Efraín E. Rivera-Serrano, MSc, PhD - University of California, Davis - Postdoctoral Research Associate

Efraín E. Rivera-Serrano

MSc, PhD

University of California, Davis

Postdoctoral Research Associate

Davis, CA | United States

Main Specialties: Biology

Additional Specialties: Cell Biology, Virology, Confocal Microscopy, Molecular Biology

ORCID logohttps://orcid.org/0000-0002-1039-7182


Top Author

Efraín E. Rivera-Serrano, MSc, PhD - University of California, Davis - Postdoctoral Research Associate

Efraín E. Rivera-Serrano

MSc, PhD

Introduction

Primary Affiliation: University of California, Davis - Davis, CA , United States

Specialties:

Additional Specialties:

Research Interests:

Education

Nov 2018
University of California, Davis
Postdoctoral Scholar
Oct 2018
University of North Carolina at Chapel Hill
Postdoctoral Fellow
Dec 2016
North Carolina State University
Ph.D. in Biomedical Sciences (Virology)
May 2012
North Carolina State University
M.Sc. in Plant (Cell) Biology
May 2009
Pontifical Catholic University of Puerto Rico
B.Sc. in Biology

Publications

10Publications

159Reads

13Profile Views

30PubMed Central Citations

TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.

Nucleic Acids Res 2019 07;47(12):6411-6424

Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar
Publisher Site
http://dx.doi.org/10.1093/nar/gkz278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614814PMC
July 2019
8 Reads
9.112 Impact Factor

Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses

eLife 2019;8:e43983

eLife

Many 'non-enveloped' viruses, including hepatitis A virus (HAV), are released non-lytically from infected cells as infectious, quasi-enveloped virions cloaked in host membranes. Quasi-enveloped HAV (eHAV) mediates stealthy cell-to-cell spread within the liver, whereas stable naked virions shed in feces are optimized for environmental transmission. eHAV lacks virus-encoded surface proteins, and how it enters cells is unknown. We show both virion types enter by clathrin- and dynamin-dependent endocytosis, facilitated by integrin β1, and traffic through early and late endosomes. Uncoating of naked virions occurs in late endosomes, whereas eHAV undergoes ALIX-dependent trafficking to lysosomes where the quasi-envelope is enzymatically degraded and uncoating ensues coincident with breaching of endolysosomal membranes. Neither virion requires PLA2G16, a phospholipase essential for entry of other picornaviruses. Thus naked and quasi-enveloped virions enter via similar endocytic pathways, but uncoat in different compartments and release their genomes to the cytosol in a manner mechanistically distinct from other Picornaviridae.

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February 2019
6 Reads

Redundant Late Domain Functions of Tandem VP2 YPXL Motifs in Nonlytic Cellular Egress of Quasi-enveloped Hepatitis A Virus.

J Virol 2018 12 12;92(23). Epub 2018 Nov 12.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/JVI.01308-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232465PMC
December 2018
4 Reads
4.440 Impact Factor

Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-β expression in cardiac myocytes.

J Mol Cell Cardiol 2017 10 16;111:102-113. Epub 2017 Aug 16.

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2017.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600710PMC
October 2017
12 Reads
4.660 Impact Factor

Protein composition of the hepatitis A virus quasi-envelope.

Proc Natl Acad Sci U S A 2017 06 10;114(25):6587-6592. Epub 2017 May 10.

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7292;

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http://dx.doi.org/10.1073/pnas.1619519114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488923PMC
June 2017
74 Reads
11 Citations
9.810 Impact Factor

A Cytoplasmic RNA Virus Alters the Function of the Cell Splicing Protein SRSF2.

J Virol 2017 04 13;91(7). Epub 2017 Mar 13.

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

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http://dx.doi.org/10.1128/JVI.02488-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355601PMC
April 2017
20 Reads
2 Citations
4.440 Impact Factor

NF-κB activation is cell type-specific in the heart.

Virology 2017 02 30;502:133-143. Epub 2016 Dec 30.

Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2016.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5276732PMC
February 2017
8 Reads
3 Citations
3.321 Impact Factor

An ITAM in a nonenveloped virus regulates activation of NF-κB, induction of beta interferon, and viral spread.

J Virol 2014 Mar 18;88(5):2572-83. Epub 2013 Dec 18.

Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina, USA.

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http://dx.doi.org/10.1128/JVI.02573-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958081PMC
March 2014
9 Reads
6 Citations
4.440 Impact Factor

A small molecule inhibitor partitions two distinct pathways for trafficking of tonoplast intrinsic proteins in Arabidopsis.

PLoS One 2012 5;7(9):e44735. Epub 2012 Sep 5.

Department of Plant Biology, North Carolina State University, Raleigh, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044735PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434187PMC
February 2013
11 Reads
8 Citations
3.234 Impact Factor

Top co-authors

Stanley M Lemon
Stanley M Lemon

Lineberger Comprehensive Cancer Center

4
Barbara Sherry
Barbara Sherry

College of Veterinary Medicine

4
Lucinda Hensley
Lucinda Hensley

The University of North Carolina at Chapel Hill

2
Xian Chen
Xian Chen

City University of Hong Kong

2
Ling Xie
Ling Xie

Institute of Radiation Medicine

1
Ethan J Fritch
Ethan J Fritch

College of Veterinary Medicine

1