Publications by authors named "El Hadji Ba"

9 Publications

  • Page 1 of 1

The Costs of Introducing the Hepatitis B Birth Dose Vaccine into the National Immunization Programme in Senegal (NéoVac Study).

Vaccines (Basel) 2021 May 18;9(5). Epub 2021 May 18.

Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13385 Marseille, France.

Some African countries are still reluctant to introduce the hepatitis B vaccine birth dose (HepB-BD) into their expanded program of immunization (EPI), partly because of logistical, economic, and cost information constraints. To assist decision-makers in these countries, we assessed the economic and financial costs of HepB-BD introduction in Senegal in 2016. We performed a micro-costing study in a representative sample of Senegal's EPI sites at all levels in 2018. Information on EPI and HepB-BD activity-related inputs and costs was collected using standardized questionnaires and semi-structured interviews. Using inverse probability weighting, we computed weighted average costs associated with HepB-BD introduction for each EPI level, country-level aggregated costs and estimated costs per newborn. Economic and financial costs from a government perspective were estimated in US dollars for 2015, 2016 and 2017. Total economic costs were USD 143,364 in 2015, USD 759,406 in 2016 and USD 867,311 in 2017, while financial costs were USD 127,745, USD 82,519 and USD 29,853, respectively. When annualizing pre-introduction and initial training costs, the economic (financial) cost per vaccinated newborn was USD 2.10 (USD 0.30) in 2016 and USD 1.90 (USD 0.20) in 2017. Our estimates provide valuable information to implement HepB-BD in Sub-Saharan African countries that have not yet integrated this vaccine.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/vaccines9050521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158493PMC
May 2021

Hepatitis B Vaccination in Senegalese Children: Coverage, Timeliness, and Sociodemographic Determinants of Non-Adherence to Immunisation Schedules (ANRS 12356 AmBASS Survey).

Vaccines (Basel) 2021 May 15;9(5). Epub 2021 May 15.

Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, Aix Marseille University, 13385 Marseille, France.

Detailed knowledge about hepatitis B virus (HBV) vaccination coverage and timeliness for sub-Saharan Africa is scarce. We used data from a community-based cross-sectional survey conducted in 2018-2019 in the area of Niakhar, Senegal, to estimate coverage, timeliness, and factors associated with non-adherence to the World Health Organisation-recommended vaccination schedules in children born in 2016 (year of the birth dose (BD) introduction in Senegal) and 2017-2018. Vaccination status was assessed from vaccination cards, surveillance data, and healthcare post vaccination records. Among 241 children with available data, for 2016 and 2017-2018, respectively, 31.0% and 66.8% received the BD within 24 h of birth (BD schedule), and 24.3% and 53.7% received the BD plus at least two pentavalent vaccine doses within the recommended timeframes (three-dose schedule). In logistic regression models, home birth, dry season birth, and birth in 2016 were all associated with non-adherence to the recommended BD and three-dose schedules. Living over three kilometres from the nearest healthcare post, being the firstborn, and living in an agriculturally poorer household were only associated with non-adherence to the three-dose schedule. The substantial proportion of children not vaccinated according to recommended schedules highlights the importance of considering vaccination timeliness when evaluating vaccination programme effectiveness. Outreach vaccination activities and incentives to bring children born at home to healthcare facilities within 24 h of birth, must be strengthened to improve timely HBV vaccination.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/vaccines9050510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155976PMC
May 2021

[Anaesthesia in on-pump cardiac surgery for congenital heart diseases at the Cuomo Pediatric Cardiology Center (Senegal)].

Pan Afr Med J 2020 21;37:362. Epub 2020 Dec 21.

Service d´Anesthésie - Réanimation, CHU de Fann, Dakar, Sénégal.

Congenital heart diseases account for 0.5-1% of births. The management of children with cardiac malformation requires treatment in a suitable center, adequate medical equipment and specific anesthetic and surgical knowledge. The purpose of this study was to evaluate the anesthetic management of patients with congenital heart diseases in our center after the first year of activity and to compare the obtained results with literature reported data. We conducted a retrospective, descriptive study over a 1-year period, from January to December 2017. All patients undergoing on-pump cardiac surgery for congenital heart disease during this period were included. We collected data from 80 records of patients undergoing surgery for congenital heart disease. Out of these 80 patients, 60 underwent on-pump cardiac surgery (75%). The average age of patients was 7.41 years, with a sex-ratio of 1.22. The mean duration of on-pump cardiac surgery was 82.82 min and the mean duration of aortic clamping was 58.31 min. At the end of the procedure catecholamine production was found in 70% of patients. The most common complication in the postoperative period was right-side heart failure (69%). The average length of stay in the Emergency room was 4.33 days. One patient died, bringing mortality to 1.6%. Congenital heart diseases are complex and highly variable. Improved management techniques have strongly reduced morbi-mortality.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2020.37.362.17659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912115PMC
March 2021

Towards harmonization of microscopy methods for malaria clinical research studies.

Malar J 2020 Sep 4;19(1):324. Epub 2020 Sep 4.

UMR 257 IRD VITROME, Campus IRD-UCAD, Dakar, Senegal.

Microscopy performed on stained films of peripheral blood for detection, identification and quantification of malaria parasites is an essential reference standard for clinical trials of drugs, vaccines and diagnostic tests for malaria. The value of data from such research is greatly enhanced if this reference standard is consistent across time and geography. Adherence to common standards and practices is a prerequisite to achieve this. The rationale for proposed research standards and procedures for the preparation, staining and microscopic examination of blood films for malaria parasites is presented here with the aim of improving the consistency and reliability of malaria microscopy performed in such studies. These standards constitute the core of a quality management system for clinical research studies employing microscopy as a reference standard. They can be used as the basis for the design of training and proficiency testing programmes as well as for procedures and quality assurance of malaria microscopy in clinical research.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12936-020-03352-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471592PMC
September 2020

Susac syndrome: about two cases.

Pan Afr Med J 2019 26;33:145. Epub 2019 Jun 26.

Neurology Unit, Fann National Teaching Hospital, Saint-Louis, Senegal.

Susac syndrome is an autoimmune endothelopathy that affects precapillary arterioles of the brain, retina and inner ear. We report for the first time observations of two patients with Susac syndrome in Senegal.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2019.33.145.17954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754840PMC
October 2019

Evaluation of the effectiveness of a targeted community-based IRS approach for malaria elimination in an area of low malaria transmission of the central-western Senegal.

Parasite Epidemiol Control 2019 Aug 27;6:e00109. Epub 2019 Apr 27.

Laboratoire d'Ecologie Vectorielle et Parasitaire, Faculté des Sciences et Techniques, Université Cheikh Anta Diop, Dakar, Sénégal.

The implementation of effective malaria control strategies in the central-western Senegal, such as Indoor Residual Spraying (IRS), long-lasting insecticide-treated nets (LLIN), Seasonal malaria chemoprophylaxis (SMC) and appropriate management of malaria cases, has led to the decline of malaria transmission in the region. However, residual malaria transmission still occurring in some localities, known as hotspots villages, making challenging the achievement of the malaria elimination goal. A pilot study was undertaken between 2013 and 2014 to test the feasibility of a community-based IRS approach for malaria elimination in four targeted health districts of the Central Western Senegal. The residual efficacy of the Actellic® 300CS formulation on the sprayed surface was monitored using WHO cone test. Overall, 615 walls were tested over the two successive years, respectively 240 and 375 in 2013 and 2014 IRS campaigns. The residual efficacy of the IRS with Actellic®300 CS was longer in the second year due to the improvement of community agents spraying skill the second year thanks to the refreshing training and a better supervision by professional agent of the National Hygiene Service. The analysis of the Incidence Rate Ratio under the Poisson model shows no significant difference of IRS effectiveness according to the building type. In conclusion, the quality of training of community agents and good supervision of IRS activities play a key role in the quality and the residual efficacy of IRS campaigns. A good planning and implementation of IRS campaign ensure a high quality and a good effectiveness of spraying with the Actellic®300 CS formulation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.parepi.2019.e00109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529714PMC
August 2019

An epidemiological study to assess Plasmodium falciparum parasite prevalence and malaria control measures in Burkina Faso and Senegal.

Malar J 2017 02 6;16(1):63. Epub 2017 Feb 6.

GSK Vaccines, Wavre, Belgium.

Background: Malariometric information is needed to decide how to introduce malaria vaccines and evaluate their impact in sub-Saharan African countries.

Methods: This cross-sectional study (NCT01954264) was conducted between October and November, 2013, corresponding to the high malaria transmission season, in four sites with Health and Demographic Surveillance Systems (DSS) [two sites with moderate-to-high malaria endemicity in Burkina Faso (Nouna and Saponé) and two sites with low malaria endemicity in Senegal (Keur Socé and Niakhar)]. Children (N = 2421) were randomly selected from the DSS lists of the study sites and were stratified into two age groups (6 months-4 years and 5-9 years). A blood sample was collected from each child to evaluate parasite prevalence of Plasmodium falciparum and other Plasmodium species and gametocyte density by microscopy, and rapid diagnosis test in the event of fever within 24 h. Case report forms were used to evaluate malaria control measures and other factors.

Results: Plasmodium falciparum was identified in 707 (29.2%) children, with a higher prevalence in Burkina Faso than Senegal (57.5 vs 0.9% of children). In Burkina Faso, prevalence was 57.7% in Nouna and 41.9% in Saponé in the 6 months-4 years age group, and 75.4% in Nouna and 70.1% in Saponé in the 5-9 years age group. Infections with other Plasmodium species were rare and only detected in Burkina Faso. While mosquito nets were used by 88.6-97.0 and 64.7-80.2% of children in Burkina Faso and Senegal, other malaria control measures evaluated at individual level were uncommon. In Burkina Faso, exploratory analyses suggested that use of malaria treatment or any other medication within 14 days, and use of insecticide spray within 7 days decreased the prevalence of malaria infection; older age, rural residence, natural floor, grass/palm roof, and unavailability of electricity in the house were factors associated with increased malaria occurrence.

Conclusions: Plasmodium falciparum infection prevalence in children younger than 10 years was 57.5% in Burkina Faso and 0.9% in Senegal, and variability was observed, among others, by age, study site and malaria control measures.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12936-017-1715-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294715PMC
February 2017

[Perioperative management of emergency abdominal surgery in adult patients at the Aristide Le Dantec University Hospital].

Pan Afr Med J 2016 1;24:190. Epub 2016 Jul 1.

Service d'Anesthésie-Réanimation CHU Le Dantec, Faculté de Médecine UCAD, Dakar, Sénégal.

Perioperative management of emergency abdominal surgery remains a major concern for anesthesiologists due to hemodynamic and/or metabolic disorders often present preoperatively as well as to potential postoperative complications. This study aims to evaluate the epidemiological, diagnostic, therapeutic and prognostic factors of abdominal emergencies. We conducted a retrospective descriptive study involving patients over 16 years old undergoing emergency abdominal surgery at the Aristide Le Dantec University Hospital over a period of six months. The parameters studied were the epidemiological, diagnostic, therapeutic and prognostic factors of emergency abdominal surgery. We collected 161 cases, nearly 20% of the activity in the department. The average age was 41 years [16, 80 years]. The sex ratio was 2.9. The mean consultation time was 4.6 days. Peritonitis was the most frequent pathologies (25.5%). The average heart rate in patients was 92 bpm (beats/ min) and 97 bpm in patients who underwent preoperative hemodynamic preparation. The average Mean Arterial Pressure (MAP) was 96.6 mmHg and 86.1 mmHg in prepared patients. 49.1% of patients were ASA class 1, 39.9% were ASA2, 8.7% ASA3, 2.5% ASA4 and 0.6% ASA5. Antibiotic prophylaxis was used in 46.30% of patients and 53.41% of them underwent antibiotic therapy. 95.6% of patients underwent general anesthesia and 4.4% underwent spinal anesthesia. The frequency of perioperative incidents was 11.08%. Morbidity was 4.3% and mortality was 4.96%. The management of emergency abdominal surgery requires a multidisciplinary approach that involves anesthetists, surgeons and biologists to further reduce morbidity and mortality rate which remains significant even today.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2016.24.190.9929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072862PMC
February 2017

(Not) Keeping the stem straight: a proteomic analysis of maritime pine seedlings undergoing phototropism and gravitropism.

BMC Plant Biol 2010 Oct 6;10:217. Epub 2010 Oct 6.

INRA, UMR Biogeco 1202, 69 route d'Arcachon, 33612 Cestas, France.

Background: Plants are subjected to continuous stimuli from the environment and have evolved an ability to respond through various growth and development processes. Phototropism and gravitropism responses enable the plant to reorient with regard to light and gravity.

Results: We quantified the speed of maritime pine seedlings to reorient with regard to light and gravity over 22 days. Seedlings were inclined at 15, 30 and 45 degrees with vertical plants as controls. A lateral light source illuminated the plants and stem movement over time was recorded. Depending on the initial angle of stem lean, the apical response to the lateral light source differed. In control and 15° inclined plants, the apex turned directly towards the light source after only 2 h. In plants inclined at 30° and 45°, the apex first reoriented in the vertical plane after 2 h, then turned towards the light source after 24 h. Two-dimensional gel electrophoresis coupled with mass spectrometry was then used to describe the molecular response of stem bending involved in photo- and gravi-tropism after 22 hr and 8 days of treatment. A total of 486 spots were quantitatively analyzed using image analysis software. Significant changes were determined in the protein accumulation of 68 protein spots. Early response gravitropic associated proteins were identified, which are known to function in energy related and primary metabolism. A group of thirty eight proteins were found to be involved in primary metabolism and energy related metabolic pathways. Degradation of Rubisco was implicated in some protein shifts.

Conclusions: Our study demonstrates a rapid gravitropic response in apices of maritime pine seedlings inclined >30°. Little or no response was observed at the stem bases of the same plants. The primary gravitropic response is concomitant with a modification of the proteome, consisting of an over accumulation of energy and metabolism associated proteins, which may allow the stem to reorient rapidly after bending.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2229-10-217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017815PMC
October 2010
-->