Publications by authors named "Ekaterina Tao"

4 Publications

  • Page 1 of 1

Sex differences in mortality in the intensive care unit patients with severe COVID-19.

J Infect 2021 02 28;82(2):282-327. Epub 2020 Sep 28.

Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, 11/5 Rossolimo, Moscow 119435, Russia.

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http://dx.doi.org/10.1016/j.jinf.2020.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521429PMC
February 2021

Predictive Value of Cardiac MRI in Patients with Fabry Disease.

Radiology 2020 08 12;296(2):E123. Epub 2020 May 12.

Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, 11/5 Rossolimo St, Moscow 119021, Russian Federation.

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http://dx.doi.org/10.1148/radiol.2020200909DOI Listing
August 2020

Heat shock protein 90 and NFkB levels in serum and urine in patients with chronic glomerulonephritis.

Cell Stress Chaperones 2020 05 2;25(3):495-501. Epub 2020 Apr 2.

Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Rossolimo 11/5, Moscow, Russia, 119435.

Heat shock proteins play an important role in immune inflammation and the formation and restoration of proteins. In recent years, the importance of heat shock protein 90 (Hsp90) in the activation of immune inflammation through nuclear factor kB (NFkB) has been discussed. To assess the activation of the Hsp90-NFkB system by measuring serum and urinary levels in patients with chronic glomerulonephritis (CGN). This study included 32 patients with active forms of CGN and 14 patients with Fabry nephropathy. The control group included 10 healthy individuals. Twenty-one out of 32 CGN patients had nephrotic syndrome (NS). Eleven out of 32 CGN patients had proteinuria levels from 1 to 3 g/day without nephrotic syndrome. A total of 17 patients had renal dysfunction (estimated glomerular filtration rate < 60 ml/min/1.73m). Fourteen patients with Fabry nephropathy had proteinuria without nephrotic syndrome. Serum and urine HSP-90 and NFkB p65 levels were determined using an enzyme-linked immunosorbent assay. The levels of HSP-90 and NFkB in the serum of patients with CGN were significantly higher than in healthy individuals and patients with Fabry nephropathy. In patients with Fabry nephropathy, the HSP-90 and NFkB levels in the urine and serum did not significantly differ from those in the control subjects. Serum Hsp90 levels were significantly higher in the CGN patients with NS than in patients without NS, as well as in patients with normal renal function compared with patients with an eGFR < 60 ml/min/1.73 m and patients with tubulo-interstitial fibrosis. Higher levels of HSP-90 and NFkB in serum were observed in patients with nephrotic forms of CGN, including focal segmental glomerulosclerosis, minimal change disease and membranous nephropathy. There were no correlations between the clinical signs of CGN and urinary HSP90/NFkB levels. Activation of the HSP-90-NFkB system, which is directly involved in the development of immune inflammation in CGN, was found in patients with an active course of CGN, especially in those with nephrotic syndrome.
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http://dx.doi.org/10.1007/s12192-020-01089-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193002PMC
May 2020
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