Publications

Efficacy and safety of pemafibrate (K-877), a selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia: Results from a 24-week, randomized, double blind, active-controlled, phase 3 trial.
J Clin Lipidol 2017 Oct 28. Epub 2017 Oct 28.
Department of Community Medicine and Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiovascular Medicine, Rinku General Medical Center, Izumisano, Japan.


Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice.
J Clin Biochem Nutr 2016 Nov 8;59(3):207-214. Epub 2016 Sep 8.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.

Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.
Sci Rep 2016 Oct 19;6:35690. Epub 2016 Oct 19.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ward, Kumamoto 860-8556, Japan.


Effects of K-877, a novel selective PPARα modulator (SPPARMα), in dyslipidaemic patients: A randomized, double blind, active- and placebo-controlled, phase 2 trial.
Atherosclerosis 2016 Jun 26;249:36-43. Epub 2016 Feb 26.
Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:

Non-invasive measurement of skin autofluorescence to evaluate diabetic complications.
J Clin Biochem Nutr 2016 Mar 20;58(2):135-40. Epub 2016 Jan 20.
Laboratory of Food and Regulation Biology, Graduate School of Agriculture, Tokai University, Kawayou, Minamiaso, Aso-gun, Kumamoto 869-1404, Japan.




Long-term safety and efficacy of tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, as monotherapy or in combination with other oral antidiabetic agents in Japanese patients with type 2 diabetes mellitus: multicenter, open-label, randomized controlled trials.
Expert Opin Pharmacother 2014 Apr 11;15(6):749-66. Epub 2014 Feb 11.
Yamaguchi University Graduate School of Medicine, Division of Endocrinology, Metabolism, Hematological Science and Therapeutics , 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505 , Japan +81 836 22 2250 (office) ; +81 836 22 2256 ;





Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.
Cardiovasc Diabetol 2013 Nov 4;12:160. Epub 2013 Nov 4.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo Ward, Kumamoto 860-8556, Japan.

Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress.
J Cell Physiol 2013 Feb;228(2):439-46
Department of Molecular Medicine, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan.

Apocynin suppresses the progression of atherosclerosis in apoE-deficient mice by inactivation of macrophages.
Biochem Biophys Res Commun 2013 Feb 11;431(2):124-30. Epub 2013 Jan 11.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Regulation of TNFα converting enzyme activity in visceral adipose tissue of obese mice.
Biochem Biophys Res Commun 2013 Jan 27;430(4):1189-94. Epub 2012 Dec 27.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

The impact of Ca²⁺/calmodulin-dependent protein kinase II on insulin gene expression in MIN6 cells.
Biochem Biophys Res Commun 2012 May 25;421(4):801-7. Epub 2012 Apr 25.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.


An intervention study to promote self-improvement of lifestyle in a Japanese community: a new health support program.
Environ Health Prev Med 2011 Jul 18;16(4):253-63. Epub 2011 Jan 18.
Department of Nursing, Kyushu University of Nursing and Social Welfare, 888 Tomio, Tamana, Kumamoto, 865-0062, Japan.


Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line.
Biochem Biophys Res Commun 2011 Apr 21;407(3):620-5. Epub 2011 Mar 21.
Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860 8556, Japan.

Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice.
Biochem Biophys Res Commun 2011 Jan 4;404(1):339-44. Epub 2010 Dec 4.
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.



Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.
Proc Natl Acad Sci U S A 2010 May 3;107(20):9240-5. Epub 2010 May 3.
Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.



Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues.
Biochem Biophys Res Commun 2008 Nov 19;376(2):434-8. Epub 2008 Sep 19.
Department of Metabolic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan.

Mild electrical stimulation increases ubiquitinated proteins and Hsp72 in A549 cells via attenuation of proteasomal degradation.
J Pharmacol Sci 2008 Oct 10;108(2):222-6. Epub 2008 Oct 10.
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, 5-1 Oe-honmachi, Kumamoto, Japan.


Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice.
Biochem Biophys Res Commun 2008 Feb 18;366(3):814-20. Epub 2007 Dec 18.
Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.
Biochem Biophys Res Commun 2007 Dec 12;364(2):301-7. Epub 2007 Oct 12.
Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.



Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling.
PLoS One 2008 30;3(12):e4068. Epub 2008 Dec 30.
Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan.









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