Eicke Latz

Eicke Latz

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DNA-Mediated Interferon Signature Induction by SLE Serum Occurs in Monocytes Through Two Pathways: A Mechanism to Inhibit Both Pathways.

Front Immunol 2018 11;9:2824. Epub 2018 Dec 11.

Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02824
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http://dx.doi.org/10.3389/fimmu.2018.02824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297782PMC
October 2019

Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome.

EMBO J 2019 Sep 30;38(17):e101064. Epub 2019 Jul 30.

Department of Neurodegenerative Disease and Geriatric Psychiatry, University Hospitals Bonn, Bonn, Germany.

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http://dx.doi.org/10.15252/embj.2018101064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717897PMC
September 2019

NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells.

Int J Nanomedicine 2019 13;14:3503-3516. Epub 2019 May 13.

Institute for Advanced Research of Biosystem Dynamics, Waseda Research Institute for Science and Engineering, Waseda University, Tokyo, Japan.

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http://dx.doi.org/10.2147/IJN.S202379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526778PMC
August 2019

Blocking Inflammasome Activation Caused by β-Amyloid Peptide (Aβ) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic.

ACS Chem Neurosci 2019 Aug 25;10(8):3703-3717. Epub 2019 Jul 25.

Division of Peptide Biochemistry , Technische Universität München , Emil-Erlenmeyer-Forum 5 , D-85354 Freising , Germany.

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http://dx.doi.org/10.1021/acschemneuro.9b00260DOI Listing
August 2019

Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency.

Biochem Biophys Rep 2019 Jul 12;18:100623. Epub 2019 Apr 12.

Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrep.2019.100623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462779PMC
July 2019

High-Density Lipoproteins Decrease Proinflammatory Activity and Modulate the Innate Immune Response.

J Interferon Cytokine Res 2019 Jul 23. Epub 2019 Jul 23.

1Grupo Inmunovirologia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

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http://dx.doi.org/10.1089/jir.2019.0029DOI Listing
July 2019

The Western lifestyle has lasting effects on metaflammation.

Nat Rev Immunol 2019 May;19(5):267-268

Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/s41577-019-0156-1DOI Listing
May 2019

Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells.

J Mol Med (Berl) 2019 Apr 10;97(4):523-532. Epub 2019 Feb 10.

Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, 53127, Germany.

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http://dx.doi.org/10.1007/s00109-019-01753-5DOI Listing
April 2019

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease.

Nat Rev Neurosci 2019 Mar;20(3):187

German Center for Neurodegenerative Diseases, Bonn, Germany.

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http://www.nature.com/articles/s41583-019-0137-1
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http://dx.doi.org/10.1038/s41583-019-0137-1DOI Listing
March 2019

Immortalization of Murine Bone Marrow-Derived Macrophages.

Methods Mol Biol 2018 ;1784:35-49

Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7837-3_4DOI Listing
January 2019

NLRP3 inflammasome activation in inflammaging.

Semin Immunol 2018 12 26;40:61-73. Epub 2018 Sep 26.

Institute of Innate Immunity, University of Bonn, 53127, Bonn, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10445323183006
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http://dx.doi.org/10.1016/j.smim.2018.09.001DOI Listing
December 2018

Inflammasome signalling in brain function and neurodegenerative disease.

Nat Rev Neurosci 2018 10;19(10):610-621

German Center for Neurodegenerative Diseases, Bonn, Germany.

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http://www.nature.com/articles/s41583-018-0055-7
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http://dx.doi.org/10.1038/s41583-018-0055-7DOI Listing
October 2018

ASC specks: a biomarker for myelodysplastic syndromes?

Lancet Haematol 2018 09 30;5(9):e379-e380. Epub 2018 Jul 30.

University Hospitals, Institute of Innate Immunity, Bonn 53127, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(18)30113-3DOI Listing
September 2018

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling.

J Biol Chem 2018 09 3;293(39):15195-15207. Epub 2018 Aug 3.

From the Inflammation Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1074/jbc.RA118.003314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166714PMC
September 2018

Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.

Proc Natl Acad Sci U S A 2018 09 20;115(36):9002-9007. Epub 2018 Aug 20.

Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605;

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http://dx.doi.org/10.1073/pnas.1801802115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130368PMC
September 2018

Targeting the NLRP3 inflammasome in inflammatory diseases.

Nat Rev Drug Discov 2018 08 20;17(8):588-606. Epub 2018 Jul 20.

Institute of Innate Immunity, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/nrd.2018.97DOI Listing
August 2018

Generation of Innate Immune Reporter Cells Using Retroviral Transduction.

Methods Mol Biol 2018 ;1714:97-117

Inflammation Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1007/978-1-4939-7519-8_7DOI Listing
July 2018

Inhibitory effects of colchicine on inflammasomes.

Atherosclerosis 2018 06 2;273:153-154. Epub 2018 Mar 2.

Institute of Innate Immunity, University Hospital, University of Bonn, Germany; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, USA; German Center for Neurodegenerative Diseases, Bonn, Germany.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.02.026DOI Listing
June 2018

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis.

Circ Res 2018 06;122(12):1722-1740

From the Institute of Innate Immunity, University Hospital Bonn, Germany (A.G., F.H., E.L.)

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http://dx.doi.org/10.1161/CIRCRESAHA.118.311362DOI Listing
June 2018

PD-L1 is expressed on human platelets and is affected by immune checkpoint therapy.

Oncotarget 2018 Jun 8;9(44):27460-27470. Epub 2018 Jun 8.

University Hospital Schleswig Holstein, Campus Lübeck, Clinic for Otorhinolaryngology - Head and Neck Surgery, Luebeck, Germany.

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http://dx.doi.org/10.18632/oncotarget.25446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007942PMC
June 2018

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.

Immunity 2018 05;48(5):911-922.e7

Institute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany; Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA; German Center for Neurodegenerative Diseases, 53175 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482051PMC
May 2018

TAK1ng control: TAK1 restrains NLRP3 activation.

J Exp Med 2018 04 5;215(4):1007-1008. Epub 2018 Mar 5.

Institute of Innate Immunity, University of Bonn, Bonn, Germany

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http://dx.doi.org/10.1084/jem.20180282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881475PMC
April 2018

Systematic evaluation of cell-SELEX enriched aptamers binding to breast cancer cells.

Biochimie 2018 Feb 18;145:53-62. Epub 2017 Oct 18.

Chemical Biology and Chemical Genetics, Life and Medical Sciences (LIMES) Institute, University of Bonn, Gerhard-Domagk-Str. 1, 53121, Bonn, Germany; Center of Aptamer Research and Development (CARD), University of Bonn, Gerhard-Domagk Str. 1, 53121, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2017.10.007DOI Listing
February 2018

Lysine-containing cationic liposomes activate the NLRP3 inflammasome: Effect of a spacer between the head group and the hydrophobic moieties of the lipids.

Nanomedicine 2018 02 8;14(2):279-288. Epub 2017 Nov 8.

Research Organization for Nano & Life Innovation, Waseda University, Tokyo, Japan; Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2017.10.011DOI Listing
February 2018

Innate Immunity and Neurodegeneration.

Annu Rev Med 2018 01 6;69:437-449. Epub 2017 Nov 6.

Institute of Innate Immunity, University Hospitals Bonn, Bonn 53127, Germany; email:

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http://dx.doi.org/10.1146/annurev-med-050715-104343DOI Listing
January 2018

Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients.

AIDS 2018 01;32(3):299-307

Department of Medicine A, Section of Rheumatology, University Medicine Greifswald, Greifswald.

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http://dx.doi.org/10.1097/QAD.0000000000001693DOI Listing
January 2018

The intra- and extracellular functions of ASC specks.

Immunol Rev 2018 01;281(1):74-87

Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1111/imr.12611DOI Listing
January 2018

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

Cell 2018 01;172(1-2):162-175.e14

Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases & Immunology, UMass Medical School, Worcester, MA 01605, USA; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324559PMC
January 2018

Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence.

Methods Mol Biol 2016 ;1417:145-58

Institute of Innate Immunity, University Hospitals, University of Bonn, Biomedizinisches Zentrum, Sigmund-Freud-Straße 25, Bonn, Germany.

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http://dx.doi.org/10.1007/978-1-4939-3566-6_9DOI Listing
December 2017

Activation of the NLRP3 inflammasome in microglia: the role of ceramide.

J Neurochem 2017 12 26;143(5):534-550. Epub 2017 Oct 26.

Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology, University of Bonn - Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1111/jnc.14225DOI Listing
December 2017

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

Cell 2017 Nov 12;171(5):1110-1124.e18. Epub 2017 Oct 12.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany; Center for Integrated Protein Science (CIPSM), Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901709PMC
November 2017

Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.

J Immunol 2017 10 30;199(8):2910-2920. Epub 2017 Aug 30.

Center of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway;

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http://dx.doi.org/10.4049/jimmunol.1700302DOI Listing
October 2017

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Cell Metab 2017 Oct 21;26(4):620-632.e6. Epub 2017 Sep 21.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Ingolstädter Landstraße, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.023DOI Listing
October 2017

CD14-New Tricks of an Old Acquaintance.

Immunity 2017 10;47(4):606-608

Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA; German Center for Neurodegenerative Diseases, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.10.003DOI Listing
October 2017

Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control.

Cell Metab 2017 Jul;26(1):71-93

Institute of Innate Immunity, University Hospitals Bonn, 53127 Bonn, Germany; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA; German Center of Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany; Centre for Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology, 7491 Trondheim, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.06.018DOI Listing
July 2017

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain.

J Exp Med 2017 06 2;214(6):1725-1736. Epub 2017 May 2.

Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany

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http://dx.doi.org/10.1084/jem.20160933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460996PMC
June 2017

Assembly and regulation of ASC specks.

Cell Mol Life Sci 2017 04 19;74(7):1211-1229. Epub 2016 Oct 19.

Institute of Innate Immunity, University Hospitals, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany.

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http://dx.doi.org/10.1007/s00018-016-2396-6DOI Listing
April 2017

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension.

Pharmacol Res 2017 02 13;116:77-86. Epub 2016 Dec 13.

Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Australia; Department of Surgery, School of Clinical Sciences, Monash Health, Clayton, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.12.015DOI Listing
February 2017

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins.

Cell Mol Immunol 2017 01 29;14(1):43-64. Epub 2016 Aug 29.

Institute of Innate Immunity, University Hospitals, University of Bonn, 53127 Bonn, Germany.

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http://dx.doi.org/10.1038/cmi.2016.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214941PMC
January 2017

PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome.

J Biol Chem 2017 01 2;292(3):826-836. Epub 2016 Dec 2.

From the Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia,

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http://dx.doi.org/10.1074/jbc.M116.756379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247656PMC
January 2017

Soluble Uric Acid Activates the NLRP3 Inflammasome.

Sci Rep 2017 01 13;7:39884. Epub 2017 Jan 13.

Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo (USP), São Paulo, Brazil.

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http://dx.doi.org/10.1038/srep39884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233987PMC
January 2017

RAGE Enhances TLR Responses through Binding and Internalization of RNA.

J Immunol 2016 11 19;197(10):4118-4126. Epub 2016 Oct 19.

Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany;

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http://dx.doi.org/10.4049/jimmunol.1502169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062438PMC
November 2016

Toll-Like Receptor Interactions Measured by Microscopic and Flow Cytometric FRET.

Methods Mol Biol 2016 ;1390:41-64

Institute of Innate Immunity, University Hospitals, University of Bonn, 53127, Bonn, Germany.

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http://dx.doi.org/10.1007/978-1-4939-3335-8_3DOI Listing
October 2016

Statins improve NASH via inhibition of RhoA and Ras.

Am J Physiol Gastrointest Liver Physiol 2016 10 15;311(4):G724-G733. Epub 2016 Sep 15.

Department of Internal Medicine I, University of Bonn, Bonn, Germany;

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http://dx.doi.org/10.1152/ajpgi.00063.2016DOI Listing
October 2016

IRGB10 Exposes Bacteria's Intimate Secrets.

Dev Cell 2016 10;39(1):7-8

Institute of Innate Immunity, University Hospitals, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2016.09.026DOI Listing
October 2016

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.

Kidney Int 2016 09 2;90(3):525-39. Epub 2016 Jun 2.

Institute of Experimental Immunology, University Hospital of the Rheinische Friedrich-Wilhelms-University, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.03.035DOI Listing
September 2016

Ursodeoxycholic acid impairs atherogenesis and promotes plaque regression by cholesterol crystal dissolution in mice.

Biochem Biophys Res Commun 2016 09 11;478(1):356-362. Epub 2016 Jul 11.

Medizinische Klinik und Poliklinik II, University Hospitals Bonn, 53105 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.07.047DOI Listing
September 2016

Automated nanoscale flow cytometry for assessing protein-protein interactions.

Cytometry A 2016 09 1;89(9):835-43. Epub 2016 Sep 1.

Miltenyi Biotec GmbH, Friedrich-Ebert-Straße 68, Bergisch Gladbach, Nordrhein Westfalen, 51429, Germany.

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http://dx.doi.org/10.1002/cyto.a.22937DOI Listing
September 2016

Long-term activation of the innate immune system in atherosclerosis.

Semin Immunol 2016 08 22;28(4):384-93. Epub 2016 Apr 22.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2016.04.004DOI Listing
August 2016

Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation.

F1000Res 2016 22;5. Epub 2016 Jun 22.

Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA; German Center for Neurodegenerative Diseases, Bonn, Germany; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.12688/f1000research.8614.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963208PMC
August 2016

A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection.

Cell Rep 2016 07 23;16(2):571-582. Epub 2016 Jun 23.

Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384574PMC
July 2016

Interferons and inflammasomes: Cooperation and counterregulation in disease.

J Allergy Clin Immunol 2016 07 24;138(1):37-46. Epub 2016 May 24.

Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Mass; German Center for Neurodegenerative Diseases, Bonn, Germany; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.05.010DOI Listing
July 2016

Crystal Formation in Inflammation.

Annu Rev Immunol 2016 05 11;34:173-202. Epub 2016 Jan 11.

Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn 53127, Germany; email: , ,

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http://dx.doi.org/10.1146/annurev-immunol-041015-055539DOI Listing
May 2016

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.

Sci Transl Med 2016 Apr;8(333):333ra50

Institute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany. German Center of Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7489 Trondheim, Norway. Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad6100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878149PMC
April 2016

Trained immunity: A program of innate immune memory in health and disease.

Science 2016 Apr 21;352(6284):aaf1098. Epub 2016 Apr 21.

The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087274PMC
http://dx.doi.org/10.1126/science.aaf1098DOI Listing
April 2016

Neutrophil extracellular trap formation in supragingival biofilms.

Int J Med Microbiol 2015 Jun-Aug;305(4-5):453-63. Epub 2015 Apr 20.

Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany; Division of EU Co-operation/Microbiology, Paul-Ehrlich Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen, Germany.

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http://dx.doi.org/10.1016/j.ijmm.2015.04.002DOI Listing
February 2016

Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology.

Immunol Rev 2016 Jan;269(1):60-75

Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.

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http://dx.doi.org/10.1111/imr.12375DOI Listing
January 2016

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.

Sci Signal 2016 Jan 5;9(409):ra3. Epub 2016 Jan 5.

Signaling Systems Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/scisignal.aab2191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381726PMC
January 2016

Erratum to: Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence.

Methods Mol Biol 2016 ;1417:E1

Institute of Innate Immunity, University Hospitals, University of Bonn, Biomedizinisches Zentrum, Sigmund-Freud-Straße 25, Bonn, Germany.

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http://dx.doi.org/10.1007/978-1-4939-3566-6_19DOI Listing
January 2016

ATF3 Is a Key Regulator of Macrophage IFN Responses.

J Immunol 2015 Nov 28;195(9):4446-55. Epub 2015 Sep 28.

Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany; Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia;

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http://dx.doi.org/10.4049/jimmunol.1500204DOI Listing
November 2015

Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage.

J Mol Med (Berl) 2015 Aug 18;93(8):905-16. Epub 2015 Mar 18.

Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Germany.

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http://dx.doi.org/10.1007/s00109-015-1275-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510924PMC
August 2015

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes.

J Immunol 2015 Aug 22;195(3):1092-9. Epub 2015 Jun 22.

Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1403173
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http://dx.doi.org/10.4049/jimmunol.1403173DOI Listing
August 2015

Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation.

J Immunol 2015 Jul 29;195(1):257-64. Epub 2015 May 29.

Department of Cancer Research and Molecular Medicine, Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, N-7491 Trondheim, Norway;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1403044
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http://dx.doi.org/10.4049/jimmunol.1403044DOI Listing
July 2015

Innate immune memory: a paradigm shift in understanding host defense.

Nat Immunol 2015 Jul;16(7):675-9

School of Biochemistry and Immunology, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1038/ni.3178DOI Listing
July 2015

Innate immunity in Alzheimer's disease.

Nat Immunol 2015 Mar;16(3):229-36

1] Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [2] German Center for Neurodegenerative Diseases, Bonn, Germany. [3] Institute of Innate Immunology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/ni.3102DOI Listing
March 2015

Synergistic activation of Toll-like receptor 8 by two RNA degradation products.

Nat Struct Mol Biol 2015 Feb;22(2):99-101

1] Institute of Innate Immunity, University Clinics Bonn, University of Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA, the German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, and the Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1038/nsmb.2967DOI Listing
February 2015

A transcriptional perspective on human macrophage biology.

Semin Immunol 2015 Feb 3;27(1):44-50. Epub 2015 Apr 3.

Institute of Innate Immunity, University Hospitals, University of Bonn, 53127 Bonn, Germany; Division of Infectious Diseases and Immunology, UMass Medical School, Worcester, MA 01605, USA; German Center of Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.

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http://dx.doi.org/10.1016/j.smim.2015.02.001DOI Listing
February 2015

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors.

Nucleic Acids Res 2015 Jan 24;43(2):1177-88. Epub 2014 Dec 24.

Centre for Cancer Research, MIMR-PHI Institute of Medical Research, Clayton, Victoria 3168, Australia Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3168, Australia

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http://dx.doi.org/10.1093/nar/gku1343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333393PMC
January 2015

Danger signaling in atherosclerosis.

Circ Res 2015 Jan;116(2):323-40

From the Medizinische Klinik und Poliklinik II (S.Z.) and Institute of Innate Immunity (A.G., E.L.), University Hospitals Bonn, Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester (E.L.); and German Center of Neurodegenerative Diseases (DZNE), Bonn, Germany (E.L.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.301135DOI Listing
January 2015