Eiji Warabi

Eiji Warabi

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Eiji Warabi

Eiji Warabi

Publications by authors named "Eiji Warabi"

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p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.

FASEB J 2019 Jul 26;33(7):8022-8032. Epub 2019 Mar 26.

Graduate School of Natural Sciences, Nagoya City University, Nagoya, Japan.

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http://dx.doi.org/10.1096/fj.201900133RDOI Listing
July 2019

Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis.

Free Radic Biol Med 2019 03 4;133:169-178. Epub 2018 Sep 4.

School of Cardiovascular Medicine and Sciences, King's British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences and Medicine, King's College London, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.09.002DOI Listing
March 2019

Use of a Caco-2 permeability assay to evaluate the effects of several Kampo medicines on the drug transporter P-glycoprotein.

J Nat Med 2018 Sep 24;72(4):897-904. Epub 2018 May 24.

Tsumura Kampo Research Laboratories, Kampo Research and Development Division, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-1192, Japan.

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http://dx.doi.org/10.1007/s11418-018-1222-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107777PMC
September 2018

Circadian control of p75 neurotrophin receptor leads to alternate activation of Nrf2 and c-Rel to reset energy metabolism in astrocytes via brain-derived neurotrophic factor.

Free Radic Biol Med 2018 05 31;119:34-44. Epub 2018 Jan 31.

School of Cardiovascular Medicine and Sciences, King's British Heart Foundation Centre of Excellence, Faculty of Life Sciences and Medicine, King's College London, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.01.026DOI Listing
May 2018

The role of peroxiredoxin I in cisplatin-induced ototoxicity.

Auris Nasus Larynx 2017 Apr 16;44(2):205-212. Epub 2016 Jun 16.

Department of Otolaryngology, Faculty of Medicine, University of Tsukuba, Japan.

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http://dx.doi.org/10.1016/j.anl.2016.06.001DOI Listing
April 2017

Autophagy controls centrosome number by degrading Cep63.

Nat Commun 2016 11 21;7:13508. Epub 2016 Nov 21.

Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

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http://dx.doi.org/10.1038/ncomms13508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473638PMC
November 2016

p62 modulates the intrinsic signaling of UVB-induced apoptosis.

J Dermatol Sci 2016 09 10;83(3):226-33. Epub 2016 May 10.

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2016.05.005DOI Listing
September 2016

Cytoprotective Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube.

PLoS One 2015 14;10(12):e0144835. Epub 2015 Dec 14.

Division of Medical Science, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144835PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681703PMC
August 2016

Ignavine: a novel allosteric modulator of the μ opioid receptor.

Sci Rep 2016 08 17;6:31748. Epub 2016 Aug 17.

Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1038/srep31748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987652PMC
August 2016

Nrf2 as an Endothelial Mechanosensitive Transcription Factor: Going With the Flow.

Hypertension 2016 Jan 23;67(1):20-9. Epub 2015 Nov 23.

From the Cardiovascular Division, British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom (S.R.M., R.C.M.S.); and Faculty of Medicine, University of Tsukuba, Tsukuba, Japan (E.W.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06146DOI Listing
January 2016

p62 Deficiency Enhances α-Synuclein Pathology in Mice.

Brain Pathol 2015 Sep 20;25(5):552-64. Epub 2014 Nov 20.

Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

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http://dx.doi.org/10.1111/bpa.12214DOI Listing
September 2015

Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice.

Hum Mol Genet 2015 Feb 9;24(4):1092-105. Epub 2014 Oct 9.

Department of Neuroscience for Neurodegenerative Disorders, Laboratory for Structural Neuropathology, Laboratory for Molecular Mechanisms of Thalamus Development, RIKEN Brain Science Institute, Saitama 351-0198, Japan, CREST (Core Research for Evolutionary Science and Technology), JST, Tokyo 102-0076, Japan

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http://dx.doi.org/10.1093/hmg/ddu522DOI Listing
February 2015

[Physiological role of p62/sequestosome1].

Authors:
Eiji Warabi

Seikagaku 2014 Dec;86(6):783-7

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December 2014

Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy.

Int J Hepatol 2014 27;2014:584650. Epub 2014 Apr 27.

Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1155/2014/584650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020457PMC
May 2014

SQSTM1/p62/A170 regulates the severity of Legionella pneumophila pneumonia by modulating inflammasome activity.

Eur J Immunol 2014 Apr 28;44(4):1084-92. Epub 2014 Jan 28.

Department of Respiratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.

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http://doi.wiley.com/10.1002/eji.201344091
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http://dx.doi.org/10.1002/eji.201344091DOI Listing
April 2014

Peroxiredoxin I plays a protective role against UVA irradiation through reduction of oxidative stress.

J Dermatol Sci 2014 Apr 12;74(1):9-17. Epub 2013 Dec 12.

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2013.12.002DOI Listing
April 2014

Exercise reduces inflammation and oxidative stress in obesity-related liver diseases.

Med Sci Sports Exerc 2013 Dec;45(12):2214-22

1Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, JAPAN; 2Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, JAPAN; 3Biomedical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, JAPAN; and 4Division of Medical Science, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, JAPAN.

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http://dx.doi.org/10.1249/MSS.0b013e31829afc33DOI Listing
December 2013

Sequestosome1/p62: a regulator of redox-sensitive voltage-activated potassium channels, arterial remodeling, inflammation, and neurite outgrowth.

Free Radic Biol Med 2013 Dec 19;65:102-116. Epub 2013 Jun 19.

Cardiovascular Division, British Heart Foundation Centre of Research Excellence, School of Medicine, King's College London, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.06.019DOI Listing
December 2013

Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.

J Neurosci 2013 Sep;33(37):14767-77

Majors of Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan, Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan, Center for Behavioral Molecular Genetics, University of Tsukuba, Ibaraki 305-8575, Japan, Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8504, Japan, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan, and Cardiovascular Division, British Heart Foundation Centre of Research Excellence, School of Medicine, King's College London, London SE1 9NH, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.2954-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705174PMC
September 2013

Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma.

Oncol Rep 2013 Jun 4;29(6):2147-53. Epub 2013 Apr 4.

Department of Oral and Maxillofacial Surgery, Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.3892/or.2013.2387DOI Listing
June 2013

Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet.

J Gastroenterol 2013 May 13;48(5):620-32. Epub 2012 Sep 13.

Division of Medical Science, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8574, Japan.

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http://dx.doi.org/10.1007/s00535-012-0659-zDOI Listing
May 2013

Amelioration of cisplatin-induced nephrotoxicity in peroxiredoxin I-deficient mice.

Cancer Chemother Pharmacol 2013 Feb 11;71(2):503-9. Epub 2012 Dec 11.

Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1007/s00280-012-2046-0DOI Listing
February 2013

Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure.

J Biochem 2012 Dec 27;152(6):595-601. Epub 2012 Sep 27.

Center for Environmental Health Sciences, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan.

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http://dx.doi.org/10.1093/jb/mvs113DOI Listing
December 2012

Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.

J Gastroenterol 2012 Aug 28;47(8):924-35. Epub 2012 Feb 28.

Field of Basic Sports Medicine, Sports Medicine, Faculty of Medicine, Graduate School of Comprehensive Human Sciences, The University of Tsukuba, Tsukuba, Ibaraki, 305-8574, Japan.

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http://link.springer.com/10.1007/s00535-012-0552-9
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http://dx.doi.org/10.1007/s00535-012-0552-9DOI Listing
August 2012

Novel roles of peroxiredoxins in inflammation, cancer and innate immunity.

J Clin Biochem Nutr 2012 Mar 18;50(2):91-105. Epub 2012 Feb 18.

Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.3164/jcbn.11-109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303482PMC
March 2012

Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity.

Biochem Biophys Res Commun 2011 Nov 12;415(1):94-8. Epub 2011 Oct 12.

Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2011.10.019DOI Listing
November 2011

Anti-atherogenic effect of laminar shear stress via Nrf2 activation.

Antioxid Redox Signal 2011 Sep 21;15(5):1415-26. Epub 2011 Apr 21.

Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1089/ars.2010.3433DOI Listing
September 2011

Aggravation of bleomycin-induced pulmonary inflammation and fibrosis in mice lacking peroxiredoxin I.

Am J Respir Cell Mol Biol 2011 Sep 14;45(3):600-9. Epub 2011 Jan 14.

Department of Respiratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1165/rcmb.2010-0137OCDOI Listing
September 2011

Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice.

Am J Physiol Gastrointest Liver Physiol 2010 Feb 19;298(2):G283-94. Epub 2009 Nov 19.

Department of Gastroenterology,Graduate School of Comprehensive Human Sciences, The University of Tsukuba, Tsukuba-shi, Ibaraki, Japan.

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http://dx.doi.org/10.1152/ajpgi.00296.2009DOI Listing
February 2010

Peroxiredoxin I plays a protective role against cisplatin cytotoxicity through mitogen activated kinase signals.

Oral Oncol 2009 Dec 18;45(12):1037-43. Epub 2009 Aug 18.

Molecular Cellular Physiology, Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.oraloncology.2009.07.002DOI Listing
December 2009

Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems.

Biochem Biophys Res Commun 2009 Nov 2;389(3):431-6. Epub 2009 Sep 2.

Department of Molecular and Cellular Physiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2009.08.156DOI Listing
November 2009

Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma.

Int Immunopharmacol 2009 Oct 5;9(11):1281-8. Epub 2009 Aug 5.

Environmental Health Sciences Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan.

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http://dx.doi.org/10.1016/j.intimp.2009.07.010DOI Listing
October 2009

Essential role of Nrf2 in keratinocyte protection from UVA by quercetin.

Biochem Biophys Res Commun 2009 Sep 1;387(1):109-14. Epub 2009 Jul 1.

Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0901303
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http://dx.doi.org/10.1016/j.bbrc.2009.06.136DOI Listing
September 2009

Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.

Am J Physiol Gastrointest Liver Physiol 2008 Oct 7;295(4):G735-47. Epub 2008 Aug 7.

Dept. of Gastroenterology, Graduate School of Comprehensive Human Sciences, Univ. of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1152/ajpgi.90321.2008DOI Listing
October 2008

Peroxiredoxin I protects gastric mucosa from oxidative injury induced by H. pylori infection.

J Gastroenterol Hepatol 2008 Apr 14;23(4):652-9. Epub 2007 Nov 14.

Department of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.

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http://doi.wiley.com/10.1111/j.1440-1746.2007.05217.x
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http://dx.doi.org/10.1111/j.1440-1746.2007.05217.xDOI Listing
April 2008

Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species.

Free Radic Biol Med 2007 Jan 20;42(2):260-9. Epub 2006 Oct 20.

Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (LSBM), University of Tokyo, 4-6-1, Komaba, Meguro, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.1016/j.freeradbiomed.2006.10.043DOI Listing
January 2007

Tissue Prx I in the protection against Fe-NTA and the reduction of nitroxyl radicals.

Biochem Biophys Res Commun 2006 Jan 10;339(1):226-31. Epub 2005 Nov 10.

Biomolecular and Integrated Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.10.192DOI Listing
January 2006

A simple method of isolating mouse aortic endothelial cells.

J Atheroscler Thromb 2005 ;12(3):138-42

Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.5551/jat.12.138DOI Listing
October 2005

Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells.

J Biol Chem 2005 Jul 25;280(29):27244-50. Epub 2005 May 25.

Environmental Response Project ERATO-Japan Science and Technology Agency, Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan.

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http://dx.doi.org/10.1074/jbc.M502551200DOI Listing
July 2005

Effect on endothelial cell gene expression of shear stress, oxygen concentration, and low-density lipoprotein as studied by a novel flow cell culture system.

Free Radic Biol Med 2004 Sep;37(5):682-94

Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8906, Japan.

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http://dx.doi.org/10.1016/j.freeradbiomed.2004.05.020DOI Listing
September 2004

A novel method of following oxidation of low-density lipoprotein using a sensitive fluorescent probe, diphenyl-1-pyrenylphosphine.

Free Radic Biol Med 2003 Sep;35(6):576-85

Research Center for Advanced Science and Technology, University of Tokyo, Meguro, Tokyo, Japan.

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http://dx.doi.org/10.1016/s0891-5849(03)00330-7DOI Listing
September 2003