Publications


Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice.
J Clin Biochem Nutr 2016 Nov 8;59(3):207-214. Epub 2016 Sep 8.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.

Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.
Sci Rep 2016 Oct 19;6:35690. Epub 2016 Oct 19.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ward, Kumamoto 860-8556, Japan.


Effects of K-877, a novel selective PPARα modulator (SPPARMα), in dyslipidaemic patients: A randomized, double blind, active- and placebo-controlled, phase 2 trial.
Atherosclerosis 2016 Jun 26;249:36-43. Epub 2016 Feb 26.
Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:

Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma.
Endocrinol Diabetes Metab Case Rep 2016 30;2016:160003. Epub 2016 Mar 30.
Faculty of Life Sciences, Department of Metabolic Medicine, Kumamoto University , 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556 , Japan.

Non-invasive measurement of skin autofluorescence to evaluate diabetic complications.
J Clin Biochem Nutr 2016 Mar 20;58(2):135-40. Epub 2016 Jan 20.
Laboratory of Food and Regulation Biology, Graduate School of Agriculture, Tokai University, Kawayou, Minamiaso, Aso-gun, Kumamoto 869-1404, Japan.



Mild electrical stimulation increases stress resistance and suppresses fat accumulation via activation of LKB1-AMPK signaling pathway in C. elegans.
PLoS One 2014 9;9(12):e114690. Epub 2014 Dec 9.
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Japan.



Long-term safety and efficacy of tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, as monotherapy or in combination with other oral antidiabetic agents in Japanese patients with type 2 diabetes mellitus: multicenter, open-label, randomized controlled trials.
Expert Opin Pharmacother 2014 Apr 11;15(6):749-66. Epub 2014 Feb 11.
Yamaguchi University Graduate School of Medicine, Division of Endocrinology, Metabolism, Hematological Science and Therapeutics , 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505 , Japan +81 836 22 2250 (office) ; +81 836 22 2256 ;




Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects.
Obes Res Clin Pract 2010 Apr-Jun;4(2):e83-e162
Department of Metabolic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. Electronic


Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.
Cardiovasc Diabetol 2013 Nov 4;12:160. Epub 2013 Nov 4.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo Ward, Kumamoto 860-8556, Japan.


Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress.
J Cell Physiol 2013 Feb;228(2):439-46
Department of Molecular Medicine, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan.

Apocynin suppresses the progression of atherosclerosis in apoE-deficient mice by inactivation of macrophages.
Biochem Biophys Res Commun 2013 Feb 11;431(2):124-30. Epub 2013 Jan 11.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Regulation of TNFα converting enzyme activity in visceral adipose tissue of obese mice.
Biochem Biophys Res Commun 2013 Jan 27;430(4):1189-94. Epub 2012 Dec 27.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth.
Nat Commun 2013 ;4:1398
Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.


The impact of Ca²⁺/calmodulin-dependent protein kinase II on insulin gene expression in MIN6 cells.
Biochem Biophys Res Commun 2012 May 25;421(4):801-7. Epub 2012 Apr 25.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.



An intervention study to promote self-improvement of lifestyle in a Japanese community: a new health support program.
Environ Health Prev Med 2011 Jul 18;16(4):253-63. Epub 2011 Jan 18.
Department of Nursing, Kyushu University of Nursing and Social Welfare, 888 Tomio, Tamana, Kumamoto, 865-0062, Japan.


Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line.
Biochem Biophys Res Commun 2011 Apr 21;407(3):620-5. Epub 2011 Mar 21.
Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860 8556, Japan.

Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice.
Biochem Biophys Res Commun 2011 Jan 4;404(1):339-44. Epub 2010 Dec 4.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.




Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.
Proc Natl Acad Sci U S A 2010 May 3;107(20):9240-5. Epub 2010 May 3.
Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.




Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling.
PLoS One 2008 30;3(12):e4068. Epub 2008 Dec 30.
Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan.

Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues.
Biochem Biophys Res Commun 2008 Nov 19;376(2):434-8. Epub 2008 Sep 19.
Department of Metabolic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan.

Mild electrical stimulation increases ubiquitinated proteins and Hsp72 in A549 cells via attenuation of proteasomal degradation.
J Pharmacol Sci 2008 Oct 10;108(2):222-6. Epub 2008 Oct 10.
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, 5-1 Oe-honmachi, Kumamoto, Japan.


Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice.
Biochem Biophys Res Commun 2008 Feb 18;366(3):814-20. Epub 2007 Dec 18.
Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.
Biochem Biophys Res Commun 2007 Dec 12;364(2):301-7. Epub 2007 Oct 12.
Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.



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