Edwin Choy

Edwin Choy

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Edwin Choy

Edwin Choy

Publications by authors named "Edwin Choy"

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Radiation-induced and neurofibromatosis-associated malignant peripheral nerve sheath tumors (MPNST) have worse outcomes than sporadic MPNST.

Radiother Oncol 2019 Aug 9;137:61-70. Epub 2019 May 9.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, USA; Harvard Medical School, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2019.03.015DOI Listing
August 2019

Characteristics and Predictors for Secondary Leukemia and Myelodysplastic Syndrome in Ewing and Osteosarcoma Survivors.

Int J Radiat Oncol Biol Phys 2019 01 28;103(1):52-61. Epub 2018 Aug 28.

Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.08.037DOI Listing
January 2019

A Phase 1 Study of Nilotinib Plus Radiation in High-Risk Chordoma.

Int J Radiat Oncol Biol Phys 2018 12 3;102(5):1496-1504. Epub 2018 Aug 3.

Division of Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts; Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2018.07.2013DOI Listing
December 2018

Clinicopathologic characteristics of poorly differentiated chordoma.

Mod Pathol 2018 08 26;31(8):1237-1245. Epub 2018 Feb 26.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41379-018-0002-1DOI Listing
August 2018

Author Correction: Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11.

Sci Rep 2018 Aug 9;8(1):12107. Epub 2018 Aug 9.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, Massachusetts, 02114, USA.

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http://www.nature.com/articles/s41598-018-30644-x
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http://dx.doi.org/10.1038/s41598-018-30644-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085288PMC
August 2018

CRISPR-Cas9-Mediated Silencing of CD44 in Human Highly Metastatic Osteosarcoma Cells.

Cell Physiol Biochem 2018 16;46(3):1218-1230. Epub 2018 Apr 16.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1159/000489072DOI Listing
July 2018

CDK4 expression in chordoma: A potential therapeutic target.

J Orthop Res 2018 06 22;36(6):1581-1589. Epub 2017 Dec 22.

UCLA Orthopaedic Surgery, Sarcoma Biology Laboratory, 615 Charles E Young Dr. South, Biomedical Sciences Research Building, Room 410, Los Angeles, CA 90095.

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http://dx.doi.org/10.1002/jor.23819DOI Listing
June 2018

Secondary Acute Leukemia in Sarcoma Patients: A Population-Based Study.

Int J Radiat Oncol Biol Phys 2018 03 14;100(3):687-694. Epub 2017 Nov 14.

Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2017.11.011DOI Listing
March 2018

Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells.

Oncotarget 2018 Mar 28;9(17):13154-13166. Epub 2017 Nov 28.

Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-6902, USA.

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http://dx.doi.org/10.18632/oncotarget.22743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862568PMC
March 2018

Next-Generation Sequencing for Patients with Sarcoma: A Single Center Experience.

Oncologist 2018 02 31;23(2):234-242. Epub 2017 Aug 31.

Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1634/theoncologist.2017-0290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813739PMC
February 2018

Extraskeletal osteosarcoma: A large series treated at a single institution.

Rare Tumors 2018 31;10:2036361317749651. Epub 2018 Jan 31.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1177/2036361317749651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811988PMC
January 2018

Expression and Therapeutic Potential of SOX9 in Chordoma.

Clin Cancer Res 2017 Sep 12;23(17):5176-5186. Epub 2017 Jun 12.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581713PMC
September 2017

Therapeutic applications of histone deacetylase inhibitors in sarcoma.

Cancer Treat Rev 2017 Sep 6;59:33-45. Epub 2017 Jul 6.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2017.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581728PMC
September 2017

Autophagy as a potential target for sarcoma treatment.

Biochim Biophys Acta Rev Cancer 2017 Aug 24;1868(1):40-50. Epub 2017 Feb 24.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA.. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.02.004DOI Listing
August 2017

Application of metabolomics in sarcoma: From biomarkers to therapeutic targets.

Crit Rev Oncol Hematol 2017 08 13;116:1-10. Epub 2017 May 13.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2017.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527996PMC
August 2017

Inhibition of CDK4 sensitizes multidrug resistant ovarian cancer cells to paclitaxel by increasing apoptosiss.

Cell Oncol (Dordr) 2017 Jun 27;40(3):209-218. Epub 2017 Feb 27.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St, Jackson 1115, Boston, MA, 02114, USA.

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http://link.springer.com/10.1007/s13402-017-0316-x
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http://dx.doi.org/10.1007/s13402-017-0316-xDOI Listing
June 2017

Targeting programmed cell death ligand 1 by CRISPR/Cas9 in osteosarcoma cells.

Oncotarget 2017 May;8(18):30276-30287

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston 02114, Massachusetts, USA.

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http://dx.doi.org/10.18632/oncotarget.16326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444742PMC
May 2017

Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11.

Sci Rep 2017 03 6;7:43941. Epub 2017 Mar 6.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, Massachusetts 02114USA.

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http://dx.doi.org/10.1038/srep43941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338289PMC
March 2017

Updated Outcome and Analysis of Tumor Response in Mobile Spine and Sacral Chordoma Treated With Definitive High-Dose Photon/Proton Radiation Therapy.

Int J Radiat Oncol Biol Phys 2017 02 13;97(2):254-262. Epub 2016 Oct 13.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2016.10.006DOI Listing
February 2017

miR-15b modulates multidrug resistance in human osteosarcoma in vitro and in vivo.

Mol Oncol 2017 02 24;11(2):151-166. Epub 2016 Oct 24.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://doi.wiley.com/10.1002/1878-0261.12015
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http://dx.doi.org/10.1002/1878-0261.12015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300234PMC
February 2017

Frequency and Risk Factors for Additional Lesions in the Axial Spine in Subjects With Chordoma: Indications for Screening.

Spine (Phila Pa 1976) 2017 Jan;42(1):E37-E40

*Musculoskeletal Radiology, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA †Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA ‡The Harris Center for Chordoma Care, Massachusetts General Hospital, Boston, MA §Department of Orthopedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA ¶Department of Hematology/Oncology, Massachusetts General Hospital and Harvard Medical Schoo, Boston, MA ||Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA **Department of Radiology, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/BRS.0000000000001723DOI Listing
January 2017

Clinical outcomes for patients after surgery and radiation therapy for mesenchymal chondrosarcomas.

J Surg Oncol 2016 Dec 28;114(8):982-986. Epub 2016 Oct 28.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24435DOI Listing
December 2016

Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistance.

Oncotarget 2016 Dec;7(50):83502-83513

Sarcoma Biology Laboratory, Department of Orthopaedic surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.18632/oncotarget.13148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347784PMC
December 2016

PICASSO III: A Phase III, Placebo-Controlled Study of Doxorubicin With or Without Palifosfamide in Patients With Metastatic Soft Tissue Sarcoma.

J Clin Oncol 2016 11 30;34(32):3898-3905. Epub 2016 Sep 30.

Christopher W. Ryan, Oregon Health & Science University, Portland, OR; Ofer Merimsky, Sackler School of Medicine, Tel-Aviv, Israel; Mark Agulnik, Northwestern University, Chicago, IL; Jean-Yves Blay, Centre Léon Bérard, Lyon; Antoine Italiano, Institut Bergonié, Bordeaux, France; Scott M. Schuetze, University of Michigan, Ann Arbor, MI; Brian A. Van Tine, Washington University in St Louis, St Louis, MO; Robin L. Jones and Ian R. Judson, The Royal Marsden Hospital, London, United Kingdom; Anthony D. Elias, University of Colorado-Denver, Aurora, CO; Edwin Choy, Massachusetts General Hospital; Jill Y. Buck and Francois Lebel, ZIOPHARM Oncology, Boston, MA; Thierry Alcindor, McGill University Health Center, Montreal, Quebec, Canada; Vicki L. Keedy, Vanderbilt University Medical Center, Nashville, TN; Damon R. Reed, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Robert N. Taub, Columbia University Medical Center; Jonathan J. Lewis, Samus Therapeutics and Molecular Ninja Group; Robert G. Maki, Mount Sinai School of Medicine, New York, NY; Xavier Garcia del Muro, Institut Català d'Oncologia L'Hospitalet, Barcelona, Spain; and Patrick Schöffski, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1200/JCO.2016.67.6684DOI Listing
November 2016

Evaluation of P-glycoprotein (Pgp) expression in human osteosarcoma by high-throughput tissue microarray.

J Orthop Res 2016 09 2;34(9):1606-12. Epub 2016 Feb 2.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114.

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http://dx.doi.org/10.1002/jor.23173DOI Listing
September 2016

Differences in sex distribution, anatomic location and MR imaging appearance of pediatric compared to adult chordomas.

BMC Med Imaging 2016 09 8;16(1):53. Epub 2016 Sep 8.

The Harris Center for Chordoma Care, Massachusetts General Hospital, 55 Fruit Street, Yawkey 3B, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1186/s12880-016-0149-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016865PMC
September 2016

CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 26-2016. A 28-Year-Old Woman with Back Pain and a Lesion in the Lumbar Spine.

N Engl J Med 2016 Aug;375(8):779-88

From the Department of Medicine, Division of Hematology-Oncology (E.C.), and the Departments of Orthopedic Surgery (F.J.H.), Radiation Oncology (Y.-L.C.), Radiology (D.I.R.), and Pathology (D.A.K.), Massachusetts General Hospital, and the Departments of Medicine (E.C.), Orthopedic Surgery (F.J.H.), Radiation Oncology (Y.-L.C.), Radiology (D.I.R.), and Pathology (D.A.K.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1505482DOI Listing
August 2016

Clinical and biological significance of PIM1 kinase in osteosarcoma.

J Orthop Res 2016 07 31;34(7):1185-94. Epub 2015 Dec 31.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1002/jor.23134DOI Listing
July 2016

Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo, and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel.

Mol Cancer Ther 2016 07 20;15(7):1691-701. Epub 2016 May 20.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936930PMC
July 2016

Pharmacokinetics and tolerability of NSC23925b, a novel P-glycoprotein inhibitor: preclinical study in mice and rats.

Sci Rep 2016 05 9;6:25659. Epub 2016 May 9.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/srep25659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860631PMC
May 2016

Prognostic factors in alveolar soft part sarcoma: A SEER analysis.

J Surg Oncol 2016 Apr 25;113(5):581-6. Epub 2016 Jan 25.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24183DOI Listing
April 2016

Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma.

Cancer Lett 2016 Apr 21;373(1):109-118. Epub 2016 Jan 21.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.01.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772675PMC
April 2016

Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro.

Sci Rep 2016 04 29;6:25239. Epub 2016 Apr 29.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, United States.

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http://dx.doi.org/10.1038/srep25239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850444PMC
April 2016

NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function.

Br J Pharmacol 2016 Feb 15;173(3):613-26. Epub 2016 Jan 15.

Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/bph.13395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728419PMC
February 2016

p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines.

Cancer Chemother Pharmacol 2016 Feb 23;77(2):349-56. Epub 2015 Dec 23.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, 100 Blossom St., Jackson 1115, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00280-015-2944-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749432PMC
February 2016

Targeting protein kinases to reverse multidrug resistance in sarcoma.

Cancer Treat Rev 2016 Feb 8;43:8-18. Epub 2015 Dec 8.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735639PMC
February 2016

Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone.

Am J Surg Pathol 2016 Jan;40(1):72-80

*Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA †Department of Pathology, Miller School of Medicine, Jackson Memorial Hospital, University of Miami, Miami, FL ‡Department of Radiology §Department of Medicine, Division of Oncology ∥Department of Orthopaedics ¶Department of Pathology, Massachusetts General Hospital, Boston, MA.

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http://pdfs.journals.lww.com/ajsp/2016/01000/Denosumab_treat
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0000000000000506DOI Listing
January 2016

Tibial stress reaction presenting as bilateral shin pain in a man taking denosumab for giant cell tumor of the bone.

Bone 2015 Dec 25;81:31-35. Epub 2015 Jun 25.

Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Address-55 Fruit Street Bulfinch 165, Boston, MA 02114, United States.

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http://dx.doi.org/10.1016/j.bone.2015.06.017DOI Listing
December 2015

The emerging roles and therapeutic potential of microRNAs (miRs) in liposarcoma.

Discov Med 2015 Nov;20(111):311-24

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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November 2015

Cluster of Differentiation 44 Targeted Hyaluronic Acid Based Nanoparticles for MDR1 siRNA Delivery to Overcome Drug Resistance in Ovarian Cancer.

Pharm Res 2015 Jun 17;32(6):2097-109. Epub 2014 Dec 17.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St, Jackson 1115, Boston, Massachusetts, 02114, USA.

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http://link.springer.com/10.1007/s11095-014-1602-1
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http://dx.doi.org/10.1007/s11095-014-1602-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425596PMC
June 2015

CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma.

Sci Rep 2015 Jun 16;5:11365. Epub 2015 Jun 16.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.

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http://www.nature.com/articles/srep11365
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http://dx.doi.org/10.1038/srep11365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468826PMC
June 2015

Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma.

Oncotarget 2015 May;6(13):11139-49

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Jackson, Boston, Massachusetts, USA.

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http://www.oncotarget.com/fulltext/3576
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484445PMC
http://dx.doi.org/10.18632/oncotarget.3576DOI Listing
May 2015

NSC23925 prevents the emergence of multidrug resistance in ovarian cancer in vitro and in vivo.

Gynecol Oncol 2015 Apr 10;137(1):134-42. Epub 2015 Feb 10.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2015.02.002DOI Listing
April 2015

MicroRNA-155 expression is independently predictive of outcome in chordoma.

Oncotarget 2015 Apr;6(11):9125-39

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496207PMC
http://dx.doi.org/10.18632/oncotarget.3273DOI Listing
April 2015

MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer.

Sci Rep 2015 Feb 17;5:8509. Epub 2015 Feb 17.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.

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http://dx.doi.org/10.1038/srep08509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330541PMC
February 2015

Sarcoma after 5 years of progression-free survival: lessons from the French sarcoma group.

Authors:
Edwin Choy

Cancer 2014 Oct 18;120(19):2942-3. Epub 2014 Jun 18.

Division of Hematology Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.28834DOI Listing
October 2014

A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.

BMC Cancer 2014 Sep 19;14:681. Epub 2014 Sep 19.

Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, 100 Blossom St,, Jackson 1115, Boston 02114, MA, USA.

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http://dx.doi.org/10.1186/1471-2407-14-681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177239PMC
September 2014

Targeting programmed cell death ligand 1 in osteosarcoma: an auto-commentary on therapeutic potential.

Oncoimmunology 2014;3(8):e954467. Epub 2014 Aug 3.

Sarcoma Biology Laboratory; Center for Sarcoma and Connective Tissue Oncology; Massachusetts General Hospital ; Boston, MA USA.

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http://dx.doi.org/10.4161/21624011.2014.954467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292524PMC
August 2014

Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordoma.

PLoS One 2013 23;8(9):e75851. Epub 2013 Sep 23.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Pathology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075851PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781148PMC
July 2014

Programmed cell death ligand 1 expression in osteosarcoma.

Cancer Immunol Res 2014 Jul 21;2(7):690-698. Epub 2014 Apr 21.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, United States.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082476PMC
July 2014

MRI surveillance following treatment of extremity soft tissue sarcoma.

J Surg Oncol 2014 May 24;109(6):593-6. Epub 2013 Dec 24.

Harvard Radiation Oncology Program, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.23541DOI Listing
May 2014

Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma.

J Orthop Res 2014 May 5;32(5):695-701. Epub 2014 Feb 5.

Sarcoma Biology Laboratory, Department of Orthopedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, 02114.

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http://dx.doi.org/10.1002/jor.22589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049352PMC
May 2014

Comparison of performance of various tumour response criteria in assessment of regorafenib activity in advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib.

Eur J Cancer 2014 Mar 2;50(5):981-6. Epub 2014 Jan 2.

Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, United States; Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02215, United States; Ludwig Center and Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, United States.

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http://dx.doi.org/10.1016/j.ejca.2013.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242716PMC
March 2014

Biosimilar safety considerations in clinical practice.

Semin Oncol 2014 Feb 6;41 Suppl 1:S3-14. Epub 2013 Dec 6.

Pfizer Emerging Markets/Established Products Medicines Development Group, New York, NY.

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http://dx.doi.org/10.1053/j.seminoncol.2013.12.001DOI Listing
February 2014

Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells.

Cancer Lett 2014 Jan 2;342(1):104-12. Epub 2013 Sep 2.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Pharmacology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

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http://dx.doi.org/10.1016/j.canlet.2013.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128631PMC
January 2014

Update in treatment and targets in Ewing sarcoma.

Hematol Oncol Clin North Am 2013 Oct 3;27(5):1007-19. Epub 2013 Aug 3.

Division of Hematology Oncology, Yawkey Center for Outpatient Care, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.hoc.2013.07.001DOI Listing
October 2013

Role of epigenetic modulation for the treatment of sarcoma.

Curr Treat Options Oncol 2013 Sep;14(3):454-64

, 32 Fruit Street, Yawkey 7A, Boston, MA, 02114, USA,

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http://dx.doi.org/10.1007/s11864-013-0239-3DOI Listing
September 2013

Targeting hedgehog-GLI-2 pathway in osteosarcoma.

J Orthop Res 2013 Mar 11;31(3):502-9. Epub 2012 Sep 11.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1002/jor.22230DOI Listing
March 2013

Desmoid tumor: analysis of prognostic factors and outcomes in a surgical series.

Ann Surg Oncol 2012 Dec 11;19(13):4028-35. Epub 2012 Sep 11.

Division of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1245/s10434-012-2638-2DOI Listing
December 2012

Establishment and characterization of a novel chordoma cell line: CH22.

J Orthop Res 2012 Oct 13;30(10):1666-73. Epub 2012 Apr 13.

Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/jor.22113DOI Listing
October 2012

Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation.

Clin Cancer Res 2012 Sep 12;18(17):4580-8. Epub 2012 Jul 12.

Center for Sarcoma and Connective Tissue Oncology and Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1157DOI Listing
September 2012

High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes.

Cancer 2012 Jun 17;118(11):2905-14. Epub 2011 Oct 17.

Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1002/cncr.26617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272156PMC
June 2012

Synthesis and evaluation of (2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol (NSC23925) isomers to reverse multidrug resistance in cancer.

J Med Chem 2012 Apr 22;55(7):3113-21. Epub 2012 Mar 22.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://pubs.acs.org/doi/10.1021/jm300117u
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http://dx.doi.org/10.1021/jm300117uDOI Listing
April 2012

ROCK1 as a potential therapeutic target in osteosarcoma.

J Orthop Res 2011 Aug 8;29(8):1259-66. Epub 2011 Mar 8.

Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1002/jor.21403DOI Listing
August 2011

MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration.

Mol Cancer Ther 2011 Aug 10;10(8):1337-45. Epub 2011 Jun 10.

Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711153PMC
August 2011

Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo.

Anticancer Drugs 2011 Jun;22(5):444-53

Department of Orthopaedic Surgery, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1097/CAD.0b013e32834513f4DOI Listing
June 2011

Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines.

Anticancer Res 2011 Apr;31(4):1115-23

Department of Orthopaedic Surgery, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744220PMC
April 2011

Effects of siltuximab on the IL-6-induced signaling pathway in ovarian cancer.

Clin Cancer Res 2010 Dec 10;16(23):5759-69. Epub 2010 Aug 10.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1095DOI Listing
December 2010

Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.

Mol Cancer Ther 2010 Dec 29;9(12):3342-50. Epub 2010 Sep 29.

Department of Orthopaedic Surgery, and SarcomaBiology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0637DOI Listing
December 2010