Eithne Costello

Eithne Costello

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Eithne Costello

Eithne Costello

Publications by authors named "Eithne Costello"

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75Publications

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Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker.

Oncotarget 2018 Aug 31;9(68):32984-32996. Epub 2018 Aug 31.

Cancer Research Program, IMIM, Hospital del Mar Medical Research Institute, Unidad Asociade CSIC, Barcelona, Spain.

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August 2018

Therapeutic developments in pancreatic cancer: current and future perspectives.

Nat Rev Gastroenterol Hepatol 2018 Jun;15(6):333-348

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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June 2018

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

Oncotarget 2018 Jun 5;9(43):27104-27116. Epub 2018 Jun 5.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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June 2018

Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer.

Drug Discov Today 2017 04 30;22(4):690-701. Epub 2017 Jan 30.

Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK. Electronic address:

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April 2017

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.

Authors:
Mingfeng Zhang Zhaoming Wang Ofure Obazee Jinping Jia Erica J Childs Jason Hoskins Gisella Figlioli Evelina Mocci Irene Collins Charles C Chung Christopher Hautman Alan A Arslan Laura Beane-Freeman Paige M Bracci Julie Buring Eric J Duell Steven Gallinger Graham G Giles Gary E Goodman Phyllis J Goodman Aruna Kamineni Laurence N Kolonel Matthew H Kulke Núria Malats Sara H Olson Howard D Sesso Kala Visvanathan Emily White Wei Zheng Christian C Abnet Demetrius Albanes Gabriella Andreotti Lauren Brais H Bas Bueno-de-Mesquita Daniela Basso Sonja I Berndt Marie-Christine Boutron-Ruault Maarten F Bijlsma Hermann Brenner Laurie Burdette Daniele Campa Neil E Caporaso Gabriele Capurso Giulia Martina Cavestro Michelle Cotterchio Eithne Costello Joanne Elena Ugo Boggi J Michael Gaziano Maria Gazouli Edward L Giovannucci Michael Goggins Myron Gross Christopher A Haiman Manal Hassan Kathy J Helzlsouer Nan Hu David J Hunter Elzbieta Iskierka-Jazdzewska Mazda Jenab Rudolf Kaaks Timothy J Key Kay-Tee Khaw Eric A Klein Manolis Kogevinas Vittorio Krogh Juozas Kupcinskas Robert C Kurtz Maria T Landi Stefano Landi Loic Le Marchand Andrea Mambrini Satu Mannisto Roger L Milne Rachel E Neale Ann L Oberg Salvatore Panico Alpa V Patel Petra H M Peeters Ulrike Peters Raffaele Pezzilli Miquel Porta Mark Purdue J Ramón Quiros Elio Riboli Nathaniel Rothman Aldo Scarpa Ghislaine Scelo Xiao-Ou Shu Debra T Silverman Pavel Soucek Oliver Strobel Malin Sund Ewa Małecka-Panas Philip R Taylor Francesca Tavano Ruth C Travis Mark Thornquist Anne Tjønneland Geoffrey S Tobias Dimitrios Trichopoulos Yogesh Vashist Pavel Vodicka Jean Wactawski-Wende Nicolas Wentzensen Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Charles Kooperberg Harvey A Risch Eric J Jacobs Donghui Li Charles Fuchs Robert Hoover Patricia Hartge Stephen J Chanock Gloria M Petersen Rachael S Stolzenberg-Solomon Brian M Wolpin Peter Kraft Alison P Klein Federico Canzian Laufey T Amundadottir

Oncotarget 2016 Oct;7(41):66328-66343

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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October 2016

miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer.

Oncoimmunology 2016 Jun 9;5(6):e1160181. Epub 2016 May 9.

Department of Gastroenterology and Endocrinology, University Hospital, Philipps-University, Marburg, Germany; Department of Internal Medicine I, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

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June 2016

Secretome protein signature of human pancreatic cancer stem-like cells.

J Proteomics 2016 Mar 2;136:1-12. Epub 2016 Feb 2.

University of Verona, Department of Biotechnology, Proteomics and Mass Spectrometry Laboratory, Verona 37134, Italy.

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March 2016

Immunobiological effects of gemcitabine and capecitabine combination chemotherapy in advanced pancreatic ductal adenocarcinoma.

Br J Cancer 2016 Mar 4;114(5):510-8. Epub 2016 Feb 4.

National Institutes of Health Research Liverpool Pancreas Biomedical Research Unit and Clinical Directorate of General Surgery, Royal Liverpool and Broadgreen University Hospitals NHS Trust and the University of Liverpool, Liverpool L69 3GA, UK.

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March 2016

Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors.

Mol Cancer Ther 2016 Feb 14;15(2):323-33. Epub 2016 Jan 14.

Epithelial Carcinogenesis Group, Cancer Cell Biology Programme, Spanish National Cancer Research Center-CNIO, Madrid, Spain. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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February 2016

Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms.

Clin Cancer Res 2015 May 23;21(10):2325-37. Epub 2015 Feb 23.

Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Centre for Stem Cells in Cancer and Ageing, Barts Cancer Institute, A CR-UK Centre of Excellence, Queen Mary University of London, United Kingdom.

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May 2015

Biomarkers for early diagnosis of pancreatic cancer.

Expert Rev Gastroenterol Hepatol 2015 Mar 6;9(3):305-15. Epub 2014 Nov 6.

Department of Molecular and Clinical Cancer Medicine, National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK.

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March 2015

Pancreatic mass in a young CFTR carrier with a heterozygous p.R117H CFTR gene mutation and homozygous 7T.

Pancreas 2015 Mar;44(2):343-5

National Institute for Health Research Liverpool Pancreas Biomedical Research Unit Royal Liverpool University Hospital Liverpool, UK Department of Cellular Pathology Royal Liverpool University Hospital Liverpool, UK National Institute for Health Research Liverpool Pancreas Biomedical Research Unit Royal Liverpool University Hospital Liverpool, UK National Institute for Health Research Liverpool Pancreas Biomedical Research Unit Royal Liverpool University Hospital Liverpool, UK

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March 2015

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.

Authors:
Brian M Wolpin Cosmeri Rizzato Peter Kraft Charles Kooperberg Gloria M Petersen Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Julie Buring Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Gary E Goodman Phyllis J Goodman Eric J Jacobs Aruna Kamineni Alison P Klein Laurence N Kolonel Matthew H Kulke Donghui Li Núria Malats Sara H Olson Harvey A Risch Howard D Sesso Kala Visvanathan Emily White Wei Zheng Christian C Abnet Demetrius Albanes Gabriella Andreotti Melissa A Austin Richard Barfield Daniela Basso Sonja I Berndt Marie-Christine Boutron-Ruault Michelle Brotzman Markus W Büchler H Bas Bueno-de-Mesquita Peter Bugert Laurie Burdette Daniele Campa Neil E Caporaso Gabriele Capurso Charles Chung Michelle Cotterchio Eithne Costello Joanne Elena Niccola Funel J Michael Gaziano Nathalia A Giese Edward L Giovannucci Michael Goggins Megan J Gorman Myron Gross Christopher A Haiman Manal Hassan Kathy J Helzlsouer Brian E Henderson Elizabeth A Holly Nan Hu David J Hunter Federico Innocenti Mazda Jenab Rudolf Kaaks Timothy J Key Kay-Tee Khaw Eric A Klein Manolis Kogevinas Vittorio Krogh Juozas Kupcinskas Robert C Kurtz Andrea LaCroix Maria T Landi Stefano Landi Loic Le Marchand Andrea Mambrini Satu Mannisto Roger L Milne Yusuke Nakamura Ann L Oberg Kouros Owzar Alpa V Patel Petra H M Peeters Ulrike Peters Raffaele Pezzilli Ada Piepoli Miquel Porta Francisco X Real Elio Riboli Nathaniel Rothman Aldo Scarpa Xiao-Ou Shu Debra T Silverman Pavel Soucek Malin Sund Renata Talar-Wojnarowska Philip R Taylor George E Theodoropoulos Mark Thornquist Anne Tjønneland Geoffrey S Tobias Dimitrios Trichopoulos Pavel Vodicka Jean Wactawski-Wende Nicolas Wentzensen Chen Wu Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Robert Hoover Patricia Hartge Charles Fuchs Stephen J Chanock Rachael S Stolzenberg-Solomon Laufey T Amundadottir

Nat Genet 2014 Sep 3;46(9):994-1000. Epub 2014 Aug 3.

1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].

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September 2014

Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease.

Mol Cancer 2014 May 20;13:114. Epub 2014 May 20.

NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool and Broadgreen University Hospital NHS Trust, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GA, UK.

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May 2014

Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial.

J Natl Cancer Inst 2014 Jan 3;106(1):djt347. Epub 2013 Dec 3.

Affiliations of authors: Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool, Liverpool, UK (WG, JPN, EG, TFC, PG, EC, CMH, CLR, FC, RJ); the Princess Margaret Hospital, Toronto, Canada (MJM); Manchester Academic Health Sciences Centre, Christie NHS Foundation Trust, School of Cancer and Enabling Sciences, University of Manchester, UK (JWV); Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK (DHP); Beatson West of Scotland Cancer Centre, Glasgow, UK (ACM); Glasgow Royal Infirmary, Glasgow, UK (RC); Hôpital Tenon, Université, Pierre et Marie Curie, Paris, France (FL); Austin Health, Melbourne, Australia (NCT); Prince of Wales Hospital and Clinical School University of New South Wales, New South Wales, Australia (DG); Nepean Cancer Centre and University of Sydney, Sydney, Australia (JS); Agia Olga Hospital, Athens, Greece (CD); Medical Oncology, Clatterbridge Centre for Oncology, Bebington, Merseyside, UK (DS); Department of Oncology, Akademiska Sjukhuset, Uppsala University, Uppsala, Sweden (BG); University Hospital, North Staffordshire, UK (MD); Freeman Hospital, Newcastle upon Tyne, UK (RMC); Service de Chirurgie Digestive et Viscérale, Hôpital Tenon, Paris, France (FL); Cross Cancer Institute and University of Alberta, Alberta, Canada (JRM, AGS); Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, UK (MRM); St James's University Hospital, Leeds, UK (AA); Department of Medicine A, University Medicine Greifswald, Greifswald, Germany (JM); Petz Aladar Hospital, Gyor, Hungary (AO); Departments of Surgery and Pathology and ARC-NET Research Center, University of Verona, Italy (AS, CB); Department of Surgery, University of Heidelberg, Heidelberg, Germany (MWB).

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January 2014

cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: effects of PKA and EPAC.

Biochim Biophys Acta 2013 Dec 22;1833(12):2664-2672. Epub 2013 Jun 22.

Department of Cellular and Molecular Physiology, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK. Electronic address:

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December 2013

The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer.

Int J Cancer 2013 Sep 8;133(6):1408-18. Epub 2013 Apr 8.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, L3 9TA, United Kingdom.

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September 2013

The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion.

Front Physiol 2012 13;3:270. Epub 2012 Jul 13.

Liverpool Cancer Research UK Centre, University of Liverpool Liverpool, UK.

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October 2012

New biomarkers and targets in pancreatic cancer and their application to treatment.

Nat Rev Gastroenterol Hepatol 2012 Aug 26;9(8):435-44. Epub 2012 Jun 26.

National Institute for Health Research Pancreas Biomedical Research Unit and Liverpool Cancer Research UK Centre, Department of Molecular, University of Liverpool, Liverpool, L69 3GA, UK.

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August 2012

Nanotechnology advances in upper gastrointestinal, liver and pancreatic cancer.

Expert Rev Gastroenterol Hepatol 2012 Jun;6(3):343-56

Liverpool Cancer Research UK Centre, Department of Molecular and Clinical Cancer Studies, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK.

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June 2012

Circulating microRNAs as potential markers of human drug-induced liver injury.

Hepatology 2011 Nov;54(5):1767-76

MRC Center for Drug Safety Science, Department of Clinical and Molecular Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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November 2011

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy.

Mol Cancer 2011 Apr 13;10:37. Epub 2011 Apr 13.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, UK.

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April 2011

Tetracycline-inducible protein expression in pancreatic cancer cells: effects of CapG overexpression.

World J Gastroenterol 2011 Apr;17(15):1947-60

Liverpool CR-UK Centre, Department of Molecular and Therapeutic Cancer Medicine, University of Liverpool, Liverpool, L69 3GA, UK.

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April 2011

Pancreatic cancer in 2010: new insights for early intervention and detection.

Nat Rev Gastroenterol Hepatol 2011 Feb;8(2):71-3

Liverpool CR-UK Centre, NIHR Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, Daulby Street, University of Liverpool, Liverpool, UK.

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February 2011

Analysis of serum proteins by LC-MS/MS.

Methods Mol Biol 2010 ;658:281-91

Division of Surgery and Oncology, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK.

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December 2010

Pancreatic cancer: proteomic approaches to a challenging disease.

Pancreatology 2009 4;9(5):567-76. Epub 2009 Aug 4.

Division of Surgery and Oncology, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK.

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February 2010

New treatment options for advanced pancreatic cancer.

Expert Rev Gastroenterol Hepatol 2008 Oct;2(5):673-96

Royal Surrey County Hospital NHS Trust, Egerton Road, Guildford, GU2 7XX, UK.

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October 2008

Genetics and prevention of pancreatic cancer.

Cancer Control 2004 Jan-Feb;11(1):6-14

Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, United Kingdom.

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September 2007

The pancreatic cancer proteome - recent advances and future promise.

Proteomics Clin Appl 2007 Sep;1(9):1066-79

Division of Surgery and Oncology, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK.

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September 2007

Biology and management of pancreatic cancer.

Gut 2007 Aug;56(8):1134-52

Division of Surgery and Oncology, University of Liverpool, Liverpool L69 3GA, UK.

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August 2007

Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma.

Gastroenterology 2005 Nov;129(5):1454-63

Molecular Oncology Unit, Cancer Research UK, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, United Kingdom.

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November 2005

Trials of gene therapy for pancreatic carcinoma.

Curr Gastroenterol Rep 2005 Jun;7(3):165-9

Division of Surgery, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK.

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June 2005

Proteomic technologies and their application to pancreatic cancer.

Expert Rev Proteomics 2004 Dec;1(4):493-501

Division of Surgery & Oncology, University of Liverpool, 5th Floor Duncan Building, Daulby St., UK.

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December 2004

Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis.

Int J Cancer 2004 Oct;112(1):100-12

Cancer Research U.K., Molecular Oncology Unit, Imperial College School of Medicine at Hammersmith Campus, London, United Kingdom.

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October 2004

MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation.

Am J Physiol Gastrointest Liver Physiol 2002 Jan;282(1):G77-85

Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool L69 3GA, United Kingdom.

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January 2002