Elaine A Ostrander

Elaine A Ostrander

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Elaine A Ostrander

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Quantitative Translation of Dog-to-Human Aging by Conserved Remodeling of the DNA Methylome.

Cell Syst 2020 Jul 1. Epub 2020 Jul 1.

Division of Genetics, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2020.06.006DOI Listing
July 2020

A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry.

Eur Urol 2020 May 12. Epub 2020 May 12.

Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2020.04.060DOI Listing
May 2020

RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors.

BMC Cancer 2020 Mar 24;20(1):251. Epub 2020 Mar 24.

National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Bldg 50, Room 5351, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1186/s12885-020-06737-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092566PMC
March 2020

DNA methylation and cis-regulation of gene expression by prostate cancer risk SNPs.

PLoS Genet 2020 03 30;16(3):e1008667. Epub 2020 Mar 30.

Division of Public Health Sciences, Fred Hutchison Cancer Research Center, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145271PMC
March 2020

Copy number alterations are associated with metastatic-lethal progression in prostate cancer.

Prostate Cancer Prostatic Dis 2020 Feb 18. Epub 2020 Feb 18.

Division of Public Health Sciences, Fred Hutchison Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41391-020-0212-8DOI Listing
February 2020

Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a Coding Variant Leads to Hairlessness.

G3 (Bethesda) 2020 01 7;10(1):293-297. Epub 2020 Jan 7.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland

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http://dx.doi.org/10.1534/g3.119.400885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945040PMC
January 2020

Dog10K: the International Consortium of Canine Genome Sequencing.

Natl Sci Rev 2019 Jul 29;6(4):611-613. Epub 2019 May 29.

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, China.

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http://dx.doi.org/10.1093/nsr/nwz068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776106PMC
July 2019

Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health.

Natl Sci Rev 2019 Jul 10;6(4):810-824. Epub 2019 Apr 10.

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.

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http://dx.doi.org/10.1093/nsr/nwz049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776107PMC
July 2019

Targeted Resequencing of the Coding Sequence of 38 Genes Near Breast Cancer GWAS Loci in a Large Case-Control Study.

Cancer Epidemiol Biomarkers Prev 2019 04 14;28(4):822-825. Epub 2019 Jan 14.

Department of Public and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0298DOI Listing
April 2019

Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology.

Nat Commun 2019 04 2;10(1):1489. Epub 2019 Apr 2.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-019-09373-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445083PMC
April 2019

Hair of the Dog: Identification of a -Regulatory Module Predicted to Influence Canine Coat Composition.

Genes (Basel) 2019 04 26;10(5). Epub 2019 Apr 26.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20894, United States of America.

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http://dx.doi.org/10.3390/genes10050323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562840PMC
April 2019

Canine Cancer Genomics: Lessons for Canine and Human Health.

Annu Rev Anim Biosci 2019 02 12;7:449-472. Epub 2018 Nov 12.

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; email:

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https://www.annualreviews.org/doi/10.1146/annurev-animal-030
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http://dx.doi.org/10.1146/annurev-animal-030117-014523DOI Listing
February 2019

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:
Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2019 02;51(2):363

Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0330-6
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http://dx.doi.org/10.1038/s41588-018-0330-6DOI Listing
February 2019

DNA methylation profiles in African American prostate cancer patients in relation to disease progression.

Genomics 2019 01 21;111(1):10-16. Epub 2016 Feb 21.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, United States.

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http://dx.doi.org/10.1016/j.ygeno.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992660PMC
January 2019

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:
Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2018 07 11;50(7):928-936. Epub 2018 Jun 11.

Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0142-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568012PMC
July 2018

Genetic selection of athletic success in sport-hunting dogs.

Proc Natl Acad Sci U S A 2018 07 3;115(30):E7212-E7221. Epub 2018 Jul 3.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892

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http://www.pnas.org/lookup/doi/10.1073/pnas.1800455115
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http://dx.doi.org/10.1073/pnas.1800455115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065024PMC
July 2018

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

Authors:
Tokhir Dadaev Edward J Saunders Paul J Newcombe Ezequiel Anokian Daniel A Leongamornlert Mark N Brook Clara Cieza-Borrella Martina Mijuskovic Sarah Wakerell Ali Amin Al Olama Fredrick R Schumacher Sonja I Berndt Sara Benlloch Mahbubl Ahmed Chee Goh Xin Sheng Zhuo Zhang Kenneth Muir Koveela Govindasami Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Hakansson Catharine West Alison M Dunning Neil Burnet Lorelei Mucci Edward Giovannucci Gerald Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry Rosenstein Sarah Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Laura Fachal Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weisher Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Chavdar Slavov Vanio Mitev Matthew Parliament Sandeep Singhal Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Andrzej Kierzek Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Peter Kraft Matthew Freedman Fredrik Wiklund Stephen Chanock Brian E Henderson Douglas F Easton Christopher A Haiman Rosalind A Eeles David V Conti Zsofia Kote-Jarai

Nat Commun 2018 06 11;9(1):2256. Epub 2018 Jun 11.

The Institute of Cancer Research, London, SW7 3RP, UK.

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http://dx.doi.org/10.1038/s41467-018-04109-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995836PMC
June 2018

Demographic history, selection and functional diversity of the canine genome.

Nat Rev Genet 2017 12 25;18(12):705-720. Epub 2017 Sep 25.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, 50 South Drive, Building 50, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrg.2017.67DOI Listing
December 2017

loss is associated with prostate cancer recurrence and alterations in tumor DNA methylation profiles.

Oncotarget 2017 Oct 15;8(48):84338-84348. Epub 2017 Sep 15.

Division of Public Health Sciences, Fred Hutchison Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.18632/oncotarget.20940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663600PMC
October 2017

Epigenetic signature of Gleason score and prostate cancer recurrence after radical prostatectomy.

Clin Epigenetics 2016;8:97. Epub 2016 Sep 15.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024 USA ; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA USA.

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http://dx.doi.org/10.1186/s13148-016-0260-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024414PMC
April 2017

Genomic Analyses Reveal the Influence of Geographic Origin, Migration, and Hybridization on Modern Dog Breed Development.

Cell Rep 2017 04;19(4):697-708

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492993PMC
April 2017

Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight, muscling and back fat thickness.

PLoS Genet 2017 Mar 3;13(3):e1006661. Epub 2017 Mar 3.

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1006661
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http://dx.doi.org/10.1371/journal.pgen.1006661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357063PMC
March 2017

The bald and the beautiful: hairlessness in domestic dog breeds.

Philos Trans R Soc Lond B Biol Sci 2017 02;372(1713)

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA

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http://dx.doi.org/10.1098/rstb.2015.0488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182420PMC
February 2017

Generating Exome Enriched Sequencing Libraries from Formalin-Fixed, Paraffin-Embedded Tissue DNA for Next-Generation Sequencing.

Curr Protoc Hum Genet 2017 01 11;92:18.10.1-18.10.25. Epub 2017 Jan 11.

Center for Inherited Disease Research, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1002/cphg.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228582PMC
January 2017

Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping.

Dis Model Mech 2016 12 17;9(12):1445-1460. Epub 2016 Nov 17.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA

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http://dx.doi.org/10.1242/dmm.027037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200897PMC
December 2016

Commonalities in Development of Pure Breeds and Population Isolates Revealed in the Genome of the Sardinian Fonni's Dog.

Genetics 2016 Oct 12;204(2):737-755. Epub 2016 Aug 12.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892

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http://dx.doi.org/10.1534/genetics.116.192427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068859PMC
October 2016

Biallelic BRCA2 Mutations Shape the Somatic Mutational Landscape of Aggressive Prostate Tumors.

Am J Hum Genet 2016 05 14;98(5):818-829. Epub 2016 Apr 14.

Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863563PMC
May 2016

Transmissible Tumors: Breaking the Cancer Paradigm.

Trends Genet 2016 Jan 11;32(1):1-15. Epub 2015 Dec 11.

Department of Biomedical Science, 600W College Ave, College of Medicine, Florida State University, Tallahassee, Tallahassee, FL 32306, USA.

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http://www.cell.com/trends/genetics/pdf/S0168-9525(15)00187-
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http://linkinghub.elsevier.com/retrieve/pii/S016895251500187
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http://dx.doi.org/10.1016/j.tig.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698198PMC
January 2016

Epigenomic profiling of DNA methylation in paired prostate cancer versus adjacent benign tissue.

Prostate 2015 Dec 18;75(16):1941-50. Epub 2015 Sep 18.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1002/pros.23093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928710PMC
December 2015

Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors.

Clin Epigenetics 2015 12;7:128. Epub 2015 Dec 12.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA USA ; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA USA.

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http://dx.doi.org/10.1186/s13148-015-0161-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676897PMC
December 2015

Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.

Cancer Epidemiol Biomarkers Prev 2015 Jul 2;24(7):1121-9. Epub 2015 Apr 2.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491026PMC
July 2015

Insights into morphology and disease from the dog genome project.

Annu Rev Cell Dev Biol 2014 9;30:535-60. Epub 2014 Jul 9.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, Bethesda, Maryland 20892; email:

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http://dx.doi.org/10.1146/annurev-cellbio-100913-012927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510473PMC
June 2015

Confirmation of genetic variants associated with lethal prostate cancer in a cohort of men from hereditary prostate cancer families.

Int J Cancer 2015 May 13;136(9):2166-71. Epub 2014 Oct 13.

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/ijc.29241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331209PMC
May 2015

Dysregulation of the homeobox transcription factor gene HOXB13: role in prostate cancer.

Pharmgenomics Pers Med 2014 5;7:193-201. Epub 2014 Aug 5.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.2147/PGPM.S38117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157396PMC
September 2014

Validation study of genes with hypermethylated promoter regions associated with prostate cancer recurrence.

Cancer Epidemiol Biomarkers Prev 2014 Jul 9;23(7):1331-9. Epub 2014 Apr 9.

Authors' Affiliations: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center; Epidemiology, University of Washington, Seattle, Washington;

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-1
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http://dx.doi.org/10.1158/1055-9965.EPI-13-1000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082437PMC
July 2014

Cancer. Hiding in plain view--an ancient dog in the modern world.

Science 2014 Jan;343(6169):376-8

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-8000, USA.

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http://dx.doi.org/10.1126/science.1248812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204361PMC
January 2014

Derived variants at six genes explain nearly half of size reduction in dog breeds.

Genome Res 2013 Dec 11;23(12):1985-95. Epub 2013 Sep 11.

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA;

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http://dx.doi.org/10.1101/gr.157339.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847769PMC
December 2013

Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis.

J Hered 2013 May-Jun;104(3):399-406. Epub 2013 Mar 21.

Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Dr., Saskatoon, SK, Canada.

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http://dx.doi.org/10.1093/jhered/est012DOI Listing
September 2013

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.

Hum Mol Genet 2013 Jun 27;22(12):2520-8. Epub 2013 Mar 27.

The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.1093/hmg/ddt086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658165PMC
June 2013

HOXB13 mutations in a population-based, case-control study of prostate cancer.

Prostate 2013 May 5;73(6):634-41. Epub 2012 Nov 5.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://doi.wiley.com/10.1002/pros.22604
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http://dx.doi.org/10.1002/pros.22604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612366PMC
May 2013

Variation in selenoenzyme genes and prostate cancer risk and survival.

Prostate 2013 May 9;73(7):734-42. Epub 2012 Nov 9.

Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/pros.22617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859305PMC
May 2013

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.

Authors:
Rosalind A Eeles Ali Amin Al Olama Sara Benlloch Edward J Saunders Daniel A Leongamornlert Malgorzata Tymrakiewicz Maya Ghoussaini Craig Luccarini Joe Dennis Sarah Jugurnauth-Little Tokhir Dadaev David E Neal Freddie C Hamdy Jenny L Donovan Ken Muir Graham G Giles Gianluca Severi Fredrik Wiklund Henrik Gronberg Christopher A Haiman Fredrick Schumacher Brian E Henderson Loic Le Marchand Sara Lindstrom Peter Kraft David J Hunter Susan Gapstur Stephen J Chanock Sonja I Berndt Demetrius Albanes Gerald Andriole Johanna Schleutker Maren Weischer Federico Canzian Elio Riboli Tim J Key Ruth C Travis Daniele Campa Sue A Ingles Esther M John Richard B Hayes Paul D P Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Elaine A Ostrander Lisa B Signorello Stephen N Thibodeau Dan Schaid Christiane Maier Walther Vogel Adam S Kibel Cezary Cybulski Jan Lubinski Lisa Cannon-Albright Hermann Brenner Jong Y Park Radka Kaneva Jyotsna Batra Amanda B Spurdle Judith A Clements Manuel R Teixeira Ed Dicks Andrew Lee Alison M Dunning Caroline Baynes Don Conroy Melanie J Maranian Shahana Ahmed Koveela Govindasami Michelle Guy Rosemary A Wilkinson Emma J Sawyer Angela Morgan David P Dearnaley Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Nicholas J Van As Christopher J Woodhouse Alan Thompson Tim Dudderidge Chris Ogden Colin S Cooper Artitaya Lophatananon Angela Cox Melissa C Southey John L Hopper Dallas R English Markus Aly Jan Adolfsson Jiangfeng Xu Siqun L Zheng Meredith Yeager Rudolf Kaaks W Ryan Diver Mia M Gaudet Mariana C Stern Roman Corral Amit D Joshi Ahva Shahabi Tiina Wahlfors Teuvo L J Tammela Anssi Auvinen Jarmo Virtamo Peter Klarskov Børge G Nordestgaard M Andreas Røder Sune F Nielsen Stig E Bojesen Afshan Siddiq Liesel M Fitzgerald Suzanne Kolb Erika M Kwon Danielle M Karyadi William J Blot Wei Zheng Qiuyin Cai Shannon K McDonnell Antje E Rinckleb Bettina Drake Graham Colditz Dominika Wokolorczyk Robert A Stephenson Craig Teerlink Heiko Muller Dietrich Rothenbacher Thomas A Sellers Hui-Yi Lin Chavdar Slavov Vanio Mitev Felicity Lose Srilakshmi Srinivasan Sofia Maia Paula Paulo Ethan Lange Kathleen A Cooney Antonis C Antoniou Daniel Vincent François Bacot Daniel C Tessier Zsofia Kote-Jarai Douglas F Easton

Nat Genet 2013 Apr;45(4):385-91, 391e1-2

The Institute of Cancer Research, Sutton, UK.

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http://dx.doi.org/10.1038/ng.2560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832790PMC
April 2013

A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit.

PLoS Genet 2013 Mar 28;9(3):e1003409. Epub 2013 Mar 28.

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610924PMC
March 2013

Identification of recent hybridization between gray wolves and domesticated dogs by SNP genotyping.

Mamm Genome 2013 Feb 12;24(1-2):80-8. Epub 2012 Oct 12.

Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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February 2013

The genetics of canine skull shape variation.

Genetics 2013 Feb;193(2):317-25

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.genetics.org/cgi/doi/10.1534/genetics.112.145284
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567726PMC
February 2013

Association of variants in estrogen-related pathway genes with prostate cancer risk.

Prostate 2013 Jan 1;73(1):1-10. Epub 2012 May 1.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1002/pros.22534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544476PMC
January 2013

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.

Authors:
Ali Amin Al Olama Zsofia Kote-Jarai Fredrick R Schumacher Fredrik Wiklund Sonja I Berndt Sara Benlloch Graham G Giles Gianluca Severi David E Neal Freddie C Hamdy Jenny L Donovan David J Hunter Brian E Henderson Michael J Thun Michael Gaziano Edward L Giovannucci Afshan Siddiq Ruth C Travis David G Cox Federico Canzian Elio Riboli Timothy J Key Gerald Andriole Demetrius Albanes Richard B Hayes Johanna Schleutker Anssi Auvinen Teuvo L J Tammela Maren Weischer Janet L Stanford Elaine A Ostrander Cezary Cybulski Jan Lubinski Stephen N Thibodeau Daniel J Schaid Karina D Sorensen Jyotsna Batra Judith A Clements Suzanne Chambers Joanne Aitken Robert A Gardiner Christiane Maier Walther Vogel Thilo Dörk Hermann Brenner Tomonori Habuchi Sue Ingles Esther M John Joanne L Dickinson Lisa Cannon-Albright Manuel R Teixeira Radka Kaneva Hong-Wei Zhang Yong-Jie Lu Jong Y Park Kathleen A Cooney Kenneth R Muir Daniel A Leongamornlert Edward Saunders Malgorzata Tymrakiewicz Nadiya Mahmud Michelle Guy Koveela Govindasami Lynne T O'Brien Rosemary A Wilkinson Amanda L Hall Emma J Sawyer Tokhir Dadaev Jonathan Morrison David P Dearnaley Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Nicholas Van As Christopher J Woodhouse Alan Thompson Tim Dudderidge Chris Ogden Colin S Cooper Artitaya Lophatonanon Melissa C Southey John L Hopper Dallas English Jarmo Virtamo Loic Le Marchand Daniele Campa Rudolf Kaaks Sara Lindstrom W Ryan Diver Susan Gapstur Meredith Yeager Angela Cox Mariana C Stern Roman Corral Markus Aly William Isaacs Jan Adolfsson Jianfeng Xu S Lilly Zheng Tiina Wahlfors Kimmo Taari Paula Kujala Peter Klarskov Børge G Nordestgaard M Andreas Røder Ruth Frikke-Schmidt Stig E Bojesen Liesel M FitzGerald Suzanne Kolb Erika M Kwon Danielle M Karyadi Torben Falck Orntoft Michael Borre Antje Rinckleb Manuel Luedeke Kathleen Herkommer Andreas Meyer Jürgen Serth James R Marthick Briony Patterson Dominika Wokolorczyk Amanda Spurdle Felicity Lose Shannon K McDonnell Amit D Joshi Ahva Shahabi Pedro Pinto Joana Santos Ana Ray Thomas A Sellers Hui-Yi Lin Robert A Stephenson Craig Teerlink Heiko Muller Dietrich Rothenbacher Norihiko Tsuchiya Shintaro Narita Guang-Wen Cao Chavdar Slavov Vanio Mitev Stephen Chanock Henrik Gronberg Christopher A Haiman Peter Kraft Douglas F Easton Rosalind A Eeles

Hum Mol Genet 2013 Jan 12;22(2):408-15. Epub 2012 Oct 12.

Strangeways Laboratory, Centre for Cancer Genetic Epidemiology, Worts Causeway, Cambridge CB1 8RN, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526158PMC
January 2013

The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs.

Mamm Genome 2012 Dec 18;23(11-12):780-90. Epub 2012 Aug 18.

Department of Biology, Colgate University, 13 Oak Drive, Hamilton, NY 13346, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511640PMC
December 2012

The monoamine oxidase A gene promoter repeat and prostate cancer risk.

Prostate 2012 Nov 2;72(15):1622-7. Epub 2012 Apr 2.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.

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http://dx.doi.org/10.1002/pros.22515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532925PMC
November 2012

So many doggone traits: mapping genetics of multiple phenotypes in the domestic dog.

Hum Mol Genet 2012 Oct 9;21(R1):R52-7. Epub 2012 Aug 9.

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459646PMC
October 2012

Androgen metabolism and JAK/STAT pathway genes and prostate cancer risk.

Cancer Epidemiol 2012 Aug 26;36(4):347-53. Epub 2012 Apr 26.

National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Building 50, 50 South Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.canep.2012.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392409PMC
August 2012

Franklin H. Epstein Lecture. Both ends of the leash--the human links to good dogs with bad genes.

N Engl J Med 2012 Aug;367(7):636-46

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1056/NEJMra1204453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508784PMC
August 2012

Leading the way: finding genes for neurologic disease in dogs using genome-wide mRNA sequencing.

BMC Genet 2012 Jul 10;13:56. Epub 2012 Jul 10.

NHGRI/National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1471-2156-13-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409065PMC
July 2012

Missteps and mistakes, friends and heroes.

Endocr Relat Cancer 2012 Jun 3;19(3):P5-8. Epub 2012 May 3.

Cancer Genetics Branch, National Human Genome Research Institute/National Institutes of Health, 50 South Drive, Room 5351, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1530/ERC-12-0027DOI Listing
June 2012

Sizing up dogs.

Curr Biol 2012 May 7;22(9):R315-6. Epub 2012 May 7.

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cub.2012.02.013DOI Listing
May 2012