Edwin K Silverman

Edwin K Silverman

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Edwin K Silverman

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Statistical considerations for the analysis of massively parallel reporter assays data.

Genet Epidemiol 2020 Jul 18. Epub 2020 Jul 18.

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/gepi.22337DOI Listing
July 2020

Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD.

Eur Respir J 2020 Jun 1. Epub 2020 Jun 1.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.1183/13993003.02347-2019DOI Listing
June 2020

Validation of a method to assess emphysema severity by spirometry in the COPDGene study.

Respir Res 2020 May 1;21(1):103. Epub 2020 May 1.

Section of Respiratory Medicine, Department of Experimental and Clinical Medicine, University of Florence, Largo A. Brambilla 3, 50134, Florence, Italy.

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http://dx.doi.org/10.1186/s12931-020-01366-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195744PMC
May 2020

Diffuse Idiopathic Skeletal Hyperostosis in Smokers and Restrictive Spirometry Pattern: An Analysis of the COPDGene Cohort.

J Rheumatol 2020 Apr 1;47(4):531-538. Epub 2019 May 1.

From the University Medical Center Utrecht and Utrecht University, Department of Radiology and Nuclear Medicine, and Department of Orthopedics, Utrecht, the Netherlands; National Jewish Health, Department of Radiology, and divisions of Oncology, Pulmonary, Critical Care, Sleep Medicine, and Rheumatology, Denver, Colorado; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Division of Pulmonary, Allergy, and Critical Care Medicine, and Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA; London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.3899/jrheum.181357DOI Listing
April 2020

Five-year Progression of Emphysema and Air Trapping at CT in Smokers with and Those without Chronic Obstructive Pulmonary Disease: Results from the COPDGene Study.

Radiology 2020 04 4;295(1):218-226. Epub 2020 Feb 4.

From the Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, PO 85500, Postbox E.03.511, Utrecht, Utrecht 3508 GA, the Netherlands (E.P.); Division of Biostatistics and Bioinformatics (M.S., B.J.M.), Department of Radiology (S.H., D.A.L.), Division of Rheumatology, Department of Medicine (E.A.R.), and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (J.D.C.), National Jewish Health, Denver, Colo; Thirona, Nijmegen, the Netherlands (E.M.v.R.); Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (E.M.v.R., J.P.C.); Departments of Biomedical Engineering, Radiology, and Internal Medicine, University of Iowa, Iowa City, Iowa (E.A.H.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); Division of Pulmonary and Critical Care, University of Michigan Health System, Ann Arbor, Mich (M.K.H.); Department of Epidemiology, University of Colorado Denver, Denver, Colo (J.E.H.); and Channing Division of Network Medicine (E.K.S.) and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, Boston, Mass.

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http://dx.doi.org/10.1148/radiol.2020191429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104704PMC
April 2020

The Network Medicine Imperative and the Need for an International Network Medicine Consortium.

Am J Med 2020 Apr 19. Epub 2020 Apr 19.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.03.034DOI Listing
April 2020

The Association of Multiparity with Lung Function and Chronic Obstructive Pulmonary Disease-Related Phenotypes.

Chronic Obstr Pulm Dis 2020 Apr;7(2):86-98

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.15326/jcopdf.7.2.2019.0166DOI Listing
April 2020

Machine Learning and Prediction of All-Cause Mortality in COPD.

Chest 2020 Apr 27. Epub 2020 Apr 27.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2020.02.079DOI Listing
April 2020

A Between Ethnicities Comparison of Chronic Obstructive Pulmonary Disease Genetic Risk.

Front Genet 2020 21;11:329. Epub 2020 Apr 21.

Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, South Korea.

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http://dx.doi.org/10.3389/fgene.2020.00329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187688PMC
April 2020

A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP.

Genet Epidemiol 2020 03 11;44(2):139-147. Epub 2019 Nov 11.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/gepi.22268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028451PMC
March 2020

Genetics of COPD.

Annu Rev Physiol 2020 02 15;82:413-431. Epub 2019 Nov 15.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; email:

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http://dx.doi.org/10.1146/annurev-physiol-021317-121224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193187PMC
February 2020

Deep Learning Enables Automatic Classification of Emphysema Pattern at CT.

Radiology 2020 02 3;294(2):434-444. Epub 2019 Dec 3.

From the Department of Radiology (S.M.H., A.M.N., J.P.C., D.A.L.), Division of Biostatistics and Bioinformatics (M.J.S.), and Department of Medicine (J.D.C.), National Jewish Health, 1400 Jackson St, Denver, CO 80206-2761; and Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass (E.K.S.).

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http://dx.doi.org/10.1148/radiol.2019191022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996603PMC
February 2020

Subtyping COPD by Using Visual and Quantitative CT Imaging Features.

Chest 2020 01 5;157(1):47-60. Epub 2019 Jul 5.

Channing Division of Network Medicine, Boston, MA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2019.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965698PMC
January 2020

Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma.

Clin Pharmacol Ther 2019 12 28;106(6):1261-1267. Epub 2019 Oct 28.

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cpt.1646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851426PMC
December 2019

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.

PLoS Genet 2019 12 23;15(12):e1008500. Epub 2019 Dec 23.

Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953885PMC
December 2019

COPDGene 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.

Authors:
Katherine E Lowe Elizabeth A Regan Antonio Anzueto Erin Austin John H M Austin Terri H Beaty Panayiotis V Benos Christopher J Benway Surya P Bhatt Eugene R Bleecker Sandeep Bodduluri Jessica Bon Aladin M Boriek Adel Re Boueiz Russell P Bowler Matthew Budoff Richard Casaburi Peter J Castaldi Jean-Paul Charbonnier Michael H Cho Alejandro Comellas Douglas Conrad Corinne Costa Davis Gerard J Criner Douglas Curran-Everett Jeffrey L Curtis Dawn L DeMeo Alejandro A Diaz Mark T Dransfield Jennifer G Dy Ashraf Fawzy Margaret Fleming Eric L Flenaugh Marilyn G Foreman Spyridon Fortis Hirut Gebrekristos Sarah Grant Philippe A Grenier Tian Gu Abhya Gupta MeiLan K Han Nicola A Hanania Nadia N Hansel Lystra P Hayden Craig P Hersh Brian D Hobbs Eric A Hoffman James C Hogg John E Hokanson Karin F Hoth Albert Hsiao Stephen Humphries Kathleen Jacobs Francine L Jacobson Ella A Kazerooni Victor Kim Woo Jin Kim Gregory L Kinney Harald Koegler Sharon M Lutz David A Lynch Neil R MacIntye Barry J Make Nathaniel Marchetti Fernando J Martinez Diego J Maselli Anne M Mathews Meredith C McCormack Merry-Lynn N McDonald Charlene E McEvoy Matthew Moll Sarah S Molye Susan Murray Hrudaya Nath John D Newell Mariaelena Occhipinti Matteo Paoletti Trisha Parekh Massimo Pistolesi Katherine A Pratte Nirupama Putcha Margaret Ragland Joseph M Reinhardt Stephen I Rennard Richard A Rosiello James C Ross Harry B Rossiter Ingo Ruczinski Raul San Jose Estepar Frank C Sciurba Jessica C Sieren Harjinder Singh Xavier Soler Robert M Steiner Matthew J Strand William W Stringer Ruth Tal-Singer Byron Thomashow Gonzalo Vegas Sánchez-Ferrero John W Walsh Emily S Wan George R Washko J Michael Wells Chris H Wendt Gloria Westney Ava Wilson Robert A Wise Andrew Yen Kendra Young Jeong Yun Edwin K Silverman James D Crapo

Chronic Obstr Pulm Dis 2019 Nov;6(5):384-399

National Jewish Health, Denver, Colorado.

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http://dx.doi.org/10.15326/jcopdf.6.5.2019.0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020846PMC
November 2019

Turning subtypes into disease axes to improve prediction of COPD progression.

Thorax 2019 09 12;74(9):906-909. Epub 2019 Jun 12.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, United States

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http://dx.doi.org/10.1136/thoraxjnl-2018-213005DOI Listing
September 2019

Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.

Authors:
Camille Moore Rachel Z Blumhagen Ivana V Yang Avram Walts Julie Powers Tarik Walker Makenna Bishop Pamela Russell Brian Vestal Jonathan Cardwell Cheryl R Markin Susan K Mathai Marvin I Schwarz Mark P Steele Joyce Lee Kevin K Brown James E Loyd James D Crapo Edwin K Silverman Michael H Cho Judith A James Joel M Guthridge Joy D Cogan Jonathan A Kropski Jeffrey J Swigris Carol Bair Dong Soon Kim Wonjun Ji Hocheol Kim Jin Woo Song Lisa A Maier Karin A Pacheco Nikhil Hirani Azin S Poon Feng Li R Gisli Jenkins Rebecca Braybrooke Gauri Saini Toby M Maher Philip L Molyneaux Peter Saunders Yingze Zhang Kevin F Gibson Daniel J Kass Mauricio Rojas John Sembrat Paul J Wolters Harold R Collard John S Sundy Thomas O'Riordan Mary E Strek Imre Noth Shwu-Fan Ma Mary K Porteous Maryl E Kreider Namrata B Patel Yoshikazu Inoue Masaki Hirose Toru Arai Shinobu Akagawa Oliver Eickelberg Isis Enlil Fernandez Jürgen Behr Nesrin Mogulkoc Tamera J Corte Ian Glaspole Sara Tomassetti Claudia Ravaglia Venerino Poletti Bruno Crestani Raphael Borie Caroline Kannengiesser Helen Parfrey Christine Fiddler Doris Rassl Maria Molina-Molina Carlos Machahua Ana Montes Worboys Gunnar Gudmundsson Helgi J Isaksson David J Lederer Anna J Podolanczuk Sydney B Montesi Elisabeth Bendstrup Vivi Danchel Moises Selman Annie Pardo Michael T Henry Michael P Keane Peter Doran Martina Vašáková Martina Sterclova Christopher J Ryerson Pearce G Wilcox Tsukasa Okamoto Haruhiko Furusawa Yasunari Miyazaki Geoffrey Laurent Svetlana Baltic Cecilia Prele Yuben Moodley Barry S Shea Ken Ohta Maho Suzukawa Osamu Narumoto Steven D Nathan Drew C Venuto Merte L Woldehanna Nurdan Kokturk Joao A de Andrade Tracy Luckhardt Tejaswini Kulkarni Francesco Bonella Seamus C Donnelly Aoife McElroy Michelle E Armstong Alvaro Aranda Roberto G Carbone Francesco Puppo Kenneth B Beckman Deborah A Nickerson Tasha E Fingerlin David A Schwartz

Am J Respir Crit Care Med 2019 07;200(2):199-208

1 National Jewish Health, Denver, Colorado.

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http://dx.doi.org/10.1164/rccm.201810-1891OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635791PMC
July 2019

DSP variants may be associated with longitudinal change in quantitative emphysema.

Respir Res 2019 Jul 19;20(1):160. Epub 2019 Jul 19.

Department of Epidemiology, Johns Hopkins School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1186/s12931-019-1097-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642569PMC
July 2019

Reported environmental exposures are inversely associated with obtaining a genetic diagnosis in the Undiagnosed Diseases Network.

Am J Med Genet A 2019 06 23;179(6):958-965. Epub 2019 Mar 23.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.61132
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http://dx.doi.org/10.1002/ajmg.a.61132DOI Listing
June 2019

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

Reply to Marruchella: Preserved Ratio Impaired Spirometry and Interstitial Lung Abnormalities in Smokers.

Am J Respir Crit Care Med 2019 05;199(10):1293-1294

1 Brigham and Women's Hospital Boston, Massachusetts and.

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http://dx.doi.org/10.1164/rccm.201901-0018LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519864PMC
May 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

Applying Functional Genomics to Chronic Obstructive Pulmonary Disease.

Ann Am Thorac Soc 2018 12;15(Suppl 4):S239-S242

Channing Division of Network Medicine and Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1513/AnnalsATS.201808-530MGDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322003PMC
December 2018

Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study.

Respir Res 2018 Oct 29;19(1):209. Epub 2018 Oct 29.

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.

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https://respiratory-research.biomedcentral.com/articles/10.1
Publisher Site
http://dx.doi.org/10.1186/s12931-018-0890-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206739PMC
October 2018

CT-based Visual Classification of Emphysema: Association with Mortality in the COPDGene Study.

Radiology 2018 09 15;288(3):859-866. Epub 2018 May 15.

From the Department of Radiology (D.A.L., D.N., T.J., S.M.H.), Division of Biostatistics (C.M.M., C.W., D.C.E.), and Department of Medicine (E.A.R., B.J.M., R.P.B., J.D.C.), National Jewish Health, 1400 Jackson St, Denver, CO 80206; Department of Radiology, Columbia University Medical Center, New York, NY (J.H.M.A.); Department of Diagnostic Radiology, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne Universités, Paris, France (P.A.G.); Department of Diagnostic and Interventional Radiology, University of Heidelberg, Translational Lung Research Center Heidelberg, Heidelberg, Germany (H.U.K.); Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Mich (M.K.H., J.L.C.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (T.H.B.); Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colo (J.E.H.); Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, Mich (J.L.C.); and Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (E.K.S.).

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http://dx.doi.org/10.1148/radiol.2018172294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122195PMC
September 2018

Distribution, temporal stability and association with all-cause mortality of the 2017 GOLD groups in the ECLIPSE cohort.

Respir Med 2018 08 19;141:14-19. Epub 2018 Jun 19.

CIBER Enfermedades Respiratorias, Spain; Institut de Recerca Biomedica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Respiratory Institute, Hospital Clinic, University of Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2018.06.015DOI Listing
August 2018

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease.

J Allergy Clin Immunol 2018 06 28;141(6):2037-2047.e10. Epub 2018 Apr 28.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183062
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http://dx.doi.org/10.1016/j.jaci.2018.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994197PMC
June 2018

Genome-wide assessment of gene-by-smoking interactions in COPD.

Sci Rep 2018 06 18;8(1):9319. Epub 2018 Jun 18.

Department of public health sciences, Seoul national university, Seoul, Korea.

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http://dx.doi.org/10.1038/s41598-018-27463-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006158PMC
June 2018

Pectoralis muscle area and mortality in smokers without airflow obstruction.

Respir Res 2018 04 10;19(1):62. Epub 2018 Apr 10.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12931-018-0771-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894181PMC
April 2018

Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.

Circ Genom Precis Med 2018 04;11(4):e002178

Cardiovascular Institute, Department of Medicine (K.M.), Department of Genetics (K.M.), and Department of Pathology and Laboratory Medicine (F.S.L.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia. Department of Pediatrics (D.B.), Cardiovascular Institute (D.B., T.Q.), and Department of Medicine (T.Q.), Stanford University, CA. Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, MO (F.S.C.). St. Louis Children's Hospital, MO (F.S.C.). Pediatric Genomics Discovery Program, Department of Pediatrics and Genetics, Yale University School of Medicine, New Haven, CT (M.K.K.). Division of Cardiology, Department of Medicine, University of Washington, Seattle (S.L.). Department of Cardiovascular Sciences, University of South Florida Morsani College of Medicine, Tampa, FL (T.V.M.). Department of Pediatrics (I.P.M.), Department of Pathology (I.P.M.), and Department of Human Genetics (I.P.M.), The University of Chicago, IL. Division of Hematology/ Oncology, Boston Children's Hospital, MA (V.G.S.). Department of Pediatric Oncology, Dana-Farber Cancer Institute (V.G.S.) and Channing Division of Network Medicine, Brigham and Women's Hospital (E.K.S., X.Z.), Harvard Medical School, Boston. Broad Institute of MIT and Harvard, Cambridge, MA (V.G.S.). University of Colorado, Aurora (D.A.S.). Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (A.A.K.H., X.-z.J.L.).

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http://dx.doi.org/10.1161/CIRCGEN.118.002178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901889PMC
April 2018

WISARD: workbench for integrated superfast association studies for related datasets.

BMC Med Genomics 2018 04 20;11(Suppl 2):39. Epub 2018 Apr 20.

Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.

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http://dx.doi.org/10.1186/s12920-018-0345-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918457PMC
April 2018

Integrative genomics identifies new genes associated with severe COPD and emphysema.

Respir Res 2018 03 22;19(1):46. Epub 2018 Mar 22.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Room 451, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12931-018-0744-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863845PMC
March 2018

Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study.

Chest 2018 02 15;153(2):368-377. Epub 2017 Dec 15.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1016/j.chest.2017.11.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815872PMC
February 2018