Publications by authors named "Edwin Wang"

71Publications

Germline genomic patterns are associated with cancer risk, oncogenic pathways, and clinical outcomes.

Sci Adv 2020 Nov 27;6(48). Epub 2020 Nov 27.

Department of Biochemistry and Molecular Biology, Medical Genetics, and Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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November 2020

Methylation-Based Signatures for Gastroesophageal Tumor Classification.

Cancers (Basel) 2020 May 11;12(5). Epub 2020 May 11.

Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.

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May 2020

Mutational landscape differences between young-onset and older-onset breast cancer patients.

BMC Cancer 2020 Mar 12;20(1):212. Epub 2020 Mar 12.

Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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March 2020

Germline variants associated with leukocyte genes predict tumor recurrence in breast cancer patients.

NPJ Precis Oncol 2019 1;3:28. Epub 2019 Nov 1.

2Department of Biochemistry & Molecular Biology, Medical Genetics, and Oncology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1 Canada.

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November 2019

Imprecise Kidney Function Thresholds in Cancer Clinical Trials and the Potential for Harm.

JNCI Cancer Spectr 2018 Oct 17;2(4):pky060. Epub 2018 Dec 17.

Division of Hematology-Oncology, Tufts Medical Center, Boston, MA.

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October 2018

Successful LVAD implantation and heart transplantation after ACORN corcap placement.

J Card Surg 2019 07 18;34(7):624-625. Epub 2019 Jun 18.

Division of Cardiac Surgery, Tufts Medical Center, Boston, Massachusetts.

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July 2019

Qualitative and quantitative variations in liver function thresholds among clinical trials in cancer: a need for harmonization.

Cancer Chemother Pharmacol 2019 07 22;84(1):213-216. Epub 2019 Apr 22.

Division of Hematology-Oncology, Tufts Medical Center, Boston, MA, 02111, USA.

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July 2019

Gene Expression-Based Predictive Markers for Paclitaxel Treatment in ER+ and ER- Breast Cancer.

Front Genet 2019 1;10:156. Epub 2019 Mar 1.

Department of Biomedical Informatics, School of Basic Medical Sciences, MOE Key Lab of Cardiovascular Sciences, Peking University, Beijing, China.

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March 2019

The Protein-Protein Interaction Network of Haemocytes.

Front Physiol 2019 25;10:156. Epub 2019 Feb 25.

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, China.

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February 2019

Gene expression atlas of embryo development in Arabidopsis.

Plant Reprod 2019 03 14;32(1):93-104. Epub 2019 Feb 14.

Aquatic and Crop Resource Development, National Research Council Canada, 110 Gymnasium Place, Saskatoon, SK, S7N 0W9, Canada.

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March 2019

Putting benchmarks in their rightful place: The heart of computational biology.

PLoS Comput Biol 2018 11 8;14(11):e1006494. Epub 2018 Nov 8.

Department of Biological Sciences, University of Maryland, College Park, Maryland, United States of America.

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November 2018

Analyzing of Molecular Networks for Human Diseases and Drug Discovery.

Curr Top Med Chem 2018 ;18(12):1007-1014

Tianjin Key Laboratory of Animal and Plant Resistance/College of Life Sciences, Tianjin Normal University, Tianjin 300387, China.

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October 2018

Cancer Biomarker Discovery for Precision Medicine: New Progress.

Curr Med Chem 2019 ;26(42):7655-7671

College of Life Science, Tianjin Normal University, Tianjin, China.

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January 2020

The Genome-Scale Integrated Networks in Microorganisms.

Front Microbiol 2018 23;9:296. Epub 2018 Feb 23.

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, China.

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February 2018

A Protocol for Epigenetic Imprinting Analysis with RNA-Seq Data.

Methods Mol Biol 2018 ;1751:199-208

Department of Experimental Medicine, McGill University, Montreal, QC, Canada.

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February 2019

Gene Regulatory Network Rewiring in the Immune Cells Associated with Cancer.

Genes (Basel) 2017 Nov 7;8(11). Epub 2017 Nov 7.

Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.

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November 2017

Network Analysis Reveals A Signaling Regulatory Loop in the PIK3CA-mutated Breast Cancer Predicting Survival Outcome.

Genomics Proteomics Bioinformatics 2017 04 7;15(2):121-129. Epub 2017 Apr 7.

National Research Council Canada, Montreal, QC H4P 2R2, Canada; Department of Experimental Medicine, McGill University, Montreal, QC H3A 2B2, Canada; Center for Bioinformatics, McGill University, Montreal, QC H3G 0B1, Canada; Center for Health Genomics and Informatics, Calgary, AB T2N 4N1, Canada; Department of Biochemistry & Molecular Biology/Medical Genetics/Oncology, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada; Alberta Children's Hospital Research Institute, Calgary, AB T2N 4N1, Canada; Arnie Charbonneau Cancer Research Institute, Calgary, AB T2N 4N1, Canada; O'Brien Institute for Public Health, Calgary, AB T2N 4N1, Canada. Electronic address:

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April 2017

Disease Biomarkers for Precision Medicine: Challenges and Future Opportunities.

Genomics Proteomics Bioinformatics 2017 04 7;15(2):57-58. Epub 2017 Apr 7.

CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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April 2017

eTumorType, An Algorithm of Discriminating Cancer Types for Circulating Tumor Cells or Cell-free DNAs in Blood.

Genomics Proteomics Bioinformatics 2017 04 4;15(2):130-140. Epub 2017 Apr 4.

National Research Council Canada, Montreal, QC H4P 2R2, Canada; Department of Experimental Medicine, McGill University, Montreal, QC H3A 2B2, Canada; Center for Bioinformatics, McGill University, Montreal, QC H3G 0B1, Canada; Center for Health Genomics and Informatics, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada; Department of Biochemistry & Molecular Biology, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada; Department of Medical Genetics, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada; Department of Oncology, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada; Alberta Children's Hospital Research Institute, Calgary, AB T2N 4N1, Canada; Arnie Charbonneau Cancer Research Institute, Calgary, AB T2N 4N1, Canada; O'Brien Institute for Public Health, Calgary, AB T2N 4N1, Canada. Electronic address:

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April 2017

Characterization of the NPC1L1 gene and proteome from an exceptional responder to ezetimibe.

Atherosclerosis 2016 Mar 24;246:78-86. Epub 2015 Dec 24.

Division of Endocrinology, Jewish General Hospital, 3755 chemin Cote Ste Catherine, Montreal, H3T 1E2, QC, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 chemin Cote Ste Catherine, Montreal, H3T 1E2, QC, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, H3A 1A3, QC, Canada.

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March 2016

Identification and Construction of Combinatory Cancer Hallmark-Based Gene Signature Sets to Predict Recurrence and Chemotherapy Benefit in Stage II Colorectal Cancer.

JAMA Oncol 2016 Jan;2(1):37-45

National Research Council Canada, Montreal, Quebec, Canada3Department of Medicine, McGill University, Montreal, Quebec, Canada5McGill University Center for Bioinformatics, Montreal, Quebec, Canada.

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January 2016

The chromatin regulator Brpf1 regulates embryo development and cell proliferation.

J Biol Chem 2015 May 15;290(18):11349-64. Epub 2015 Mar 15.

From the The Rosalind and Morris Goodman Cancer Research Center, Department of Medicine, and Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, McGill University Health Center, Montreal, Quebec H3A 1A3, Canada

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May 2015

The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors.

PLoS Genet 2015 Mar 10;11(3):e1005034. Epub 2015 Mar 10.

The Rosalind & Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Biochemistry, McGill University, Montreal, Quebec, Canada; McGill University Health Center, Montreal, Quebec, Canada.

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March 2015

Glycoproteomic comparison of clinical triple-negative and luminal breast tumors.

J Proteome Res 2015 Mar 16;14(3):1376-88. Epub 2015 Feb 16.

Human Health Therapeutics, National Research Council Canada , 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.

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March 2015

Deficiency of the chromatin regulator BRPF1 causes abnormal brain development.

J Biol Chem 2015 Mar 7;290(11):7114-29. Epub 2015 Jan 7.

From the Rosalind & Morris Goodman Cancer Research Center, Department of Medicine, McGill University, Quebec H3A 1A3, the Department of Biochemistry, McGill University and McGill University Health Center, Montreal, Quebec H3A 1A3, Canada

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March 2015

Proteomic-coupled-network analysis of T877A-androgen receptor interactomes can predict clinical prostate cancer outcomes between White (non-Hispanic) and African-American groups.

PLoS One 2014 19;9(11):e113190. Epub 2014 Nov 19.

Lady Davis Institute for Medical Research, Segal Cancer Centre - Jewish General Hospital, Montréal, QC, Canada; Department of Medicine, Department of Oncology and Division of Experimental Medicine, McGill University, Montréal, QC, Canada.

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July 2015

Cancer modeling and network biology: accelerating toward personalized medicine.

Semin Cancer Biol 2015 Feb 24;30:1-3. Epub 2014 Jun 24.

National Research Council Canada, Montreal, QC H4P 2R2, Canada; Center for Bioinformatics, McGill University, Montreal, QC H3G 0B1, Canada. Electronic address:

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February 2015

Cancer systems biology and modeling: microscopic scale and multiscale approaches.

Semin Cancer Biol 2015 Feb 18;30:60-9. Epub 2014 Mar 18.

National Research Council Canada, Montreal, QC H4P 2R2, Canada; Center for Bioinformatics, McGill University, Montreal, QC H3G 0B1, Canada.

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February 2015

Targeted amplification of delivery to cell surface receptors by dendrimer self-assembly.

Bioorg Med Chem Lett 2014 Mar 31;24(5):1290-3. Epub 2014 Jan 31.

Department of Chemistry, New York University, New York, NY 10003, USA; Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address:

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March 2014

Signaling network assessment of mutations and copy number variations predict breast cancer subtype-specific drug targets.

Cell Rep 2013 Oct 26;5(1):216-23. Epub 2013 Sep 26.

National Research Council Canada, Montreal, QC H4P 2R2, Canada; Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 2B2, Canada; Center for Bioinformatics, McGill University, Montreal, QC H3G 0B1, Canada.

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October 2013

Cancer systems biology in the genome sequencing era: part 1, dissecting and modeling of tumor clones and their networks.

Semin Cancer Biol 2013 Aug 19;23(4):279-85. Epub 2013 Jun 19.

National Research Council Canada, Montreal, Canada; Center for Bioinformatics, McGill University, Montreal, Canada.

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August 2013

Target of rapamycin signaling regulates metabolism, growth, and life span in Arabidopsis.

Plant Cell 2012 Dec 28;24(12):4850-74. Epub 2012 Dec 28.

Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada.

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December 2012

Understanding genomic alterations in cancer genomes using an integrative network approach.

Authors:
Edwin Wang

Cancer Lett 2013 Nov 22;340(2):261-9. Epub 2012 Dec 22.

Lab of Bioinformatics and Systems Biology, National Research Council Canada, Montreal, Canada; McGill University Center for Bioinformatics, Montreal, Canada. Electronic address:

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November 2013

A mass spectrometry-based plasma protein panel targeting the tumor microenvironment in patients with breast cancer.

J Proteomics 2013 Apr 20;81:135-47. Epub 2012 Nov 20.

National Research Council - Human Health Therapeutics, 1411 Oxford Street, Halifax, NS, Canada B3H 3Z1.

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April 2013

An upstream interacting context based framework for the computational inference of microRNA functions.

Mol Biosyst 2012 Apr 23;8(5):1492-8. Epub 2012 Feb 23.

Department of Biomedical Informatics, School of Basic Medical Sciences, Beijing 100191, China.

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April 2012

3 Tesla turbo-FLASH magnetic resonance imaging of deglutition.

Laryngoscope 2012 Apr 17;122(4):860-4. Epub 2012 Jan 17.

New York University Voice Center, Department of Otolaryngology/Head and Neck Surgery, New York University School of Medicine, New York, New York 10016, USA.

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April 2012

Flat-panel computed tomography versus multislice computed tomography to evaluate cochlear implant positioning.

Cochlear Implants Int 2011 Nov;12(4):216-22

Department of Otolaryngolgy, University of Miami School of Medicine, Miami, FL, USA.

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November 2011

The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer.

Genome Res 2012 Jul 22;22(7):1222-30. Epub 2011 Dec 22.

Department of Biochemistry and the Siebens-Drake Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

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July 2012

A quantitative three-dimensional analysis of coronoid hypertrophy in pediatric craniofacial malformations.

Plast Reconstr Surg 2012 Feb;129(2):312e-318e

New York, N.Y.; and Santiago, Chile From the Institute of Reconstructive Plastic Surgery and Department of Radiology, New York University School of Medicine; and Department of Maxillofacial Surgery, Hospital de Salvador, Children's Hospital Exequiel González Cortés, Universidad Mayor.

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February 2012

Dynamic rewiring of the androgen receptor protein interaction network correlates with prostate cancer clinical outcomes.

Integr Biol (Camb) 2011 Oct 7;3(10):1020-32. Epub 2011 Sep 7.

Lady Davis Institute for Medical Research - Jewish General Hospital, Montreal, QC H3T 1E2, Canada.

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October 2011

Dynamic modeling and analysis of cancer cellular network motifs.

Integr Biol (Camb) 2011 Jul 15;3(7):724-32. Epub 2011 Jun 15.

Computational Chemistry and Bioinformatics Group, Biotechnology Research Institute, National Research Council Canada, 6100 Royalmount Avenue, Montreal, Quebec H4P 2R2, Canada.

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July 2011

Identification of vascular breast tumor markers by laser capture microdissection and label-free LC-MS.

J Proteome Res 2011 May 1;10(5):2479-93. Epub 2011 Apr 1.

Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, Canada.

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May 2011

Identification of high-quality cancer prognostic markers and metastasis network modules.

Nat Commun 2010 Jul 13;1:34. Epub 2010 Jul 13.

Computational Chemistry and Bioinformatics Group, Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, Canada.

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July 2010

microRNA evolution in a human transcription factor and microRNA regulatory network.

BMC Syst Biol 2010 Jun 29;4:90. Epub 2010 Jun 29.

Department of Biomedical Informatics, Peking University Health Science Center, Beijing, China.

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June 2010

Airway changes following Le Fort III distraction osteogenesis for syndromic craniosynostosis: a clinical and cephalometric study.

Plast Reconstr Surg 2009 Aug;124(2):590-601

Indianapolis, Ind.; and New York, N.Y. From the Division of Plastic Surgery, Riley Children's Hospital, Indiana University Medical Center, and the Institute of Reconstructive Plastic Surgery and the Departments of Otolaryngology and Radiology, New York University Medical Center.

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August 2009

Signaling network analysis of ubiquitin-mediated proteins suggests correlations between the 26S proteasome and tumor progression.

Mol Biosyst 2009 Dec;5(12):1809-16

College of Life Sciences, Beijing Normal University, Beijing, China.

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December 2009

Flat panel cone beam computed tomography of the sinuses.

Otolaryngol Head Neck Surg 2009 Jun;140(6):841-4

Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY 10016, USA.

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June 2009

Protein evolution on a human signaling network.

BMC Syst Biol 2009 Feb 18;3:21. Epub 2009 Feb 18.

Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, Canada.

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February 2009

Cepred: predicting the co-expression patterns of the human intronic microRNAs with their host genes.

PLoS One 2009 10;4(2):e4421. Epub 2009 Feb 10.

Department of Medical Informatics, Peking University Health Science Center, Beijing, China.

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March 2009

A map of human cancer signaling.

Mol Syst Biol 2007 18;3:152. Epub 2007 Dec 18.

Computational Chemistry and Biology Group, Biotechnology Research Institute, National Research Council Canada, Montreal, QC, Canada.

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January 2008

Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers.

Nucleic Acids Res 2007 21;35(13):4535-41. Epub 2007 Jun 21.

Health Sector, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Québec, Canada.

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August 2007

MicroRNA regulation and interspecific variation of gene expression.

Trends Genet 2007 Aug 4;23(8):372-5. Epub 2007 May 4.

Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, H4P 2R2, Canada.

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August 2007

Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos.

Nucleic Acids Res 2007 7;35(1):152-64. Epub 2006 Dec 7.

Mammalian Cell Genetics Group, Biotechnology Research Institute, National Research Council Canada Montreal, Quebec, H4P 2R2, Canada.

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February 2007

MicroRNAs preferentially target the genes with high transcriptional regulation complexity.

Biochem Biophys Res Commun 2007 Jan 27;352(3):733-8. Epub 2006 Nov 27.

Biotechnology Research Institute, National Research Council Canada, Montreal, Que., Canada H4P 2R2.

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January 2007

Principles of microRNA regulation of a human cellular signaling network.

Mol Syst Biol 2006 12;2:46. Epub 2006 Sep 12.

Computational Chemistry and Biology Group, Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, Canada.

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October 2006

Viral nanoparticles donning a paramagnetic coat: conjugation of MRI contrast agents to the MS2 capsid.

Nano Lett 2006 Jun;6(6):1160-4

Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, USA.

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June 2006

Low-grade gliomas: dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging--prediction of patient clinical response.

Radiology 2006 Feb 5;238(2):658-67. Epub 2006 Jan 5.

Department of Radiology, New York University Medical Center, MRI Department, Schwartz Building, Basement HCC, 530 First Ave, New York, NY 10016, USA.

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February 2006

Network motifs are enriched with transcription factors whose transcripts have short half-lives.

Trends Genet 2005 Sep;21(9):492-5

Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, Canada H4P 2R2.

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September 2005