Elai Davicioni

Elai Davicioni

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Elai Davicioni

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Genomic Validation of 3-Tiered Clinical Subclassification of High-Risk Prostate Cancer.

Authors:
Vinayak Muralidhar Jingbin Zhang Qiqi Wang Brandon A Mahal Santino S Butler Daniel E Spratt Elai Davicioni Oliver Sartor Felix Y Feng Kent W Mouw Paul L Nguyen

Int J Radiat Oncol Biol Phys 2019 Nov 2;105(3):621-627. Epub 2019 Jul 2.

Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2019.06.2510DOI Listing
November 2019

Genomic Analysis and Treatment Response of a Bladder Urothelial Carcinoma With Sarcomatoid Variant Histology.

Authors:
Vikram M Narayan Shilpa Gupta Elai Davicioni Paari Murugan Ewan A Gibb Badrinath Konety

Clin Genitourin Cancer 2019 Oct 25;17(5):e888-e892. Epub 2019 May 25.

Department of Urology, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1016/j.clgc.2019.05.019DOI Listing
October 2019

A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: Development and validation studies.

Authors:
Anqi Cheng Shanshan Zhao Liesel M FitzGerald Jonathan L Wright Suzanne Kolb R Jeffrey Karnes Robert B Jenkins Elai Davicioni Elaine A Ostrander Ziding Feng Jian-Bing Fan James Y Dai Janet L Stanford

Prostate 2019 Oct 2;79(14):1589-1596. Epub 2019 Aug 2.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1002/pros.23882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715522PMC
October 2019

Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer.

Authors:
Vera Genitsch Attila Kollár Gillian Vandekerkhove Jennifer Blarer Marc Furrer Matti Annala Cameron Herberts Armin Pycha Joep J de Jong Yang Liu Friedemann Krentel Elai Davicioni Ewan A Gibb Marianna Kruithof-de Julio Alexander W Wyatt Roland Seiler

Urol Oncol 2019 Oct 1. Epub 2019 Oct 1.

Department of Urology, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2019.09.025DOI Listing
October 2019

Validation of the Decipher Test for predicting adverse pathology in candidates for prostate cancer active surveillance.

Authors:
Hyung L Kim Ping Li Huei-Chung Huang Samineh Deheshi Tara Marti Beatrice Knudsen Hatem Abou-Ouf Ridwan Alam Tamara L Lotan Lucia L C Lam Marguerite du Plessis Elai Davicioni Neil Fleshner Brian R Lane Ashley E Ross John W Davis James L Mohler Bruce J Trock Eric A Klein Jeffrey J Tosoian M Eric Hyndman Tarek A Bismar

Prostate Cancer Prostatic Dis 2019 Sep 12;22(3):399-405. Epub 2018 Dec 12.

University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1038/s41391-018-0101-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760567PMC
September 2019

Correlation between MRI phenotypes and a genomic classifier of prostate cancer: preliminary findings.

Authors:
Andrei S Purysko Cristina Magi-Galluzzi Omar Y Mian Sarah Sittenfeld Elai Davicioni Marguerite du Plessis Christine Buerki Jennifer Bullen Lin Li Anant Madabhushi Andrew Stephenson Eric A Klein

Eur Radiol 2019 Sep 7;29(9):4861-4870. Epub 2019 Mar 7.

Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1007/s00330-019-06114-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684343PMC
September 2019

Radiomics Features Measured with Multiparametric Magnetic Resonance Imaging Predict Prostate Cancer Aggressiveness.

Authors:
Stefanie J Hectors Mathew Cherny Kamlesh K Yadav Alp Tuna Beksaç Hari Thulasidass Sara Lewis Elai Davicioni Pei Wang Ashutosh K Tewari Bachir Taouli

J Urol 2019 09 8;202(3):498-505. Epub 2019 Aug 8.

Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1097/JU.0000000000000272DOI Listing
September 2019

Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer.

Authors:
Vera Genitsch Attila Kollár Gillian Vandekerkhove Jennifer Blarer Marc Furrer Matti Annala Cameron Herberts Armin Pycha Joep J de Jong Yang Liu Friedemann Krentel Elai Davicioni Ewan A Gibb Marianna Kruithof-de Julio Alexander W Wyatt Roland Seiler

Urol Oncol 2019 Sep 26;37(9):573.e19-573.e29. Epub 2019 Jul 26.

Department of Urology, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2019.06.021DOI Listing
September 2019

Validation of the Decipher Test for Predicting Distant Metastatic Recurrence in Men with High-risk Nonmetastatic Prostate Cancer 10 Years After Surgery.

Authors:
Thomas Van den Broeck Lisa Moris Thomas Gevaert Lorenzo Tosco Elien Smeets Nick Fishbane Yang Liu Christine Helsen Jennifer Margrave Christine Buerki Elai Davicioni Hendrik Van Poppel Wouter Everaerts Sheila Weinmann Robert Den John Davis Edward Schaeffer R Jeffrey Karnes Frank Claessens Steven Joniau

Eur Urol Oncol 2019 Sep 11;2(5):589-596. Epub 2019 Jan 11.

Department of Urology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2018.12.007DOI Listing
September 2019

Transcriptomic Heterogeneity of Androgen Receptor Activity Defines a low AR-Active Subclass in Treatment Naïve Primary Prostate Cancer.

Authors:
Daniel E Spratt Mohammed Alshalalfa Nick Fishbane Adam B Weiner Rohit Mehra Brandon A Mahal Jonathan Lehrer Yang Liu Shuang G Zhao Corey Speers Todd M Morgan Adam P Dicker Stephen J Freedland R Jeffery Karnes Sheila Weinmann Elai Davicioni Ashley E Ross Robert B Den Paul L Nguyen Felix Y Feng Tamara L Lotan Arul M Chinnaiyan Edward M Schaeffer

Clin Cancer Res 2019 Sep 12. Epub 2019 Sep 12.

Department of Urology, Feinberg School of Medicine, Northwestern University, Illinois.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1587DOI Listing
September 2019

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.

Authors:
David P Labbé Giorgia Zadra Meng Yang Jaime M Reyes Charles Y Lin Stefano Cacciatore Ericka M Ebot Amanda L Creech Francesca Giunchi Michelangelo Fiorentino Habiba Elfandy Sudeepa Syamala Edward D Karoly Mohammed Alshalalfa Nicholas Erho Ashley Ross Edward M Schaeffer Ewan A Gibb Mandeep Takhar Robert B Den Jonathan Lehrer R Jeffrey Karnes Stephen J Freedland Elai Davicioni Daniel E Spratt Leigh Ellis Jacob D Jaffe Anthony V DʼAmico Philip W Kantoff James E Bradner Lorelei A Mucci Jorge E Chavarro Massimo Loda Myles Brown

Nat Commun 2019 Sep 25;10(1):4358. Epub 2019 Sep 25.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41467-019-12298-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761092PMC
September 2019

---Comprehensive transcriptomic profiling identifies breast cancer patients who may be spared adjuvant systemic therapy.

Authors:
Martin Sjöström S Laura Chang Nick Fishbane Elai Davicioni Linda Hartman Erik Holmberg Felix Y Feng Corey Speers Lori J Pierce Per Malmström Mårten Fernö Per Karlsson

Clin Cancer Res 2019 Sep 26. Epub 2019 Sep 26.

Department of Oncology, Institute of Clinical Sciences, Department of Oncology, Sahlgrenska Academy, University of Gothenburg.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1038DOI Listing
September 2019

Divergent Biological Response to Neoadjuvant Chemotherapy in Muscle-invasive Bladder Cancer.

Authors:
Roland Seiler Ewan A Gibb Natalie Q Wang Htoo Zarni Oo Hung-Ming Lam Kim E van Kessel Charlotte S Voskuilen Brian Winters Nicholas Erho Mandeep M Takhar James Douglas Funda Vakar-Lopez Simon J Crabb Bas W G van Rhijn Elisabeth E Fransen van de Putte Ellen C Zwarthoff George N Thalmann Elai Davicioni Joost L Boormans Marc Dall'Era Michiel S van der Heijden Jonathan L Wright Peter C Black

Clin Cancer Res 2019 Aug 17;25(16):5082-5093. Epub 2018 Sep 17.

Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1106DOI Listing
August 2019

Molecular Subtyping of Clinically Localized Urothelial Carcinoma Reveals Lower Rates of Pathological Upstaging at Radical Cystectomy Among Luminal Tumors.

Authors:
Yair Lotan Stephen A Boorjian Jingbin Zhang Trinity J Bivalacqua Sima P Porten Thomas Wheeler Seth P Lerner Ryan Hutchinson Franto Francis Elai Davicioni Robert S Svatek Chun-Liang Chen Peter C Black Ewan A Gibb

Eur Urol 2019 Aug 12;76(2):200-206. Epub 2019 May 12.

GenomeDx Inc, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.eururo.2019.04.036DOI Listing
August 2019

African American Specific Gene Panel Predictive of Poor Prostate Cancer Outcome.

Authors:
Michelle I Echevarria Shivanshu Awasthi Chia-Ho Cheng Anders E Berglund Robert J Rounbehler Travis A Gerke Mandeep Takhar Elai Davicioni Eric A Klein Stephen J Freedland Ashley E Ross Edward M Schaeffer Robert B Den John L Cleveland Jong Y Park Walter Rayford Kosj Yamoah

J Urol 2019 08 8;202(2):247-255. Epub 2019 Jul 8.

H. Lee Moffitt Cancer Center and Research Institute , Tampa , Florida.

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http://dx.doi.org/10.1097/JU.0000000000000193DOI Listing
August 2019

The evolution of long noncoding RNA acceptance in prostate cancer initiation, progression, and its clinical utility in disease management.

Authors:
Varune Rohan Ramnarine Maxim Kobelev Ewan A Gibb Mannan Nouri Dong Lin Yuzhuo Wang Ralph Buttyan Elai Davicioni Amina Zoubeidi Colin C Collins

Eur Urol 2019 Aug 22. Epub 2019 Aug 22.

Vancouver Prostate Centre, Vancouver, BC, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2019.07.040DOI Listing
August 2019

Decipher identifies men with otherwise clinically favorable-intermediate risk disease who may not be good candidates for active surveillance.

Authors:
Annika Herlemann Huei-Chung Huang Ridwan Alam Jeffery J Tosoian Hyung L Kim Eric A Klein Jeffry P Simko June M Chan Brian R Lane John W Davis Elai Davicioni Felix Y Feng Peter McCue Hyun Kim Robert B Den Tarek A Bismar Peter R Carroll Matthew R Cooperberg

Prostate Cancer Prostatic Dis 2019 Aug 27. Epub 2019 Aug 27.

Department of Urology, University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41391-019-0167-9DOI Listing
August 2019

Impact of Immune and Stromal Infiltration on Outcomes Following Bladder-Sparing Trimodality Therapy for Muscle-Invasive Bladder Cancer.

Authors:
Jason A Efstathiou Kent W Mouw Ewan A Gibb Yang Liu Chin-Lee Wu Michael R Drumm Jose Batista da Costa Marguerite du Plessis Natalie Q Wang Elai Davicioni Felix Y Feng Roland Seiler Peter C Black William U Shipley David T Miyamoto

Eur Urol 2019 Jul 1;76(1):59-68. Epub 2019 Feb 1.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.eururo.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571058PMC
July 2019

Molecular Characterization of Neuroendocrine-like Bladder Cancer.

Authors:
José Batista da Costa Ewan A Gibb Trinity J Bivalacqua Yang Liu Htoo Zarni Oo David T Miyamoto Mohammed Alshalalfa Elai Davicioni Jonathan Wright Marc A Dall'Era James Douglas Joost L Boormans Michiel S Van der Heijden Chin-Lee Wu Bas W G van Rhijn Shilpa Gupta Petros Grivas Kent W Mouw Paari Murugan Ladan Fazli Seong Ra Badrinath R Konety Roland Seiler Siamak Daneshmand Omar Y Mian Jason A Efstathiou Yair Lotan Peter C Black

Clin Cancer Res 2019 Jul 5;25(13):3908-3920. Epub 2019 Apr 5.

Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3558DOI Listing
July 2019

Novel RB1-Loss Transcriptomic Signature Is Associated with Poor Clinical Outcomes across Cancer Types.

Authors:
William S Chen Mohammed Alshalalfa Shuang G Zhao Yang Liu Brandon A Mahal David A Quigley Ting Wei Elai Davicioni Timothy R Rebbeck Philip W Kantoff Christopher A Maher Karen E Knudsen Eric J Small Paul L Nguyen Felix Y Feng

Clin Cancer Res 2019 Jul 22;25(14):4290-4299. Epub 2019 Apr 22.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0404DOI Listing
July 2019

Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression.

Authors:
Robert M Hughes Brian W Simons Hamda Khan Rebecca Miller Valentina Kugler Samantha Torquato Debebe Theodros Michael C Haffner Tamara Lotan Jessie Huang Elai Davicioni Steven S An Ryan C Riddle Daniel L J Thorek Isla P Garraway Elana J Fertig John T Isaacs W Nathaniel Brennen Ben H Park Paula J Hurley

Cancer Res 2019 Jul 23;79(14):3636-3650. Epub 2019 May 23.

The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734938PMC
July 2019

Transcriptomic and Clinical Characterization of Neuropeptide Y Expression in Localized and Metastatic Prostate Cancer: Identification of Novel Prostate Cancer Subtype with Clinical Implications.

Authors:
Mohammed Alshalalfa Paul L Nguyen Himisha Beltran William S Chen Elai Davicioni Shuang G Zhao Timothy R Rebbeck Edward M Schaeffer Tamara L Lotan Felix Y Feng Brandon A Mahal

Eur Urol Oncol 2019 Jul 2;2(4):405-412. Epub 2019 Jun 2.

Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.euo.2019.05.001DOI Listing
July 2019

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes.

Authors:
Elizabeth J Adams Wouter R Karthaus Elizabeth Hoover Deli Liu Antoine Gruet Zeda Zhang Hyunwoo Cho Rose DiLoreto Sagar Chhangawala Yang Liu Philip A Watson Elai Davicioni Andrea Sboner Christopher E Barbieri Rohit Bose Christina S Leslie Charles L Sawyers

Nature 2019 07 26;571(7765):408-412. Epub 2019 Jun 26.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41586-019-1318-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661172PMC
July 2019

Prostate Cancer Genomic-risk Differences Between African-American and White Men Across Gleason Scores.

Authors:
Brandon A Mahal Mohammed Alshalalfa Daniel E Spratt Elai Davicioni Shuang G Zhao Felix Y Feng Timothy R Rebbeck Paul L Nguyen Franklin W Huang

Eur Urol 2019 Jun 22;75(6):1038-1040. Epub 2019 Jan 22.

University of California at San Francisco, San Francisco, CA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03022838193001
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http://dx.doi.org/10.1016/j.eururo.2019.01.010DOI Listing
June 2019

Development of a predictive model for stromal content in prostate cancer samples to improve signature performance.

Authors:
Nadia Boufaied Mandeep Takhar Claire Nash Nicholas Erho Tarek A Bismar Elai Davicioni Axel A Thomson

J Pathol 2019 Jun 17. Epub 2019 Jun 17.

Division of Urology and Cancer Research Program, McGill University Health Centre Research Institute, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada.

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http://dx.doi.org/10.1002/path.5315DOI Listing
June 2019

Distinct transcriptional repertoire of the androgen receptor in ETS fusion-negative prostate cancer.

Authors:
Anders E Berglund Robert J Rounbehler Travis Gerke Shivanshu Awasthi Chia-Ho Cheng Mandeep Takhar Elai Davicioni Mohammed Alshalalfa Nicholas Erho Eric A Klein Stephen J Freedland Ashley E Ross Edward M Schaeffer Bruce J Trock Robert B Den John L Cleveland Jong Y Park Jasreman Dhillon Kosj Yamoah

Prostate Cancer Prostatic Dis 2019 05 26;22(2):292-302. Epub 2018 Oct 26.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

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http://www.nature.com/articles/s41391-018-0103-4
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http://dx.doi.org/10.1038/s41391-018-0103-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760558PMC
May 2019

Characterization of transcriptomic signature of primary prostate cancer analogous to prostatic small cell neuroendocrine carcinoma.

Authors:
Mohammed Alshalalfa Yang Liu Alexander W Wyatt Ewan A Gibb Harrison K Tsai Nicholas Erho Jonathan Lehrer Mandeep Takhar Varune R Ramnarine Colin C Collins Robert B Den Edward M Schaeffer Elai Davicioni Tamara L Lotan Tarek A Bismar

Int J Cancer 2019 May 24. Epub 2019 May 24.

Department of Pathology & Laboratory Medicine, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1002/ijc.32430DOI Listing
May 2019

Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas.

Authors:
Shuang G Zhao William S Chen Rajdeep Das S Laura Chang Scott A Tomlins Jonathan Chou David A Quigley Ha X Dang Travis J Barnard Brandon A Mahal Ewan A Gibb Yang Liu Elai Davicioni Linda R Duska Edwin M Posadas Shruti Jolly Daniel E Spratt Paul L Nguyen Christopher A Maher Eric J Small Felix Y Feng

Clin Cancer Res 2019 Apr 20;25(8):2450-2457. Epub 2018 Dec 20.

Department of Radiation Oncology, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3121DOI Listing
April 2019

The Immune Landscape of Prostate Cancer and Nomination of PD-L2 as a Potential Therapeutic Target.

Authors:
Shuang G Zhao Jonathan Lehrer S Laura Chang Rajdeep Das Nicholas Erho Yang Liu Martin Sjöström Robert B Den Stephen J Freedland Eric A Klein R Jeffrey Karnes Edward M Schaeffer Melody Xu Corey Speers Paul L Nguyen Ashley E Ross June M Chan Matthew R Cooperberg Peter R Carroll Elai Davicioni Lawrence Fong Daniel E Spratt Felix Y Feng

J Natl Cancer Inst 2019 Mar;111(3):301-310

Department of Radiation Oncology, Helen Diller Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA.

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https://academic.oup.com/jnci/advance-article/doi/10.1093/jn
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http://dx.doi.org/10.1093/jnci/djy141DOI Listing
March 2019

Low Tristetraprolin Expression Is Associated with Lethal Prostate Cancer.

Authors:
Travis Gerke Himisha Beltran Xiaodong Wang Gwo-Shu Mary Lee Andrea Sboner R Jeffrey Karnes Eric A Klein Elai Davicioni Kasra Yousefi Ashley E Ross Daniela Börnigen Curtis Huttenhower Lorelei A Mucci Bruce J Trock Christopher J Sweeney

Cancer Epidemiol Biomarkers Prev 2019 Mar 12;28(3):584-590. Epub 2018 Nov 12.

Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
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http://dx.doi.org/10.1158/1055-9965.EPI-18-0667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494092PMC
March 2019

ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer.

Authors:
Laura Cato Jonas de Tribolet-Hardy Irene Lee Jaice T Rottenberg Ilsa Coleman Diana Melchers René Houtman Tengfei Xiao Wei Li Takuma Uo Shihua Sun Nane C Kuznik Bettina Göppert Fatma Ozgun Martin E van Royen Adriaan B Houtsmuller Raga Vadhi Prakash K Rao Lewyn Li Steven P Balk Robert B Den Bruce J Trock R Jeffrey Karnes Robert B Jenkins Eric A Klein Elai Davicioni Friederike J Gruhl Henry W Long X Shirley Liu Andrew C B Cato Nathan A Lack Peter S Nelson Stephen R Plymate Anna C Groner Myles Brown

Cancer Cell 2019 Mar 14;35(3):401-413.e6. Epub 2019 Feb 14.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.01.008DOI Listing
March 2019

Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer.

Authors:
Ye Feng Varune Rohan Ramnarine Robert Bell Stanislav Volik Elai Davicioni Vanessa M Hayes Shancheng Ren Colin C Collins

BMC Genomics 2019 Feb 18;20(1):146. Epub 2019 Feb 18.

Vancouver Prostate Centre, Vancouver, Canada.

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http://dx.doi.org/10.1186/s12864-019-5457-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379980PMC
February 2019

Genomic Classifier for Guiding Treatment of Intermediate-Risk Prostate Cancers to Dose-Escalated Image Guided Radiation Therapy Without Hormone Therapy.

Authors:
Alejandro Berlin Jure Murgic Ali Hosni Melania Pintilie Adriana Salcedo Michael Fraser Suzanne Kamel-Reid Jingbin Zhang Qiqi Wang Carolyn Ch'ng Samineh Deheshi Elai Davicioni Theodorus van der Kwast Paul C Boutros Robert G Bristow Melvin L K Chua

Int J Radiat Oncol Biol Phys 2019 01 29;103(1):84-91. Epub 2018 Aug 29.

Princess Margaret Cancer Centre, University Health Network, Ontario, Canada; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore; Division of Medical Sciences, National Cancer Centre Singapore, Singapore; Oncology Academic Program, Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.1016/j.ijrobp.2018.08.030DOI Listing
January 2019

Genomic Risk Predicts Molecular Imaging-detected Metastatic Nodal Disease in Prostate Cancer.

Authors:
Melody J Xu Zachary Kornberg Adam J Gadzinski Dongmei Diao Janet E Cowan Susan Y Wu Lauren Boreta Daniel E Spratt Spencer C Behr Hao G Nguyen Matthew R Cooperberg Elai Davicioni Mack Roach Thomas A Hope Peter R Carroll Felix Y Feng

Eur Urol Oncol 2019 Jan 14. Epub 2019 Jan 14.

Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA; Department of Urology, University of California San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2018.11.002DOI Listing
January 2019

Multiparametric Magnetic Resonance Imaging Features Identify Aggressive Prostate Cancer at the Phenotypic and Transcriptomic Level.

Authors:
Alp Tuna Beksac Shivaram Cumarasamy Ugo Falagario Paige Xu Mandeep Takhar Mohamed Alshalalfa Akriti Gupta Sonya Prasad Alberto Martini Hari Thulasidass Richa Rai Mark Berger Stefanie Hectors Jennifer Jordan Elai Davicioni Sujit Nair Kenneth Haines Sara Lewis Ardeshir Rastinehad Kamlesh Yadav Isuru Jayaratna Bachir Taouli Ashutosh Tewari

J Urol 2018 12 3;200(6):1241-1249. Epub 2018 Jul 3.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00225347184344
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http://dx.doi.org/10.1016/j.juro.2018.06.041DOI Listing
December 2018

Tristetraprolin Is a Prognostic Biomarker for Poor Outcomes among Patients with Low-Grade Prostate Cancer.

Authors:
Robert J Rounbehler Anders E Berglund Travis Gerke Mandeep M Takhar Shivanshu Awasthi Weimin Li Elai Davicioni Nicholas G Erho Ashley E Ross Edward M Schaeffer Eric A Klein R Jeffrey Karnes Robert B Jenkins John L Cleveland Jong Y Park Kosj Yamoah

Cancer Epidemiol Biomarkers Prev 2018 11 14;27(11):1376-1383. Epub 2018 Aug 14.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214732PMC
November 2018

The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer.

Authors:
Matthew R Cooperberg Nicholas Erho June M Chan Felix Y Feng Nick Fishbane Shuang G Zhao Jeffry P Simko Janet E Cowan Jonathan Lehrer Mohammed Alshalalfa Tyler Kolisnik Jijumon Chelliserry Jennifer Margrave Maria Aranes Marguerite du Plessis Christine Buerki Imelda Tenggara Elai Davicioni Peter R Carroll

Eur Urol 2018 10 28;74(4):444-452. Epub 2018 May 28.

Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.eururo.2018.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586429PMC
October 2018

ETS2 is a prostate basal cell marker and is highly expressed in prostate cancers aberrantly expressing p63.

Authors:
Alba Torres Mohammed Alshalalfa Elai Davicioni Anuj Gupta Srinivasan Yegnasubramanian Sarah J Wheelan Jonathan I Epstein Angelo M De Marzo Tamara L Lotan

Prostate 2018 09 15;78(12):896-904. Epub 2018 May 15.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://doi.wiley.com/10.1002/pros.23646
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http://dx.doi.org/10.1002/pros.23646DOI Listing
September 2018

Clinical and Genomic Characterization of Low-Prostate-specific Antigen, High-grade Prostate Cancer.

Authors:
Brandon A Mahal David D Yang Natalie Q Wang Mohammed Alshalalfa Elai Davicioni Voleak Choeurng Edward M Schaeffer Ashley E Ross Daniel E Spratt Robert B Den Neil E Martin Kent W Mouw Peter F Orio Toni K Choueiri Mary-Ellen Taplin Quoc-Dien Trinh Felix Y Feng Paul L Nguyen

Eur Urol 2018 08 22;74(2):146-154. Epub 2018 Feb 22.

Harvard Medical School, Boston, MA, USA; Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.01.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615042PMC
August 2018

Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy.

Authors:
R Jeffrey Karnes Vidit Sharma Voleak Choeurng Hussam Al-Deen Ashab Nicholas Erho Mohammed Alshalalfa Bruce Trock Ashley Ross Kasra Yousefi Harrison Tsai Shuang G Zhao Jeffrey J Tosoian Zaid Haddad Mandeep Takhar S Laura Chang Daniel E Spratt Firas Abdollah Robert B Jenkins Eric A Klein Paul L Nguyen Adam P Dicker Robert B Den Elai Davicioni Felix Y Feng Tamara L Lotan Edward M Schaeffer

Clin Cancer Res 2018 08 14;24(16):3908-3916. Epub 2018 May 14.

Department of Urology, Feinberg School of Medicine, Northwestern University, Evanston, Illinois.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512950PMC
August 2018

Transcriptome Wide Analysis of Magnetic Resonance Imaging-targeted Biopsy and Matching Surgical Specimens from High-risk Prostate Cancer Patients Treated with Radical Prostatectomy: The Target Must Be Hit.

Authors:
Jan Philipp Radtke Mandeep Takhar David Bonekamp Claudia Kesch Nicholas Erho Marguerite du Plessis Christine Buerki Kaye Ong Elai Davicioni Markus Hohenfellner Boris A Hadaschik

Eur Urol Focus 2018 07 26;4(4):540-546. Epub 2017 Jan 26.

Department of Urology, University Hospital Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2017.01.005DOI Listing
July 2018

Performance of a Prostate Cancer Genomic Classifier in Predicting Metastasis in Men with Prostate-specific Antigen Persistence Postprostatectomy.

Authors:
Daniel E Spratt Darlene L Y Dai Robert B Den Patricia Troncoso Kasra Yousefi Ashley E Ross Edward M Schaeffer Zaid Haddad Elai Davicioni Rohit Mehra Todd M Morgan Walter Rayford Firas Abdollah Edouard Trabulsi Mary Achim Elsa Li Ning Tapia Mireya Guerrero Robert Jeffrey Karnes Adam P Dicker Mark A Hurwitz Paul L Nguyen Felix F Y Feng Stephen J Freedland John W Davis

Eur Urol 2018 07 10;74(1):107-114. Epub 2017 Dec 10.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.eururo.2017.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582359PMC
July 2018

Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate Cancer.

Authors:
Deli Liu Mandeep Takhar Mohammed Alshalalfa Nicholas Erho Jonathan Shoag Robert B Jenkins R Jeffrey Karnes Ashley E Ross Edward M Schaeffer Mark A Rubin Bruce Trock Eric A Klein Robert B Den Scott A Tomlins Daniel E Spratt Elai Davicioni Andrea Sboner Christopher E Barbieri

JCO Precis Oncol 2018 24;2018. Epub 2018 Jul 24.

Weill Cornell Medicine, NewYork-Presbyterian Hospital, New York, NY.

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http://dx.doi.org/10.1200/PO.18.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370327PMC
July 2018

The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications.

Authors:
Varune Rohan Ramnarine Mohammed Alshalalfa Fan Mo Noushin Nabavi Nicholas Erho Mandeep Takhar Robert Shukin Sonal Brahmbhatt Alexander Gawronski Maxim Kobelev Mannan Nouri Dong Lin Harrison Tsai Tamara L Lotan R Jefferey Karnes Mark A Rubin Amina Zoubeidi Martin E Gleave Cenk Sahinalp Alexander W Wyatt Stanislav V Volik Himisha Beltran Elai Davicioni Yuzhuo Wang Colin C Collins

Gigascience 2018 06;7(6)

Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1093/gigascience/giy050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007253PMC
June 2018

Validation of a 10-gene molecular signature for predicting biochemical recurrence and clinical metastasis in localized prostate cancer.

Authors:
Hatem Abou-Ouf Mohammed Alshalalfa Mandeep Takhar Nicholas Erho Bryan Donnelly Elai Davicioni R Jeffrey Karnes Tarek A Bismar

J Cancer Res Clin Oncol 2018 May 6;144(5):883-891. Epub 2018 Mar 6.

Department of Pathology and Laboratory Medicine, University of Calgary, Cumming School of Medicine, Calgary, AB, Canada.

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http://dx.doi.org/10.1007/s00432-018-2615-7DOI Listing
May 2018

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

Authors:
Lingjian Yang Darren Roberts Mandeep Takhar Nicholas Erho Becky A S Bibby Niluja Thiruthaneeswaran Vinayak Bhandari Wei-Chen Cheng Syed Haider Amy M B McCorry Darragh McArt Suneil Jain Mohammed Alshalalfa Ashley Ross Edward Schaffer Robert B Den R Jeffrey Karnes Eric Klein Peter J Hoskin Stephen J Freedland Alastair D Lamb David E Neal Francesca M Buffa Robert G Bristow Paul C Boutros Elai Davicioni Ananya Choudhury Catharine M L West

EBioMedicine 2018 May 23;31:182-189. Epub 2018 Apr 23.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester M20 4BX, UK; NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014579PMC
May 2018

Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer.

Authors:
Fan Mo Dong Lin Mandeep Takhar Varune Rohan Ramnarine Xin Dong Robert H Bell Stanislav V Volik Kendric Wang Hui Xue Yuwei Wang Anne Haegert Shawn Anderson Sonal Brahmbhatt Nicholas Erho Xinya Wang Peter W Gout James Morris R Jeffrey Karnes Robert B Den Eric A Klein Edward M Schaeffer Ashley Ross Shancheng Ren S Cenk Sahinalp Yingrui Li Xun Xu Jun Wang Jian Wang Martin E Gleave Elai Davicioni Yinghao Sun Yuzhuo Wang Colin C Collins

Eur Urol 2018 04 19;73(4):524-532. Epub 2017 Mar 19.

Vancouver Prostate Centre & Laboratory for Advanced Genome Analysis, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada; School of Computing Sciences, Simon Fraser University, Burnaby, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685211PMC
April 2018

Neoadjuvant degarelix with or without apalutamide followed by radical prostatectomy for intermediate and high-risk prostate cancer: ARNEO, a randomized, double blind, placebo-controlled trial.

Authors:
Lorenzo Tosco Annouschka Laenen Thomas Gevaert Isabelle Salmon Christine Decaestecker Elai Davicioni Christine Buerki Frank Claessens Johan Swinnen Karolien Goffin Raymond Oyen Wouter Everaerts Lisa Moris Gert De Meerleer Karin Haustermans Steven Joniau

BMC Cancer 2018 04 2;18(1):354. Epub 2018 Apr 2.

Urology, Department of Development and Regeneration, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s12885-018-4275-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879743PMC
April 2018

Validation of a Genomic Risk Classifier to Predict Prostate Cancer-specific Mortality in Men with Adverse Pathologic Features.

Authors:
R Jeffrey Karnes Voleak Choeurng Ashley E Ross Edward M Schaeffer Eric A Klein Stephen J Freedland Nicholas Erho Kasra Yousefi Mandeep Takhar Elai Davicioni Matthew R Cooperberg Bruce J Trock

Eur Urol 2018 02 8;73(2):168-175. Epub 2017 Apr 8.

James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.03.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632569PMC
February 2018

Gene Expression Correlates of Site-specific Metastasis Among Men With Lymph Node Positive Prostate Cancer Treated With Radical Prostatectomy: A Case Series.

Authors:
Vidit Sharma Kasra Yousefi Zaid Haddad Christine Buerki Robert B Jenkins Elai Davicioni R Jeffrey Karnes

Urology 2018 Feb 25;112:29-32. Epub 2017 Oct 25.

Department of Urology, Mayo Clinic, Rochester, MN. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00904295173109
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http://dx.doi.org/10.1016/j.urology.2017.10.016DOI Listing
February 2018

Development and Validation of a Novel Integrated Clinical-Genomic Risk Group Classification for Localized Prostate Cancer.

Authors:
Daniel E Spratt Jingbin Zhang María Santiago-Jiménez Robert T Dess John W Davis Robert B Den Adam P Dicker Christopher J Kane Alan Pollack Radka Stoyanova Firas Abdollah Ashley E Ross Adam Cole Edward Uchio Josh M Randall Hao Nguyen Shuang G Zhao Rohit Mehra Andrew G Glass Lucia L C Lam Jijumon Chelliserry Marguerite du Plessis Voleak Choeurng Maria Aranes Tyler Kolisnik Jennifer Margrave Jason Alter Jennifer Jordan Christine Buerki Kasra Yousefi Zaid Haddad Elai Davicioni Edouard J Trabulsi Stacy Loeb Ashutosh Tewari Peter R Carroll Sheila Weinmann Edward M Schaeffer Eric A Klein R Jeffrey Karnes Felix Y Feng Paul L Nguyen

J Clin Oncol 2018 02 29;36(6):581-590. Epub 2017 Nov 29.

Daniel E. Spratt, Robert T. Dess, Adam Cole, Shuang G. Zhao, and Rohit Mehra, University of Michigan, Ann Arbor; Firas Abdollah, Henry Ford Health System, Detroit, MI; Jingbin Zhang, María Santiago-Jiménez, Lucia L.C. Lam, Jijumon Chelliserry, Marguerite du Plessis, Voleak Choeurng, Maria Aranes, Tyler Kolisnik, Jennifer Margrave, Jason Alter, Jennifer Jordan, Christine Buerki, Kasra Yousefi, Zaid Haddad, and Elai Davicioni, GenomeDx Biosciences, Vancouver, British Columbia, Canada; John W. Davis, The University of Texas MD Anderson Cancer Center, Houston, TX; Robert B. Den, Adam P. Dicker, and Edouard J. Trabulsi, Thomas Jefferson University, Philadelphia, PA; Christopher J. Kane, University of California San Diego, San Diego; Edward Uchio, University of California Irvine; Josh M. Randall, Orange County Urology Associates, Irvine; Hao Nguyen, Peter R. Carroll and Felix Y. Feng, University of California San Francisco, San Francisco, CA; Alan Pollack and Radka Stoyanova, University of Miami, Miami, FL; Ashley E. Ross, Johns Hopkins School of Medicine, Baltimore, MD; Andrew G. Glass and Sheila Weinmann, Kaiser Permanente Northwest, Portland, OR; Stacy Loeb, New York University; Ashutosh Tewari, Icahn School of Medicine at Mount Sinai, New York, NY; Edward M. Schaeffer, Northwestern University, Evanston, IL; Eric A. Klein, Cleveland Clinic, Cleveland, OH; R. Jeffrey Karnes, Mayo Clinic, Rochester, MN; and Paul L. Nguyen, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://ascopubs.org/doi/10.1200/JCO.2017.74.2940
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http://dx.doi.org/10.1200/JCO.2017.74.2940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530900PMC
February 2018

Associations of Luminal and Basal Subtyping of Prostate Cancer With Prognosis and Response to Androgen Deprivation Therapy.

Authors:
Shuang G Zhao S Laura Chang Nicholas Erho Menggang Yu Jonathan Lehrer Mohammed Alshalalfa Corey Speers Matthew R Cooperberg Won Kim Charles J Ryan Robert B Den Stephen J Freedland Edwin Posadas Howard Sandler Eric A Klein Peter Black Roland Seiler Scott A Tomlins Arul M Chinnaiyan Robert B Jenkins Elai Davicioni Ashley E Ross Edward M Schaeffer Paul L Nguyen Peter R Carroll R Jeffrey Karnes Daniel E Spratt Felix Y Feng

JAMA Oncol 2017 12;3(12):1663-1672

Department of Radiation Oncology, University of Michigan, Ann Arbor

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http://dx.doi.org/10.1001/jamaoncol.2017.0751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824281PMC
December 2017

Ability of a Genomic Classifier to Predict Metastasis and Prostate Cancer-specific Mortality after Radiation or Surgery based on Needle Biopsy Specimens.

Authors:
Paul L Nguyen Zaid Haddad Ashley E Ross Neil E Martin Samineh Deheshi Lucia L C Lam Jijumon Chelliserry Jeffrey J Tosoian Tamara L Lotan Daniel E Spratt Radka S Stoyanova Sanoj Punnen Kaye Ong Christine Buerki Maria Aranes Tyler Kolisnik Jennifer Margrave Kasra Yousefi Voleak Choeurng Elai Davicioni Bruce J Trock Christopher J Kane Alan Pollack John W Davis Felix Y Feng Eric A Klein

Eur Urol 2017 11 19;72(5):845-852. Epub 2017 May 19.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1016/j.eururo.2017.05.009DOI Listing
November 2017

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup.

Authors:
David P Labbé Christopher J Sweeney Myles Brown Phillip Galbo Spencer Rosario Kristine M Wadosky Sheng-Yu Ku Martin Sjöström Mohammed Alshalalfa Nicholas Erho Elai Davicioni R Jeffrey Karnes Edward M Schaeffer Robert B Jenkins Robert B Den Ashley E Ross Michaela Bowden Ying Huang Kathryn P Gray Felix Y Feng Daniel E Spratt David W Goodrich Kevin H Eng Leigh Ellis

Clin Cancer Res 2017 Nov 12;23(22):7072-7083. Epub 2017 Sep 12.

Department of Oncologic Pathology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690819PMC
November 2017

Gene expression signatures of neuroendocrine prostate cancer and primary small cell prostatic carcinoma.

Authors:
Harrison K Tsai Jonathan Lehrer Mohammed Alshalalfa Nicholas Erho Elai Davicioni Tamara L Lotan

BMC Cancer 2017 Nov 13;17(1):759. Epub 2017 Nov 13.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1186/s12885-017-3729-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683385PMC
November 2017

Impact of Molecular Subtypes in Muscle-invasive Bladder Cancer on Predicting Response and Survival after Neoadjuvant Chemotherapy.

Authors:
Roland Seiler Hussam Al Deen Ashab Nicholas Erho Bas W G van Rhijn Brian Winters James Douglas Kim E Van Kessel Elisabeth E Fransen van de Putte Matthew Sommerlad Natalie Q Wang Voleak Choeurng Ewan A Gibb Beatrix Palmer-Aronsten Lucia L Lam Christine Buerki Elai Davicioni Gottfrid Sjödahl Jordan Kardos Katherine A Hoadley Seth P Lerner David J McConkey Woonyoung Choi William Y Kim Bernhard Kiss George N Thalmann Tilman Todenhöfer Simon J Crabb Scott North Ellen C Zwarthoff Joost L Boormans Jonathan Wright Marc Dall'Era Michiel S van der Heijden Peter C Black

Eur Urol 2017 10 5;72(4):544-554. Epub 2017 Apr 5.

Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.03.030DOI Listing
October 2017

LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression.

Authors:
Yi Liang Musaddeque Ahmed Haiyang Guo Fraser Soares Junjie T Hua Shuai Gao Catherine Lu Christine Poon Wanting Han Jens Langstein Muhammad B Ekram Brian Li Elai Davicioni Mandeep Takhar Nicholas Erho R Jeffrey Karnes Dianne Chadwick Theodorus van der Kwast Paul C Boutros Cheryl H Arrowsmith Felix Y Feng Anthony M Joshua Amina Zoubeidi Changmeng Cai Housheng H He

Cancer Res 2017 10 15;77(20):5479-5490. Epub 2017 Sep 15.

Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0496DOI Listing
October 2017

Decipher test impacts decision making among patients considering adjuvant and salvage treatment after radical prostatectomy: Interim results from the Multicenter Prospective PRO-IMPACT study.

Authors:
John L Gore Marguerite du Plessis María Santiago-Jiménez Kasra Yousefi Darby J S Thompson Lawrence Karsh Brian R Lane Michael Franks David Y T Chen Mark Bandyk Fernando J Bianco Gordon Brown William Clark Adam S Kibel Hyung L Kim William Lowrance Murugesan Manoharan Paul Maroni Scott Perrapato Paul Sieber Edouard J Trabulsi Robert Waterhouse Elai Davicioni Yair Lotan Daniel W Lin

Cancer 2017 Aug 19;123(15):2850-2859. Epub 2017 Apr 19.

Department of Urology, Seattle Cancer Care Alliance, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1002/cncr.30665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573983PMC
August 2017

Low PCA3 expression is a marker of poor differentiation in localized prostate tumors: exploratory analysis from 12,076 patients.

Authors:
Mohammed Alshalalfa Gerald W Verhaegh Ewan A Gibb Maria Santiago-Jiménez Nicholas Erho Jennifer Jordan Kasra Yousefi Lucia L C Lam Tyler Kolisnik Jijumon Chelissery Roland Seiler Ashley E Ross R Jeffrey Karnes Edward M Schaeffer Tamara T Lotan Robert B Den Stephen J Freedland Elai Davicioni Eric A Klein Jack A Schalken

Oncotarget 2017 Aug 7;8(31):50804-50813. Epub 2017 Feb 7.

Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.15133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584206PMC
August 2017

Pan-Cancer Analysis of Genomic Sequencing Among the Elderly.

Authors:
Daniel R Wahl Paul L Nguyen Maria Santiago Kasra Yousefi Elai Davicioni Dean A Shumway Corey Speers Rohit Mehra Felix Y Feng Joseph R Osborne Daniel E Spratt

Int J Radiat Oncol Biol Phys 2017 07 7;98(4):726-732. Epub 2017 Jan 7.

Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.01.002DOI Listing
July 2017

An Oncofetal Glycosaminoglycan Modification Provides Therapeutic Access to Cisplatin-resistant Bladder Cancer.

Authors:
Roland Seiler Htoo Zarni Oo Davide Tortora Thomas M Clausen Chris K Wang Gunjan Kumar Marina Ayres Pereira Maj S Ørum-Madsen Mette Ø Agerbæk Tobias Gustavsson Mie A Nordmaj Jamie R Rich Nada Lallous Ladan Fazli Sherry S Lee James Douglas Tilman Todenhöfer Shaghayegh Esfandnia Dulguun Battsogt John S Babcook Nader Al-Nakouzi Simon J Crabb Igor Moskalev Bernhard Kiss Elai Davicioni George N Thalmann Paul S Rennie Peter C Black Ali Salanti Mads Daugaard

Eur Urol 2017 07 10;72(1):142-150. Epub 2017 Apr 10.

Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada; Vancouver Prostate Centre, Vancouver, BC, Canada; Zymeworks Inc., Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.03.021DOI Listing
July 2017

Cost-effectiveness of the Decipher Genomic Classifier to Guide Individualized Decisions for Early Radiation Therapy After Prostatectomy for Prostate Cancer.

Authors:
Jennifer M Lobo Daniel M Trifiletti Vanessa N Sturz Adam P Dicker Christine Buerki Elai Davicioni Matthew R Cooperberg R Jeffrey Karnes Robert B Jenkins Robert B Den Timothy N Showalter

Clin Genitourin Cancer 2017 06 17;15(3):e299-e309. Epub 2016 Aug 17.

Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA.

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http://dx.doi.org/10.1016/j.clgc.2016.08.012DOI Listing
June 2017

Evaluation of a 24-gene signature for prognosis of metastatic events and prostate cancer-specific mortality.

Authors:
Kathryn L Pellegrini Martin G Sanda Dattatraya Patil Qi Long María Santiago-Jiménez Mandeep Takhar Nicholas Erho Kasra Yousefi Elai Davicioni Eric A Klein Robert B Jenkins R Jeffrey Karnes Carlos S Moreno

BJU Int 2017 06 11;119(6):961-967. Epub 2017 Feb 11.

Winship Cancer Institute, Atlanta, GA, USA.

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http://dx.doi.org/10.1111/bju.13779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444982PMC
June 2017

Transcriptome evaluation of the relation between body mass index and prostate cancer outcomes.

Authors:
Hyun Kim Ingrid Kalchman María Santiago-Jiménez Jonathan Lehrer Jenny Guo Gretchen Hermann Kosj Yamoah Mohammed Alshalalfa Huei-Chung Huang Ashley E Ross Edward M Schaeffer Elai Davicioni Nicholas Erho Kasra Yousefi Robert B Den

Cancer 2017 Jun 31;123(12):2240-2247. Epub 2017 Jan 31.

Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/cncr.30580DOI Listing
June 2017

Genomic Classifier Augments the Role of Pathological Features in Identifying Optimal Candidates for Adjuvant Radiation Therapy in Patients With Prostate Cancer: Development and Internal Validation of a Multivariable Prognostic Model.

Authors:
Deepansh Dalela María Santiago-Jiménez Kasra Yousefi R Jeffrey Karnes Ashley E Ross Robert B Den Stephen J Freedland Edward M Schaeffer Adam P Dicker Mani Menon Alberto Briganti Elai Davicioni Firas Abdollah

J Clin Oncol 2017 Jun 28;35(18):1982-1990. Epub 2017 Mar 28.

Deepansh Dalela, Mani Menon, and Firas Abdollah, Henry Ford Health System, Detroit, MI; María Santiago-Jiménez, Kasra Yousefi, and Elai Davicioni, GenomeDx Biosciences, Vancouver, British Columbia, Canada; R. Jeffrey Karnes, Mayo Clinic, Rochester, MN; Ashley E. Ross, Johns Hopkins Hospital, Baltimore, MD; Adam P. Dicker and Robert B. Den, Thomas Jefferson University, Philadelphia, PA; Stephen J. Freedland, Cedars-Sinai Medical Center, Los Angeles, CA; Edward M. Schaeffer, Northwestern University Feinberg School of Medicine, Chicago, IL; and Alberto Briganti, Vita Salute San Raffaele Hospital, Milan, Italy.

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http://dx.doi.org/10.1200/JCO.2016.69.9918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530898PMC
June 2017

Individual Patient-Level Meta-Analysis of the Performance of the Decipher Genomic Classifier in High-Risk Men After Prostatectomy to Predict Development of Metastatic Disease.

Authors:
Daniel E Spratt Kasra Yousefi Samineh Deheshi Ashley E Ross Robert B Den Edward M Schaeffer Bruce J Trock Jingbin Zhang Andrew G Glass Adam P Dicker Firas Abdollah Shuang G Zhao Lucia L C Lam Marguerite du Plessis Voleak Choeurng Zaid Haddad Christine Buerki Elai Davicioni Sheila Weinmann Stephen J Freedland Eric A Klein R Jeffrey Karnes Felix Y Feng

J Clin Oncol 2017 Jun 30;35(18):1991-1998. Epub 2017 Mar 30.

Daniel E. Spratt and Shuang G. Zhao, University of Michigan, Ann Arbor; Firas Abdollah, Henry Ford Health System, Detroit, MI; Kasra Yousefi, Samineh Deheshi, Jingbin Zhang, Lucia L.C. Lam, Marguerite du Plessis, Voleak Choeurng, Zaid Haddad, Christine Buerki, and Elai Davicioni, GenomeDx Biosciences, Vancouver, British Columbia, Canada; Ashley E. Ross and Bruce J. Trock, Johns Hopkins Hospital, Baltimore, MD; Robert B. Den and Adam P. Dicker, Thomas Jefferson University, Philadelphia, PA; Edward M. Schaeffer, Northwestern University, Evanston, IL; Andrew G. Glass and Sheila Weinmann, Center for Health Research, Kaiser Permanente Northwest, Portland, OR; Stephen J. Freedland, Cedars-Sinai Medical Center, Los Angeles; Felix Y. Feng, University of California, San Francisco, CA; Eric A. Klein, Cleveland Clinic, Cleveland, OH; and R. Jeffrey Karnes, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1200/JCO.2016.70.2811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530581PMC
June 2017

Lipid degradation promotes prostate cancer cell survival.

Authors:
Harri M Itkonen Michael Brown Alfonso Urbanucci Gregory Tredwell Chung Ho Lau Stefan Barfeld Claire Hart Ingrid J Guldvik Mandeep Takhar Hannelore V Heemers Nicholas Erho Katarzyna Bloch Elai Davicioni Rita Derua Etienne Waelkens James L Mohler Noel Clarke Johan V Swinnen Hector C Keun Ole P Rekvig Ian G Mills

Oncotarget 2017 Jun;8(24):38264-38275

Prostate Cancer Research Group, Centre for Molecular Medicine Norway, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.18632/oncotarget.16123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503531PMC
June 2017

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.

Authors:
Alfonso Urbanucci Stefan J Barfeld Ville Kytölä Harri M Itkonen Ilsa M Coleman Daniel Vodák Liisa Sjöblom Xia Sheng Teemu Tolonen Sarah Minner Christoph Burdelski Kati K Kivinummi Annika Kohvakka Steven Kregel Mandeep Takhar Mohammed Alshalalfa Elai Davicioni Nicholas Erho Paul Lloyd R Jeffrey Karnes Ashley E Ross Edward M Schaeffer Donald J Vander Griend Stefan Knapp Eva Corey Felix Y Feng Peter S Nelson Fahri Saatcioglu Karen E Knudsen Teuvo L J Tammela Guido Sauter Thorsten Schlomm Matti Nykter Tapio Visakorpi Ian G Mills

Cell Rep 2017 06;19(10):2045-2059

Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Forskningsparken, University of Oslo, 21 0349 Oslo, Norway; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway; PCUK Movember Centre of Excellence, CCRCB, Queen's University, Belfast BT7 1NN, Northern Ireland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675034PMC
June 2017

Comprehensive Determination of Prostate Tumor ETS Gene Status in Clinical Samples Using the CLIA Decipher Assay.

Authors:
Alba Torres Mohammed Alshalalfa Scott A Tomlins Nicholas Erho Ewan A Gibb Jijumon Chelliserry Lony Lim Lucia L C Lam Sheila F Faraj Stephania M Bezerra Elai Davicioni Kasra Yousefi Ashley E Ross George J Netto Edward M Schaeffer Tamara L Lotan

J Mol Diagn 2017 05 21;19(3):475-484. Epub 2017 Mar 21.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417038PMC
May 2017

Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.

Authors:
Mannan Nouri Josselin Caradec Amy Anne Lubik Na Li Brett G Hollier Mandeep Takhar Manuel Altimirano-Dimas Mengqian Chen Mani Roshan-Moniri Miriam Butler Melanie Lehman Jennifer Bishop Sarah Truong Shih-Chieh Huang Dawn Cochrane Michael Cox Colin Collins Martin Gleave Nicholas Erho Mohamed Alshalafa Elai Davicioni Colleen Nelson Sheryl Gregory-Evans R Jeffrey Karnes Robert B Jenkins Eric A Klein Ralph Buttyan

Oncotarget 2017 Mar;8(12):18949-18967

Vancouver Prostate Centre, Vancouver, Canada.

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http://dx.doi.org/10.18632/oncotarget.14850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386661PMC
March 2017

Multi-institutional Analysis Shows that Low PCAT-14 Expression Associates with Poor Outcomes in Prostate Cancer.

Authors:
Nicole M White Shuang G Zhao Jin Zhang Emily B Rozycki Ha X Dang Sandra D McFadden Abdallah M Eteleeb Mohammed Alshalalfa Ismael A Vergara Nicholas Erho Jeffrey M Arbeit Robert Jeffrey Karnes Robert B Den Elai Davicioni Christopher A Maher

Eur Urol 2017 02 22;71(2):257-266. Epub 2016 Jul 22.

Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA; Beaumont Hospital-Dearborn, Transitional Year Program, Dearborn, MI, USA; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.07.012DOI Listing
February 2017

MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2.

Authors:
Rajdeep Das Philip A Gregory Rayzel C Fernandes Iza Denis Qingqing Wang Scott L Townley Shuang G Zhao Adrienne R Hanson Marie A Pickering Heather K Armstrong Noor A Lokman Esmaeil Ebrahimie Elai Davicioni Robert B Jenkins R Jeffrey Karnes Ashley E Ross Robert B Den Eric A Klein Kim N Chi Hayley S Ramshaw Elizabeth D Williams Amina Zoubeidi Gregory J Goodall Felix Y Feng Lisa M Butler Wayne D Tilley Luke A Selth

Cancer Res 2017 02 23;77(4):1021-1034. Epub 2016 Dec 23.

Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, The University of Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2529DOI Listing
February 2017

Her2 alterations in muscle-invasive bladder cancer: Patient selection beyond protein expression for targeted therapy.

Authors:
Bernhard Kiss Alexander W Wyatt James Douglas Veronika Skuginna Fan Mo Shawn Anderson Diana Rotzer Achim Fleischmann Vera Genitsch Tetsutaro Hayashi Maja Neuenschwander Christine Buerki Elai Davicioni Colin Collins George N Thalmann Peter C Black Roland Seiler

Sci Rep 2017 02 16;7:42713. Epub 2017 Feb 16.

Department of Urology, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1038/srep42713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311866PMC
February 2017

Molecular Analysis of Low Grade Prostate Cancer Using a Genomic Classifier of Metastatic Potential.

Authors:
Eric A Klein María Santiago-Jiménez Kasra Yousefi Bruce A Robbins Edward M Schaeffer Bruce J Trock Jeffrey Tosoian Zaid Haddad Seong Ra R Jeffrey Karnes Robert B Jenkins John C Cheville Robert B Den Adam P Dicker Elai Davicioni Stephen J Freedland Ashley E Ross

J Urol 2017 01 26;197(1):122-128. Epub 2016 Aug 26.

The James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.juro.2016.08.091DOI Listing
January 2017

Potential Impact on Clinical Decision Making via a Genome-Wide Expression Profiling: A Case Report.

Authors:
Hyun Kim Mohammed Alshalalfa Jean Hoffman-Censits Costas D Lallas Elai Davicioni Jianqing Lin Ruth Birbe Nicholas Erho Jonathan Lehrer Hussam Al-Deen Ashab Mandeep Takhar Anders Olson Lucia L C Lam W Kevin Kelly Karen E Knudsen Chellappagounder Thangavel Roland Seiler Felix Y Feng Edward M Schaeffer Edouard J Trabulsi Leonard G Gomella Mark D Hurwitz Adam P Dicker Robert B Den

Urol Case Rep 2016 Nov 1;9:51-54. Epub 2016 Oct 1.

Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.

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http://dx.doi.org/10.1016/j.eucr.2016.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050262PMC
November 2016

Development and validation of a 24-gene predictor of response to postoperative radiotherapy in prostate cancer: a matched, retrospective analysis.

Authors:
Shuang G Zhao S Laura Chang Daniel E Spratt Nicholas Erho Menggang Yu Hussam Al-Deen Ashab Mohammed Alshalalfa Corey Speers Scott A Tomlins Elai Davicioni Adam P Dicker Peter R Carroll Matthew R Cooperberg Stephen J Freedland R Jeffrey Karnes Ashley E Ross Edward M Schaeffer Robert B Den Paul L Nguyen Felix Y Feng

Lancet Oncol 2016 Nov 12;17(11):1612-1620. Epub 2016 Oct 12.

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Radiation Oncology, University of California at San Francisco, San Francisco, CA, USA; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA; Helen Diller Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30491-0DOI Listing
November 2016

SPINK1 Defines a Molecular Subtype of Prostate Cancer in Men with More Rapid Progression in an at Risk, Natural History Radical Prostatectomy Cohort.

Authors:
Michael H Johnson Ashley E Ross Mohammed Alshalalfa Nicholas Erho Kasra Yousefi Stephanie Glavaris Helen Fedor Misop Han Sheila F Faraj Stephania M Bezerra George Netto Alan W Partin Bruce J Trock Elai Davicioni Edward M Schaeffer

J Urol 2016 11 27;196(5):1436-1444. Epub 2016 May 27.

Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2016.05.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615051PMC
November 2016

Utilization of a Genomic Classifier for Prediction of Metastasis Following Salvage Radiation Therapy after Radical Prostatectomy.

Authors:
Stephen J Freedland Voleak Choeurng Lauren Howard Amanda De Hoedt Marguerite du Plessis Kasra Yousefi Lucia L Lam Christine Buerki Seong Ra Bruce Robbins Edouard J Trabulsi Nikhil L Shah Firas Abdollah Felix Y Feng Elai Davicioni Adam P Dicker Robert J Karnes Robert B Den

Eur Urol 2016 10 21;70(4):588-596. Epub 2016 Jan 21.

Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.01.008DOI Listing
October 2016

Prediction of Lymph Node Metastasis in Patients with Bladder Cancer Using Whole Transcriptome Gene Expression Signatures.

Authors:
Roland Seiler Lucia L Lam Nicholas Erho Mandeep Takhar Anirban P Mitra Christine Buerki Elai Davicioni Eila C Skinner Siamak Daneshmand Peter C Black

J Urol 2016 Oct 19;196(4):1036-41. Epub 2016 Apr 19.

Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2016.04.061DOI Listing
October 2016

Integrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome.

Authors:
Sungyong You Beatrice S Knudsen Nicholas Erho Mohammed Alshalalfa Mandeep Takhar Hussam Al-Deen Ashab Elai Davicioni R Jeffrey Karnes Eric A Klein Robert B Den Ashley E Ross Edward M Schaeffer Isla P Garraway Jayoung Kim Michael R Freeman

Cancer Res 2016 09 14;76(17):4948-58. Epub 2016 Jun 14.

Division of Cancer Biology and Therapeutics, Departments of Surgery & Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047668PMC
http://dx.doi.org/10.1158/0008-5472.CAN-16-0902DOI Listing
September 2016

Association of multiparametric MRI quantitative imaging features with prostate cancer gene expression in MRI-targeted prostate biopsies.

Authors:
Radka Stoyanova Alan Pollack Mandeep Takhar Charles Lynne Nestor Parra Lucia L C Lam Mohammed Alshalalfa Christine Buerki Rosa Castillo Merce Jorda Hussam Al-Deen Ashab Oleksandr N Kryvenko Sanoj Punnen Dipen J Parekh Matthew C Abramowitz Robert J Gillies Elai Davicioni Nicholas Erho Adrian Ishkanian

Oncotarget 2016 Aug;7(33):53362-53376

Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.18632/oncotarget.10523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288193PMC
August 2016

Prostate cancer radiomics and the promise of radiogenomics.

Authors:
Radka Stoyanova Mandeep Takhar Yohann Tschudi John C Ford Gabriel Solórzano Nicholas Erho Yoganand Balagurunathan Sanoj Punnen Elai Davicioni Robert J Gillies Alan Pollack

Transl Cancer Res 2016 Aug;5(4):432-447

Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703221PMC
August 2016

Racial Variations in Prostate Cancer Molecular Subtypes and Androgen Receptor Signaling Reflect Anatomic Tumor Location.

Authors:
Farzana A Faisal Debasish Sundi Jeffrey J Tosoian Voleak Choeurng Mohammed Alshalalfa Ashley E Ross Eric Klein Robert Den Adam Dicker Nicholas Erho Elai Davicioni Tamara L Lotan Edward M Schaeffer

Eur Urol 2016 07 9;70(1):14-17. Epub 2015 Oct 9.

Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.eururo.2015.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826623PMC
July 2016

Evaluation of a genomic classifier in radical prostatectomy patients with lymph node metastasis.

Authors:
Hak J Lee Kasra Yousefi Zaid Haddad Firas Abdollah Lucia Lc Lam Heesun Shin Mohammed Alshalalfa Elana Godebu Song Wang Ahmed Shabaik Elai Davicioni Christopher J Kane

Res Rep Urol 2016 28;8:77-84. Epub 2016 Jun 28.

Department of Urology, University of California, San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.2147/RRU.S99997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935177PMC
July 2016

Validation of a Genomic Classifier for Predicting Post-Prostatectomy Recurrence in a Community Based Health Care Setting.

Authors:
Andrew G Glass Michael C Leo Zaid Haddad Kasra Yousefi Marguerite du Plessis Chuhe Chen Voleak Choeurng Firas Abdollah Bruce Robbins Seong Ra Kathryn E Richert-Boe Christine Buerki Kathy Pearson Elai Davicioni Sheila Weinmann

J Urol 2016 06 26;195(6):1748-53. Epub 2015 Nov 26.

Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon.

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http://dx.doi.org/10.1016/j.juro.2015.11.044DOI Listing
June 2016

Clinical Validation of the 2005 ISUP Gleason Grading System in a Cohort of Intermediate and High Risk Men Undergoing Radical Prostatectomy.

Authors:
Sheila F Faraj Stephania M Bezerra Kasra Yousefi Helen Fedor Stephanie Glavaris Misop Han Alan W Partin Elizabeth Humphreys Jeffrey Tosoian Michael H Johnson Elai Davicioni Bruce J Trock Edward M Schaeffer Ashley E Ross George J Netto

PLoS One 2016 5;11(1):e0146189. Epub 2016 Jan 5.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146189PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712132PMC
June 2016

AXIN2 expression predicts prostate cancer recurrence and regulates invasion and tumor growth.

Authors:
Brian R Hu Adrian S Fairey Anisha Madhav Dongyun Yang Meng Li Susan Groshen Craig Stephens Philip H Kim Navneet Virk Lina Wang Sue Ellen Martin Nicholas Erho Elai Davicioni Robert B Jenkins Robert B Den Tong Xu Yucheng Xu Inderbir S Gill David I Quinn Amir Goldkorn

Prostate 2016 May 15;76(6):597-608. Epub 2016 Jan 15.

Division of Medical Oncology, Department of Medicine, University of Southern California Keck School of Medicine and Translational and Clinical Science Program, USC Norris Comprehensive Cancer Center, Los Angeles, California.

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http://dx.doi.org/10.1002/pros.23151DOI Listing
May 2016

Application of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens.

Authors:
Beatrice S Knudsen Hyung L Kim Nicholas Erho Heesun Shin Mohammed Alshalalfa Lucia L C Lam Imelda Tenggara Karen Chadwich Theo Van Der Kwast Neil Fleshner Elai Davicioni Peter R Carroll Matthew R Cooperberg June M Chan Jeffry P Simko

J Mol Diagn 2016 05 3;18(3):395-406. Epub 2016 Mar 3.

Department of Urology, University of California San Francisco, San Francisco, California; Department of Anatomic Pathology, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1016/j.jmoldx.2015.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851733PMC
May 2016

The Landscape of Prognostic Outlier Genes in High-Risk Prostate Cancer.

Authors:
Shuang G Zhao Joseph R Evans Vishal Kothari Grace Sun Ashley Larm Victor Mondine Edward M Schaeffer Ashley E Ross Eric A Klein Robert B Den Adam P Dicker R Jeffrey Karnes Nicholas Erho Paul L Nguyen Elai Davicioni Felix Y Feng

Clin Cancer Res 2016 Apr 2;22(7):1777-86. Epub 2015 Dec 2.

Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan. Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan.

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http://clincancerres.aacrjournals.org/content/early/2016/01/
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http://dx.doi.org/10.1158/1078-0432.CCR-15-1250DOI Listing
April 2016

Patient-Level DNA Damage and Repair Pathway Profiles and Prognosis After Prostatectomy for High-Risk Prostate Cancer.

Authors:
Joseph R Evans Shuang G Zhao S Laura Chang Scott A Tomlins Nicholas Erho Andrea Sboner Matthew J Schiewer Daniel E Spratt Vishal Kothari Eric A Klein Robert B Den Adam P Dicker R Jeffrey Karnes Xiaochun Yu Paul L Nguyen Mark A Rubin Johann de Bono Karen E Knudsen Elai Davicioni Felix Y Feng

JAMA Oncol 2016 Apr;2(4):471-80

Department of Radiation Oncology, University of Michigan, Ann Arbor13Michigan Center for Translational Pathology, University of Michigan, Ann Arbor14Comprehensive Cancer Center, University of Michigan, Ann Arbor.

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http://dx.doi.org/10.1001/jamaoncol.2015.4955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469505PMC
April 2016

Decipher Genomic Classifier Measured on Prostate Biopsy Predicts Metastasis Risk.

Authors:
Eric A Klein Zaid Haddad Kasra Yousefi Lucia L C Lam Qiqi Wang Voleak Choeurng Beatrix Palmer-Aronsten Christine Buerki Elai Davicioni Jianbo Li Michael W Kattan Andrew J Stephenson Cristina Magi-Galluzzi

Urology 2016 Apr 22;90:148-52. Epub 2016 Jan 22.

Cleveland Clinic, Anatomic Pathology, Cleveland, OH.

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http://dx.doi.org/10.1016/j.urology.2016.01.012DOI Listing
April 2016

Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1.

Authors:
Lien Spans Thomas Van den Broeck Elien Smeets Stefan Prekovic Bernard Thienpont Diether Lambrechts R Jeffrey Karnes Nicholas Erho Mohammed Alshalalfa Elai Davicioni Christine Helsen Thomas Gevaert Lorenzo Tosco Karin Haustermans Evelyne Lerut Steven Joniau Frank Claessens

Oncotarget 2016 Apr;7(17):24326-38

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, University of Leuven, Campus Gasthuisberg, Leuven, Belgium.

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http://dx.doi.org/10.18632/oncotarget.8220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029704PMC
April 2016

Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men.

Authors:
Ashley E Ross Michael H Johnson Kasra Yousefi Elai Davicioni George J Netto Luigi Marchionni Helen L Fedor Stephanie Glavaris Voleak Choeurng Christine Buerki Nicholas Erho Lucia L Lam Elizabeth B Humphreys Sheila Faraj Stephania M Bezerra Misop Han Alan W Partin Bruce J Trock Edward M Schaeffer

Eur Urol 2016 Jan 6;69(1):157-65. Epub 2015 Jun 6.

James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA; Department of Oncology, Johns Hopkins Hospital, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.05.042DOI Listing
January 2016

Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer.

Authors:
Paula J Hurley Debasish Sundi Brian Shinder Brian W Simons Robert M Hughes Rebecca M Miller Benjamin Benzon Sheila F Faraj George J Netto Ismael A Vergara Nicholas Erho Elai Davicioni R Jeffrey Karnes Guifang Yan Charles Ewing Sarah D Isaacs David M Berman Jennifer R Rider Kristina M Jordahl Lorelei A Mucci Jessie Huang Steven S An Ben H Park William B Isaacs Luigi Marchionni Ashley E Ross Edward M Schaeffer

Clin Cancer Res 2016 Jan 7;22(2):448-58. Epub 2015 Oct 7.

Brady Urological Institute, Department of Urology, Johns Hopkins University, Baltimore, Maryland. Department of Oncology, Johns Hopkins University, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Institute, Johns Hopkins University, Baltimore, Maryland.

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http://clincancerres.aacrjournals.org/content/22/2/448.full.
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http://dx.doi.org/10.1158/1078-0432.CCR-15-0256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715968PMC
January 2016

Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas.

Authors:
Harrison Tsai Carlos L Morais Mohammed Alshalalfa Hsueh-Li Tan Zaid Haddad Jessica Hicks Nilesh Gupta Jonathan I Epstein George J Netto William B Isaacs Jun Luo Rohit Mehra Robert L Vessella R Jeffrey Karnes Edward M Schaeffer Elai Davicioni Angelo M De Marzo Tamara L Lotan

Clin Cancer Res 2015 Dec 5;21(24):5619-29. Epub 2015 Aug 5.

Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681606PMC
December 2015

Characterization of 1577 primary prostate cancers reveals novel biological and clinicopathologic insights into molecular subtypes.

Authors:
Scott A Tomlins Mohammed Alshalalfa Elai Davicioni Nicholas Erho Kasra Yousefi Shuang Zhao Zaid Haddad Robert B Den Adam P Dicker Bruce J Trock Angelo M DeMarzo Ashley E Ross Edward M Schaeffer Eric A Klein Cristina Magi-Galluzzi R Jeffrey Karnes Robert B Jenkins Felix Y Feng

Eur Urol 2015 Oct 8;68(4):555-67. Epub 2015 May 8.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562381PMC
October 2015

Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression.

Authors:
Paula J Hurley Robert M Hughes Brian W Simons Jessie Huang Rebecca M Miller Brian Shinder Michael C Haffner David Esopi Yasunori Kimura Javaneh Jabbari Ashley E Ross Nicholas Erho Ismael A Vergara Sheila F Faraj Elai Davicioni George J Netto Srinivasan Yegnasubramanian Steven S An Edward M Schaeffer

Cancer Res 2015 Oct 20;75(20):4322-34. Epub 2015 Aug 20.

The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins University, Baltimore, Maryland. The Department of Oncology, Johns Hopkins University, Baltimore, Maryland. The Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609262PMC
October 2015

Novel Biomarker Signature That May Predict Aggressive Disease in African American Men With Prostate Cancer.

Authors:
Kosj Yamoah Michael H Johnson Voleak Choeurng Farzana A Faisal Kasra Yousefi Zaid Haddad Ashley E Ross Mohammed Alshalafa Robert Den Priti Lal Michael Feldman Adam P Dicker Eric A Klein Elai Davicioni Timothy R Rebbeck Edward M Schaeffer

J Clin Oncol 2015 Sep 20;33(25):2789-96. Epub 2015 Jul 20.

Kosj Yamoah, Robert Den, and Adam P. Dicker, Thomas Jefferson University Hospital; Priti Lal, Michael Feldman, and Timothy R. Rebbeck, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Kosj Yamoah, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL; Michael H. Johnson, Farzana A. Faisal, Ashley E. Ross, and Edward M. Schaeffer, Johns Hopkins University, Baltimore, MD; Voleak Choeurng, Kasra Yousefi, Zaid Haddad, Mohammed Alshalafa, and Elai Davicioni, GenomeDx Biosciences, Vancouver, British Columbia, Canada; and Eric A. Klein, The Cleveland Clinic Foundation, Cleveland, OH.

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http://dx.doi.org/10.1200/JCO.2014.59.8912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550692PMC
September 2015

Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies.

Authors:
Wolfgang Jäger Hui Xue Tetsutaro Hayashi Claudia Janssen Shannon Awrey Alexander W Wyatt Shawn Anderson Igor Moskalev Anne Haegert Mohammed Alshalalfa Nicholas Erho Elai Davicioni Ladan Fazli Estelle Li Colin Collins Yuzhuo Wang Peter C Black

Oncotarget 2015 Aug;6(25):21522-32

The Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.18632/oncotarget.3974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673283PMC
August 2015

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.

Authors:
Jonathan F Goodwin Vishal Kothari Justin M Drake Shuang Zhao Emanuela Dylgjeri Jeffry L Dean Matthew J Schiewer Christopher McNair Jennifer K Jones Alvaro Aytes Michael S Magee Adam E Snook Ziqi Zhu Robert B Den Ruth C Birbe Leonard G Gomella Nicholas A Graham Ajay A Vashisht James A Wohlschlegel Thomas G Graeber R Jeffrey Karnes Mandeep Takhar Elai Davicioni Scott A Tomlins Cory Abate-Shen Nima Sharifi Owen N Witte Felix Y Feng Karen E Knudsen

Cancer Cell 2015 Jul;28(1):97-113

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531387PMC
July 2015