Elahe A Mostaghel

Elahe A Mostaghel

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Elahe A Mostaghel

Elahe A Mostaghel

Publications by authors named "Elahe A Mostaghel"

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Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion.

Prostate 2019 Sep 2;79(13):1530-1542. Epub 2019 Aug 2.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1002/pros.23874DOI Listing
September 2019

Alternative Acts: Oncogenic Splicing of Steroidogenic Enzymes in Prostate Cancer.

Clin Cancer Res 2019 Feb 10;25(4):1139-1141. Epub 2018 Dec 10.

Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377826PMC
February 2019

Downregulation of Accelerates Progression to Castration-Resistant Prostate Cancer.

Cancer Res 2018 11 21;78(22):6354-6362. Epub 2018 Sep 21.

Department of Medicine and Cancer Center, Hematology-Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239953PMC
November 2018

Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer.

Prostate Cancer Prostatic Dis 2018 06 23;21(2):196-203. Epub 2018 May 23.

Department of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41391-018-0045-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026483PMC
June 2018

DNA Repair Pathway Alterations in Metastatic Castration-resistant Prostate Cancer Responders to Radium-223.

Clin Genitourin Cancer 2018 04 6;16(2):106-110. Epub 2017 Dec 6.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Medicine, Division of Oncology, University of Washington, Seattle, WA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2017.11.009DOI Listing
April 2018

Co-clinical Analysis of a Genetically Engineered Mouse Model and Human Prostate Cancer Reveals Significance of NKX3.1 Expression for Response to 5α-reductase Inhibition.

Eur Urol 2017 10 4;72(4):499-506. Epub 2017 Apr 4.

Departments of Urology, Medicine, Pathology & Cell Biology, and Systems Biology, Institute of Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600823PMC
October 2017

Testicular vs adrenal sources of hydroxy-androgens in prostate cancer.

Endocr Relat Cancer 2017 08 29;24(8):393-404. Epub 2017 Jun 29.

Department of Systems Pharmacology & Translational TherapeuticsPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1530/ERC-17-0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593253PMC
August 2017

Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer.

Cancer Discov 2017 07 14;7(7):736-749. Epub 2017 Apr 14.

Departments of Urology, Medicine, Systems Biology, and Pathology and Cell Biology, Institute of Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-16-1174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501744PMC
July 2017

Androgen receptor expression in mantle cell lymphoma: Potential novel therapeutic implications.

Exp Hematol 2017 05 21;49:34-38.e2. Epub 2017 Jan 21.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393923PMC
May 2017

Harnessing Solute Carrier Transporters for Precision Oncology.

Molecules 2017 Mar 28;22(4). Epub 2017 Mar 28.

Division of Oncology, Department of Medicine, University of Washington, Seattle, WA 98195 USA.

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http://dx.doi.org/10.3390/molecules22040539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570559PMC
March 2017

ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer.

Clin Cancer Res 2016 07 2;22(14):3672-82. Epub 2016 Mar 2.

Center for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, Massachusetts. Hematology-Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947432PMC
July 2016

Docetaxel-related toxicity in metastatic hormone-sensitive and metastatic castration-resistant prostate cancer.

Med Oncol 2016 Jul 14;33(7):77. Epub 2016 Jun 14.

Division of Oncology, Department of Medicine, University of Washington, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1007/s12032-016-0793-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298886PMC
July 2016

UDP-glucuronosyltransferase Enzymes in Prostate Cancer Progression: Is Only Androgen Catabolism Involved?

Eur Urol 2016 Apr 28;69(4):610-612. Epub 2015 Aug 28.

Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.08.025DOI Listing
April 2016

Classical and Non-Classical Roles for Pre-Receptor Control of DHT Metabolism in Prostate Cancer Progression.

Horm Cancer 2016 Apr 21;7(2):104-13. Epub 2016 Jan 21.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MS D5-380, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1007/s12672-016-0250-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859429PMC
April 2016

Prostate cancer characteristics associated with response to pre-receptor targeting of the androgen axis.

PLoS One 2014 30;9(10):e111545. Epub 2014 Oct 30.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111545PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214744PMC
December 2015

In Reply to Bhattacharyya et al.

Int J Radiat Oncol Biol Phys 2015 Nov;93(3):719-20

University of Washington School of Medicine, Seattle, Washington.

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http://dx.doi.org/10.1016/j.ijrobp.2015.06.026DOI Listing
November 2015

Persistent, Unexplained Leukocytosis Is a Paraneoplastic Syndrome Associated With a Poor Prognosis in Patients With Urothelial Carcinoma.

Clin Genitourin Cancer 2015 Aug 5;13(4):e253-e258. Epub 2015 Mar 5.

Division of Oncology, Department of Medicine, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1016/j.clgc.2015.02.008DOI Listing
August 2015

Integrative clinical genomics of advanced prostate cancer.

Cell 2015 May;161(5):1215-1228

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484602PMC
May 2015

Beyond T and DHT - novel steroid derivatives capable of wild type androgen receptor activation.

Int J Biol Sci 2014 3;10(6):602-13. Epub 2014 Jun 3.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle WA, USA.

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http://dx.doi.org/10.7150/ijbs.8844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062953PMC
February 2015

Glucocorticoids and prostate cancer treatment: friend or foe?

Asian J Androl 2014 May-Jun;16(3):354-8

Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.4103/1008-682X.125392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023359PMC
December 2014

Minireview: SLCO and ABC transporters: a role for steroid transport in prostate cancer progression.

Endocrinology 2014 Nov 22;155(11):4124-32. Epub 2014 Aug 22.

School of Medicine (E.C., R.B.M.), University of Washington, Seattle, Washington 98195; and Division of Clinical Research (E.A.M.), Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.

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http://dx.doi.org/10.1210/en.2014-1337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298565PMC
November 2014

Intense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadjuvant study.

J Clin Oncol 2014 Nov 13;32(33):3705-15. Epub 2014 Oct 13.

Mary-Ellen Taplin, Massimo Loda, Rosina T. Lis, Wanling Xie, Zhenyang Jiang, and Philip W. Kantoff, Dana-Farber Cancer Institute, Harvard Medical School; Glenn J. Bubley, Huihui Ye, and Steven P. Balk, Beth Israel Deaconess Medical Center; Jerome P. Richie, Massimo Loda, and Rosina T. Lis, Brigham and Women's Hospital, Boston, MA; Bruce Montgomery, Bruce L. Dalkin, Lawrence D. True, and Alvin M. Matsumoto, University of Washington; Brett T. Marck and Alvin M. Matsumoto, Geriatric Research, Education and Clinical Center, Veterans' Affairs Puget Sound Health Care System; Elahe A. Mostaghel and Peter S. Nelson, Fred Hutchinson Cancer Research Center, Seattle, WA; Christopher J. Logothetis, John W. Davis, and Patricia Troncoso, University of Texas MD Anderson Cancer Center, Houston, TX; Martin G. Sanda, Emory University School of Medicine, Atlanta, GA; Massimo Loda, King's College London, London, United Kingdom; Trevor M. Penning and Daniel Tamae, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and Christopher M. Haqq, NamPhuong Tran, Weimin Peng, Thian Kheoh, and Arturo Molina, Janssen Research and Development, Los Angeles, CA.

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http://dx.doi.org/10.1200/JCO.2013.53.4578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226804PMC
November 2014

Abiraterone in the treatment of metastatic castration-resistant prostate cancer.

Cancer Manag Res 2014 28;6:39-51. Epub 2014 Jan 28.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.2147/CMAR.S39318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912049PMC
June 2014

Practical guide to the use of abiraterone in castration resistant prostate cancer.

Can J Urol 2014 Apr;21(2 Supp 1):57-63

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139288PMC
April 2014

Rapid induction of androgen receptor splice variants by androgen deprivation in prostate cancer.

Clin Cancer Res 2014 Mar 21;20(6):1590-600. Epub 2014 Jan 21.

Authors' Affiliations: Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; and Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-13-1863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022291PMC
March 2014

Molecular pathways: targeting resistance in the androgen receptor for therapeutic benefit.

Clin Cancer Res 2014 Feb 4;20(4):791-8. Epub 2013 Dec 4.

Authors' Affiliations: Division of Clinical Research, Fred Hutchinson Cancer Research Center; and Department of Medicine, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944407PMC
February 2014

Targeted androgen pathway suppression in localized prostate cancer: a pilot study.

J Clin Oncol 2014 Jan 9;32(3):229-37. Epub 2013 Dec 9.

Elahe A. Mostaghel, Rachel Hunter Merrill, and Roman Gulati, Fred Hutchinson Cancer Research Center; Elahe A. Mostaghel, Peter S. Nelson, Paul Lange, Daniel W. Lin, William Ellis, Robert Vessella, and Bruce Montgomery, University of Washington; Brett Marck, Alvin M. Matsumoto, and Lawrence D. True, Veterans Affairs Puget Sound Health Care System, Seattle, WA; Mary Ellen Taplin and Philip Kantoff, Dana-Farber Cancer Institute, Harvard Medical School; Steven Balk, Beth Israel Deaconess Medical Center, Boston, MA; and Daniel Tamae and Trevor Penning, University of Pennsylvania, Philadelphia, PA.

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http://jco.ascopubs.org/content/early/2013/12/09/JCO.2012.48
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2012.48.6431
Publisher Site
http://dx.doi.org/10.1200/JCO.2012.48.6431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887479PMC
January 2014

Steroid hormone synthetic pathways in prostate cancer.

Transl Androl Urol 2013 Sep;2(3):212-227

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle WA, USA.

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http://dx.doi.org/10.3978/j.issn.2223-4683.2013.09.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219921PMC
September 2013

Androgen action and metabolism in prostate cancer.

Mol Cell Endocrinol 2012 Sep 20;360(1-2):3-13. Epub 2012 Mar 20.

Divisions of Human Biology, Fred Hutchinson Cancer Research Center, Seattle WA, United States.

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http://dx.doi.org/10.1016/j.mce.2011.09.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124858PMC
September 2012

Impact of male hormonal contraception on prostate androgens and androgen action in healthy men: a randomized, controlled trial.

J Clin Endocrinol Metab 2012 Aug 1;97(8):2809-17. Epub 2012 Jun 1.

Division of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1210/jc.2012-1536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410271PMC
August 2012

Impact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumors.

PLoS One 2012 18;7(1):e30062. Epub 2012 Jan 18.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030062PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261168PMC
July 2012

Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants.

Clin Cancer Res 2011 Sep 1;17(18):5913-25. Epub 2011 Aug 1.

Division of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184252PMC
September 2011

New hormonal therapies for castration-resistant prostate cancer.

Endocrinol Metab Clin North Am 2011 Sep 14;40(3):625-42, x. Epub 2011 Jul 14.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.ecl.2011.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167094PMC
September 2011

Testosterone regulates tight junction proteins and influences prostatic autoimmune responses.

Horm Cancer 2011 Jun;2(3):145-56

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, D4-100, 1100 Fairview Ave. N, Seattle, WA 98109-1024, USA.

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http://dx.doi.org/10.1007/s12672-010-0063-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467375PMC
June 2011

Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a randomized-controlled trial.

J Clin Endocrinol Metab 2011 Feb 22;96(2):430-7. Epub 2010 Dec 22.

Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine, Box 357138, 1959 NE Pacific Street, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1210/jc.2010-1865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048323PMC
February 2011

Variability in the androgen response of prostate epithelium to 5alpha-reductase inhibition: implications for prostate cancer chemoprevention.

Cancer Res 2010 Feb 2;70(4):1286-95. Epub 2010 Feb 2.

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4-100, Seattle, WA 91809, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822890PMC
February 2010

Reduced tumor necrosis factor receptor-associated death domain expression is associated with prostate cancer progression.

Cancer Res 2009 Dec;69(24):9448-56

Department of Urology Research/Biochemistry, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795008PMC
December 2009

Castration-resistant prostate cancer: targeting androgen metabolic pathways in recurrent disease.

Urol Oncol 2009 May-Jun;27(3):251-7

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.urolonc.2009.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705999PMC
July 2009

Prostate tissue androgens: history and current clinical relevance.

Urology 2008 Aug 27;72(2):247-54. Epub 2008 May 27.

Department of Urology, University of California, Los Angeles, Geffen School of Medicine, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/j.urology.2008.03.033DOI Listing
August 2008

Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications.

Best Pract Res Clin Endocrinol Metab 2008 Apr;22(2):243-58

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.beem.2008.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474812PMC
April 2008

Analysis of testosterone and dihydrotestosterone from biological fluids as the oxime derivatives using high-performance liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom 2007 ;21(19):3200-6

Mass Spectrometry Center, Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195-7610, USA.

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http://dx.doi.org/10.1002/rcm.3205DOI Listing
November 2007

The basic biochemistry and molecular events of hormone therapy.

Curr Urol Rep 2007 May;8(3):224-32

Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA 98109, USA.

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May 2007

Persistent intraprostatic androgen concentrations after medical castration in healthy men.

J Clin Endocrinol Metab 2006 Oct 1;91(10):3850-6. Epub 2006 Aug 1.

University of Washington Medical Center, Division of Metabolism, Endocrinology and Nutrition, Box 357138, 1959 NE Pacific, Seattle, WA 98195.

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http://dx.doi.org/10.1210/jc.2006-0968DOI Listing
October 2006

Pulmonary surfactant proteins A and D directly suppress CD3+/CD4+ cell function: evidence for two shared mechanisms.

J Immunol 2002 Nov;169(10):5844-50

Departments of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.4049/jimmunol.169.10.5844DOI Listing
November 2002