Edwin Chen

Edwin Chen

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Edwin Chen

Publications by authors named "Edwin Chen"

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Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN.

Blood 2018 02 29;131(7):782-786. Epub 2017 Dec 29.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1182/blood-2017-08-800896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814933PMC
February 2018

Native Mass Spectrometry, Ion mobility, and Collision-Induced Unfolding Categorize Malaria Antigen/Antibody Binding.

J Am Soc Mass Spectrom 2017 11 5;28(11):2515-2518. Epub 2017 Sep 5.

Department of Chemistry, Washington University in St. Louis, St. Louis, MO, 63130, USA.

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http://dx.doi.org/10.1007/s13361-017-1782-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647250PMC
November 2017

Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein.

Proc Natl Acad Sci U S A 2016 May 18;113(22):6277-82. Epub 2016 May 18.

Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine in St. Louis, St. Louis, MO 63110

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http://dx.doi.org/10.1073/pnas.1600488113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896725PMC
May 2016

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.

Cancer Discov 2016 Apr 7;6(4):368-81. Epub 2016 Mar 7.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Broad Institute, Cambridge, Massachusetts. Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851866PMC
April 2016

STAT1 activation in association with JAK2 exon 12 mutations.

Haematologica 2016 Jan 3;101(1):e15-9. Epub 2015 Dec 3.

Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, UK Department of Haematology, Addenbrooke's Hospital, UK Department of Haematology, University of Cambridge, Cambridge, UK

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http://dx.doi.org/10.3324/haematol.2015.128546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697901PMC
January 2016

RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability.

Cell Rep 2015 Dec 10;13(11):2345-2352. Epub 2015 Dec 10.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Broad Institute of the Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142; Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691544PMC
December 2015

Structural analysis of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for Plasmodium vivax malaria vaccine design.

PLoS Negl Trop Dis 2015 Mar 20;9(3):e0003644. Epub 2015 Mar 20.

Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, Saint Louis, Missouri, United States of America; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368114PMC
March 2015

Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.

PLoS One 2014 26;9(2):e89649. Epub 2014 Feb 26.

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada ; Department of Molecular and Cellular Biology, Sunnybrook Research Institute, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089649PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935916PMC
January 2015

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.

Blood 2015 Jan 3;125(2):327-35. Epub 2014 Oct 3.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Broad Institute, Cambridge, MA.

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http://dx.doi.org/10.1182/blood-2014-04-567024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287639PMC
January 2015

How does JAK2V617F contribute to the pathogenesis of myeloproliferative neoplasms?

Hematology Am Soc Hematol Educ Program 2014 Dec 18;2014(1):268-76. Epub 2014 Nov 18.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1182/asheducation-2014.1.268DOI Listing
December 2014

Postnatal Notch1 activation induces T‑cell malignancy in conditional and inducible mouse models.

Int J Oncol 2014 Nov 29;45(5):1997-2004. Epub 2014 Aug 29.

Molecular and Cellular Biology Division, Sunnybrook Health Science Centre, Toronto, ON M4N 3M5, Canada.

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http://dx.doi.org/10.3892/ijo.2014.2626DOI Listing
November 2014

JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response.

Proc Natl Acad Sci U S A 2014 Oct 6;111(42):15190-5. Epub 2014 Oct 6.

Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Cambridge Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom; and

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http://dx.doi.org/10.1073/pnas.1401873111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210350PMC
October 2014

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease.

Blood 2014 May 1;123(20):3139-51. Epub 2014 Apr 1.

Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom;

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-06-51
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http://dx.doi.org/10.1182/blood-2013-06-510222DOI Listing
May 2014

Structural and functional basis for inhibition of erythrocyte invasion by antibodies that target Plasmodium falciparum EBA-175.

PLoS Pathog 2013 23;9(5):e1003390. Epub 2013 May 23.

Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1003390
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http://dx.doi.org/10.1371/journal.ppat.1003390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662668PMC
December 2013

The transcription factor encyclopedia.

Authors:
Dimas Yusuf Stefanie L Butland Magdalena I Swanson Eugene Bolotin Amy Ticoll Warren A Cheung Xiao Yu Cindy Zhang Christopher T D Dickman Debra L Fulton Jonathan S Lim Jake M Schnabl Oscar H P Ramos Mireille Vasseur-Cognet Charles N de Leeuw Elizabeth M Simpson Gerhart U Ryffel Eric W-F Lam Ralf Kist Miranda S C Wilson Raquel Marco-Ferreres Jan J Brosens Leonardo L Beccari Paola Bovolenta Bérénice A Benayoun Lara J Monteiro Helma D C Schwenen Lars Grontved Elizabeth Wederell Susanne Mandrup Reiner A Veitia Harini Chakravarthy Pamela A Hoodless M Michela Mancarelli Bruce E Torbett Alison H Banham Sekhar P Reddy Rebecca L Cullum Michaela Liedtke Mario P Tschan Michelle Vaz Angie Rizzino Mariastella Zannini Seth Frietze Peggy J Farnham Astrid Eijkelenboom Philip J Brown David Laperrière Dominique Leprince Tiziana de Cristofaro Kelly L Prince Marrit Putker Luis del Peso Gieri Camenisch Roland H Wenger Michal Mikula Marieke Rozendaal Sylvie Mader Jerzy Ostrowski Simon J Rhodes Capucine Van Rechem Gaylor Boulay Sam W Z Olechnowicz Mary B Breslin Michael S Lan Kyster K Nanan Michael Wegner Juan Hou Rachel D Mullen Stephanie C Colvin Peter John Noy Carol F Webb Matthew E Witek Scott Ferrell Juliet M Daniel Jason Park Scott A Waldman Daniel J Peet Michael Taggart Padma-Sheela Jayaraman Julien J Karrich Bianca Blom Farhad Vesuna Henriette O'Geen Yunfu Sun Richard M Gronostajski Mark W Woodcroft Margaret R Hough Edwin Chen G Nicholas Europe-Finner Magdalena Karolczak-Bayatti Jarrod Bailey Oliver Hankinson Venu Raman David P LeBrun Shyam Biswal Christopher J Harvey Jason P DeBruyne John B Hogenesch Robert F Hevner Christophe Héligon Xin M Luo Marissa Cathleen Blank Kathleen Joyce Millen David S Sharlin Douglas Forrest Karin Dahlman-Wright Chunyan Zhao Yuriko Mishima Satrajit Sinha Rumela Chakrabarti Elodie Portales-Casamar Frances M Sladek Philip H Bradley Wyeth W Wasserman

Genome Biol 2012 ;13(3):R24

Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada.

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http://digital.csic.es/bitstream/10261/53044/2/gb-2012-13-3-
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http://genomebiology.com/2012/13/3/R24
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http://dx.doi.org/10.1186/gb-2012-13-3-r24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439975PMC
September 2012

Janus kinase deregulation in leukemia and lymphoma.

Immunity 2012 Apr;36(4):529-41

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/j.immuni.2012.03.017DOI Listing
April 2012

Mouse models of myeloproliferative neoplasms: JAK of all grades.

Dis Model Mech 2011 May;4(3):311-7

Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.006817
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http://dx.doi.org/10.1242/dmm.006817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097453PMC
May 2011

Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling.

Cancer Cell 2010 Nov;18(5):524-35

Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1016/j.ccr.2010.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996868PMC
November 2010

Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.

Mol Cancer 2010 Sep 16;9:246. Epub 2010 Sep 16.

Institute of Medical Science, University of Toronto, Toronto, Ontario M5S1A8, Canada.

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http://dx.doi.org/10.1186/1476-4598-9-246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949800PMC
September 2010

Descemet's stripping automated endothelial keratoplasty: innovations in surgical technique.

Curr Opin Ophthalmol 2010 Jul;21(4):283-7

Cornea Service, Wills Eye Institute, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1097/ICU.0b013e32833a8cc9DOI Listing
July 2010

ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling.

Blood 2009 Aug 1;114(9):1820-30. Epub 2009 Jul 1.

Department of Hematology, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2009-02-206573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942052PMC
August 2009

Endothelial keratoplasty: vision, endothelial survival, and complications in a comparative case series of fellows vs attending surgeons.

Am J Ophthalmol 2009 Jul 17;148(1):26-31.e2. Epub 2009 Apr 17.

Spectrum Eye Physicians, San Jose, California 95129, USA.

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http://dx.doi.org/10.1016/j.ajo.2009.01.022DOI Listing
July 2009

Precut tissue for Descemet's stripping automated endothelial keratoplasty: vision, astigmatism, and endothelial survival.

Ophthalmology 2009 Feb 16;116(2):248-56. Epub 2008 Dec 16.

Devers Eye Institute, Portland, Oregon 97210, USA.

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http://dx.doi.org/10.1016/j.ophtha.2008.09.017DOI Listing
February 2009

Epithelial downgrowth after Descemet-stripping automated endothelial keratoplasty.

J Cataract Refract Surg 2009 Jan;35(1):193-6

Devers Eye Institute, 1040 Northwest 22nd Avenue, Portland, Oregon 97210, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S088633500800988
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http://dx.doi.org/10.1016/j.jcrs.2008.07.036DOI Listing
January 2009

Endothelial keratoplasty a simplified technique to minimize graft dislocation, iatrogenic graft failure, and pupillary block.

Ophthalmology 2008 Jul 3;115(7):1179-86. Epub 2007 Dec 3.

Devers Eye Institute, Portland, Oregon 97210, USA.

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http://dx.doi.org/10.1016/j.ophtha.2007.09.005DOI Listing
July 2008

Descemet-stripping endothelial keratoplasty: improvement in vision following replacement of a healthy endothelial graft.

J Cataract Refract Surg 2008 Jun;34(6):1044-6

Spectrum Eye Physicians, San Jose, California 95129, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S088633500800254
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http://dx.doi.org/10.1016/j.jcrs.2008.01.030DOI Listing
June 2008

Endothelial keratoplasty: improvement of vision after healthy donor tissue exchange.

Cornea 2008 Apr;27(3):279-82

Devers Eye Institute, Portland, OR 97210, USA.

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http://dx.doi.org/10.1097/ICO.0b013e31815be9e0DOI Listing
April 2008

Endothelial cell loss after Descemet's stripping endothelial keratoplasty in a large prospective series.

Ophthalmology 2008 Mar 27;115(3):488-496.e3. Epub 2007 Dec 27.

Corneal Services, Devers Eye Institute, Portland, Oregon 97210, USA.

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http://dx.doi.org/10.1016/j.ophtha.2007.10.035DOI Listing
March 2008

Precut tissue in Descemet's stripping automated endothelial keratoplasty donor characteristics and early postoperative complications.

Ophthalmology 2008 Mar 25;115(3):497-502. Epub 2008 Jan 25.

Devers Eye Institute, Portland, Oregon 97210, USA.

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http://dx.doi.org/10.1016/j.ophtha.2007.11.032DOI Listing
March 2008

Endothelial keratoplasty: first report of a ruptured globe after deep lamellar endothelial keratoplasty.

Cornea 2007 Aug;26(7):874-5

Devers Eye Institute, Portland, OR 97210, USA.

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http://dx.doi.org/10.1097/ICO.0b013e31806c7981DOI Listing
August 2007

Gene expression profiling in the inductive human hematopoietic microenvironment.

Biochem Biophys Res Commun 2004 Oct;323(2):703-11

Department of Molecular and Cellular Biology, Sunnybrook and Women's College Health Science Centre, Toronto, Ont., Canada.

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http://dx.doi.org/10.1016/j.bbrc.2004.08.140DOI Listing
October 2004

Risk factors for overweight in five- to six-year-old Hispanic-American children: a pilot study.

J Urban Health 2004 Mar;81(1):150-61

Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Children's Memorial Hospital, #157, 2300 Children's Plaza, Chicago, IL 60614, USA.

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http://link.springer.com/content/pdf/10.1093%2Fjurban%2Fjth0
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http://link.springer.com/10.1093/jurban/jth091
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http://dx.doi.org/10.1093/jurban/jth091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456141PMC
March 2004

Urinary p-nitrophenol as a biomarker of household exposure to methyl parathion.

Environ Health Perspect 2002 Dec;110 Suppl 6:1041-6

Great Lakes Center for Occupational and Environmental Safety and Health, University of Illinois School of Public Health, Chicago, Illinois 60612, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241290PMC
http://dx.doi.org/10.1289/ehp.02110s61041DOI Listing
December 2002

Smoking among Chinese Americans: behavior, knowledge, and beliefs.

Am J Public Health 2002 Jun;92(6):1007-12

Division of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, San Diego, CA 92182, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447502PMC
http://dx.doi.org/10.2105/ajph.92.6.1007DOI Listing
June 2002

Assessment of the diet quality of middle-aged and older adult Korean Americans living in Chicago.

J Am Diet Assoc 2002 Apr;102(4):552-4

American Dietetic Association, Chicago, IL, USA.

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http://dx.doi.org/10.1016/s0002-8223(02)90128-8DOI Listing
April 2002

Breast Cancer Screening Knowledge and Practices Among Korean American Women.

Asian Am Pac Isl J Health 1998 ;6(2):263-275

Grand Valley State University, 1450 Broadview Drive, Jenison, MI 49428, USA.

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January 1998