Publications











Structure-based design of a streptavidin mutant specific for an artificial biotin analogue.
J Biochem 2015 Jun 2;157(6):467-75. Epub 2015 Feb 2.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan; and Radioisotope Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan



The N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein.
FEBS Lett 2015 Apr 31;589(10):1136-42. Epub 2015 Mar 31.
Health Research Institute, National Institute of Advanced Industrial Science and Technology, 3-11-46 Nakoji, Amagasaki, Hyogo 661-0974, Japan. Electronic address:



Water-mediated recognition of simple alkyl chains by heart-type fatty-acid-binding protein.
Angew Chem Int Ed Engl 2015 Jan 9;54(5):1508-11. Epub 2014 Dec 9.
JST-ERATO and Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Project Research Centre for Fundamental Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560-0043 (Japan).

In vivo crystallography at X-ray free-electron lasers: the next generation of structural biology?
Philos Trans R Soc Lond B Biol Sci 2014 Jul;369(1647):20130497
Photon Factory, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki 305-0801, Japan Center for Free-Electron Laser science, Notkestrasse 85, Building 99, Hamburg 22607, Germany

Structural insights into the function of a thermostable copper-containing nitrite reductase.
J Biochem 2014 Feb 30;155(2):123-35. Epub 2013 Nov 30.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan; Department of Applied Chemistry, School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Faculty of Life and Environmental Sciences, Department of Environmental Information, Kyoto Prefectural University, Shimogamo-Hanki-cho, Sakyou, Kyoto 606-8522, Japan; Molecular-Recognition Structure Analysis Team, Molecular Profiling Research Center for Drug Discovery (molprof) National Institute of Advanced Industrial Science and Technology (AIST) 2-3-26 Aomi, Koto-ku, Tokyo 135-0064, Japan; Microbial Genome Research Group, Japan Agency of Marine-Earth Science and Technology, 2-15 Natsushima, Yokosuka, Kanagawa 237-0061, Japan; and RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo, Hyogo 679-5148, Japan.


Construction and characterization of functional anti-epiregulin humanized monoclonal antibodies.
Biochem Biophys Res Commun 2013 Nov 12;441(4):1011-7. Epub 2013 Nov 12.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.


Expression, purification, crystallization and preliminary crystallographic study of FtsA from methicillin-resistant Staphylococcus aureus.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Aug 27;69(Pt 8):895-8. Epub 2013 Jul 27.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.


Crystallization and preliminary X-ray crystallographic analysis of UDP-glucuronic acid:flavonol-3-O-glucuronosyltransferase (VvGT5) from the grapevine Vitis vinifera.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Jan 25;69(Pt 1):65-8. Epub 2012 Dec 25.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Crystal structure of rice Rubisco and implications for activation induced by positive effectors NADPH and 6-phosphogluconate.
J Mol Biol 2012 Sep 17;422(1):75-86. Epub 2012 May 17.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, Osaka 565-0871, Japan.


Crystallization and preliminary X-ray diffraction analysis of orotate phosphoribosyltransferase from the human malaria parasite Plasmodium falciparum.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Feb 27;68(Pt 2):244-6. Epub 2012 Jan 27.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan.


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