Publications by authors named "Edward M Kennedy"

50Publications

Epitranscriptomic Addition of mC to HIV-1 Transcripts Regulates Viral Gene Expression.

Cell Host Microbe 2019 08;26(2):217-227.e6

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714563PMC
August 2019

Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression.

mBio 2019 06 11;10(3). Epub 2019 Jun 11.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.01209-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561033PMC
June 2019

Targeting HPV16 DNA using CRISPR/Cas inhibits anal cancer growth .

Future Virol 2018 Jul 12;13(7):475-482. Epub 2018 Jun 12.

Departments of Medicine & Molecular Genetics & Microbiology, Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.2217/fvl-2018-0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136077PMC
July 2018

Influenza A virus-derived siRNAs increase in the absence of NS1 yet fail to inhibit virus replication.

RNA 2018 09 14;24(9):1172-1182. Epub 2018 Jun 14.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://rnajournal.cshlp.org/lookup/doi/10.1261/rna.066332.11
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http://dx.doi.org/10.1261/rna.066332.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097656PMC
September 2018

Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication.

Cell Host Microbe 2017 Sep;22(3):377-386.e5

Department of Molecular Genetics & Microbiology and Center for Virology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615858PMC
September 2017

A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor.

Cell Rep 2017 08;20(7):1503-1512

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568676PMC
August 2017

A lentiviral vector bearing a reverse intron demonstrates superior expression of both proteins and microRNAs.

RNA Biol 2017 11 21;14(11):1570-1579. Epub 2017 Jul 21.

a Department of Molecular Genetics & Microbiology and Center for Virology , Duke University Medical Center , Durham , North Carolina , USA.

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http://dx.doi.org/10.1080/15476286.2017.1334755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785219PMC
November 2017

Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.

Cell 2017 03;169(1):72-84.e13

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Center for RNA Biology, Duke University, Durham, NC 27710, USA; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456452PMC
March 2017

Viral Epitranscriptomics.

J Virol 2017 05 13;91(9). Epub 2017 Apr 13.

Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/JVI.02263-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391447PMC
May 2017

Induced Packaging of Cellular MicroRNAs into HIV-1 Virions Can Inhibit Infectivity.

mBio 2017 01 17;8(1). Epub 2017 Jan 17.

Center for Virology and Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.02125-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241401PMC
January 2017

Partial reconstitution of the RNAi response in human cells using Drosophila gene products.

RNA 2017 02 11;23(2):153-160. Epub 2016 Nov 11.

Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1261/rna.059345.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238790PMC
February 2017

N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.

Cell Host Microbe 2016 Nov 20;20(5):654-665. Epub 2016 Oct 20.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123813PMC
November 2016

Gene Editing: A New Tool for Viral Disease.

Annu Rev Med 2017 01 26;68:401-411. Epub 2016 Aug 26.

Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina 27710; email: ,

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http://dx.doi.org/10.1146/annurev-med-051215-031129DOI Listing
January 2017

SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells.

Virology 2016 08 14;495:92-100. Epub 2016 May 14.

Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912869PMC
August 2016

Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression.

Cell Host Microbe 2016 05 21;19(5):675-85. Epub 2016 Apr 21.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867121PMC
May 2016

Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators.

Proc Natl Acad Sci U S A 2015 Dec 14;112(52):E7249-56. Epub 2015 Dec 14.

Department of Molecular Genetics and Microbiology, Center for Virology, Duke University Medical Center, Durham, NC 27710

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http://www.pnas.org/lookup/doi/10.1073/pnas.1516305112
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http://dx.doi.org/10.1073/pnas.1516305112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703010PMC
December 2015

Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer.

Proc Natl Acad Sci U S A 2015 Dec 30;112(50):E6945-54. Epub 2015 Nov 30.

Department of Molecular Genetics & Microbiology, Center for Virology, Duke University Medical Center, Durham, NC 27710

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http://dx.doi.org/10.1073/pnas.1513421112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687602PMC
December 2015

Targeting hepatitis B virus cccDNA using CRISPR/Cas9.

Antiviral Res 2015 Nov 22;123:188-92. Epub 2015 Oct 22.

Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1016/j.antiviral.2015.10.004DOI Listing
November 2015

Optimization of a multiplex CRISPR/Cas system for use as an antiviral therapeutic.

Methods 2015 Dec 17;91:82-86. Epub 2015 Aug 17.

Department of Molecular Genetics & Microbiology and Center for Virology, Duke University Medical Center, Durham, NC 27710, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2015.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684739PMC
December 2015

Expression of CRISPR/Cas single guide RNAs using small tRNA promoters.

RNA 2015 Sep 17;21(9):1683-9. Epub 2015 Jul 17.

Department of Molecular Genetics & Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1261/rna.051631.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536327PMC
September 2015

Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment.

Virology 2015 May 7;479-480:213-20. Epub 2015 Mar 7.

Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, NC, USA. Electronic address:

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https://sites.duke.edu/cullenlaboratory/files/2015/11/Kenned
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http://linkinghub.elsevier.com/retrieve/pii/S004268221500070
Publisher Site
http://dx.doi.org/10.1016/j.virol.2015.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424069PMC
May 2015

Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from ribonucleoside-containing DNA template.

Antiviral Res 2015 Mar 31;115:75-82. Epub 2014 Dec 31.

Center for Drug Discovery, Emory Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2014.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323949PMC
March 2015

Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease.

Virology 2015 Feb 29;476:196-205. Epub 2014 Dec 29.

Department of Molecular Genetics & Microbiology and Center for Virology, Duke University Medical Center, Durham, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323668PMC
February 2015

Derivation and characterization of Dicer- and microRNA-deficient human cells.

RNA 2014 Jun 22;20(6):923-37. Epub 2014 Apr 22.

Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1261/rna.044545.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024645PMC
June 2014

Differential RISC association of endogenous human microRNAs predicts their inhibitory potential.

Nucleic Acids Res 2014 Apr 23;42(7):4629-39. Epub 2014 Jan 23.

Department of Molecular Genetics & Microbiology and Center for Virology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1093/nar/gkt1393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985621PMC
April 2014

Effect of ribonucleotides embedded in a DNA template on HIV-1 reverse transcription kinetics and fidelity.

J Biol Chem 2013 May 11;288(18):12522-32. Epub 2013 Mar 11.

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M113.458398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642300PMC
May 2013

The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents.

Mol Biol Int 2012 1;2012:625983. Epub 2012 Jul 1.

Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30022, USA.

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http://dx.doi.org/10.1155/2012/625983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395185PMC
August 2012

Frequent incorporation of ribonucleotides during HIV-1 reverse transcription and their attenuated repair in macrophages.

J Biol Chem 2012 Apr 1;287(17):14280-8. Epub 2012 Mar 1.

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M112.348482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340154PMC
April 2012

The impact of molecular manipulation in residue 114 of human immunodeficiency virus type-1 reverse transcriptase on dNTP substrate binding and viral replication.

Virology 2012 Jan 5;422(2):393-401. Epub 2011 Dec 5.

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.virol.2011.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804253PMC
January 2012

Abundant non-canonical dUTP found in primary human macrophages drives its frequent incorporation by HIV-1 reverse transcriptase.

J Biol Chem 2011 Jul 31;286(28):25047-55. Epub 2011 Mar 31.

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M111.234047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137078PMC
July 2011

The mechanistic architecture of thermostable Pyrococcus furiosus family B DNA polymerase motif A and its interaction with the dNTP substrate.

Biochemistry 2009 Dec;48(47):11161-8

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1021/bi9010122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097049PMC
December 2009

'The cause of my life.' Inside the fight for universal healthcare.

Authors:
Edward M Kennedy

Newsweek 2009 Jul;154(4):34-9

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July 2009

Functional analysis of NsrR, a nitric oxide-sensing Rrf2 repressor in Neisseria gonorrhoeae.

Mol Microbiol 2009 Jan;71(1):227-39

Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Rochester, NY, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2008.06522.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630374PMC
January 2009

Risk management and intrusions on medical practice: striking a balance.

Health Aff (Millwood) 2007 May-Jun;26(3):678-80

Senate Health, Education, Labor, and Pensions Committee, USA.

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http://dx.doi.org/10.1377/hlthaff.26.3.678DOI Listing
July 2007

Public health: an essential commitment to the nation.

Authors:
Edward M Kennedy

J Public Health Manag Pract 2007 Mar-Apr;13(2):93-4

United States Senate, Washington, District of Columbia 20510, USA.

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http://dx.doi.org/10.1097/00124784-200703000-00002DOI Listing
May 2007

The role of the federal government in eliminating health disparities.

Authors:
Edward M Kennedy

Health Aff (Millwood) 2005 Mar-Apr;24(2):452-8

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http://dx.doi.org/10.1377/hlthaff.24.2.452DOI Listing
May 2005

The need for FDA regulation of tobacco products.

Authors:
Edward M Kennedy

Yale J Health Policy Law Ethics 2002 ;3(1):101-8

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July 2003

Sterilization regulations.

Authors:
Edward M Kennedy

Congr Rec (Dly Ed) 1977 Dec;123(197):S19808-14

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December 1977

Legislation to regulate and control recombinant DNA research.

Authors:
Edward M Kennedy

Congr Rec (Dly Ed) 1977 Apr;123(58):S5335-7

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April 1977

A letter to the President on recombinant DNA research.

Boston Univ J 1976 ;24(3):22-3

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April 1979