicholson John Draper John C Mathers Elaine Holmes Gary Frost

Lancet Diabetes Endocrinol 2017 03 13;5(3):184-195. Epub 2017 Jan 13.

Nutrition and Dietetic Research Group, Division of Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK. Electronic address:

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March 2017

Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview.

Authors:
Queenie Chan Ruey Leng Loo Timothy M D Ebbels Linda Van Horn Martha L Daviglus Jeremiah Stamler Jeremy K Nicholson Elaine Holmes Paul Elliott

Hypertens Res 2017 Apr 22;40(4):336-345. Epub 2016 Dec 22.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

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April 2017

Metabolic Phenotype of Obesity in a Saudi Population.

Authors:
Muhammad Saeed Ahmad Munirah Alsaleh Torben Kimhofer Sultan Ahmad Wisam Jamal Siraj Omar Wali Jeremy Kirk Nicholson Zoheir Abdullah Damanhouri Elaine Holmes

J Proteome Res 2017 02 20;16(2):635-644. Epub 2017 Jan 20.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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February 2017

Correction to 2-Furoylglycine as a Candidate Biomarker of Coffee Consumption.

Authors:
Silke S Heinzmann Elaine Holmes Sunil Kochhar Jeremy K Nicholson Philippe Schmitt-Kopplin

J Agric Food Chem 2016 Nov 11;64(46):8958. Epub 2016 Nov 11.

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November 2016

Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using Proton Nuclear Magnetic Resonance Spectroscopy.

Authors:
Mohamed I F Shariff Jin U Kim Nimzing G Ladep Mary M E Crossey Larry K Koomson Abigail Zabron Helen Reeves Matthew Cramp Stephen Ryder Shaun Greer I Jane Cox Roger Williams Elaine Holmes Kathryn Nash Simon D Taylor-Robinson

J Clin Exp Hepatol 2016 Sep 20;6(3):186-194. Epub 2016 Apr 20.

Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary's Campus, South Wharf Road, London W2 1NY, United Kingdom.

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September 2016

Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series.

Authors:
Marc-Emmanuel Dumas Céline Domange Sophie Calderari Andrea Rodríguez Martínez Rafael Ayala Steven P Wilder Nicolas Suárez-Zamorano Stephan C Collins Robert H Wallis Quan Gu Yulan Wang Christophe Hue Georg W Otto Karène Argoud Vincent Navratil Steve C Mitchell John C Lindon Elaine Holmes Jean-Baptiste Cazier Jeremy K Nicholson Dominique Gauguier

Genome Med 2016 09 30;8(1):101. Epub 2016 Sep 30.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College, London, SW7 2AZ, UK.

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September 2016

New technologies - new insights into the pathogenesis of hepatic encephalopathy.

Authors:
Luisa Baker Bernard Lanz Fausto Andreola Javier Ampuero Anisha Wijeyesekera Elaine Holmes Nicolaas Deutz

Metab Brain Dis 2016 12 30;31(6):1259-1267. Epub 2016 Sep 30.

Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA.

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December 2016

Role of human milk oligosaccharides in Group B Streptococcus colonisation.

Authors:
Nicholas J Andreas Asmaa Al-Khalidi Mustapha Jaiteh Edward Clarke Matthew J Hyde Neena Modi Elaine Holmes Beate Kampmann Kirsty Mehring Le Doare

Clin Transl Immunology 2016 Aug 26;5(8):e99. Epub 2016 Aug 26.

Department of Paediatrics, Centre for International Child Health, Imperial College London, St Mary's Hospital, London, UK; Wellcome Trust Centre for Global Health Research, London, UK.

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August 2016

Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage.

Authors:
Lindsay M Kindinger David A MacIntyre Yun S Lee Julian R Marchesi Ann Smith Julie A K McDonald Vasso Terzidou Joanna R Cook Christoph Lees Fidan Israfil-Bayli Yazmin Faiza Philip Toozs-Hobson Mark Slack Stefano Cacciatore Elaine Holmes Jeremy K Nicholson T G Teoh Phillip R Bennett

Sci Transl Med 2016 08;8(350):350ra102

Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK. Queen Charlotte's Hospital, Imperial College Healthcare National Health Service (NHS) Trust, London W12 0HS, UK.

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August 2016

Development and Application of Ultra-Performance Liquid Chromatography-TOF MS for Precision Large Scale Urinary Metabolic Phenotyping.

Authors:
Matthew R Lewis Jake T M Pearce Konstantina Spagou Martin Green Anthony C Dona Ada H Y Yuen Mark David David J Berry Katie Chappell Verena Horneffer-van der Sluis Rachel Shaw Simon Lovestone Paul Elliott John Shockcor John C Lindon Olivier Cloarec Zoltan Takats Elaine Holmes Jeremy K Nicholson

Anal Chem 2016 09 26;88(18):9004-13. Epub 2016 Aug 26.

MRC-NIHR National Phenome Centre, Department of Surgery and Cancer, Imperial College London , IRDB Building, Du Cane Road, London W12 0NN, United Kingdom.

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September 2016

Development of a Pipeline for Exploratory Metabolic Profiling of Infant Urine.

Authors:
Frances Jackson Nancy Georgakopoulou Manuja Kaluarachchi Michael Kyriakides Nicholas Andreas Natalia Przysiezna Matthew J Hyde Neena Modi Jeremy K Nicholson Anisha Wijeyesekera Elaine Holmes

J Proteome Res 2016 09 23;15(9):3432-40. Epub 2016 Aug 23.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London , South Kensington Campus, London SW7 2AZ, United Kingdom.

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September 2016

Impact of maternal BMI and sampling strategy on the concentration of leptin, insulin, ghrelin and resistin in breast milk across a single feed: a longitudinal cohort study.

Authors:
Nicholas J Andreas Matthew J Hyde Bronwen R Herbert Suzan Jeffries Shalini Santhakumaran Sundhiya Mandalia Elaine Holmes Neena Modi

BMJ Open 2016 07 7;6(7):e010778. Epub 2016 Jul 7.

Section of Neonatal Medicine, Department of Medicine, Chelsea & Westminster Hospital Campus, Imperial College London, London, UK.

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July 2016

Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods.

Authors:
Claire S Byrne Edward S Chambers Habeeb Alhabeeb Navpreet Chhina Douglas J Morrison Tom Preston Catriona Tedford Julie Fitzpatrick Cherag Irani Albert Busza Isabel Garcia-Perez Sofia Fountana Elaine Holmes Anthony P Goldstone Gary S Frost

Am J Clin Nutr 2016 Jul 11;104(1):5-14. Epub 2016 May 11.

Nutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine,

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July 2016

Automatic Spectroscopic Data Categorization by Clustering Analysis (ASCLAN): A Data-Driven Approach for Distinguishing Discriminatory Metabolites for Phenotypic Subclasses.

Authors:
Xin Zou Elaine Holmes Jeremy K Nicholson Ruey Leng Loo

Anal Chem 2016 06 13;88(11):5670-9. Epub 2016 May 13.

Medway Metabonomics Research Group, Medway School of Pharmacy, Universities of Kent and Greenwich , Chatham Maritime, Kent, ME4 4TB, U.K.

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June 2016

Power Analysis and Sample Size Determination in Metabolic Phenotyping.

Authors:
Benjamin J Blaise Gonçalo Correia Adrienne Tin J Hunter Young Anne-Claire Vergnaud Matthew Lewis Jake T M Pearce Paul Elliott Jeremy K Nicholson Elaine Holmes Timothy M D Ebbels

Anal Chem 2016 05 6;88(10):5179-88. Epub 2016 May 6.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , London SW7 2AZ, U.K.

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May 2016

Systemic Characterization of an Obese Phenotype in the Zucker Rat Model Defining Metabolic Axes of Energy Metabolism and Host-Microbial Interactions.

Authors:
Jutarop Phetcharaburanin Hannah Lees Julian R Marchesi Jeremy K Nicholson Elaine Holmes Florian Seyfried Jia V Li

J Proteome Res 2016 06 3;15(6):1897-906. Epub 2016 May 3.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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June 2016

Optimized Sample Handling Strategy for Metabolic Profiling of Human Feces.

Authors:
Jasmine Gratton Jutarop Phetcharaburanin Benjamin H Mullish Horace R T Williams Mark Thursz Jeremy K Nicholson Elaine Holmes Julian R Marchesi Jia V Li

Anal Chem 2016 05 21;88(9):4661-8. Epub 2016 Apr 21.

Center for Digestive and Gut Health, Institute of Global Health Innovation, Imperial College London , South Kensington, London SW7 2AZ, U.K.

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May 2016