Elaine Holmes

Elaine Holmes

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Elaine Holmes

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Metabolic Phenotyping in Venous Disease: The Need for Standardization.

J Proteome Res 2019 Oct 16. Epub 2019 Oct 16.

Academic Section of Vascular Surgery, Department of Surgery and Cancer , Imperial College London , Floor 4 East, Charing Cross Hospital, Fulham Palace Road , London W6 8RF , U.K.

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http://dx.doi.org/10.1021/acs.jproteome.9b00460DOI Listing
October 2019

A Unified Conceptual Framework for Metabolic Phenotyping in Diagnosis and Prognosis.

Trends Pharmacol Sci 2019 Sep 9. Epub 2019 Sep 9.

Division of Computational and Systems Medicine and Medical Research Council (MRC) National Institute for Health Research (NIHR) National Phenome Centre, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2019.08.004DOI Listing
September 2019

Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus.

Liver Int 2019 May 25;39(5):967-975. Epub 2019 Feb 25.

Institute of Cellular Medicine and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/liv.14069DOI Listing
May 2019

Obesity and Cage Environment Modulate Metabolism in the Zucker Rat: A Multiple Biological Matrix Approach to Characterizing Metabolic Phenomena.

J Proteome Res 2019 May 18;18(5):2160-2174. Epub 2019 Apr 18.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine , Imperial College London , London , SW7 2AZ , United Kingdom.

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http://dx.doi.org/10.1021/acs.jproteome.9b00040DOI Listing
May 2019

Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.

Nutrients 2019 Apr 16;11(4). Epub 2019 Apr 16.

Section for Nutrition Research, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.

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https://www.mdpi.com/2072-6643/11/4/861
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http://dx.doi.org/10.3390/nu11040861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520886PMC
April 2019

The metabolic fate and effects of 2-Bromophenol in male Sprague-Dawley rats.

Xenobiotica 2018 Dec 17:1-8. Epub 2018 Dec 17.

a Department of Surgery and Cancer Faculty of Medicine , Imperial College London, South Kensington Campus , London , United Kingdom.

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https://www.tandfonline.com/doi/full/10.1080/00498254.2018.1
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http://dx.doi.org/10.1080/00498254.2018.1559376DOI Listing
December 2018

Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota.

Gastroenterology 2018 11 17;155(5):1495-1507.e15. Epub 2018 Jul 17.

Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom; School of Biosciences, Cardiff University, Cardiff, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183477
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http://dx.doi.org/10.1053/j.gastro.2018.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347096PMC
November 2018

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism.

J Proteome Res 2018 10 20;17(10):3565-3573. Epub 2018 Sep 20.

Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine , Imperial College London , South Kensington Campus , London SW7 2AZ , United Kingdom.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00583
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http://dx.doi.org/10.1021/acs.jproteome.8b00583DOI Listing
October 2018

Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Direct Infusion-High-Resolution Mass Spectrometry for Combined Exploratory and Targeted Metabolic Profiling of Human Urine.

J Proteome Res 2018 10 19;17(10):3492-3502. Epub 2018 Sep 19.

Division of Integrative Systems and Digestive Medicine, Department of Surgery and Cancer , Imperial College London , Sir Alexander Fleming Building, South Kensington Campus , London SW7 2AZ , United Kingdom.

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http://dx.doi.org/10.1021/acs.jproteome.8b00413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184476PMC
October 2018

Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by H NMR Spectroscopy in a Multilaboratory Trial.

Anal Chem 2018 10 27;90(20):11962-11971. Epub 2018 Sep 27.

The Imperial Clinical Phenotyping Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer , QEQM Building, Saint Mary's Hospital , London W2 1NY , United Kingdom.

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http://dx.doi.org/10.1021/acs.analchem.8b02412DOI Listing
October 2018

Profiling inflammatory markers in patients with pneumonia on intensive care.

Sci Rep 2018 10 3;8(1):14736. Epub 2018 Oct 3.

Section of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK.

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http://www.nature.com/articles/s41598-018-32938-6
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http://dx.doi.org/10.1038/s41598-018-32938-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170441PMC
October 2018

The effect of L-rhamnose on intestinal transit time, short chain fatty acids and appetite regulation: a pilot human study using combined CO/H breath tests.

J Breath Res 2018 08 6;12(4):046006. Epub 2018 Aug 6.

Nutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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http://stacks.iop.org/1752-7163/12/i=4/a=046006?key=crossref
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http://dx.doi.org/10.1088/1752-7163/aad3f1DOI Listing
August 2018

Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model.

Eur J Vasc Endovasc Surg 2018 05 8;55(5):703-713. Epub 2018 Mar 8.

Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejvs.2018.01.027DOI Listing
May 2018

The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level.

Gut 2018 04 30;67(4):625-633. Epub 2017 Mar 30.

Alimentary Pharmabiotic Centre Microbiome Institute, University College Cork, National University of Ireland, Cork, Ireland.

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http://dx.doi.org/10.1136/gutjnl-2016-313627DOI Listing
April 2018

Optimized Phenotypic Biomarker Discovery and Confounder Elimination via Covariate-Adjusted Projection to Latent Structures from Metabolic Spectroscopy Data.

J Proteome Res 2018 04 27;17(4):1586-1595. Epub 2018 Feb 27.

Department of Preventive Medicine, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.7b00879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891819PMC
April 2018

Characterization of metabolic responses to healthy diets and association with blood pressure: application to the Optimal Macronutrient Intake Trial for Heart Health (OmniHeart), a randomized controlled study.

Am J Clin Nutr 2018 03;107(3):323-334

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1093/ajcn/nqx072DOI Listing
March 2018

Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin.

BMC Med 2018 01 24;16(1). Epub 2018 Jan 24.

Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London, W12 0NN, UK.

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http://dx.doi.org/10.1186/s12916-017-0999-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782380PMC
January 2018

Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense Infection.

J Infect Dis 2017 12;216(10):1273-1280

Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, United Kingdom.

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http://dx.doi.org/10.1093/infdis/jix466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853393PMC
December 2017

Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms.

J Proteome Res 2017 11 4;16(11):4208-4216. Epub 2017 Oct 4.

Department of Urogynaecology, St. Mary's Hospital, Imperial College Healthcare NHS Trust , London W2 1NY, U.K.

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http://dx.doi.org/10.1021/acs.jproteome.7b00568DOI Listing
November 2017

Lessons from Metabonomics on the Neurobiology of Stroke.

Neuroscientist 2017 08 24;23(4):374-382. Epub 2016 Oct 24.

1 Section of Vascular Surgery, Imperial College London, Charing Cross Hospital, London, UK.

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http://dx.doi.org/10.1177/1073858416673327DOI Listing
August 2017

Application of Metabolic Profiling to Abdominal Aortic Aneurysm Research.

J Proteome Res 2017 07 19;16(7):2325-2332. Epub 2017 Jun 19.

Section of Vascular Surgery, Imperial College London , 4 North, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom.

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http://dx.doi.org/10.1021/acs.jproteome.6b00894DOI Listing
July 2017

The Plasma and Serum Metabotyping of Hepatocellular Carcinoma in a Nigerian and Egyptian Cohort using Proton Nuclear Magnetic Resonance Spectroscopy.

J Clin Exp Hepatol 2017 Jun 15;7(2):83-92. Epub 2017 Mar 15.

Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary's Campus, South Wharf Road, London W2 1NY, United Kingdom.

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http://dx.doi.org/10.1016/j.jceh.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478965PMC
June 2017

Deep learning and 3D-DESI imaging reveal the hidden metabolic heterogeneity of cancer.

Chem Sci 2017 May 21;8(5):3500-3511. Epub 2017 Feb 21.

Department of Surgery and Cancer - Division of Computational and Systems Medicine , Imperial College London , London , UK . Email: ; Email: ; Email:

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http://xlink.rsc.org/?DOI=C6SC03738K
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http://dx.doi.org/10.1039/c6sc03738kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418631PMC
May 2017

Optimization and Application of Direct Infusion Nanoelectrospray HRMS Method for Large-Scale Urinary Metabolic Phenotyping in Molecular Epidemiology.

J Proteome Res 2017 04 14;16(4):1646-1658. Epub 2017 Mar 14.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.jproteome.6b01003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387673PMC
April 2017

Metabolic Profiling in Patients with Pneumonia on Intensive Care.

EBioMedicine 2017 Apr 29;18:244-253. Epub 2017 Mar 29.

Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405179PMC
April 2017

Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery.

J Transl Med 2017 04 26;15(1):83. Epub 2017 Apr 26.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, UK.

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http://dx.doi.org/10.1186/s12967-017-1171-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405545PMC
April 2017

Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial.

Lancet Diabetes Endocrinol 2017 03 13;5(3):184-195. Epub 2017 Jan 13.

Nutrition and Dietetic Research Group, Division of Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(16)30419-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357736PMC
March 2017

Integrated Analytical and Statistical Two-Dimensional Spectroscopy Strategy for Metabolite Identification: Application to Dietary Biomarkers.

Anal Chem 2017 03 10;89(6):3300-3309. Epub 2017 Mar 10.

Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, South Kensington Campus, Imperial College London , London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.analchem.6b03324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379249PMC
March 2017

Metabolic Phenotype of Obesity in a Saudi Population.

J Proteome Res 2017 02 20;16(2):635-644. Epub 2017 Jan 20.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.jproteome.6b00710DOI Listing
February 2017

Medical Swab Analysis Using Desorption Electrospray Ionization Mass Spectrometry: A Noninvasive Approach for Mucosal Diagnostics.

Anal Chem 2017 02 11;89(3):1540-1550. Epub 2017 Jan 11.

Computational and Systems Medicine, Imperial College London , South Kensington Campus, London, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.analchem.6b03405DOI Listing
February 2017

The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk.

Microbiome 2017 01 19;5(1). Epub 2017 Jan 19.

Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Hammersmith Campus, London, W12 0NN, UK.

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http://dx.doi.org/10.1186/s40168-016-0223-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244550PMC
January 2017

Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.

Arch Toxicol 2016 Dec 9;90(12):3073-3085. Epub 2016 Jan 9.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1007/s00204-015-1655-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104807PMC
December 2016

New technologies - new insights into the pathogenesis of hepatic encephalopathy.

Metab Brain Dis 2016 12 30;31(6):1259-1267. Epub 2016 Sep 30.

Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.1007/s11011-016-9906-yDOI Listing
December 2016

Development of a Pipeline for Exploratory Metabolic Profiling of Infant Urine.

J Proteome Res 2016 09 23;15(9):3432-40. Epub 2016 Aug 23.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London , South Kensington Campus, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.jproteome.6b00234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716460PMC
September 2016

Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using Proton Nuclear Magnetic Resonance Spectroscopy.

J Clin Exp Hepatol 2016 Sep 20;6(3):186-194. Epub 2016 Apr 20.

Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary's Campus, South Wharf Road, London W2 1NY, United Kingdom.

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http://dx.doi.org/10.1016/j.jceh.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052404PMC
September 2016

Porcupine quill migration in the thoracic cavity of a German shorthaired pointer.

J Am Anim Hosp Assoc 2015 Mar-Apr;51(2):101-6. Epub 2015 Feb 19.

From the Dallas Veterinary Surgical Center, Dallas, TX (J.G.); Veterinary Specialty Hospital of the Carolinas, Cary, NC (E.H.); and the University of Pennsylvania, Philadelphia, PA (J.R., D.H.).

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http://jaaha.org/doi/10.5326/JAAHA-MS-6093
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http://dx.doi.org/10.5326/JAAHA-MS-6093DOI Listing
August 2016

Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage.

Sci Transl Med 2016 08;8(350):350ra102

Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK. Queen Charlotte's Hospital, Imperial College Healthcare National Health Service (NHS) Trust, London W12 0HS, UK.

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http://dx.doi.org/10.1126/scitranslmed.aag1026DOI Listing
August 2016

Role of human milk oligosaccharides in Group B Streptococcus colonisation.

Clin Transl Immunology 2016 Aug 26;5(8):e99. Epub 2016 Aug 26.

Department of Paediatrics, Centre for International Child Health, Imperial College London, St Mary's Hospital, London, UK; Wellcome Trust Centre for Global Health Research, London, UK.

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http://dx.doi.org/10.1038/cti.2016.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007626PMC
August 2016

Systemic Characterization of an Obese Phenotype in the Zucker Rat Model Defining Metabolic Axes of Energy Metabolism and Host-Microbial Interactions.

J Proteome Res 2016 06 3;15(6):1897-906. Epub 2016 May 3.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.jproteome.6b00090DOI Listing
June 2016

Automatic Spectroscopic Data Categorization by Clustering Analysis (ASCLAN): A Data-Driven Approach for Distinguishing Discriminatory Metabolites for Phenotypic Subclasses.

Anal Chem 2016 06 13;88(11):5670-9. Epub 2016 May 13.

Medway Metabonomics Research Group, Medway School of Pharmacy, Universities of Kent and Greenwich , Chatham Maritime, Kent, ME4 4TB, U.K.

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http://dx.doi.org/10.1021/acs.analchem.5b04020DOI Listing
June 2016

Optimized Sample Handling Strategy for Metabolic Profiling of Human Feces.

Anal Chem 2016 05 21;88(9):4661-8. Epub 2016 Apr 21.

Center for Digestive and Gut Health, Institute of Global Health Innovation, Imperial College London , South Kensington, London SW7 2AZ, U.K.

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http://pubs.acs.org/doi/10.1021/acs.analchem.5b04159
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http://dx.doi.org/10.1021/acs.analchem.5b04159DOI Listing
May 2016

Power Analysis and Sample Size Determination in Metabolic Phenotyping.

Anal Chem 2016 05 6;88(10):5179-88. Epub 2016 May 6.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , London SW7 2AZ, U.K.

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http://dx.doi.org/10.1021/acs.analchem.6b00188DOI Listing
May 2016

Hepatocellular carcinoma: Review of disease and tumor biomarkers.

World J Hepatol 2016 Apr;8(10):471-84

Jin Un Kim, Mohamed I F Shariff, Mary M E Crossey, Maria Gomez-Romero, Simon D Taylor-Robinson, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, London W2 1NY, United Kingdom.

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http://dx.doi.org/10.4254/wjh.v8.i10.471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820639PMC
April 2016

Discovery of Infection Associated Metabolic Markers in Human African Trypanosomiasis.

PLoS Negl Trop Dis 2015 27;9(10):e0004200. Epub 2015 Oct 27.

Institute of Biological and Environmental Sciences, University Of Aberdeen, Aberdeen, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0004200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624234PMC
March 2016

An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake.

J Agric Food Chem 2016 Mar 8;64(11):2423-31. Epub 2016 Mar 8.

Nutrition and Dietetic Research Group, Division of Endocrinology and Metabolism, Imperial College London , London W12 0NN, U.K.

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http://dx.doi.org/10.1021/acs.jafc.5b05878DOI Listing
March 2016

Identification of a novel human circulating metabolite of tenofovir disoproxil fumarate with LC-MS/MS.

Bioanalysis 2015 ;7(6):643-52

Division of Computational & Systems Medicine, Department of Surgery & Cancer, Faculty of Medicine, Imperial College, London, SW7 2AZ, UK.

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http://dx.doi.org/10.4155/bio.14.300DOI Listing
January 2016

Development and Validation of a High-Throughput Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry Approach for Screening of Oxylipins and Their Precursors.

Anal Chem 2015 Dec 18;87(23):11721-31. Epub 2015 Nov 18.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London , Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, United Kingdom.

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http://pubs.acs.org/doi/10.1021/acs.analchem.5b02794
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http://dx.doi.org/10.1021/acs.analchem.5b02794DOI Listing
December 2015

Plasma Lipid Profiling in a Rat Model of Hepatocellular Carcinoma: Potential Modulation Through Quinolone Administration.

J Clin Exp Hepatol 2015 Dec 18;5(4):286-94. Epub 2015 Jul 18.

Liver Unit, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jceh.2015.07.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723654PMC
December 2015

Optimization of metabolite extraction of human vein tissue for ultra performance liquid chromatography-mass spectrometry and nuclear magnetic resonance-based untargeted metabolic profiling.

Analyst 2015 Nov;140(22):7586-97

Section of Biomolecular Medicine, Division of Computational and Systems Biology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK and Centre for Digestive and Gut Health, Institute of Global Health Innovation, Imperial College London, London, UK.

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http://xlink.rsc.org/?DOI=C5AN01041A
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http://dx.doi.org/10.1039/c5an01041aDOI Listing
November 2015

Perturbations in fatty acid metabolism and apoptosis are manifested in calcific coronary artery disease: An exploratory lipidomic study.

Int J Cardiol 2015 Oct 23;197:192-9. Epub 2015 Jun 23.

Department of Public Health and Clinical Medicine, Heart Centre, Umea University, Umea, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01675273150134
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http://dx.doi.org/10.1016/j.ijcard.2015.06.048DOI Listing
October 2015

Bile acid profiling and quantification in biofluids using ultra-performance liquid chromatography tandem mass spectrometry.

Anal Chem 2015 Oct 30;87(19):9662-70. Epub 2015 Sep 30.

Imperial College of London , Division of Computational Systems Medicine, Department of Surgery and Cancer, Sir Alexander Building, Exhibition Road, South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.analchem.5b01556DOI Listing
October 2015

Multiplatform characterization of dynamic changes in breast milk during lactation.

Electrophoresis 2015 Sep 25;36(18):2269-2285. Epub 2015 Jun 25.

Section of Computational and Systems Medicine, Division of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1002/elps.201500011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744768PMC
September 2015

(1)H NMR Spectroscopy of Fecal Extracts Enables Detection of Advanced Colorectal Neoplasia.

J Proteome Res 2015 Sep 7;14(9):3871-81. Epub 2015 Aug 7.

Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , SW7 2AZ London, U.K.

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http://dx.doi.org/10.1021/acs.jproteome.5b00277DOI Listing
September 2015

2-Furoylglycine as a Candidate Biomarker of Coffee Consumption.

J Agric Food Chem 2015 Sep 22;63(38):8615-21. Epub 2015 Sep 22.

Helmholtz Zentrum München, Research Unit Analytical BioGeoChemistry , 85764 Neuherberg, Germany.

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http://pubs.acs.org/doi/10.1021/acs.jafc.5b03040
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http://dx.doi.org/10.1021/acs.jafc.5b03040DOI Listing
September 2015

Hippocampal Proteomic and Metabonomic Abnormalities in Neurotransmission, Oxidative Stress, and Apoptotic Pathways in a Chronic Phencyclidine Rat Model.

J Proteome Res 2015 Aug 30;14(8):3174-87. Epub 2015 Jun 30.

†Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 1QT, U.K.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.5b00105
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http://dx.doi.org/10.1021/acs.jproteome.5b00105DOI Listing
August 2015

The promise of metabolic phenotyping in gastroenterology and hepatology.

Nat Rev Gastroenterol Hepatol 2015 Aug 21;12(8):458-71. Epub 2015 Jul 21.

MRC-NIHR National Phenome Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1038/nrgastro.2015.114DOI Listing
August 2015

Metabolic Profiling of Children Undergoing Surgery for Congenital Heart Disease.

Crit Care Med 2015 Jul;43(7):1467-76

1Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, United Kingdom. 2School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, United Kingdom. 3Paediatric Intensive Care Unit, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom. 4Department of Intensive Care, Southampton General University Hospital, Southampton, United Kingdom. 5Paediatric Intensive Care Unit, Imperial College London NHS Foundation Trust, London, United Kingdom. 6Department of Nutrition and Dietetics, Faculty of Medicine, Imperial College London, United Kingdom. 7University Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1097/CCM.0000000000000982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467581PMC
July 2015

Bariatric surgery and nonalcoholic fatty liver disease.

Eur J Gastroenterol Hepatol 2015 Jul;27(7):755-68

Department of Surgery and Cancer, Imperial College London, Imperial College Healthcare NHS Trust at St Mary's Hospital, London, UK.

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http://dx.doi.org/10.1097/MEG.0000000000000375DOI Listing
July 2015

A new gender-specific model for skin autofluorescence risk stratification.

Sci Rep 2015 May 14;5:10198. Epub 2015 May 14.

1] Drug Metabolism Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia [2] Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, SW7 2AZ, United Kingdom.

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http://www.nature.com/articles/srep10198
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http://dx.doi.org/10.1038/srep10198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431468PMC
May 2015

Untargeted UPLC-MS profiling pipeline to expand tissue metabolome coverage: application to cardiovascular disease.

Anal Chem 2015 Apr 8;87(8):4184-93. Epub 2015 Apr 8.

†Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, U.K.

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http://pubs.acs.org/doi/10.1021/ac503775m
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http://dx.doi.org/10.1021/ac503775mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407508PMC
April 2015

Urinary metabolic signatures of human adiposity.

Sci Transl Med 2015 Apr 29;7(285):285ra62. Epub 2015 Apr 29.

Biomolecular Medicine, Division of Computational and Systems Medicine, MRC-National Institute for Health Research (MRC-NIHR) National Phenome Centre, MRC-PHE Centre for Environment and Health, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1126/scitranslmed.aaa5680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598200PMC
April 2015