Publications by authors named "Eileen Bradley"

5 Publications

  • Page 1 of 1

A call for transparent reporting to optimize the predictive value of preclinical research.

Nature 2012 Oct;490(7419):187-91

National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA.

The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.
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http://dx.doi.org/10.1038/nature11556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511845PMC
October 2012

Placental 3-D power Doppler angiography--regional variation and reliability of two ultrasonic sphere biopsy techniques.

Ultrasound Med Biol 2011 Mar 26;37(3):364-75. Epub 2011 Jan 26.

Nottingham University Hospitals NHS Trust, Queen's Medical Centre Campus, Nottingham, United Kingdom.

Three-dimensional power Doppler angiography and 4D View allows quantification of placental "vascularity" using sonobiopsy or manual tracing. We used two vascular "biopsy" techniques: nontargeted sphere placement and systematic uniform random sphere placement (SURS). We hypothesised that random application of spheres would result in less reliability and the basal zone would display higher values than the chorionic zone. Forty women between 18+6 to 21+6 weeks gestation were recruited. A single volume of the placenta was acquired. Data was analysed twice by a single observer. Significantly higher values were seen for all vascular indices in the basal zone. Reliability was greatest for the whole placental technique with intraclass correlation coefficients of 0.9 and limits of agreement for flow index (FI) of -3.81 to 2.50 (equivalent to -7.8% to 5.1%) compared with 0.6 and -13.2 to 18.3 (-64.6% to 78.2%) for the nontargeted sphere technique. Whole placental values are more reliable than biopsy techniques with significantly different results seen with each technique.
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http://dx.doi.org/10.1016/j.ultrasmedbio.2010.12.008DOI Listing
March 2011

Evaluating the intra- and interobserver reliability of three-dimensional ultrasound and power Doppler angiography (3D-PDA) for assessment of placental volume and vascularity in the second trimester of pregnancy.

Ultrasound Med Biol 2011 Mar 21;37(3):376-85. Epub 2011 Jan 21.

Nottingham University Hospitals NHS Trust, Queen's Medical Centre Campus, Nottingham, United Kingdom.

Three-dimensional (3-D) power Doppler angiography (3-D-PDA) allows visualisation of Doppler signals within the placenta and their quantification is possible by the generation of vascular indices by the 4-D View software programme. This study aimed to investigate intra- and interobserver reproducibility of 3-D-PDA analysis of stored datasets at varying gestations with the ultimate goal being to develop a tool for predicting placental dysfunction. Women with an uncomplicated, viable singleton pregnancy were scanned at 12, 16 or 20 weeks gestational age groups. 3-D-PDA datasets acquired of the whole placenta were analysed using the VOCAL software processing tool. Each volume was analysed by three observers twice in the A plane. Intra- and interobserver reliability was assessed by intraclass correlation coefficients (ICCs) and Bland Altman plots. At each gestational age group, 20 low risk women were scanned resulting in 60 datasets in total. The ICC demonstrated a high level of measurement reliability at each gestation with intraobserver values >0.90 and interobserver values of >0.6 for the vascular indices. Bland Altman plots also showed high levels of agreement. Systematic bias was seen at 20 weeks in the vascular indices obtained by different observers. This study demonstrates that 3-D-PDA data can be measured reliably by different observers from stored datasets up to 18 weeks gestation. Measurements become less reliable as gestation advances with bias between observers evident at 20 weeks.
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http://dx.doi.org/10.1016/j.ultrasmedbio.2010.11.018DOI Listing
March 2011

Evaluation of the intraobserver and interobserver reliability of data acquisition for three-dimensional power Doppler angiography of the whole placenta at 12 weeks gestation.

Ultrasound Med Biol 2010 Sep;36(9):1405-11

Nottingham University Hospitals NHS Trust, Queen's Medical Centre Campus Nottingham, UK.

The aim of this study was to investigate the intra- and interobserver reproducibility of three-dimensional (3-D) power Doppler (3-DPD) data acquisition from women at 12 weeks gestation, which were then subsequently measured by a single observer. Women with an uncomplicated, viable singleton pregnancy were scanned between 12 + 0 and 13 + 6 weeks gestations with a Voluson 730 Expert. 3-DPD data were acquired of the whole placenta by two observers: the first observer captured two datasets and the second a single dataset. Each dataset was analysed using VOCAL in the A plane with 9 degree rotation steps. Eighteen low risk women were recruited with a total of 54 datasets analysed. The intraclass correlation coefficient (ICC) was highest for the vascular indices vascularisation index (VI) and vascularisation-flow index (VFI), greater than 0.75. ICC for flow index (FI) showed moderate correlation at 0.47 to 0.65. Bland Altman plots showed the most precise vascular index to be the FI (-15% to 10% for interobserver agreement). There was no bias between datasets. Prospective studies are now required to identify if this analysis tool and method is sensitive enough to recognise patients with early-onset placental dysfunction.
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http://dx.doi.org/10.1016/j.ultrasmedbio.2010.05.023DOI Listing
September 2010

They answered the call: Nebraska nurses join the ranks in World War II.

Nebr Nurse 2004 Dec-2005 Feb;37(4):15

On December 7, 1941, there were fewer than 1,000 nurses in the Army Nurse Corps. That infamous day, 82 of those brave nurses were stationed in Hawaii. Their bravery, leadership and calmness under extreme duress foreshadowed the amazing role nurses would play in World War II. In the months and years that followed Japan's bombing of Pearl Harbor, over 59,000 American nurses would answer the call and join the Army Nurse Corps. Courageous Nebraskan women were among them.
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March 2005